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国际医学放射学杂志 2024年第2期 252-253页

作者： Y.Guo x.T.xie W.j.Tang S.Y.Chen M.Y.Wang Y.H.fan 侯唯姝

摘要目的建立基于深度学习的MRI影像组学（DLR）特征模型，以预测人表皮生长因子受体2(HER2)低表达状态，并进一步通过DLR模型验证乳腺癌病人在预后方面的

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Two-dimensional atomically thin Pt layers on Mxenes: The role of electronic effects during catalytic dehydrogenation of ethane and propane

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Nano Research 2024年第3期17卷 1251-1258页

作者： Zhe Li Tobias K.Misicko fan Yang xiaopeng Liu Zhenwei Wu xiaoyang Gao Tao Ma jeffrey T.Miller Daniela S.Mainardi Collin D.Wick Zhenhua Zeng Yang xiao Yue Wu Department of Chemical and Biological Engineering Iowa State University618 Bissell RoadAmesIA 50011USA Institute for Micromanufacturing Louisiana Tech University505 Tech DriveRustonLA 71272USA Davidson School of Chemical Engineering Purdue University480 Stadium Mall DriveWest LafayetteIN 47907USA Michigan Center for Materials Characterization University of Michigan2800 Plymouth RdAnn Arbor MI 48109USA College of Engineering and Science Louisiana Tech UniversityRustonLA 71272USA

Atomically thin Pt nanolayers were synthesized on the surface of Mo2TiC2 Mxenes and used for the catalytic dehydrogenation of ethane and propane into ethylene and propylene,two important chemicals for the petrochemical *** compared with Pt nanoparticles,the atomically thin Pt nanolayer catalyst showed superior coke-resistance(no deactivation for 24 h),high activity(turnover frequencies(TOFs)of 0.4–1.2 s^(-1)),and selectivity(>95%)toward ethylene and *** unique Pt nanolayer has a similar geometric surface to Pt nanoparticles,enabling the investigations of the electronic effect on the catalytic performance,where the geometric effect is *** is found that the electronic effect plays a critical role in dehydrogenative product selectivity and catalyst *** metal–support interaction is found dependent on the substrate and metal components,providing wide opportunities to explore high-performance Mxene-supported metallic catalysts.

关键词： Mxene catalysis alkane dehydrogenation nanolayers

Association between glucose levels of children with type 1 diabetes and parental economic status in mobile health application

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World journal of Diabetes 2024年第7期15卷 1477-1488页

作者： Wen-Hao Zhang Chao-fan Wang Hao Wang jie Tang Hong-Qiang Zhang jiang-Yu Zhu xue-Ying Zheng Si-Hui Luo Yu Ding Department of Endocrinology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of DiabetologyGuangzhou 510000Guangdong ProvinceChina Graduate School Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND The glycemic control of children with type 1 diabetes(T1D)may be influenced by the economic status of their *** To investigate the association between parental economic status and blood glucose levels of children with T1D using a mobile health *** Data from children with T1D in China's largest T1D online community,Tang-TangQuan■.Blood glucose levels were uploaded every three months and parental economic status was evaluated based on annual household *** were divided into three groups:Low-income(100000 yuan)(1 Yuan=0.145 United States Dollar approximately).Blood glucose levels were compared among the groups and associations were explored using Spearman’s correlation analysis and multivariable logistic *** From September 2015 to August 2022,1406 eligible children with T1D were included(779 female,55.4%).Median age was 8.1 years(Q1-Q3:4.6-11.6)and duration of T1D was 0.06 years(0.02-0.44).Participants were divided into three groups:Low-income(n=320),middle-income(n=724),and high-income(n=362).Baseline hemoglobin A1c(HbA1c)levels were comparable among the three groups(P=0.072).However,at month 36,the low-income group had the highest HbA1c levels(P=0.036).Within three years after registration,glucose levels increased significantly in the low-income group but not in the middle-income and high-income *** economic status was negatively correlated with pre-dinner glucose(r=-0.272,P=0.012).After adjustment for confounders,parental economic status remained a significant factor related to pre-dinner glucose levels(odds ratio=13.02,95%CI:1.99 to 126.05,P=0.002).CONCLUSION The blood glucose levels of children with T1D were negatively associated with parental economic *** is suggested that parental economic status should be taken into consideration in the management of T1D for children.

