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Morphine induces dysfunction of PINK1/Parkin-mediated mitophagy in spinal cord neurons implying involvement in antinociceptive tolerance

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Journal of Molecular Cell Biology 2019年第12期11卷 1056-1068页

作者： Hong Kong Chun-yi Jiang Liang Hu Peng Teng yan Zhang xiu-xiu Pan xiao-Di Sun Wen-Tao Liu Neuroprotective Drug Discovery Key Laboratory of Nanjing Medical University Department of PharmacologyNanjing Medical UniversityNanjingChina Research Division of Pharmacology China Pharmaceutical UniversityNanjingChina Department of Anesthesiology The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina Department of Pharmacy Sir Run Run Shaw Hospital Affiliated to Nanjing Medical UniversityNanjingChina

The development of opioid-induced analgesic tolerance is a clinical challenge in long-term use for managing chronic pain. The mechanisms of morphine tolerance are poorly understood. Mitochondria-derived reactive oxygen species (ROS) is a crucial signal inducing analgesic tolerance and pain. Chronic administration of morphine leads to robust ROS production and accumulation of damaged mitochondria, which are immediately removed by mitophagy. Here, we show that morphine inhibits mitochondria damage-induced accumulation of PTEN-induced putative kinase 1 (PINK1) in neurons. It interrupts the recruitment of Parkin to the impaired mitochondria and inhibits the ubiquitination of mitochondrial proteins catalyzed by Parkin. Consequently, morphine suppresses the recognition of autophagosomes to the damaged mitochondria mediated by LC3 and sequestosome-1 (SQSTM1/p62). Thus, morphine inhibits autophagy flux and leads to the accumulation of SQSTM1/p62. Finally, the impaired mitochondria cannot be delivered to lysosomes for degradation and ultimately induces robust ROS production and morphine tolerance. Our findings suggest that the dysfunction of mitophagy is involved in morphine tolerance. The deficiency of PINK1/Parkin-mediated clearance of damaged mitochondria is crucial for the generation of excessive ROS and important to the development of analgesic tolerance. These findings suggest that the compounds capable of stabilizing PINK1 or restoring mitophagy may be utilized to prevent or reduce opioid tolerance during chronic pain management.

关键词： mitophagy PINK1 Parkin ROS SQSTM1/p62 morphine tolerance

The Optimal Investment,Liability and Dividends in Insurance

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Journal of the Operations Research Society of China 2021年第2期9卷 395-409页

作者： Ping-Jin Deng xiu-Fang Li xiao-Wei Chen School of Finance Collaborative Innovation Center for China EconomyNankai UniversityTianjin 300071China

In this paper,we build an optimal control model with the objective to maximize the expected value of the time discount utility by selecting optimal investment,liability and dividend strategies for insurance *** then use the techniques from Merton(J Econ Theory 3(4):373–413,1971)to solve our optimal control problem and deduce the optimal control ***,we analyze the economic impacts on the optimal controls of the parameters in insurance market.

关键词： Asset and liability management Optimal dividends HJB equation

A Comprehensive Lagrangian Transport Study in A Long-Narrow Bay,xiangshan Bay,China

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China Ocean Engineering 2020年第4期34卷 581-588页

作者： HAN Song-lin LIANG Shu-xiu WANG xing-gang SUN Zhao-chen Hydraulics Department Changjiang River Scientific Research InstituteWuhan 430010China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Nanjing Hydraulic Research Institute Nanjing 210029China

Study on the transport and mixing in coastal waters is of great concern to the ocean resources exploitation and ecological system *** methods are direct and effective of researching mass *** Lagrangian tools were adopted and combined to describe water transport in a long-narrow bay,xiangshan Bay,*** on the fields of tidal velocity simulated from the 3-D hydrodynamic model,Lagrangian Coherent Structures(LCSs)and synoptic Lagrangian maps(SLMs)were calculated in the study *** comparison of the results,the features and relation of the two tools were *** results show that the LCSs act as the separatrix of the water regions with different transport characteristics and can identify the water areas with different transport time *** comprehensive application of the Lagrangian tools is helpful to obtain more insight into the water transport process.

