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Creeping fat and gut microbiota in Crohn’s disease

World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla o Magro Marcello Imbrizi Ellen CS De oliveira luiz C Di Stasi ligia y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease

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Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

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FINITE ElEMENT ANAlySIS oF VISCoUS FloW PAST A RoTATING SPHERE

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Journal of Hydrodynamics 2001年第2期13卷 80-85页

作者： Wang, y.x. lu, x.y. Zhuang, l.x. Dept. of Modern Mech. Univ. of Sci. and Technol. of China Hefei 230026 China

Viscous flow past a rotating sphere with a constant rotating speed about an axis aligned with the free stream was investigated numerically by solving the three-dimensional Navier-Stokes equations using the finite element method. To elucidate the character of this flow in the near wake, the flow structures at different Reynolds numbers and rotating speeds are examined. The axisymmetric and non-axisymmetric flow structures were observed at Re=200 and 250, respectively, which rotate as a whole around the rotating axis steadily. At Re=300, the vortex shedding appears and the wake becomes more complicated. At low rotating speeds, the flow is dominated by the vortex shedding at higher Reynolds numbers. As the rotating speed increases, the rotating effect gets stronger and the interaction between the rotating action and the vortex shedding results a swirling vortex pattern in the near wake of the sphere.

关键词： Finite element method Navier Stokes equations Numerical methods Three dimensional

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Effect of perforation on flow past a conic cylinder at Re =100: wavy vortex and sign laws

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Acta Mechanica Sinica 2018年第5期34卷 812-829页

作者： l.M.lin x.F.Zhong y.x.Wu Key laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Sciences University of Chinese Academy of SciencesBeijing 100049China

In order to find the intrinsic physical mechanism of the original Kármán vortex wavily distorted across the span due to the introduction of three-dimensional (3-D) geometric disturbances,a flow past a peak-perforated conic shroud is numerically simulated at a Reynolds number of *** on previous work by Meiburg and lasheras (1988),the streamwise and vertical interactions with spanwise vortices are introduced and *** vortex-shedding patterns in the near wake for different flow regimes are reinspected and illustrated from the view of these two ***,in regime Ⅰ,spanwise vortices are a little distorted due to the weak *** in regime Ⅱ,spanwise vortices,even though curved obviously,are still shed synchronously with moderate streamwise and vertical *** in regime Ⅲ,violently wavy spanwise vortices in some vortex-shedding patterns,typically an Ω-type vortex,are mainly attributed to the strong vertical interactions,while other cases,such as multiple vortex-shedding patterns in sub-regime Ⅲ-D,are resulted from complex streamwise and vertical interactions.A special phenomenon,spacial distribution of streamwise and vertical components of vorticity with specific signs in the near wake,is analyzed based on two models of streamwise and vertical vortices in explaining physical reasons of top and bottom shear layers wavily varied across the *** these two models and above two interactions are *** two sign laws are summarized:the first sign law for streamwise and vertical components of vorticity is positive in the upper shear layer,but negative in the lower shear layer,while the second sign law for three vorticity components is always negative in the wake.

关键词： Vortex-shedding pattern Flow control Vortex dynamics Conic disturbance Perforation Sign law

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Effect of perforation on flow past a conic cylinder at Re=100:vortex-shedding pattern and force history

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Acta Mechanica Sinica 2018年第2期34卷 238-256页

作者： l.M.lin x.F.Zhong y.x.Wu Key laboratory for Mechanics in Fluid Solid Coupling Systems Institute of Mechanics Chinese Academy of Sciences

The flow past a circular-section cylinder with a conic shroud perforated with four holes at the peak was simulated numerically at Re = 100, considering two factors, *** angle of attack and the diameter of the holes. The effects of the perforated conic shroud on the vortex shedding pattern in the near wake was mainly investigated, as well as the time history of the drag and lift forces. In the investigated parameter space, three flow regimes were generally identified, corresponding to weak, moderate, and strong disturbance *** regime I, the wake can mainly be described by alternately shedding Kármán or Kármán-like vortices. In regime II, the spanwise vortices are obviously disturbed along the span due to the appearance of additional vorticity components and their interactions with the spanwise vortices, but still shed in synchronization along the spanwise direction. In regime III,the typical Kármán vortices partially or totally disappear,and some new vortex shedding patterns appear, such as-type, obliquely shedding, and crossed spanwise vortices with opposite sign. Corresponding to these complex vortex shedding patterns in the near wake, the fluid forces no longer oscillate regularly at a single vortex shedding frequency, but rather with a lower modulation frequency and multiple amplitudes. An overview of these flow regimes is presented.

