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Enhancing electrochemical capacity and interfacial stability of lithium-ion batteries through side reaction modulation with ultrathin carbon nanotube film and optimized lithium cobalt oxide particle size

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Nano Research 2024年第8期17卷 7230-7241页

作者： wei xi xiaogang xia Jiacheng Zhu Dehua Yang Sishen xie Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Advanced Passivation Technology Lab College of Physics Science and TechnologyHebei UniversityBaoding 071002China

Lithium cobalt oxide(LCO),the first commercialized cathode active material for lithium-ion batteries,is known for high voltage and ***,its application has been limited by relatively low capacity and stability at high *** particle size is considered one of the most straightforward and effective strategies to enhance ion transfer,thus increasing the rate ***,side reactions are simultaneously enhanced as the specific surface area ***,we investigate the impact of LCO particles with varying size distributions and optimize the particle *** modulate the side reactions associated with particle size reduction,an ultrathin carbon nanotube film(UCNF)is introduced to coat the cathode *** this simple process and optimized particle size,the rate performance improves significantly,normal commercial LCO achieves 118 mA·h·g^(−1)at 3.0–4.3 V and 20 C(0.72 mA·h·cm^(−2)),corresponding to power density of 8732 W·kg^(−1).This method is applied to high voltage as well,152 mA·h·g^(−1)at 3.0–4.6 V and 20 C(0.99 mA·h·cm^(−2))was achieved with high-voltage LCO(hVLCO),corresponding to power density of 11,552 W·kg^(−1).The cycling stability is also enhanced,with the capacity retention maintaining more than 96%after 100 cycles at 0.1 *** the first time,UCNF is demonstrated to suppress the excessive decomposition of the electrolytes and solvents by blocking electron injection/extraction between LCO and electrolyte *** findings provide a simple method for improving LCO rate performance,especially at high C-rates.

关键词： lithium-ion batteries lithium cobalt oxides carbon nanomaterials side reactions

Drug repurposing for cancer therapy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1981-2013页

作者： Ying xia Ming Sun hai huang wei-Lin Jin Center for Clinical Laboratories The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004PR China The First Affiliated hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001PR China School of Clinical Laboratory Science Guizhou Medical UniversityGuiyang 550004PR China Division of Gastroenterology and hepatology Department of Medicine andDepartment of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21287USA Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000PR China

Cancer,a complex and multifactorial disease,presents a significant challenge to global *** significant advances in surgical,radiotherapeutic and immunological approaches,which have improved cancer treatment outcomes,drug therapy continues to serve as a key therapeutic ***,the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects,and thus there remains a critical need to develop novel cancer *** promising strategy that has received widespread attention in recent years is drug repurposing:the identification of new applications for existing,clinically approved *** repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective,proven to be safe,and can significantly expedite the drug development process due to their already established safety *** light of this,the present review offers a comprehensive overview of the various methods employed in drug repurposing,specifically focusing on the repurposing of drugs to treat *** describe the antitumor properties of candidate drugs,and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor *** addition,we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug *** also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy *** conclude,we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

关键词： drugs integrating spite

NQO1 Mediates Lenvatinib Resistance by Regulating ROS-induced Apoptosis in hepatocellular Carcinoma

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Current Medical Science 2024年第1期44卷 168-179页

作者： wei xUE Ting WANG Wen-jing TIAN Si-qi PANG hua-feng ZhANG wei-dong JIA Department of General Surgery The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Institute of health and Medicine Hefei Comprehensive National Science CenterHefei 230601China The Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease School of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China

