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E674Q(shanghai APP mutant),a novel amyloid precursor protein mutation,in familial late-onset Alzheimer's disease

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Genes & Diseases 2024年第2期11卷 1022-1034页

作者： Yongfang Zhang xinyi xie Boyu Chen Lina Pan Jianping Li Wanbing wang Jintao wang Ran Tang Qiang Huang xiaofen Chen Rujing Ren Zhentao Zhang Wei Fu Gang wang Department of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of NeuroscienceSchool of MedicineXiamen UniversityXiamenFujian 361102China shenzhen Research Institute of xiamen University ShenzhenGuangdong 518063China

Identified as the pathogenic genes of Alzheimer's disease(AD),APP,PsEN1,and PsEN2 mainly lead to early-onset AD,whose course is more aggressive,and atypical symptoms are more common than sporadic ***,a novel missense mutation,APP E674Q(also named“shanghai APP”),was detected in a Chinese index patient with typical late-onset AD(LOAD)who developed memory decline in his *** results from neuroimaging were consistent with AD,where widespread amyloidβdeposition was demonstrated in 18 F-florbetapir Positron Emission Tomography(PET).APP E674Q is close to theβ-secretase cleavage site and the well-studied swedish APP mutation(KM670/671NL),which was predicted to be pathogenic in *** dynamics simulation indicated that the E674Q mutation resulted in a rearrangement of the interaction mode between APP and BACE1 and that the E674Q mutation was more prone to cleavage by *** in vitro results suggested that the E674Q mutation was pathogenic by facilitating the BACE1-mediated processing of APP and the production of Aβ.Furthermore,we applied an adeno-associated virus(AAV)-mediated transfer of the human E674Q mutant APP gene to the hippocampi of two-month-old C57Bl/6 J ***-E674Q-injected mice exhibited impaired learning behavior and increased pathological burden in the brain,implying that the E674Q mutation had a pathogenicity that bore a comparison with the classical swedish ***,we report a strong amyloidogenic effect of the E674Q substitution in *** our knowledge,E674Q is the only pathogenic mutation within the amyloid processing sequence causing LOAD.

关键词： Alzheimer's disease Amyloid beta APP mutation E674Q Late onset

A direct polymeric carbon nitride/tungsten oxide Z-scheme heterostructure for efficient photocatalytic hydrogen generation via reforming of plastics into value-added chemicals

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Rare Metals 2024年第8期43卷 3771-3783页

作者： Rui-Zhe wang Zhi Lin Yi-Qing wang Kai-Ni Zhang Ge-Hong Zhang Jie Zhang samuel s.Mao shao-Hua shen International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi'an Jiaotong UniversityXi'an 710049China school of Civil and Architecture Engineering Xi'an Technological UniversityXi'an 710021China Department of Mechanical Engineering University of California at BerkeleyBerkeleyCA94720USA

To promote charge transfer and separation for efficient photocatalysis,a direct Z-scheme heterostructure was constructed by coupling polymeric carbon nitride(PCN) and WO_(3).Interestingly,the obtained PCN/WO_(3)Z-scheme heterostructure could photocataly tic ally produce hydrogen and value-added chemicals(e.g.,formate and acetate) by reforming of plastic polylactic acid(PLA) in alkaline aqueous *** optimizing WO_(3) contents and reaction conditions,the obtained PCN/WO_(3)heterostructure exhibits much increased photocatalytic activity for PLA photoreforming under visible light,with hydrogen evolution rate reaching 402.90 μmol·g~(-1)·h~(-1),which is 3.5 times that of *** is revealed that the Z-scheme charge transfer between PCN and WO_(3) mainly contributes to the promoted charge separation and thus the improved photocatalytic ***,with h+and·OH experimentally evidenced as the predominant active species,a possible reaction pathway for the reforming of PLA into value-added chemicals(e.g.,formate and acetate)over PCN/WO_(3) Z-scheme heterostructure is cleared by monitoring the reaction intermediates and *** work paves a carbon neutrality and scalable route toward the synergistical production of hydrogen and value-added chemicals by utilizing and recycling plastic waste.

