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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

Neural regeneration research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting Yang Danfeng Gong Haiying Liang Tingting chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

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Individualized treatment guided by endoscopic ultrasound-guided fine-needle aspiration for adrenocortical oncocytoma:A case report

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World Journal of Clinical Oncology 2025年第2期16卷 158-164页

作者： Han chen xue Jing Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGrOUND Adrenocortical oncocytoma is a rare,mostly benign,nonfunctional tumor that is typically detected *** diagnosis is challenging because of the absence of distinctive imaging characteristics,necessitating pathological *** SUMMArY We present a case report of a 35-year-old woman with an adrenal mass located on the left side,where endoscopic ultrasound-guided fine-needle aspiration(EUSFNA)was performed after comprehensive diagnostic *** results are consistent with those of previously documented cases regarding tumor demographics and anatomical *** the limited number of reports on this condition,long-term follow-up is crucial to enhance our understanding of its *** For patients with adrenocortical oncocytoma,EUS-FNA can enables collection of preoperative tissue specimens leading to suitable treatment strategies.

关键词： Adrenocortical oncocytoma Non-functioning tumor Endoscopic ultrasound guided fine-needle aspiration Diagnosis Case report

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Effects of Mn content on recrystallization resistance of AA6082 aluminum alloys during post-deformation annealing

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Journal of Materials Science & Technology 2020年第17期52卷 189-197页

作者： xiaoming Qian Nick Parson x.-Grant chen Department of Applied Science University of Quebec at ChicoutimiSaguenay G7H 2B1Canada Arvida research and Development Centre Rio Tinto AluminumSaguenay G7S 4K8Canada

The microstructural evolutions under as-homogenized and as-deformed conditions and after the postdeformation annealing of AA6082 aluminum alloys with different Mn content(0.05 wt.%-1 wt.%)were studied by optical,scanning electron,and transmission electron *** results showed that the presence of a large amount ofα-Al(Mn,Fe)Si dispersoids induced by Mn addition significantly improved the recrystallization *** the base alloy free of Mn,static recrystallization occurred after 2 h of annealing,and grain growth commenced after 4 h of annealing,whereas in Mn-containing alloys,the recovered grain structure was well-retained after even 8 h of *** alloy with 0.5%Mn exhibited the best recrystallization resistance,and a further increase of the Mn levels to 1%resulted in a gradual reduction of the recrystallization resistance,the reason for which was that recrystallization occurred only in the dispersoid-free zones(DFZs)and the increased DFZ fraction with Mn content led to an increase in the recrystallization *** variation in the dispersoid number density and a coarsening of dispersoids during annealing have a limited influence on the static recrystallization in Mn-containing alloys.

关键词： AA6082 alloys Mn effects recrystallization resistance Dispersoid precipitation Post-deformation annealing

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Effect of solute atom concentration and precipitates on serrated flow in Mg-3Nd-Zn alloy

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Journal of Materials Science & Technology 2018年第7期34卷 1236-1242页

作者： W.H.Wang D.Wu r.S.chen x.N.Zhang State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University The Group of Magnesium Alloys and Their Applications Institute of Metal Research Chinese Academy of Sciences

Influence of solute atom concentration and precipitates on serrated flow, i.e., Portevin-Le Chatelier effect, was studied in Mg-3Nd-Zn alloy by tensile test at 250℃ with a strain rate of l x 10^-3 s^-1 Microstructure and tensile property of the Mg-3Nd-Zn alloy in solution and aging conditions were also investigated. results indicate that the serrated flow was weakened with aging time, and geometry of the serrations changed from sharp to rounded corner. Through analyzing the mechanism of the interactions between dislocations and solute atoms, it was identified that the precipitates did not only weaken the serrated flow due to the decrease in the concentration of solute atom, but also regulate the serration type by restraining the movement of dislocations during high temperature deformation.2017 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science ＆ Technology.

关键词： Magnesium alloy Serrated flow Precipitate Heat treatment Deformation behavior

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Nomogram for overall survival in ampullary adenocarcinoma using the surveillance,epidemiology,and end results database and external validation

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World Journal of Clinical Oncology 2025年第2期16卷 36-51页

作者： Jia Yang Zi-Yi Wang Jing chen Yao Zhang Lei chen Department of Gastroenterology The First Affiliated Hospital of Army Medical UniversityChongqing 400038China Department of Epidemiology College of Preventive MedicineArmy Medical UniversityChongqing 400038China

BACKGrOUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal ***,only a few cases have been reported,resulting in limited information on *** To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary *** Data were sourced from the surveillance,epidemiology,and end results stat *** patients in the database were randomized in a 7:3 ratio into training and validation *** Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the *** nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical *** For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the *** area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific *** internal and external validation cohorts indicated good consistency of the *** The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.

关键词： Ampullary adenocarcinoma Dynamic nomogram Gastrointestinal tract Surveillance Epidemiology End results database Survival rate

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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural regeneration research 2025年第9期20卷 2706-2726页

作者： Biao xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

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MICrO-DESCrIPTION OF THE SOLUTE-FIELD AND THE PHASE-FIELD MODEL FOr ISOTHErMAL PHASE TrANSITION IN BINArY ALLOYS

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Acta Metallurgica Sinica(English Letters) 2004年第6期17卷 835-839页

作者： H.M.Ding L.L.chen r.x.Liu researchStudioofSolidificationSimulation CollegeofMaterialsScienceandEngineeringHuazhongUniversityofScienceandTechnologyWuhan430074China

A new phase field method for two-dimensional simulations of binary alloy solidification was studied. A model basing on solute conservative in every unit was developed for solving the solute diffusion equation during solidification. Two-dimensional computations were performed for ideal solutions and Ni-Cu dendritic growth into an isothermal and highly supersaturated liquid phase.