Objective hepatocellular carcinoma(hCC)is the third leading cause of cancer-associated death *** a first-line drug for advanced hCC treatment,lenvatinib faces a significant hurdle due to the development of both intrinsic and acquired resistance among patients,and the underlying mechanism remains largely *** present study aims to identify the pivotal gene responsible for lenvatinib resistance in hCC,explore the potential molecular mechanism,and propose combinatorial therapeutic targets for hCC *** Cell viability and colony formation assays were conducted to evaluate the sensitivity of cells to lenvatinib and ***-Seq was used to determine the differences in transcriptome between parental cells and lenvatinib-resistant(LR)*** upregulated genes were analyzed by GO and KEGG ***,qPCR and Western blotting were employed to determine the relative gene expression ***,the intracellular reactive oxygen species(ROS)and apoptosis were detected by flow *** PLC-LR and hep3B-LR were *** was a total of 116 significantly upregulated genes common to both LR cell *** GO and KEGG analyses indicated that these genes were involved in oxidoreductase and dehydrogenase activities,and reactive oxygen species ***,NAD(P)h:quinone oxidoreductase 1(NQO1)was highly expressed in LR cells,and was involved in the lenvatinib *** high expression of NQO1 decreased the production of ROS induced by lenvatinib,and subsequently suppressed the *** combination of lenvatinib and NQO1 inhibitor,dicoumarol,reversed the resistance of LR *** The high NQO1 expression in hCC cells impedes the lenvatinib-induced apoptosis by regulating the ROS levels,thereby promoting lenvatinib resistance in hCC cells.

关键词： hepatocellular carcinoma lenvatinib resistance NAD(P)h quinone oxidoreductase 1 reactive oxygen species apoptosis dicoumarol

Insight into the nitrogen-vacancy center formation in type-Ib diamond by irradiation and annealing approach

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Materials Futures 2024年第4期3卷 181-191页

作者： Taiqiao Liu Fanglin Lyu Tian Shao Diwei Zou wei Shen Yuzheng Guo Yuan Zhong Chaoyang Chen Liangchen Yi Zhaofu Zhang Andy h Shen The Institute of Technological Sciences Wuhan UniversityWuhan 430072People’s Republic of China Gemmological Institute China University of GeosciencesWuhan 430074People’s Republic of China School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072People’s Republic of China Zhongnan Diamond Company Nanyang 473264People’s Republic of China hubei Key Laboratory of Electronic Manufacturing and Packaging Integration Wuhan UniversityWuhan 430072People’s Republic of China

Comprehending the microscopic formation of nitrogen vacancy(NV)centers in nitrogen-doped diamonds is crucial for enhancing the controllable preparation of NV centers and quantum *** followed by annealing simulations for a type-Ib diamond with a 900 ppm concentration of isolated nitrogen is conducted along different orientations and at different annealing *** these simulations,molecular dynamics(MD)with smoothly connected potential functions are *** simulations revealed the dynamic formation process of the NV center,which was subsequently verified by first-principles calculations and *** results indicate that vacancies undergo one or multiple migrations by ex.h.nging sites with neighboring *** are three mechanisms for the formation of NV centers:direct irradiation-induced NV formation,irradiation with further annealing to form NV and vacancy migration(VM)during the annealing ***,the results show that both VM and NV center formations are affected by *** study clarifies the formation of NV centers across multiple scales and provides a solid foundation for the targeted preparation of NV centers.

关键词： diamond NV center irradiation annealing molecular dynamics

New strategy for boosting cathodic performance of low temperature solid oxide fuel cells via chlorine doping

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Nano Research 2024年第9期17卷 8086-8094页

作者： Shaohua xu hao Qiu Shanshan Jiang Jingjing Jiang wei Wang xiaomin xu wei Kong Tanaka Dennis Chivurugwi Arkadii Proskurin Daifen Chen Chao Su School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212100China Institute of Analysis and Testing Beijing Academy of Science and TechnologyBeijing 100089China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerthWA6102Australia Admiral Makarov National University of Shipbuilding Heroiv Ukrainy av.9Mykolaiv54025Ukraine

To enhance the performance and widespread use of solid oxide fuel cells(SOFCs),addressing the low-temperature(<650℃)electrochemical performance and operational stability issues of cathode materials is ***,we propose ... 详细信息

