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家族性高胆固醇血症国内外诊疗异同

中国全科医学 2025年第6期28卷 655-665页

作者：马弘阳岳岸娜孙康云南京医科大学附属苏州市立医院心血管内科江苏省苏州市215000

家族性高胆固醇血症(FH)是一种常见的遗传代谢性疾病,主要特征是低密度脂蛋白胆固醇(LDL-C)异常升高,可表现为角膜弓、黄色瘤等症状。长期高水平的LDL-C会增加动脉粥样硬化性心血管疾病(ASCVD)的风险。FH患者早发ASCVD的风险较高,纯合型... 详细信息

家族性高胆固醇血症(FH)是一种常见的遗传代谢性疾病,主要特征是低密度脂蛋白胆固醇(LDL-C)异常升高,可表现为角膜弓、黄色瘤等症状。长期高水平的LDL-C会增加动脉粥样硬化性心血管疾病(ASCVD)的风险。FH患者早发ASCVD的风险较高,纯合型的FH病情更为严重。全球FH的流行率逐渐受到重视,但诊断和治疗仍存在不足。借着《2023年中国血脂管理指南》的发布,本文主要比较了国内外关于FH筛查、诊断的不同,用于强调筛查血脂情况的重要性,并建议早期识别FH患者。同时,基因检测也被推荐,不仅限于少数基因,还应包含其他相关基因或全基因组检测。此外,本文也比较了不同指南对于FH患者LDL-C控制管理水平的差异,以及对于不同LDL-C划分的ASCVD危险因素新要素;比较了不同指南在饮食、生活方式、药物控制等方面的差别,指出国内外一致认为他汀类药物是主要的降脂药物,联合应用尤为重要,但对于最大剂量后LDL-C控制未达标的患者国际血脂护理指南有一定更新。同时,对于纯合型FH(HoFH)患者,高强度他汀类药物联合其他药物治疗是首选,早期的治疗更为关键,适当提早脂蛋白单采术与前蛋白转换酶枯草溶菌素9(PCSK9)抑制剂的应用有助于降低ASCVD的发病率和死亡率。

关键词：高胆固醇血症分子基础诊断诊疗方案指南差异

Effect of Temperature on Material Transfer Behavior at Different Stages of Friction Stir Welded 7075-T6 Aluminum Alloy

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Journal of Materials Science & Technology 2013年第10期29卷 955-960页

作者： S.D.Ji Y.Y.Jin Y.M.yue S.S.Gao Y.x.Huang L.Wang Faculty of Aerospace Engineering Shenyang Aerospace University State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology

In this work, the morphologies of weld of 7075-T6 aluminum alloy via friction stir welding （FSW） were analyzed by optical microscopy, the temperature field was attained by numerical simulation, and the effect of temperature on material transfer behavior in the thermal-mechanical affected zone （TMAZ） at different stages was mainly investigated. The FSW process consists of three stages. It is very interesting to find that the maximum transfer displacement of material appears at the final stage of welding process, then at the stable stage and at the initial stage, which results from the difference of peak temperatures at different stages. At any stage, the material in TMAZ near the surface of weld transfers downwards, the material in the middle of weld moves upwards and the material near the bottom of weld hardly moves. In any cross section of weld, the largest transfer displacement of material appears in the middle of weld. The increase of rotational velocity and the decrease of welding speed are both beneficial to the transfer displacement of material in the middle of weld.

关键词： Friction stir welding 7075-T6 aluminum alloy Thermal-mechanical affected zone Material transfer Numerical simulation

A novel(2+1)-dimensional integrable KdV equation with peculiar solution structures

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Chinese Physics B 2020年第8期29卷 176-181页

作者： Sen-yue Lou School of Physical Science and Technology Ningbo UniversityNingbo 315211China

The celebrated(1+1)-dimensional Korteweg de-Vries(KdV)equation and its(2+1)-dimensional extension,the Kadomtsev-Petviashvili(KP)equation,are two of the most important models in physical *** KP hierarchy is explicitly written out by means of the linearized operator of the KP equation.A novel(2+1)-dimensional KdV extension,the cKP3-4 equation,is obtained by combining the third member(KP3,the usual KP equation)and the fourth member(KP4)of the KP *** integrability of the cKP3-4 equation is guaranteed by the existence of the Lax pair and dual Lax *** cKP3-4 system can be bilinearized by using Hirota's bilinear operators after introducing an additional auxiliary *** solutions of the cKP3-4 equation possess some peculiar and interesting properties which are not valid for the KP3 and KP4 *** instance,the soliton molecules and the missing D'Alembert type solutions(the arbitrary travelling waves moving in one direction with a fixed model dependent velocity)including periodic kink molecules,periodic kink-antikink molecules,few-cycle solitons,and envelope solitons exist for the cKP3-4 equation but not for the separated KP3 equation and the KP4 equation.

