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STcF conceptual design report (Volume 1): Physics & detector

Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov x.c.Ai L.P.An R.Aliberti Q.An x.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.cai H.cai J.J.cao Q.H.cao x.cao Z.cao Q.chang K.T.chao D.Y.chen H.chen H.x.chen J.F.chen K.chen L.L.chen P.chen S.L.chen S.M.chen S.chen S.P.chen W.chen x.chen x.F.chen x.R.chen Y.chen Y.Q.chen H.Y.cheng J.cheng S.cheng T.G.cheng J.P.dai L.Y.dai x.c.dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich c.Q.Feng x.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge c.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.c.Gui A.Q.Guo F.K.Guo J.c.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han x.Q.Hao J.B.He S.Q.He x.G.He Y.L.He Z.B.He Z.x.Heng B.L.Hou T.J.Hou Y.R.Hou c.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu x.H.Hu Y.c.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang x.T.Huang x.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing x.L.Kang x.S.Kang B.c.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev c.H.Li c.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li x.Li x.H.Li x.Q.Li x.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao c.x.Lin D.x.Lin x.S.Lin B.J.Liu c.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu x.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long c.G.Lu J.x.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo x.F.Luo Y.H.Luo H.J.Lyu x.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.x.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova x.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng x.Y.Peng x.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian c.F.Qiao J.J.Qin J.J.Qin L.Q.Qin x.S.Qin T.L.Qiu J.Rademacker c.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia cAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom central china Normal University Wuhan 430079China central South University Changsha 410083China china University of Geosciences Wuhan 430074China china University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STcF)is an electron–positron collider proposed by the chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STcF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPcII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STcF project in china is under development with an extensive R&D *** document presents the physics opportunities at the STcF,describes conceptual designs of the STcF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STcF detector conceptual design

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A multi-enzymatic cascade reaction for the synthesis of bioactive c-oligosaccharides

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chinese chemical Letters 2024年第6期35卷 451-455页

作者： Kebo xie Qian Zhang Fei Ye Jungui dai State Key Laboratory of Bioactive Substance and Function of Natural Medicines CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs and NHC Key Laboratory of Biosynthesis of Natural ProductsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

c-Oligosaccharides are rare in nature and possess diverse ***,their chemical synthesis faces many *** this work,enzymatic introduction of c-linked sugar chains to target aglycones was successfully achieved by multi-enzymatic cascade reactions.A c-glycosyltransferase from Aloe barbadensis was employed to introduce the first c-linked glucose and then a cyclomaltodextrin glucanotransferase from Bacillus licheniformis was used to extend the sugar chain.A total of twenty c-oligosaccharides with 2-6 sugars were synthesized from scale-up reactions and exhibited good water solubility and sodium-dependent glucose transporter 2(SGLT2)inhibitory ***,a glucoamylase was used to control the length of the sugar chain and the c-maltosides were efficiently *** findings not only expanded the structural diversity of c-oligosaccharides,but also provided a strategy for the modification of c-glycoside drugs to improve the druggability.

关键词： c-Oligosaccharides c-Glycosyltransferase cyclomaltodextrin glucanotransferase Glucoamylase Enzymatic synthesis SGLT2 inhibitory activity

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Defect Detection in c-Si Photovoltaic Modules via Transient Thermography and Deconvolution Optimization

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chinese Journal of Electrical Engineering 2024年第1期10卷 3-11页

作者： Zekai Shen Hanqi dai Hongwei Mei Yanxin Tu Liming Wang State Grid Hangzhou Power Supply company State Grid Zhejiang Electric Power Co.Ltd.Hangzhou 310000China Huairou Power Supply Branch State Grid Beijing Electric Power Co.Ltd.Beijing 101400China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China

Defects may occur in photovoltaic(PV)modules during production and long-term use,thereby threatening the safe operation of PV power *** thermography is a promising defect detection technology;however,its detection is limited by transverse thermal *** phenomenon is particularly noteworthy in the panel glasses of PV modules.A dynamic thermography testing method via transient thermography and Wiener filtering deconvolution optimization is *** on the time-varying characteristics of the point spread function,the selection rules of the first-order difference image for deconvolution are *** with a broken grid and artificial cracks were tested to validate the performance of the optimization *** with the feature images generated by traditional methods,the proposed method significantly improved the visual *** defect size detection can be realized by combining the deconvolution optimization method with adaptive threshold *** the same batch of PV products,the detection error could be controlled to within 10%.