To enhance the performance and widespread use of solid oxide fuel cells(SOFCs),addressing the low-temperature(hemical performance and operational stability issues of cathode materials is ***,we propose an innovative approach to enhance oxygen ion mobility and electrochemical performance of perovskite oxide by substituting some oxygen sites with chlorine *** designed SrTa_(0.1)Fe_(0.9)O_(3-δ-x)Clx(x=0.05 and 0.10)exhibits improved performance compared to SrTa_(0.1)Fe_(0.9)O_(3-δ)(STF).SrTa_(0.1)Fe_(0.9)O_(2.95-δ)Cl_(0.05)(STFCl0.05)shows the lowest area-specific resistance(ASR)value on Sm0.2Ce0.8O1.9(SDC)*** 600℃,STFCl0.05 achieves an ASR value of 0.084Ω·cm^(2),and a single cell with STFCl0.05 reaches a higher peak power density(PPD)value(1143 mW·cm^(-2))than that with STF(672 mW·cm^(-2)).Additionally,besides exhibiting excellent oxygen reduction reaction(ORR)activity at lower temperatures,the STFCl0.05 cathode demonstrates good CO_(2)tolerance and operational *** cell operation lasts for 150 h,and single cell operation endures for 720 h without significant performance *** chlorine doping approach effectively enhances ORR activity and stability,making STFCl0.05 a promising cathode material for low-temperature SOFCs.

关键词： low-temperature solid oxide fuel cells(LT-SOFCs) oxygen reduction reaction(ORR) CO_(2)tolerance chlorine doping

In situ embedded bismuth nanoparticles among highly porous carbon fibers for efficient carbon dioxide reduction

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Rare Metals 2024年第9期43卷 4312-4320页

作者： wei-Jian Guo Ao Zhou Wen-Wen Cai Jin-Tao Zhang Key Laboratory for Colloid and Interface Chemistry(Ministry of Education) School of Chemistry and Chemical EngineeringShandong UniversityJinan 250100China

Electrocatalysis provides an optimal approach for the conversion of carbon dioxide(CO_(2))into high-value chemicals,thereby presenting a promising avenue toward achieve carbon ***,addressing the selectivity and stability challenges of metal catalysts in electrolytic reduction remains a daunting *** this study,the electrospinning method is employed to fabricate porous carbon nanofibers loaded with bismuth nanoparticles with the help of in situ *** porous carbon nanofibers as conductive support would facilitate the dispersion of bismuth active sites while inhibiting their aggregation and promoting the mass transfer,thus enhancing their electrocatalytic activity and ***,nitrogen doping induces electron delocalization in bismuth atoms through metal-support interactions,thus enabling efficient adsorption of intermediates for improving selectivity based on the theoretical ***,Bi@PCNF-500 exhibits the exceptional selectivity and stability across a wide range of potential ***,its faradaic efficiency(FE)of formate reaches 92.7%in h-cell and94.9%in flow cell,respectively,with good electrocatalytic *** in situ characterization and theoretical calculations elucidate the plausible reaction mechanism to obtain basic rules for designing efficient electrocatalyst.

关键词： Porous carbon nanofiber N-doping Electron delocalization Carbon dioxide reduction

A novel profile modification hPF-Co gel satisfied with fractured low permeability reservoirs in high temperature and high salinity

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Petroleum Science 2024年第1期21卷 683-693页

作者： Ya-Kai Li Ji-Rui hou wei-Peng Wu Ming Qu Tuo Liang wei-xin Zhong Yu-Chen Wen hai-Tong Sun Yi-Nuo Pan China University of Petroleum Beijing Beijing102249China PetroChina Tarim Oilfield Company Korla 841000XinjiangChina Key Laboratory of Improving Oil and Gas Recovery of Ministry of Education Northeast Petroleum University Daqing 163318HeilongjiangChina xi'an Shiyou University Xi'an 710065ShaanxiChina Northwest Oilfield Company SINOPECUrumqi 830011XinjiangChina

