检索结果-南通市图书馆

Pharmacovigilance guidelines of Chinese patent medicines

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Zhongguo Zhongyao Zazhi 2024年第16期49卷 4261-4265页

作者： Wang l.-x. Wang M.-M. li Y.-Y. Wang Z.-F. Cui x. Zhao x.-x. liu F.-M. Yang S. Wei R.-l. Wang Y.-x. Zhang B. xie Y.-M. Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing 100700 China Beijing University of Chinese Medicine Beijing 100029 China

Drug administration law of the People′s Republic of China (2019 revised edition), which came into effect on December 1, 2019, proposed that " the state shall establish a pharmacovigilance system" . Pharmacovigilance work of Chinese patent medicines is more difficult, and it is necessary to carry out Pharmacovigilance activities that are in line with the characteristics of Chinese patent medicines. Pharmacovigilance guidelines of Chinese patent medicines (T / CACM 1563. 1-2024), based on the principles of Drug Administration law of the People′ s Republic of China (2019 revised edition) and Pharmacovigilance quality management standards (No. 65 of 2021) of the National Medical Products Administration, draws on the EU Pharmacovigilance regulation and the secondary guidelines of International Council for harmonization of Technical Requirements for Pharmaceuticals for human Use (ICh), and it is drafted in accordance with the provisions of Guidelines for standardization work part 1: structure and drafting rules of standardization documents (GB / T1. 1-2020) based on the characteristics of Chinese patent medicines. It serves as a general document for a series of pharmacovigilance guidelines of Chinese patent medicines, such as Guidelines for construction of traditional Chinese medicine pharmacovigilance system in medical institutions (T / CACM 1563. 2-2024), Pharmacovigilance guidelines for clinical application of oral Chinese patent medicines (T / CACM 1563. 3-2024), Pharmacovigilance guidelines for clinical application of traditional Chinese medicine injections (T / CACM 1563. 4-2024), Pharmacovigilance guidelines for clinical application of Chinese patent medicines for external use (T / CACM 1563. 5-2024), and Pharmacovigilance guidelines for clinical application of Chinese patent medicines for mucosal administration (T / CACM 1563. 6-2024), including four major elements of pharmacovigilance monitoring and reporting of Chinese patent medicines, signal identification, ri

关键词： Chinese patent medicine group standard guideline pharmacovigilance safe drug use

Impacts of brood parasitism by shiny cowbird Molothrus bonariensis on the breeding success of a small host, the black-backed water tyrant Fluvicola albiventer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2024年第4期70卷 539-547页

作者： lorena Vanesa Sovrano Evelina Jesica leon Rodrigo Ezequiel lorenzón Pamela Fernanda Olguin Adolfo héctor Beltzer Alejandro Raúl Giraudo laboratorio de Biodiversidad y Conservacion de Tetrapodos Instituto Nacional de Limnologia(INALICONICET-UNL)Paraje El Pozo s/nSanta Fe(3000)Argentina Departamento de Biologia Universidad Autonoma de Entre RiosKm 10.5 RP 11Oro Verde(3100)Entre RiosArgentina Departamento de Biologia Universidad Nacional del LitoralFacultad de Humanidades y CienciasParaje Ei Pozo s/nSanta Fe(3000)Argentina

The shiny cowbird Molothrus bonariensis parasitizes many species with different life-history traits and has a detrimental effect on the survival of the progeny of the *** response,hosts have developed numerous antiparasitic ***,we examined the effects of brood parasitism by shiny cowbird on the clutch and brood sizes(83 nests)in a small host,the black-backed water tyrant Fluvicola *** also studied whether the death of parasite nestlings was related to the care of the foster parents and whether the host had any antiparasitic defense against the shiny *** results indicate that brood parasitism significantly decreased the host hatching and fledging *** majority of nest failures(57%)were caused by brood *** cowbird parasitism occurred in 52%of nests and the intensity of parasitism was 1.23±0.53 eggs per parasitized *** the total host eggs,54%were *** the incubation stage,20 nests(47%)were abandoned because of egg punctures by shiny cowbirds *** two parasitic fledglings were recorded,while the remaining nestlings either died from starvation(n=12)or predation(n=3).Foster parents abandoned parasitic nestlings between 5 and 10 days *** findings demonstrate that the shiny cowbird has very low rates of fledging success when parasitizing black-backed water ***,parasitism had a high reproductive cost in the black-backed water tyrant because a very low proportion(7%)of the parasitized nests(n=43)were successful.

关键词： brood parasitism host defenses nest desertion shiny cowbird small host.