关键词： Photovoltaic module transient thermography point spread function deconvolution optimization quantitative detection

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Two-dimensional c2N-based single-atom catalyst with complex microenvironment for enhanced electrochemical nitrogen reduction:A descriptor-based design

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Journal of Energy chemistry 2024年第10期97卷 110-119页

作者： Enduo dai Wei An Ruixian Guo xugen Shi Yunyi Li Yibo Wang Mingming Liu college of chemistry and chemical Engineering Shanghai University of Engineering Science

The catalytic descriptor with operational feasibility is highly desired towards rational design of high-performance catalyst especially the electrode/electrolyte solution interface working under mild ***,we demonstrate that the descriptor Ω parameterized by readily accessible intrinsic properties of metal center and coordination is highly operational and efficient in rational design of single-atom catalyst（SAc） for driving electrochemical nitrogen reduction（NRR）.Using twodimensional metal（M）-BxPySzNm@c2N as prototype SAc models,we reveal that*N2+（H++e-）→*N2H acts predominantly as the potential-limiting step（PLS） of NRR on M-B2P2S2@c2N and M-B1P1S1N3@c2N regardless of the distinction in coordination *** the 28 screened M active sites,with Ω values close to the optimal 4,M-B2P2S2@c2N(M=V（Ω=3.53）,Mo（Ω=5.12）,and W（Ω=3.92）) and M-B1P1S1N3@c2N(M=V（Ω=3.00）,Mo（Ω=4.34）,and W（Ω=3.32）) yield the lowered limiting potential（UL） as-0.45,-0.54.-0.36,-0.58,-0.25,and-0.24 V,respectively,thus making them the promising NRR *** importantly,these SAcs are located around the top of volcano-shape plot of ULversus Ω,re-validating Ω as an effective descriptor for accurately predicting the high-activity NRR SAcs even with complex *** study unravels the relationship between active-site structure and NRR performance via the descriptor Ω,which can be applied to other important sustainable electrocatalytic reactions involving activation of small molecules via σ-donation and π*-backdonation mechanism.

关键词： Descriptor DFT Electrocatalysis N2 reduction Single-atom catalyst

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Defects in phospholipase c zeta cause polyspermy and low fertilization after conventional IVF:not just IcSI failure

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Asian Journal of Andrology 2024年第2期26卷 175-182页

作者： Jian-Fang che Hui-xia Wu Si-cong Zeng Yue-Ren Wu Jing dai De-Hua cheng Fei Gong Guang-xiu Lu Ge Lin can dai School of Medicine Hunan Normal UniversityChangsha 410013China Reproductive and Genetic Hospital of cITIc-xiangya Changsha 410008China clinical Research center for Reproduction and Genetics in Hunan Province Changsha 410078China National Engineering and Research center of Human Stem cell Changsha 410205China