关键词： Carbon nitride Z-scheme heterojunction Plastic waste conversion Photocatalytic H_(2)production Value-added chemicals

Coal/Gangue Volume Estimation with Convolutional Neural Network and separation Based on Predicted Volume and Weight

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Computers, Materials & Continua 2024年第4期79卷 279-306页

作者： Zenglun Guan Murad s.Alfarzaeai Eryi Hu Taqiaden Alshmeri wang Peng school of Mechatronic Engineering China University of Mining and TechnologyXuzhou221116China China National Coal Group Corp. Beijing100029China Information Institute Ministry of Emergency Management of the ChinaBeijing100029China school of Mechanical Engineering Sana’a UniversitySana’a31220Yemen

In the coal mining industry,the gangue separation phase imposes a key challenge due to the high visual similaritybetween coal and ***,separation methods have become more intelligent and efficient,using newtechnologies and applying different features for *** such method exploits the difference in substancedensity,leading to excellent coal/gangue ***,this study uses density differences to distinguishcoal from gangue by performing volume prediction on the *** training samples maintain a record of3-side images as input,volume,and weight as the ground truth for the *** prediction process relieson a Convolutional neural network(CGVP-CNN)model that receives an input of a 3-side image and then extractsthe needed features to estimate an approximation for the *** classification was comparatively performedvia ten different classifiers,namely,K-Nearest Neighbors(KNN),Linear support Vector Machines(Linear sVM),Radial Basis Function(RBF)sVM,Gaussian Process,Decision Tree,Random Forest,Multi-Layer Perceptron(MLP),Adaptive Boosting(AdaBosst),Naive Bayes,and Quadratic Discriminant Analysis(QDA).After severalexperiments on testing and training data,results yield a classification accuracy of 100%,92%,95%,96%,100%,100%,100%,96%,81%,and 92%,*** test reveals the best timing with KNN,which maintained anaccuracy level of 100%.Assessing themodel generalization capability to newdata is essential to ensure the efficiencyof the model,so by applying a cross-validation experiment,the model generalization was *** useddataset was isolated based on the volume values to ensure the model generalization not only on new images of thesame volume but with a volume outside the trained ***,the predicted volume values were passed to theclassifiers group,where classification reported accuracy was found to be(100%,100%,100%,98%,88%,87%,100%,87%,97%,100%),*** obtaining a classification with hi

关键词： Coal coal gangue convolutional neural network CNN object classification volume estimation separation system

Hierarchical Fe_(x)Bi_(2−x.s.(3) solid solutions for boosted supercapacitor performance

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Nano Research 2024年第5期17卷 3997-4005页

作者： Fengming Zhou xiaodong wang Ruijie Jing xiaoyu Li Qi Zhang Zhenjiang Li Yunmei Du Zhenyu xiao Lei wang International Cooperation United Laboratory of Eco-chemical Engineering and Green Manufacturing College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China Technology Innovation Center of Battery safety and Energy storage Technology QingdaoInternational Science and Technology Cooperation Base of QingdaoCollege of Environment and Safety EngineeringQingdao University of Science and TechnologyQingdao 266042China

For the pursuit of high energy supercapacitors,the development of high performance pseudocapacitance or battery-type negative electrode material is urgently needed to make up for the capacity shortage of commercial electric double layer capacitor(EDLC)type ***,a porous and defect-rich Fe_(x)Bi_(2-x.s.(3) solid solution structure is firstly constructed by employing Fe-doped Bi_(2)O_(2)CO_(3) porous nanosheets as a precursor,which presents dramatically increased energy storage performance than Bi_(2)s_(3) and Fes_(2) *** the optimized Fe_(x)Bi_(2-x.s.(3) solid solution(FeBis-60%),the Fe solute is free and random dispersed in Bi_(2)s_(3) framework,which can effectively modulate the electronic structure of Bi element and introduce rich-defect due to the ex.s.ence of Fe(II).Meanwhile,the FeBis-60%,constructed by pore nanosheets that are assembled by self-supported basic nanorod units,presents rich mesoporous channels for fast mass transfer and abundant active sites for promoting capacity ***,a high capacitance of 832.8 F·g^(-1) at a current density of 1 A·g^(-1) is achieved by the FeBis-60%***,a fabricated Ni3s_(2)@Co_(3)s_(4)(NCs)//FeBis-60%hybrid supercapacitor device delivers an outstanding energy density of 85.33 Wh·kg^(-1) at the power density of 0.799 kW·kg^(-1),and ultra-long lifespan of remaining 86.7%initial capacitance after 8700 cycles.

关键词： supercapacitor solid solutions defect structure hierarchical structure Bi_(2)s_(3)

Applications and grants of the National Natural science Foundation of China's General Program and Young scientists Fund in immunology research:a 10-year review(2013–2022)

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science China(Life sciences) 2024年第6期67卷 1321-1324页

作者： Baoman Li Yanyan Tian Puyue wang Department of Life sciences National Natural Science Foundation of ChinaBeijing 100085China

Immunology,a biomedical discipline with an ancient history of maintaining thriving research vitality to date,refers to the study of the structure and function of the immune system of the body,the pathogenesis of immune-related diseases,immunological diagnoses,and prevention mechanisms(National Natural science Foundation of China,2023).Immunological research is the foundation of research in biology,as well as basic and clinical medicine(Kubli et al.,2021).