Optimization of performance of the KM2A full array using the Crab Nebula

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第6期48卷 169-178页

作者：曹臻 F.Aharonian 安琪阿西克古白云翔包逸炜 D.Bastieri 毕效军毕玉江蔡金庭曹晴曹文羽曹喆常进常劲帆陈尚明陈恩生陈亮陈林陈龙陈明君陈玛丽陈起辉陈素弘陈天禄陈阳程宁程耀东崔明阳崔树旺崔晓红崔昱东戴本忠代洪亮戴子高单增罗布 D.della Volpe 董绪强段凯凯樊军辉范一中方军方堃冯存峰封莉冯少辉丰晓婷冯有亮 S.Gabici 高博高川东高林青高启高卫高伟康葛茂茂耿利斯 G.Giacinti 龚光华苟全补顾旻皓郭福来郭晓磊郭义庆郭莹莹韩毅昂何会海贺昊宁何佳银何新波何钰 M.heller 贺远强侯博文侯超侯贤胡红波胡铨胡世聪黄代绘黄天奇黄文俊黄性涛黄晓渊黄勇黄志成季筱璐贾焕玉贾康江琨姜晓巍姜泽军金敏康明铭柯通 D.Kuleshov.K.Kurinov 李兵兵李澄李骢李丹李飞李海波李会财李华阳李军李剑李捷李凯李文龙李文莲李秀荣李昕李一卓李哲黎卓梁恩维梁云峰林苏杰刘冰刘成刘栋刘虎刘海东刘佳刘江来刘金艳刘茂元柳若愚刘四明刘伟刘怡刘以农鲁睿罗晴吕洪魁马伯强马玲玲马欣华毛基荣闵振 W.Mitthumsiri 穆慧君南云程 A.Neronov 区子维庞彬宇 P.Pattarakijwanich 裴致远齐孟尧祁业情乔冰强秦家军 D.Ruffolo A.Sáiz D.Semikoz 邵澄宇邵琅 O.Shchegolev 盛祥东舒富文宋慧超 Yu.V.Stenkin V.Stepanov 苏扬孙秦宁孙晓娜孙志斌谭柏轩唐庆文唐泽波田文武王超王昌贝王广威王洪光王惠惠王建成汪凯王利苹王玲玉王培汉王冉王为王祥高王祥玉王阳王玉东王岩谨王忠海王仲翔王振王铮韦大明魏俊杰魏永健文韬吴超勇吴含荣武莎吴雪峰吴雨生席邵强夏捷夏君集项光漫肖迪泫肖刚辛广广辛玉良邢祎熊峥徐东莲徐仁峰徐仁新徐伟立薛良闫大海颜景志颜田杨朝文杨帆杨冯帆杨何文杨佳盈杨莉莉杨明洁杨睿智杨深邦姚玉华姚志国叶一锰尹丽巧尹娜游晓浩游智勇于艳红袁强岳华曾厚敦曾婷轩曾玮查敏张彬彬张丰张海明张恒英张建立张丽霞张力张鹏飞张佩佩张瑞张少博张少如张寿山张潇张笑鹏张云峰张毅张勇赵兵赵静赵雷赵立志赵世平郑福周斌周浩周佳能周猛周平周荣周勋秀祝成光祝凤荣朱辉朱科军左雄 lhAASO Collaboration Key laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Tianfu Cosmic Ray Research Center Chengdu 610000China Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key laboratory of Particle Detection and Electronics China University of Science and Technology of China Hefei 230026China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China hebei Normal University Shijiazhuang 050024China Key laboratory of Dark Matter and Space Astronomy&Key laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Tsung-Dao lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Key laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275China School of Physics and Astronomy Yunnan UniversityKunming 650091China Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève24 Quai Ernest Ansermet1211 GenevaSwitzerland Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC Universit'e Paris Cit'eCNRS/IN2P3CEA/IRFUObservat

The full array of the large high Altitude Air Shower Observatory(lhAASO)has been in operation since July *** its kilometer-square array(KM2A),we optimized the selection criteria for very high and ultrahigh energyγ-rays using data collected from August 2021 to August 2022,resulting in an improvement in significance of the detection in the Crab Nebula of approximately 15%,compared with that of previous *** the implementation of these new selection criteria,the angular resolution was also significantly improved by approximately 10%at tens of *** aspects of the full KM2A array performance,such as the pointing error,were also calibrated using the Crab *** resulting energy spectrum of the Crab Nebula in the energy range of 10-1000 TeV are well fitted by a log-parabola model,which is consistent with the previous results from lhAASO and other experiments.