关键词： phase field isothermal phase field model diffusion

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Measurement of integrated luminosity of data collected at 3.773 GeV by BESIII from 2021 to 2024

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Chinese Physics C 2024年第12期48卷 1-10页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis x.C.Ai r.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-r.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko r.A.Briere A.Brueggemann H.Cai x.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang G.r.Che G.Chelkov C.chen C.H.chen Chao chen G.chen H.S.chen H.Y.chen M.L.chen S.J.chen S.L.chen S.M.chen T.chen x.r.chen x.T.chen Y.B.chen Y.Q.chen Z.J.chen Z.Y.chen S.K.Choi G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi r.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Ding x.x.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong x.Dong M.C.Du S.x.Du Y.Y.Duan Z.H.Duan P.Egorov Y.H.Fan J.Fang J.Fang S.S.Fang W.x.Fang Y.Fang Y.Q.Fang r.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao x.B.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.x.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan A.Q.Guo L.B.Guo M.J.Guo r.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han F.Hanisch x.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou x.T.Hou Y.r.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu S.L.Hu T.Hu Y.Hu G.S.Huang K.x.Huang L.Q.Huang x.T.Huang Y.P.Huang Y.S.Huang T.Hussain F.Hölzken N.Hüsken N.in der Wiesche J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji x.B.Ji x.L.Ji Y.Y.Ji x.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang x.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing x.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki x.L.Kang x.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz r.Kiuchi O.B.Kolcu B.Kopf M.Kuessner x.Kui N.Kumar A.Kupsc W.Kühn J.J.Lane L.Lavezzi T.T.Lei Z.H.Lei M.Lellmann T.Lenz C.Li C.Li C.H.Li cheng Li D.M.Li F.Li G.Li H.B.Li H.J.Li H.N.Li Hui Li J.r.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.r.Li Q.M.Li Q.x.Li r.Li S.x.Li T.Li W.D.Li W.G.Li x.Li x.H.Li x.L.Li x.Y.Li x.Z.Li Y.G Institute of High Energy Physics Beijing 18049China Beihang University Beijing 18191China Bochum ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB rAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 41883China China Center of Advanced Science and Technology Beijing 18190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 54184China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 31836China Hebei University Baoding 07182China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 47183China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 41881China Hunan University Changsha 41882China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-0618PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-0618PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 01821China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de Tarapacá

We present a measurement of the integrated luminosity of e^(+)e^(-)collision data collected by the BESIII detector at the BEPCII collider at a center-of-mass energy of Ecm=3.773 *** integrated luminosities of the datasets taken from December 2021 to June 2022,from November 2022 to June 2023,and from October 2023 to February 2024 were determined to be 4.995±0.019 fb^(-1),8.157±0.031 fb^(-1),and 4.191±0.016 fb^(-1),respectively,by analyzing large angle Bhabha scattering *** uncertainties are dominated by systematic effects,and the statistical uncertainties are *** results provide essential input for future analyses and precision measurements.

关键词： Bhabha scattering events integrated luminosity cross-section

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Effect of compressibility on the hypervelocity penetration

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Acta Mechanica Sinica 2018年第1期34卷 82-98页

作者： W.J.Song x.W.chen P.chen Department of Mechanics and Engineering Science College of Engineering Peking University Advanced research Institute for Multidisciplinary Science Beijing Institute of Technology The State Key Lab of Explosion Science and Technology Beijing Institute of Technology Centre for Applied Physics and Technology (CAPT) Peking University

We further consider the effect of rod strength by employing the compressible penetration model to study the effect of compressibility on hypervelocity ***, we define different instances of penetration efficiency in various modified models and compare these penetration efficiencies to identify the effects of different factors in the compressible model. To systematically discuss the effect of compressibility in different metallic rod-target combinations, we construct three cases, i.e., the penetrations by the more compressible rod into the less compressible target, rod into the analogously compressible target, and the less compressible rod into the more compressible target. The effects of volumetric strain, internal energy, and strength on the penetration efficiency are analyzed simultaneously. It indicates that the compressibility of the rod and target increases the pressure at the rod/target interface. The more compressible rod/target has larger volumetric strain and higher internal energy. Both the larger volumetric strain and higher strength enhance the penetration or anti-penetration ability. On the other hand, the higher internal energy weakens the penetration or anti-penetration ability. The two trends conflict, but the volumetric strain dominates in the variation of the penetration efficiency, which would not approach the hydrodynamic limit if the rod and target are not analogously compressible. However, if the compressibility of the rod and target is analogous, it has little effect on the penetration efficiency.

关键词： Compressibility Hypervelocity penetration Equation of state(EOS) Shockwave Bernoulli equation

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Potential dependence in electrocatalysis: a theoretical perspective

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Science China Chemistry 2025年第01期 21-25页

作者： Leyu Liu Zhaoming xia Zeyu Wang Yinjuan chen Hai xiao Department of Chemistry Tsinghua University Fundamental Science Center of rare Earths Ganjiang Innovation Academy Chinese Academy of Sciences Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation Center Changzhou University

Electrocatalysis is a key technology for the new energy era and sustainable development, serving as the interface for interconversion of electrical and chemical energies, which spans a wide spectrum of applications in sustainable energy and environmental engineering. Electrocatalytic reactions including electrochemical CO2reduction reaction （eCO2rr）, hydrogen evolution reaction （HEr）, and oxygen evolution/reduction reactions （OEr/Orr）, hold essential promise for renewable energy technologies as well as complement the biogeochemical carbon and oxygen cycles.

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