Conformance control and water plugging are a widely used EOR method in mature ***,majority of conformance control and water plugging agents are unavoidable dehydrated situation in high-temperature and high-salinity low permeability ***,a novel conformance control system hPF-Co gel,based on high-temperature stabilizer(CoCl_(2)·h_(2)O,CCh)is *** hPF-Co bulk gel has better performances with high temperature(120℃)and high salinity(1×10^(5)mg/L).According to Sydansk coding system,the gel strength of hPF-Co with CCh is increased to code *** dehydration rate of hPF-Co gel is 32.0%after aging for 150 d at 120℃,showing excellent thermal *** rheological properties of hPF gel and hPF-Co gel are also *** results show that the storage modulus(G′)of hPF-Co gel is always greater than that of hPF *** effect of CCh on the microstructure of the gel is *** results show that the hPF-Co gel with CCh has a denser gel network,and the diameter of the three-dimensional network skeleton is 1.5-3.5μ*** 90 d of aging,hPF-Co gel still has a good three-dimensional *** spectroscopy results show that CCh forms coordination bonds with N and O atoms in the gel amide group,which can suppress the vibration of cross-linked sites and improve the stability at high *** core plugging test determines the optimized polymer gel injection strategy and injection velocity with hPF-Co bulk gel system,plugging rate exceeding 98%.Moreover,the results of subsequent waterflooding recovery can be improved by 17%.

关键词： Low permeability reservoir high-temperature resistant gel Complexation reaction Polymer gel injection strategy Plugging rate Enhanced oil recovery

胸部挤压伤致声带麻痹、发声障碍法医学鉴定1例

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法医学杂志 2024年第1期40卷 101-103页

作者：虢洪松刘晓贺韦红红李长征济宁医学院法医学与医学检验学院山东济宁272002 济宁医学院司法鉴定中心山东济宁272002

1案例1.1简要案情桑某,女,13岁,某年10月6日因意外被挤伤胸部后出现声带麻痹、发声障碍。受某法院委托,要求就其声带麻痹、发声障碍与胸部挤压伤之间是否存在因果关系及原因力大小进行法医学鉴定。1.2病史摘要某年10月6日桑某因“被机... 详细信息

1案例1.1简要案情桑某,女,13岁,某年10月6日因意外被挤伤胸部后出现声带麻痹、发声障碍。受某法院委托,要求就其声带麻痹、发声障碍与胸部挤压伤之间是否存在因果关系及原因力大小进行法医学鉴定。1.2病史摘要某年10月6日桑某因“被机器挤压胸部后不省人事、烦躁不安1 h”入住甲医院。体格检查:神志不清,烦躁不安;前胸及后背皮肤散在擦伤;双肺呼吸音粗,可闻及大量湿啰音。胸部CT示:双肺上叶挫伤并肺气囊形成;双侧气胸(肺组织压缩约10%);肋骨多发骨折。

关键词：法医学胸部损伤挤压伤声带麻痹发声障碍

Divergent Synthesis of Primary Amides via Modular Dearomative Carbamoylations of Areneπ-Systems

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CCS Chemistry 2024年第8期6卷 2066-2074页

作者： Chu-Qiao Li xu Jiang Ming-Yang Wang wei-Long Zeng wei Li Department of Chemistry Zhejiang UniversityHangzhou 310058

In sharp contrast to the well researched and well developed aminocarbonylation of alkenes,the dearomative carbamoylation of abundant areneπ-systems has scarcely been studied despite its great potential to enrich the diversity-oriented synthesis of high-value *** formidable challenges associated with such dearomatization include the low reactivity of stable aromaticπ-systems and intricate selectivity ***,we disclose a general approach toward highly selective dearomative carbamoylations of areneπ-bonds under CO-gas-free *** extraordinary versatility was demonstrated by tolerating a broad range of nucleophilic partners with high yields and excellent selectivities,thus providing modular access to the divergent synthesis ofβ-functionalized primary *** addition,diverse downstream derivatizations including a formal C–h 1,2-olefination/carbamoylation reaction were conducted,exhibiting great potential in synthetic and medicinal chemistry.

关键词： aminocarbonylation arene carbamoylation dearomatization primary amide