关键词： γ-ray Crab Nebula significance

A Pooling Method Developed for Use in Convolutional Neural Networks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第10期141卷 751-770页

作者： Ìsmail Akgül Departmant of Computer Engineering Faculty of Engineering and ArchitectureErzincan Binali Yıldırım UniversityErzincan24002Turkiye

In convolutional neural networks,pooling methods are used to reduce both the size of the data and the number of parameters after the convolution of the *** methods reduce the computational amount of convolutional neural networks,making the neural network more *** pooling,average pooling,and minimum pooling methods are generally used in convolutional neural ***,these pooling methods are not suitable for all datasets used in neural network *** this study,a new pooling approach to the literature is proposed to increase the efficiency and success rates of convolutional neural *** method,which we call MAM(Maximum Average Minimum)pooling,is more interactive than other traditional maximum pooling,average pooling,and minimum pooling methods and reduces data loss by calculating the more appropriate pixel *** proposed MAM pooling method increases the performance of the neural network by calculating the optimal value during the training of convolutional neural *** determine the success accuracy of the proposed MAM pooling method and compare it with other traditional pooling methods,training was carried out on the leNet-5 model using CIFAR-10,CIFAR-100,and MNIST *** to the results obtained,the proposed MAM pooling method performed better than the maximum pooling,average pooling,and minimum pooling methods in all pool sizes on three different datasets.

关键词： Pooling convolutional neural networks deep learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

老年共病患者自我管理现状及影响因素分析

中国全科医学 2024年第21期27卷 2565-2566页

作者：吴兰心张艳孟李雪刘莉赵婷郑州大学护理与健康学院河南省郑州市450001

老年共病易导致多重用药、住院时间延长等不良后果,致使患者身体功能下降和致残率提高,严重影响患者生命质量[1]。有效的自我管理既能对疾病预后产生积极影响,又能减轻家庭负担,使老年共病患者的生活更有意义[2]。目前,国际上对老年共... 详细信息

老年共病易导致多重用药、住院时间延长等不良后果,致使患者身体功能下降和致残率提高,严重影响患者生命质量[1]。有效的自我管理既能对疾病预后产生积极影响,又能减轻家庭负担,使老年共病患者的生活更有意义[2]。目前,国际上对老年共病患者的自我管理尚未形成统一的模式及标准[3],针对该人群的自我管理研究尚不完善。本研究通过调查老年共病患者的自我管理现状并分析其影响因素,以期为后续干预方案的构建提供参考依据。

关键词：老年共病自我管理现状影响因素

维普期刊数据库

On the functions of astrocyte-mediated neuronal slow inward currents

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第12期19卷 2602-2612页

作者： Balázs Pál Department of Physiology Faculty of MedicineUniversity of DebrecenDebrecenHungary

Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of *** events are significantly slower than the excitatory postsynaptic *** of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto *** are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback *** as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological *** is a growing body of evidence on the roles of slow inward currents on a single neuron or local network *** events often occur in synchro ny on neurons located in the same astrocytic *** synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic *** addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory *** note,there might be important regionspecific differences in the roles and actions triggering slow inward *** greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological *** inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural *** inward currents are significant contributors to paroxysmal depolarizational shifts/interictal *** events are related to epilepsy,but also found in Alzheimer's disease,Parkinson's disease,and stroke,leading to the decline of cognitive *** with features overlapping with slow inward currents(excitatory,N-methyl-Dasp

关键词： astrocyte cortical spreading depolarization gliotransmission glutamate neural synchronization NMDA receptor paroxysmal depolarizational shift slow inward current

维普期刊数据库

Obstructive sleep apnea:Overlooked comorbidity in patients with diabetes

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第7期15卷 1448-1460页

作者： Eric D Tenda Joshua henrina Jin h Cha Muhammad R Triono Ersananda A Putri Dahliana J Aristy Dicky l Tahapary Division of Respirology and Critical Care Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia head of Research Group Artificial Intelligence and Digital health Indonesian Medical Education and Research InstituteFaculty of Medicine University of IndonesiaDKI JakartaJakarta Pusat 10430Indonesia Division of Endocrinology Metabolism and DiabetesDepartment of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia

In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),highlighting a significant yet often overlooked *** delve into the pathophysiological links between OSA and diabetes,specifically how OSA exacerbates insulin resistance and disrupts glucose *** research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related *** the importance of comprehensive management,including weight control and positive airway pressure therapy,the study advocates integrated approaches to improve outcomes for patients with T2DM and *** review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.