关键词： Type 1 diabetes Children and adolescents Glycemic control Economic status Mobile health application

Cryo-EM structure of cannabinoid receptor CB1-β-arrestincomplex

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Protein & Cell 2024年第3期15卷 230-234页

作者： Yuxia Wang Lijie Wu Tian Wang junlin Liu Fei Li Longquan jiang Zhongbo fan Yanan Yu Na Chen Qianqian Sun Qiwen Tan Tian Hua Zhi-jie Liu iHuman Institute ShanghaiTech UniversityShanghai 201210China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Institute of Molecular and Clinical Medicine Kunming Medical UniversityKunming 650500China

Dear Editor,G protein-coupled receptors(GPCRs)play a vital role in regulating almost every aspect of human physiology,making up more than one-third of marketed drug targets(Santos et al.,2017).GPCRs orchestrate their signalling through interactions with three distinct downstream protein families:G proteins,G protein-coupled receptor kinases(GRKs),and arrestins(Santos et al.,2017).While G protein-mediated signalling is initiated upon GPCR stimulation,activated GPCRs return to their basal levels through a GRK-and arrestin-regulated desensitization process(Santos et al.,2017).In addition to modulating receptor desensitization,β-arrestin also regulates downstream events that are distinct from classical G protein signalling(Ahn et al.,2020).

关键词： stimulation return

原位气/液或液/液界面分子的动态行为表征技术进展

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科学通报 2024年第7期69卷 878-890页

作者：樊漪陈思桐侯旭厦门大学化学化工学院厦门361005 厦门大学固体表面物理化学国家重点实验室厦门361005 厦门大学物理科学与技术学院厦门361005

气/液和液/液界面在生产生活中无处不在,一直以来都是动态表界面研究领域的热点.为了更深入理解表界面分子结构、分子运动行为模式以及界面动态变化机制,发展原位界面分子的动态行为表征技术将有助于实现动态表界面的实际应用.本文综述... 详细信息

气/液和液/液界面在生产生活中无处不在,一直以来都是动态表界面研究领域的热点.为了更深入理解表界面分子结构、分子运动行为模式以及界面动态变化机制,发展原位界面分子的动态行为表征技术将有助于实现动态表界面的实际应用.本文综述了原位气/液和液/液界面分子的动态行为表征技术所取得的一些研究成果.首先介绍了动态表界面分子的结构和动态行为模式特性;然后重点介绍了宏观和分子层面的动态表界面表征技术的进展,包括新型的表征技术;最后,综合分析了当前领域中存在的问题和发展方向,希望为未来表征技术的开发与应用奠定基础.

关键词：气/液界面液/液界面界面分子动态行为原位表征

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于阗语《佛本生赞》的“结构精妙”与“文采铺赡”

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首都师范大学学报（社会科学版） 2024年第1期 11-19页

作者：范晶晶北京大学南亚学系北京大学东方文学研究中心

于阗语《佛本生赞》选取了以大光明王初发道心为首的51个本生故事,对其进行诗体化的文学加工。这部《佛本生赞》延续了佛典中佛赞文类的传统——之前被洛伊曼拟为“观世音赞”的1叶于阗语残片实际上当属某种佛本生赞写本,在礼佛之外,可... 详细信息

于阗语《佛本生赞》选取了以大光明王初发道心为首的51个本生故事,对其进行诗体化的文学加工。这部《佛本生赞》延续了佛典中佛赞文类的传统——之前被洛伊曼拟为“观世音赞”的1叶于阗语残片实际上当属某种佛本生赞写本,在礼佛之外,可能还有辅助禅修之用,因此影响到其本生故事的选择。这些故事与龟兹菱格本生图像的绘制也有共通之处,体现了丝路南道与北道之间存在佛教故事的图文交流。于阗语《佛本生赞》还是难得的文学佳作,在比喻修辞手法的运用、场景的铺叙、心理活动的刻画方面都极富感染力,与同类的梵语佛典比起来也不遑多让。

关键词：于阗语《佛本生赞》大光明王文采

云贵高原一座典型高原水库浮游植物群落演替特征及其与环境因子的关系

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湖泊科学 2024年第3期36卷 695-707页

作者：周帆陈晨徐韬杨阳贵州师范大学生命科学学院贵阳550025 贵州师范大学应急管理学院贵阳550025

浮游植物是水体的初级生产者,可以指示环境变化。高原水库由于其蒸发量大、雨季短、旱季长、抗污染能力差的特点,生态系统脆弱,其浮游植物群落的变化对环境条件更为敏感。为了解云贵高原地区乌江渡水库浮游植物的群落结构和演替特征,于2... 详细信息