关键词： Vortex shedding pattern Fluid forces Flow control Conical shroud Perforation

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Mechanism of wavy vortex and sign laws in flow past a bluff body:vortex-induced vortex

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Acta Mechanica Sinica 2019年第1期35卷 1-14,I0001页

作者： l.M.lin S.y.Shi x.F.Zhong y.x.Wu Key laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Sciences University of Chinese Academy of SciencesBeijing 100049China

As reported in a previous work by lin et al.(Acta Meeh Sin, 2018. https://***/10.1007/s 10409-018-0758-z), an interesting phenomenon was discovered based on the analysis of wavy vortex and vorticity distribution in the shear layers and near wake of a peak-perforated conic shroud, and two sign laws were summarized. In the present paper, the theory of a vortex-induced vortex is introduced to explore mechanisms in a wavy vortex and applicable sign laws for uniform and incompressible flow past a fixed bluff body. Based on the analysis of the nearest-wall How, two vortex-induced models for streamwise and vertical vortex pairs, respectively, are proposed under two boundary cases, denoting the induced vorticity introduced or distributed on and near the walls. As a result, the first sign law, for only streamwise and vertical components of vorticity, and the second sign law, for three components of vorticity, are obtained under their own particular conditions. The first sign law reveals the intrinsic physical relationship between streamwise and vertical vorticities, independent of the distribution of spanwise vortices in the whole flow field. It is also confirmed that the spanwise vortices, as well as the shear layers and wake width, distributed wavily across the span, are attributed to the introduced streamwise or vertical vortices. The two sign laws for vorticity are independent of the disturbed spanwise wavelength and the Reynolds number. Through the analysis of flow past the conic shroud, the two sign laws are successfully used to summarize typical spacial distributions of vorticity in three flow regions: on and near the front cylinder surfaces, the separated shear layers and the near wake.

关键词： Wavy vortex Sign law Vortex-induced vortex Wake Bluff body

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Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.BAlIlASHAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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EFFECT oF CHEMICAl CoMPoSITIoN AND PRoCESSES oN THE TExTURE oF HoT-RollED DEEP DRAWING STEEl SHEET

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Acta Metallurgica Sinica(English letters) 2002年第3期15卷 324-330页

作者： y.Chen x.Chen C.y.li x.y.li y.l.Kang Technical Center of Wuhan Iron and Steel Group Co. Wuhan 430080China Wuhan University of Science and Technology Wuhan 430080China Central General Iron and Steel Research Institute Beijing 100081China University of Science and Technology Beijing Beijing 100083China

A hot-rolled deep drawing(HDD)steel with high r-value and uniformdistribution of{111}texture in thickness was developed by hot rolling in ferrite region withlubricating between the roller and the *** experimental results show that the carbon contentand finish rolling temperature have significant effects on beneficial texture{111},and lubricatingduring hot rolling at low temperature in alpha-region makes the distribution of the *** basic requirements needed to meet for HDD steel were concluded by comparing differentcarbon contents and hot rolling processes.

关键词： ultra low carbon hot rolling in alpha-region lubricating r-value {111}texture

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Homotopy analysis solutions for the asymmetric laminar flow in a porous channel with expanding or contracting walls

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Acta Mechanica Sinica 2011年第2期27卷 208-214页

作者： x.-H. Si l.-C. Zheng x.-x. Zhang y. Chao Applied Science School University of Science and Technology Beijing 100083 Beijing China Department of Mechanical Engineering University of Science and Technology Beijing100083 Beijing China Research Institute of Chemical Defense of the El.A 102205 Beijing China

In this paper, the asymmetric laminar flow in a porous channel with expanding or contracting walls is investigated. The governing equations are reduced to ordinary ones by using suitable similar transformations. Homotopy analysis method （HAM） is employed to obtain the expres- sions for velocity fields. Graphs are sketched for values of parameters and associated dynamic characteristics, especially the expansion ratio, are analyzed in detail.

关键词： Homotopy analysis method · Expanding or contracting wall · Asymmetric laminar flow · Porous channel · Expansion ratio

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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

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