关键词： Obstructive sleep apnea Type 2 diabetes mellitus Macrovascular Microvascular Weight loss Positive airway pressure

Methionine sources and genotype affect embryonic intestinal development,antioxidants,tight junctions,and growth-related gene expression in chickens

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Nutrition 2024年第1期16卷 218-230页

作者： James K.lugata Sawadi F.Ndunguru Gebrehaweria K.Reda xénia E.Ozsváth Eszter Angyal levente Czeglédi Gabriella Gulyás Renáta Knop János Oláh Zoltán Mészár Rita Varga Brigitta Csernus Csaba Szabó Department of Animal Nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Department of Animal husbandry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Faculty of Agriculture and Food Sciences and Environmental Management Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary Institutes for Agricultural Research and Educational Farm University of DebrecenDebrecenHungary Department of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Evolutionary Zoology and human Biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Methionine(Met)is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and *** present study examined the effect of in ovo injection of Dl-Met and l-Met sources and genotypes on chicken embryonic-intestinal development and *** eggs of the two genotypes,TETRA-Sl layer hybrid(TSl)—commercial layer hybrid and hungarian Partridge colored hen breed(hPC)—a native genotype,were randomly distributed into four treatments for each *** treatment groups include the following:1)control non-injected eggs(NoIn);2)saline-injected(SaIn);3)Dl-Met injected(DlM);and 4)l-Met injected(lM).The in ovo injection was carried out on 17.5 d of embryonic development;after hatching,eight chicks per group were sacrificed,and the jejunum was extracted for *** results showed that both DlM and lM groups had enhanced intestinal development as evidenced by increased villus width,villus height,and villus area(Phe *** DlM group had significantly reduced crypt depth,glutathione(GSh)content,glutathione S-transferase 3 alpha(GST3),occludin(OClN)gene expression and increased villus height to crypt depth ratio in the TSl genotype than the lM group(Phe hPC genotype has overexpressed insulin-like growth factor 1(IGF1)gene,tricellulin(MD2),occludin(OClN),superoxide dismutase 1(SOD1),and GST3 genes than the TSl genotype(Plusion,these findings showed that in ovo injection of Met enhanced intestinal development,and function,with genotypes responding differently under normal *** also influenced the expression of intestinal antioxidants,tight junction,and growth-related genes.

关键词： Dl-Methionine l-Methionine In ovo injection Intestinal development Poultry

维普期刊数据库

Improving the utility of locally differentially private protocols for longitudinal and multidimensional frequency estimates

在线全文

学校读者我要写书评

暂无评论

Digital Communications and Networks 2024年第2期10卷 369-379页

作者： héber h.Arcolezi Jean-François Couchot Bechara Al Bouna xiaokui xiao Inria andÉcole Polytechnique(IPP) PalaiseauFrance Femto-ST Institute Univ.Bourg.Franche-ComtéUBFCCNRSBelfortFrance TICKET lab. Antonine University Hadat-BaabdaBaabdaLebanon School of Computing National University of SingaporeSingaporeSingapore

This paper investigates the problem of collecting multidimensional data throughout time(i.e.,longitudinal studies)for the fundamental task of frequency estimation under local Differential Privacy(lDP)*** to frequency estimation of a single attribute,the multidimensional aspect demands particular attention to the privacy ***,when collecting user statistics longitudinally,privacy progressively ***,the“multiple”settings in combination(i.e.,many attributes and several collections throughout time)impose several challenges,for which this paper proposes the first solution for frequency estimates under *** tackle these issues,we extend the analysis of three state-of-the-art lDP protocols(Generalized Randomized Response–GRR,Optimized Unary Encoding–OUE,and Symmetric Unary Encoding–SUE)for both longitudinal and multidimensional data *** the known literature uses OUE and SUE for two rounds of sanitization(***),i.e.,l-OUE and l-SUE,respectively,we analytically and experimentally show that starting with OUE and then with SUE provides higher data utility(i.e.,l-OSUE).Also,for attributes with small domain sizes,we propose longitudinal GRR(l-GRR),which provides higher utility than the other protocols based on unary ***,we also propose a new solution named Adaptive lDP for lOngitudinal and Multidimensional FREquency Estimates(AllOMFREE),which randomly samples a single attribute to be sent with the whole privacy budget and adaptively selects the optimal protocol,i.e.,either l-GRR or *** shown in the results,AllOMFREE consistently and considerably outperforms the state-of-the-art l-SUE and l-OUE protocols in the quality of the frequency estimates.

关键词： local differential privacy Discrete distribution estimation Frequency estimation Multidimensional data longitudinal studies