Phospholipase c zeta(PLc)is a key sperm-borne oocyte-activating factor that triggers ca^(2+)oscillations and the subsequent block to polyspermy following gamete *** in PLcZ1,the gene encoding PLcζ,cause male infertility and intracytoplasmic sperm injection(IcSI)fertilization failure;and PLcζ expression and localization patterns are significantly correlated with IcSI fertilization rate(FR).However,in conventional in vitro fertilization(cIVF),whether and how sperm PLcζ affects fertilization remain ***,we identified one previously reported and two novel PLcZ1 mutations associated with polyspermy in vitro that are characterized by excessive sperm-zona binding and a delay in pronuclei(PN)*** staining and oocyte activation testing revealed that virtually all spermatozoa from patients lacked functional PLcζ and were thus unable to evoke ca^(2+) *** with an artificial oocyte activation treatment successfully rescued the polyspermic phenotype and resulted in a live ***,we analyzed PLcζ in an additional 58 males after cIVF treatment in the Reproductive and Genetic Hospital of ciTic-xiangya(changsha,china)between February 2019 and January *** found that the proportion of spermatozoa that expressed PLcζ was positively correlated with both 2PN rate and total *** optimal cutoff value below which males were likely to experience low FR(total FR≤30%)after clVF was 56.7%for the proportion of spermatozoa expressing *** study expands the mutation and the phenotypic spectrum of PLcZ1 and further suggests that PLcζ constitutes a promising biomarker for identifying low FRs cases in cIVF due to sperm-related oocyte activation deficiency and that sperm PLcζ analysis may benefit the widermale population and not onlymen with IcsI failure.

关键词： conventional IVF gene variants PLcζ polyspermy

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Distinct Electrical and Mechanical Responses of a cu-10Fe composite Prepared by Hot-Pressed Sintering and Post Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 255-265页

作者： x.Y.Yue S.Y.Peng x.Zhang c.N.He Y.Z.Tian Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China School of Materials Science and Engineering and Tianjin Key Laboratory of composite and Functional Materials Tianjin UniversityTianjin300350China Research centre for Metallic Wires Northeastern UniversityShenyang110819China

A cu-10wt%Fe composite was prepared through hot-pressed sintering,and the material was subsequently solution *** hot-pressed sintered and solution treated materials were rolled and *** precipitation behavior and performance changes were systematically studied by using scanning electron microscopy and transmission electron *** contrast to the hot-pressed sintered specimen,the solution treatment significantly affects the thermal stability and properties of the cu-10wt%Fe *** cu-10wt%Fe composite was prepared after solid solution,cold rolling and aging at 773 K for 1 h,and it obtained excellent tensile strength of 494 MPa,uniform elongation of 16.3%,electrical conductivity of 51.1%IAcS and softening temperature of 838 *** for the distinct difference in thermal stability and properties between hot-pressed sintered and solution treated specimens were *** findings provide a theoretical basis for designing high-performance cu-based in-situ composites by post treatment.

关键词： cu-Fe composite Hot-pressed sintering Thermal stability Strength Electrical conductivity

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Immune functions of c-type lectins in medical arthropods

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Insect Science 2024年第3期31卷 652-662页

作者： Zhihao Ming Zhiqiang chen Hao Tong xia Zhou Tingting Feng Jianfeng dai Institute of Biology and Medical Sciences Jiangsu Key Laboratory of Infection and ImmunitySoochow UniversitySuzhouJiangsu ProvinceChina School of Biology and Basic Medical Science Suzhou Medical College of Soochow UniversitySuzhouJiangsu ProvinceChina

c-type lectins(cTLs)are a family of proteins that contain 1 or more carbohydrate-recognition domains(cRDs)and bind to a broad repertoire of ligands in the presence of calcium *** play important roles in innate immune defenses against microorganisms by acting as pattern-recognition receptors(PRRs)for invading pathogens,such as bacteria,viruses,and *** binding to pathogen-associated ligands,cTLs mediate immune responses,such as agglutination,phagocytosis,and the activation of phenol oxidase progenitors,thereby clearing *** are an evolutionarily conserved family found in almost all vertebrates and *** arthropods can acquire and transmit a range pathogens through various approaches,such as bloodsucking,lancing,and parasitism,thus infecting humans and animals with related diseases,some of which can be *** studies have shown that lectins are important components of the arthropod immune system and are essential for the immune responses of arthropods to arthropod-borne *** article reviews the current understanding of the structure,function,and signaling pathways involved in cTLs derived from important medical arthropods.