关键词： transport and mixing Lagrangian coherent structures synoptic Lagrangian maps xiangshan Bay

Mrakia psychrophila ***.,a new species isolated from Antarctic soil

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第4期8卷 260-265页

作者： xIN Ming-xiu ZHOU Pei-jin College of Life Sciences Beijing Normal University Beijing 100875 China Institute of Microbiology Academia Sinica Beijing 100080 China

The yeast strain （y18） was isolated from a soil sample collected from Fildes Peninsula, Antarctica. The strain is a psychrophilic yeast with optimum and maximum growth temperatures of 10 ℃ and 18 ℃, respectively. Teliospores were formed after 7 d on malt agar, when the germination of teliospores was observed. Both inositol and D-glucuronate were assimilated. Positive results of the DBB （diazonium blue B） color reaction, urease test, and starch formation were observed. The major CoQ is Qs. All results indicated that y18 belongs to the genes of Mrakia. The 18S rDNA sequence analyses showed that y18 is closely related to Mrakiafrigida. DNA-DNA relatedness study, and some biochemistry characteristics indicated that y18 represents a new species for which Mrakia psychrophila sp. nov. is proposed.

关键词： Mrakiapsychrophila Psychrophilic yeast 18S rDNA sequence Teliospores

Theoretical optimization of complete forbidden bands in woodpile-type photonic crystals

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Optoelectronics Letters 2008年第5期4卷 358-360页

作者： ZHAN yi ZHENG yi LI xiu-xia College of Graphic Arts Qufu Normal University Rizhao 276826 China College of Science Beijing Jiaotong University Beijing 100044 China

Based on the plane-wave method, the optical properties of complete forbidden bands of woodpile structure photonic crystal with an entire Lattice rotation of 45° in the x-y plane were theoretically studied in terms of height-to-pitch ratios, filling factors, and rotation angles. The calculated results show that the gap to mid-gap ratio changes slightly with a filling fraction ranging from 0.25 to 0.30. The optimum height-to-pitch ratio is about 1.3. The gap to mid-gap ratio reaches more than 0.18 when the rotation angle increases from 40° to 50° and the maximum gap to mid-gap ratio of 0.2 remains unchanged for the rotation angle from 42°to 48° with a constant height-to-pitch ratio of 1.3. The gap to mid-gap ratio reaches the maximum value of 0.2 when the height-to-pitch ratio is 1.3. This woodpile-type photonic crystal can provide large band gaps within a wider parameter range, which makes it convenient to manufacture three-dimensional photonic crystals in the laboratory.

关键词：晶体平面波方法禁用波段木料堆结构

DEFORMATION INVESTIGATION ON iPP/SiO_2 COMPOSITES: INFLUENCE OF STRETCHING TEMPERATURE AND PARTICLE SIZE ON MORPHOLOGy EVOLUTION AND CRySTALLINE STRUCTURE OF THIN FILMS

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Chinese Journal of Polymer Science 2013年第2期31卷 275-284页

作者： xiu-qin Zhang Qian xing Rong-bo Li 王锐 Du-jin Wang Beijing Key Laboratory of Clothing Materials R & D and Assessment Department of Materials Science & Engineering Beijing Institute of Fashion Technology Beijing National Laboratory for Molecular Sciences Key Laboratory of Engineering Plastics Institute of Chemistry Chinese Academy of Sciences

In the present work, structure changes during （SiO2） composites have been investigated systematically stretching of isotactic polypropylene （iPP） and iPP/silicon dioxide The or-form crystal structure of both iPP and iPP/SiO2 composites is destroyed and transforms into the mesophase as the samples are stretched at a low temperature （35℃）, while stretching at high temperatures （90℃ and 120℃） can restrain the appearance of defects and keep the perfection of crystal structure. FTIR results reveal that the stretching temperatures show no obvious difference of the effect on the orientation of pure iPP, however, the orientation of iPP/SiO2 composites is greatly changed by the tensile temperature. In the case of micron-sized SiO2 particles （average particle diameter d 〉 1 μm）, the orientation of the composites is lower than that of pure iPP at all stretching temperatures. The above results suggest that the stretching temperature and the SiO2 particle size have great influence on the structure variation and orientation behavior of iPP/SiO2 composites.