关键词： prevention Foundation Natural

Rubik's cube as in-situ programmable matter and a reconfigurable mechanical metamaterial

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science China Technological sciences 2024年第10期67卷 3221-3234页

作者： ZHU shaoWei CHEN Huan YANG xiaoQiang TAN Li JIN shuai CHEN LiMing LIU Tao TAN xiaoJun wang LianChao wang Bing MUAMER Kadic College of Aerospace Engineering Chongqing University state Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing University school of Civil Aviation Northwestern Polytechnical University National Key Laboratory of science and Technology on Advanced Composites in special Environments Harbin Institute of Technology Institut FEMTO-sT CNRS UMR 6174University Bourgogne

As part of the 4th industrial revolution, programmable mechanical metamaterials exhibit great application potential in flexible robotics, vibration control, and impact protection. However, maintaining a programmed state without sustaining the external stimulus is often challenging and leads to additional energy consumption. Inspired by Rubik's cube, we design and study an insitu programmable and distribution-reconfigurable mechanical metamaterial(IPDR-MM). A matrix model is developed to model IPDR-MMs and describe their morphological transitions. Based on this model, the reinforcement learning method is employed to find the pathways for morphological transitions. We find that IPDR-MMs have controllable stiffness across several orders of magnitude and a wide range of adjustable anisotropies through morphology transformation. Additionally, because of the independence of the directions of morphology transformation and bearing, IPDR-MMs exhibit good stability in bearing and can readily achieve high stiffness. The Rubik's cube-inspired design concept is also instructive for other deformable structures and metamaterials, and the current version of the proposal should be sufficiently illustrative to attract and broaden interdisciplinary interests.

关键词： mechanical metamaterials in-situprogrammable distribution-reconfigurable Rubik's cube controllable stiffness and anisotropy

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Altered synaptic currents,mitophagy,mitochondrial dynamics in Alzheimer's disease models and therapeutic potential of Dengzhan shengmai capsules intervention

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Journal of Pharmaceutical Analysis 2024年第3期14卷 348-370页

作者： Binbin Zhao Dongfeng Wei Qinghua Long Qingjie Chen Fushun wang Linlin Chen Zefei Li Tong Li Tao Ma Wei Liu Linshuang wang Caishui Yang xiaxia Zhang Ping wang Zhanjun Zhang state Key Laboratory of Cognitive Neuroscience and Learning&IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing100875China Institute of Gerontology Hubei University of Chinese MedicineWuhan430065China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China Medical school Hubei Minzu UniversityEnshiHubei445000China HuBei University of science and Technology XianningHubei437100China Institute of Brain and Psychological science Sichuan Normal UniversityChengdu610066China Key Laboratory of Traditional Chinese Medicine Resource and Compound Prescription Ministry of EducationHubei University of Chinese MedicineWuhan430065China Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing100700China school of systems science Beijing Normal UniversityBeijing100875China BABRI Centre Beijing Normal UniversityBeijing100875China

Emerging research suggests a potential association of progression of Alzheimer's disease(AD)with alterations in synaptic currents and mitochondrial ***,the specific associations between these pathological changes remain *** this study,we utilized Aβ42-induced AD rats and primary neural cells as in vivo and in vitro *** investigations included behavioural tests,brain magnetic resonance imaging(MRI),liquid chromatography-tandem mass spectrometry(UPLC-Ms/Ms)analysis,Nissl staining,thioflavin-s staining,enzyme-linked immunosorbent assay,Golgi-Cox.s.aining,transmission electron microscopy(TEM),immunofluorescence staining,proteomics,adenosine triphosphate(ATP)detection,mitochondrial membrane potential(MMP)and reactive oxygen species(ROs)assessment,mitochondrial morphology analysis,electrophysiological studies,Western blotting,and molecular *** results revealed changes in synaptic currents,mitophagy,and mitochondrial dynamics in the AD ***,intervention with Dengzhan shengmai(DZsM)capsules emerged as a pivotal element in this investigation.Aβ42-induced synaptic dysfunction was significantly mitigated by DZsM intervention,which notably amplified the frequency and amplitude of synaptic *** cognitive impairment observed in AD rats was ameliorated and accompanied by robust protection against structural damage in key brain regions,including the hippocampal CA3,primary cingular cortex,prelimbic system,and dysgranular insular *** intervention led to increased IDE levels,augmented long-term potential(LTP)amplitude,and enhanced dendritic spine density and ***,DZsM intervention led to favourable changes in mitochondrial parameters,including ROs expression,MMP and ATP contents,and mitochondrial *** conclusion,our findings delved into the realm of altered synaptic currents,mitophagy,and mitochondrial dynamics in AD,concurrently highlighting the therapeutic potential of DZsM intervention.