关键词： arthropod c-type lectin innate immunity vector-borne disease

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The preface: Interplay of topological and magnetic orders in the Mn-Bi-Te family

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National Science Review 2024年第2期11卷 6-7页

作者： Fu-chun Zhang Hai-Zhou Lu x.c.xie Kavli Institute for Theoretical Sciences University of Chinese Academy of Sciences Department of Physics Southern University of Science and Technology (SUSTech) International center for Quantum Materials School of Physics Peking University

The discovery and synthesis of MnBi2Te4in 2013 initially garnered little attention [1]. Yet, the revelation of its topological properties in 2019 [2–6] sparked a surge of research into the MnBiTe family. These extensive studies are primarily driven by two objectives:the realization of a high-temperature quantum anomalous Hall effect （QAHE） and the exploration of exotic phases born from the interplay of topological and magnetic orders,

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Stereoselective synthesis of substituted 1,3-dienes from propargylic esters: electrophilic-metal or redox catalysis?

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Science china chemistry 2024年第5期67卷 1384-1396页

作者： Mengfu dai Liangliang Song Liang-An chen Jiangsu collaborative Innovation center of Biomedical Functional Materials Jiangsu Key Laboratory of New Power BatteriesSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Jiangsu co-Innovation center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China

1,3-Diene architectures are not only widely present in natural products, pharmaceuticals, and functional organic materials but also serve as versatile building blocks to furnish important functionalized molecules in synthetic chemistry due to conjugated repeating c=c units. Accordingly, various strategies to access substituted 1,3-dienes in a stereoselective manner have been developed. However, chemo-, regio-and stereoselective synthesis of highly substituted 1,3-dienes still remains elusive and challenging. Readily available propargylic esters have emerged as an appealing class of synthetic intermediates for accessing functionalized 1,3-dienes, especially challenging tri-or tetrasubstituted variants, via transition-metal catalysis, including electrophilic metal and redox neutral catalysis. This review, for the first time, systematically highlights recent advances in transitionmetal catalyzed synthesis of substituted 1,3-dienes from propargylic esters, discusses the mechanisms and synthetic utilities, and gives the remaining challenges and potential opportunities in this field.

关键词： 1 3-diene propargylic ester Lewis acid redox catalysis transition metal

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Evolution of Monkeypox c9L RNA G-Quadruplex Elevates the Translation of Its Only Kelch-like Protein by Accelerating G-Quadruplex Unfolding Kinetics

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ccS chemistry 2024年第4期6卷 953-963页

作者： Yicong dai xucong Teng Difei Hu Qiushuang Zhang Jinghong Li Department of chemistry Center for Bioanalytical ChemistryKey Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084 New cornerstone Science Laboratory Shenzhen 518054 Beijing Life Science Academy Beijing 102209 center for Bioanalytical chemistry Hefei National Laboratory of Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026

Genomic surveillance of monkeypox virus(MPxV)is essential to explore the reason of its unusual *** phylogenomic analysis of the MPxV genome mainly focuses on the effect of amino acid ***,we explore the evolutionary variation of RNA G-quadruplex(RG4)of MPxV and find that the genome evolution of MPxV can also produce new effects through changes in the RG4 *** RG4 is located in MPxV’s only Kelch-like c9L gene,which encodes for an antagonist of the innate immune *** evolution of this virus increases the unfolding kinetic constant of c9L RG4 and promotes the c9 protein level in living ***,all reported MPxV genomes in 2022 carry the c9L-RG4-5 pattern with the highest unfolding kinetic ***,the RG4 ligand,RGB-1,can impede the unfolding of c9L-RG4-5 and thereby reduce the c9 protein *** findings carve out a new path to comprehensively understanding MPxV virology.

关键词： G-quadruplex RNA secondary structure unfolding kinetics monkeypox virus genomic evolution immune evasion

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