关键词： iPP/SiO2 composites Stretching Morphology Structure variation.

Preparation of Crack-free 3y-TZP/Al_2O_3 Composite Ceramic Fiber by Electrolysis-sol-gel Method

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Chemical Research in Chinese Universities 2007年第4期23卷 377-380页

作者： LI Jian-jun JIAO xiu-ling CHEN Dai-rong Department of Chemistry Shandong University Jinan 250100 P. R. China

Polycrystalline 3y-TZP/Al2O3 tetragonal zirconia fiber was obtained by the pyrolysis of gel fibers using zirconium oxychloride octahydrate（ZOC） as the raw material. The spinnable zirconia sol was prepared by electrolyzing the zirco-nium oxychloride octahydrate（ZOC） solution in the presence of acetic acid and sugar（ sucrose, glucrose or fructose） , in which the molar ratios of CH3 COOH/ZOC and sugar/ZOC were 1.0-4.0 and 0.2-0.4, respectively. The pre- pared tetragonal zireonia fibers sintered at different temperatures showed smooth and crack-free surfaces with diame, ters of 5-10 μm. The addition of Al2O3 enhanced the sintering process and prevented the crystals from growing. Thermogravimetric analysis（TG）, x-ray diffraction （ xRD ）, Fourier transform infrared spectroscopy（FTIR）, and scanning electron microscope（SEM） techniques were used to characterize the prepared fibers.

关键词： Electrolysis Sol-gel Zirconia Ceramic fiber Al2O3

Ordered Charge Distribution in Superconductor Tl-Ba-Ca-Cu-O

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Chemical Research in Chinese Universities 1999年第3期15卷 271-280页

作者： LI Ping xIAO Shen xiu WANG Rong shun Department of Chemistry Sichuan UniversityChengdu 610064P.R.China

The layered charges were calculated by means of constructing the complete structure of Tl Ba Ca Cu O superconductor. The weak link between Cu O and Ba O, or between Cu O and Tl O or Ba O or Tl O layers is explained with the aid of the charge of limited layer unit calculated from the values of ions obtained, in addition to the possibility of forming charges fluctuation, which depends on the π coordination covalent bond on Cu O plane and O Tl O structure. The possible chemical tight bonding orbitals are in accordance with those of other superconductors obtained by quantum theoretical method, which occur at Cu 3d (x 2-y 2) and O 2p x,y . The valence band composed of Cu 3d and O 2p orbital energy levels is obviously an energy band of conduction. The ordered charge on layers is the main reason that raises T c of superconductors. The difference of electronic structure of ab plane and c axis leads to the anisotropy properties.

关键词： Superconductor Ordered charge Completing structure Exchange and correlation potential Layer

Calcium carbonate crystallization controlled by functional groups： A mini-review

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Frontiers of Materials Science 2013年第1期7卷 62-68页

作者： Hua DENG xing-Can SHEN xiu-Mei WANG Chang DU State Key Laboratory of New Ceramics and Fine Processing Department of Materials Science and Engineering Tsinghua University Beijing 100084 China Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Chemical Engineering Guangxi Normal University Guilin 541004 China School of Materials Science and Engineering South China University of Technology Guangzhou 510641 China

Various functional groups have been suggested to play essential roles on biomineralization of calcium carbonate (CaCO3) in natural system. 2D and 3D models of regularly arranged functional groups have been established to investigate their effect on CaCO3 crystallization. This mini-review summarizes the recent progress and the future development is prospected.

关键词： functional group biomineralization crystallization CaCO3