浮游植物是水体的初级生产者,可以指示环境变化。高原水库由于其蒸发量大、雨季短、旱季长、抗污染能力差的特点,生态系统脆弱,其浮游植物群落的变化对环境条件更为敏感。为了解云贵高原地区乌江渡水库浮游植物的群落结构和演替特征,于2021年6月—2022年5月对乌江渡水库浮游植物群落进行调查,并应用功能群的方法对浮游植物进行分类。结果发现:1)2021年6月—2022年5月,乌江渡水库表层水体中共鉴定出浮游植物106种,共8门67属,其中,生物量最高的为硅藻门,种类数最多的为绿藻门;2)乌江渡水库表层水体理化性质和浮游植物群落存在显著的季节性差异,而相同季节内不同位置差异不显著;3)乌江渡水库表层水体春夏秋季为中—轻度富营养状态,而冬季为中营养状态;4)乌江渡水库中共有浮游植物群落功能群24类,基于优势度,其季节性演替模式为B/C/L0/P(春季)→B/j/L0/P/S1/T(夏季)→B/L0/P/S1/T(秋季)→B/P(冬季),春季和秋季优势功能群关联显著,而夏季和冬季优势功能群关联不显著,相对独立,即浮游植物群落演替伴随着群落稳定性的变化;5)氮磷营养盐、温度和溶解氧是影响乌江渡水库表层浮游植物群落的关键环境因子。本研究提供了云贵高原地区典型高原水体中浮游植物群落结构的背景信息,并从功能群的角度分析了群落的特征及其主要影响因子。

关键词：浮游植物功能群多样性优势度乌江渡水库

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Integrated proteomic profiling identifies amino acids selectively cytotoxic to pancreatic cancer cells

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The Innovation 2024年第3期5卷 138-145页

作者： Alfred Akinlalu Zachariah Flaten Komila Rasuleva Md Saimon Mia Aaron Bauer Santhalingam Elamurugan Nega Ejjigu Sudipa Maity Amara Arshad Min Wu Wenjie xia jia fan Ang Guo Sijo Mathew Dali Sun Department of Electrical and Computer Engineering University of Denver2155 E Wesley AvenueDenverCO 80210USA Biomedical Engineering Program North Dakota State University1401 Centennial BoulevardEngineering AdministrationRoom 203FargoND 58102USA Department of Pharmaceutical Sciences School of PharmacyNorth Dakota State University1001 S.1401 Albrecht Boulevard Sudro HallFargoND 58102USA Materials and Nanotechnology Program North Dakota State University1410 North 14th AvenueCIE 201FargoND 58102USA Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang 325000China Department of Aerospace Engineering Iowa State UniversityAmesIA 50011USA Center for Cellular and Molecular Diagnostics Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Department of Biochemistry and Molecular Biology Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Knoebel Institute for Healthy Aging University of Denver2155 E Wesley AvenueDenverCO 80210USA

Pancreatic adenocarcinoma(PDAC)is one of the most deadly cancers,characterized by extremely limited therapeutic options and a poor prognosis,as it is often diagnosed during late disease *** and selective treatments are urgently needed,since current therapies have limited efficacy and significant side *** proteomics analysis of extracellular vesicles,we discovered an imbalanced distribution of amino acids secreted by PDAC tumor *** findings revealed that PDAC cells preferentially excrete proteins with certain preferential amino acids,including isoleucine and histidine,via extracellular *** amino acids are associated with disease progression and can be targeted to elicit selective toxicity to PDAC tumor *** in vitro and in vivo experiments demonstrated that supplementation with these specific amino acids effectively eradicated PDAC ***,we also identified xRN1 as a potential target for these amino *** high selectivity of this treatment method allows for specific targeting of tumor metabolism with very low toxicity to normal ***,we found this treatment approach is easy-to-administer and with sustained tumor-killing ***,our findings reveal that exocytosed amino acids may serve as therapeutic targets for designing treatments of intractable PDAC and potentially offer alternative treatments for other types of cancers.