关键词： (2+1)-dimensional KdV equations Lax and dual Lax pairs soliton and soliton molecules D’Alembert type waves

Co_(4)^(Ⅱ)O_(4)立方烷簇的合成、结构、质谱学和电催化性质研究

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湖北大学学报（自然科学版） 2025年第1期47卷 146-152页

作者：张越胡泉源湖北大学化学化工学院湖北武汉430062

以2-甲基-2-(1 H-苯并咪唑基)-1,3丙二醇配体与3d过渡金属Co离子通过溶剂热法配位合成配合物,借助x-射线单晶衍射仪进行晶体结构检测。结果表明:中心离子C_(O)(Ⅱ)以六配位形成八面体构型,该晶体属于单斜晶系,其中a(nm)=1.25579(3),b(nm... 详细信息

以2-甲基-2-(1 H-苯并咪唑基)-1,3丙二醇配体与3d过渡金属Co离子通过溶剂热法配位合成配合物,借助x-射线单晶衍射仪进行晶体结构检测。结果表明:中心离子C_(O)(Ⅱ)以六配位形成八面体构型,该晶体属于单斜晶系,其中a(nm)=1.25579(3),b(nm)=1.88920(8),c(nm)=2.39851(5),α(°)=90,β(°)=95.379(2),γ(°)=90(2),ESI-MS、xRD、TG-MS等常规测试手段研究了此配合物的基本结构、固液性质和物化性能,同时电催化氧化表征测试结果表明在电流密度为10 mA^(-2)时,其催化过电位为344 mV。

关键词：配合物晶体结构质谱电催化

Synthesis and Crystal Structure of 4,5-Diazafluorene-9-one Azine Hydrochloride Hydrate

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Chinese Journal of Structural Chemistry 2002年第3期21卷 249-251页

作者：骆yue 徐端钧 Zhejiang Univ Dept Chem Hangzhou 310027 Peoples R China

Crystals of the title compound C22H12N62HCl?H2O (DAA稨Cl) were obtained from a HCl aqueous solution of 4, 5-diazafluorene-9-one azine. The crystal belongs to monoclinic, space group P21/c with a = 5.203(3), b = 8.991(3), c = 22.17(1) , b = 92.13(4), V = 1036.2(9) 3, Z = 2, C22H18N6O2Cl2, Mr = 468.1, Dc = 1.503 g/cm3, F(000) = 484, m(MoKa) = 0.344 mm-1, R = 0.052 and wR = 0.056 for 755 observed reflections. The Cl…N(2) distance of 2.999(6) ?and Cl…HN(2) angle of 160.8(8)o imply the existence of a stronger H-bond between Cl and DAA. And both the rather longer ClH distance of 1.814(2) ?and the unexpected shorter N(2)H distance of 1.236(6) ?suggest the protonation of DAA molecule and explain the weak coordination ability of DAA to a metal center in the acidic solution.

关键词： diazafluorene-9-one azine crystal structure protonation coordination ability

New Chief, New Journey, New Excellence

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IEEE/CAA Journal of Automatica Sinica 2018年第1期5卷 1-2页

作者： Fei-yue Wang IEEE

After five years planning and working for its creation,and four years serving as its Founding Editor-in-Chief,it is time for me to step down and free IEEE/CAA Journal of Automatica Sinica to the new journey for its ne... 详细信息

关键词： New Journey New Chief New Excellence Man

A Study of the Molecular Cloud S64 with Multiple Lines of CO Isotopes

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Chinese Journal of Astronomy and Astrophysics 2006年第1期6卷 61-68页

作者： Lei Zhu yue-Fang Wu yue Wei Department of Astronomy Peking University Beijing 100871

We report on a study of the molecular cloud S64 with observations at millimeter wavelengths of multiple molecular lines of CO isotopes. A weak outflow is found, and its physical parameters are estimated. The departure of the core of S64 from the S64 HII region indicates that there are still other star formation activities in that region.

关键词： stars: formation -- ISM: clouds -- ISM: individual: S64 -- ISM: jets and outflows -- ISM: evolution -- ISM: kinematics and dynamics

Can ChatGPT Boost Artistic Creation:The Need of Imaginative Intelligence for Parallel Art

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IEEE/CAA Journal of Automatica Sinica 2023年第4期10卷 835-838页

作者： Chao Guo yue Lu Yong Dou Fei-yue Wang The State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Institute of Systems Engineering Macao University of Science and TechnologyMacao 999078China

CHATGPT,one of the leading Large Language Models(LLMs),has acquired linguistic capabilities such as text comprehension and logical reasoning,enabling it to engage in natural conversations with humans.

关键词： such has reasoning

Unified field theory of basic forces and elementary particles with gravitational origin of gauge symmetry in hyper-spacetime

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Science Bulletin 2017年第16期62卷 1109-1113页

作者： yue-Liang Wu International Centre for Theoretical Physics Asia-Pacific(ICTP-AP).Beijing 100190 China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190.China University of Chinese Academy of Sciences(UCAS) Beijing 100049China

The theory of general relativity(GR)[1,2]has successfully built a relation between the geometry of spacetime and the energymomentum tensor of *** has extensively quested for potential unified models of electromagnetis... 详细信息

关键词：统一场论引力源对称性时空基本粒子中尺度能量-动量张量广义相对论