关键词： Alzheimer's disease synaptic currents Mitophagy Mitochondrial fusion and fission Dengzhan shengmai capsules

Photocatalytic seawater splitting by 2D heterostructure of ZnIn_(2)s_(4)/WO_(3) decorated with plasmonic Au for hydrogen evolution under visible light

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Journal of Energy Chemistry 2024年第6期93卷 55-63,I0003页

作者： Huiqin An Yanjun wang xing xiao Jiaxin Liu Zhiyao Ma Tianxin Gao Wanyu Hong Lizhi Zhao Hong wang Qingjun Zhu shanshan Chen Zhen Yin school of Chemistry Tiangong UniversityTianjin 300387China school of Materials science and Engineering Tiangong UniversityTianjin 300387China Deutsches Elektronen-synchrotron DEsY 15738 ZeuthenGermany schoolof Materials science and Engineering & National Institutefor Advanced Materials Nankai University Tianjin300350 China College of Chemical Engineering and Materials science Tianjin University of Science and TechnologyTianjin 300457China

Photocatalytic H_(2) evolution from seawater splitting presents a promising approach to tackle the fossil energy crisis and mitigate carbon emission due to the abundant source of seawater and sunlight on the ***,the development of efficient photocatalysts for seawater splitting remains a formidable ***,a 2D/2D ZnIn_(2)s_(4)/WO_(3)(ZIs/WO_(3))heterojunction nanostructure is fabricated to efficiently separate the photoinduced carriers by steering electron transfer from the conduction band minimum of WO_(3) to the valence band maximum of ZIs via constructing internal electric ***,plasmonic Au nanoparticles(NPs)as a novel photosensitizer and a reduction cocatalyst are anchored on ZIs/WO_(3) surface to further enhance the optical absorption of ZIs/WO_(3) heterojunction and accelerate the catalytic *** obtained Au/ZIs/WO_(3) photocatalyst exhibits an outstanding H_(2) evolution rate of 2610.6 or 3566.3μmol g^(-1)h~(-1)from seawater splitting under visible or full-spectrum light irradiation,*** rates represent an impressive increase of approximately 7.3-and 6,6-fold compared to those of ZIs under the illumination of the same light *** unique 2D/2D structure,internal electric field,and plasmonic metal modification together boost the photocatalytic H_(2) evolution rate of Au/ZIs/WO_(3),making it even comparable to H_(2) evolution from pure water *** present work sheds light on the development of efficient photocatalysts for seawater splitting.

关键词： Photocatalytic seawater splitting 2D/2D ZnIn_(2)s_(4)/WO_(3) surface plasmon resonance effect Interfacial electric field

Topology Optimization of Metamaterial Microstructures for Negative Poisson’s Ratio under Large Deformation Using a Gradient-Free Method

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Computer Modeling in Engineering & sciences 2024年第5期139卷 2001-2026页

作者： Weida Wu Yiqiang wang Zhonghao Gao Pai Liu state Key Laboratory of structural Analysis for Industrial Equipment Dalian University of TechnologyDalian116024China

Negative Poisson’s ratio(NPR)metamaterials are attractive for their unique mechanical behaviors and potential applications in deformation control and energy ***,when subjected to significant stretching,NPR metamaterials designed under small strain assumption may experience a rapid degradation in NPR *** address this issue,this study aims to design metamaterials maintaining a targeted NPR under large deformation by taking advantage of the geometry nonlinearity mechanism.A representative periodic unit cell is modeled considering geometry nonlinearity,and its topology is designed using a gradient-free *** unit cell microstructural topologies are described with the material-field series-expansion(MFsE)*** MFsE method assumes spatial correlation of the material distribution,which greatly reduces the number of required design *** conveniently design metamaterials with desired NPR under large deformation,we propose a two-stage gradient-free metamaterial topology optimization method,which fully takes advantage of the dimension reduction benefits of the MFsE method and the Kriging surrogate model ***,we use homogenization to find a preliminary NPR design under a small deformation *** the second stage,we begin with this preliminary design and minimize deviations in NPR from a targeted value under large *** this strategy and solution technique,we successfully obtain a group of NPR metamaterials that can sustain different desired NPRs in the range of[−0.8,−0.1]under uniaxial stretching up to 20% ***,typical microstructure designs are fabricated and tested through *** experimental results show good consistency with our numerical results,demonstrating the effectiveness of the present gradientfree NPR metamaterial design strategy.

关键词： Topology optimization microstructural design negative Poisson’s ratio large deformation