关键词： finding identif selectivity

Gut microbial metabolite targets HDAC3-FOxK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis

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Bone Research 2024年第2期12卷 421-437页

作者： Hongzhen Chen xuekun Fu xiaohao Wu junyi Zhao fang Qiu Zhenghong Wang Zhuqian Wang xinxin Chen Duoli xie jie Huang junyu fan xu Yang Yi Song jie Li Dongyi He Guozhi xiao Aiping Lu Chao Liang Department of Systems Biology School of Life SciencesSouthern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentShenzhen 518055China Institute of Integrated Bioinfomedicine and Translational Science(IBTS) School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 999077China Department of Biochemistry School of MedicineSouthern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentShenzhen 518055China Division of Immunology and Rheumatology Stanford UniversityStanfordCA 94305USA VA Palo Alto Health Care System Palo AltoCA 94304USA Institute of Plant and Food Science Department of BiologySouthern University of Science and TechnologyShenzhen 518055China Department of Rheumatology Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Computational Biology St.Jude Children’s Research HospitalMemphisTNUSA Department of Laboratory Medicine Peking University Shenzhen HospitalShenzhenChina Guangdong-Hong Kong-Macao joint Lab on Chinese Medicine and Immune Disease Research Guangzhou 510006China Shanghai University of Traditional Chinese Medicine Shanghai 200032China State Key Laboratory of Proteomics National Center for Protein Sciences(Beijing)Beijing Institute of Lifeomics100850 BeijingChina

Rheumatoid arthritis(RA)is an autoimmune *** studies hold an opinion that gut microbiota is environmentally acquired and associated with RA ***,accumulating evidence demonstrates that genetics also shape the gut *** is known that some strains of inbred laboratory mice are highly susceptible to collagen-induced arthritis(CIA),while the others are resistant to ***,we show that transplantation of fecal microbiota of CIA-resistant C57BL/6j mice to CIA-susceptible DBA/1j mice confer CIA resistance in DBA/1j mice.C57BL/6j mice and healthy human individuals have enriched *** than DBA/1j mice and RA *** of *** prevents CIA in DBA/1j *** identify that *** mainly produces propionate and C57BL/6j mice and healthy human individuals have higher level of ***-like synoviocytes(FLSs)in RA are activated to undergo tumor-like *** disrupts HDAC3-FOxK1 interaction to increase acetylation of FOxK1,resulting in reduced FOxK1 stability,blocked interferon signaling and deactivation of *** treat CIA mice with propionate and show that propionate attenuates ***,a combination of propionate with anti-TNF etanercept synergistically relieves *** results suggest that *** or propionate could be an alternative or complementary approach to the current therapies.

关键词： HDAC3 cytes interferon

Gut|基于纵向数据的乙型肝炎临床治愈预测新模型

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临床肝胆病杂志 2024年第7期40卷 1320-1320页

作者：赵思如南方医科大学南方医院感染内科

乙型肝炎临床治愈(即HBsAg转阴,伴或不伴有抗-HBs出现)是慢性乙型肝炎(CHB)患者的理想治疗终点。对CHB患者实现临床治愈的可能性进行精准预测,对于推动相关临床策略的实施以及新药随机对照临床研究的受试者筛选具有重要作用,通过科学的... 详细信息

乙型肝炎临床治愈(即HBsAg转阴,伴或不伴有抗-HBs出现)是慢性乙型肝炎(CHB)患者的理想治疗终点。对CHB患者实现临床治愈的可能性进行精准预测,对于推动相关临床策略的实施以及新药随机对照临床研究的受试者筛选具有重要作用,通过科学的方法预测并平衡各组受试者的特征,可以有效提升临床研究的效率和准确性。既往已发现多种与实现临床治愈相关的标志物,例如HBV RNA、HBV核心相关抗原(HBcrAg)和HBsAg定量(qHBsAg)等。然而,以上绝大部分预测标志物或模型仅基于单个时间点临床数据,或两个特定时间点的差值变化,尚无法完全反映CHB患者长期病程中qHBsAg动态变化对实现HBsAg转阴的影响。2024年6月,南方医科大学南方医院侯金林教授及樊蓉教授等依托一项来自我国50家中心的长期随访的真实世界前瞻性队列(Search-B研究),基于纵向判别分析(LoDA)建模算法,高效利用患者随访期间的多时间点HBsAg定量数据,构建并验证了一项新型、精准的乙型肝炎临床治愈预测模型(GOLDEN评分)。该评分可平均提前18.94个月预测乙型肝炎临床治愈的发生[受试者工作特征曲线下面积(AUC):0.979~0.981]。

关键词：临床治愈南方医科大学 HBsAg定量临床数据随机对照临床研究乙型肝炎南方医院长期随访

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