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非编码RNA与间充质干细胞研究的相关计量学分析

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中国组织工程研究 2025年第1期29卷 87-94页

作者：周嘉欣陶疆上海交通大学医学院附属第九人民医院口腔综合科上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床医学研究中心上海市口腔医学重点实验室上海市口腔医学研究所中国医学科学院口腔颌面再生医学创新单元上海市200011

背景:非编码RNA作为一类不编码蛋白质的RNA分子,在细胞调控中发挥关键作用。同时,间充质干细胞具有多向分化潜能,对组织修复和再生至关重要。近年来,研究者们对非编码RNA在调控间充质干细胞功能中的作用展开了深入探讨。目的:通过文献... 详细信息

背景:非编码RNA作为一类不编码蛋白质的RNA分子,在细胞调控中发挥关键作用。同时,间充质干细胞具有多向分化潜能,对组织修复和再生至关重要。近年来,研究者们对非编码RNA在调控间充质干细胞功能中的作用展开了深入探讨。目的:通过文献计量学分析方法系统地了解非编码RNA与间充质干细胞相关研究的发展趋势与关键领域。方法:从Web of Science核心合集1990年至今的科学引文索引扩展获取非编码RNA与间充质干细胞相关研究的文献数据,运用VOSviewer和Cite Space计量学软件对年份、国家或地区、研究机构、被引文献和关键词进行发文量、聚类、被引频次、突增性和中介中心性进行分析,揭示该研究领域的知识基础及前沿热点。结果与结论:(1)最终纳入5348篇文献,发表在1997-2021年,相关文献呈现明显的增长趋势,尽管在2022年略有减少,其发文量仍保持较高水平,中国在该领域的研究中占据主导地位,其中上海交通大学为最活跃的机构。(2)对被引文献分析发现,高突增性、高中介中心性、高被引的文献主要与微小RNA、细胞外囊泡和骨代谢等内容相关,这些文献构成了非编码RNA与间充质干细胞研究领域的重要知识基础。(3)对关键词进行突增性分析发现,至今保持高突增性的关键词包括外泌体、环状RNA、细胞外囊泡和损伤。(4)对关键词进行聚类演变分析,发文量仍保持增长趋势的关键词聚类包括:肿瘤微环境、骨关节炎、氧化应激和细胞外囊泡,这些关键词反映了目前以及未来该领域的研究热点。(5)文章结果不仅展示了非编码RNA与间充质干细胞研究领域的研究态势,更重要的是有望为研究人员提供潜在的方向和启示。

关键词：非编码RNA 间充质干细胞计量学分析可视化分析热点前瞻知识基础 CiteSpace 作用机制细胞外囊泡转化应用

马克思“机器论片段”语境下的数字技术再反思

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海南大学学报（人文社会科学版） 2025年第1期43卷 60-67页

作者：王文陶厚兴中国人民大学重阳金融研究院北京100872 兰州大学马克思主义学院甘肃兰州730000

马克思“机器论片段”重点论述了机器体系的产生及其在社会生产中的应用所引起的劳动资料技术化、一般智力对象化、固定资本扩大化、人机关系异化等一系列深刻变革。数字技术具有物质技术与社会历史双重属性,其一方面作为人造的“物体系... 详细信息

马克思“机器论片段”重点论述了机器体系的产生及其在社会生产中的应用所引起的劳动资料技术化、一般智力对象化、固定资本扩大化、人机关系异化等一系列深刻变革。数字技术具有物质技术与社会历史双重属性,其一方面作为人造的“物体系”,克服与弥补人类自身劳动力的不足,另一方面作为生产关系与资本权力的物性表达。数字技术的广泛应用导致工业时代的“机器悖论”演化为数字时代的“智能悖论”,集中表现为“劳动悖论”“时间悖论”与“解放悖论”。马克思“机器论片段”的机器技术思想对我们在数字时代审思数字技术,探索扬弃技术的权力与宰制,消解人与技术的异化关系,使技术真正摆脱压迫、剥削人的工具地位,成为提高劳动生产率,缩短必要劳动时间和增加自由支配时间,促进人类劳动解放与自由全面发展的现实路径依然具有理论与实践价值。

关键词：马克思机器论片段一般智力固定资本数字技术

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反垄断执法约谈的规范化续造——兼评《反垄断法》第五十五条

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中国矿业大学学报（社会科学版） 2025年第1期27卷 140-157页

作者：冯涛武汉大学法学院

修法之前,执法约谈从未见于反垄断相关的正式且生效的规范性文件,但实践中却被作为一种柔性执法方式在不同程度上运用。考察执法实践发现,约谈手段在反垄断领域呈现多种样态,反映出约谈泛化的现象,并存在延续的倾向。新《反垄断法》第... 详细信息

修法之前,执法约谈从未见于反垄断相关的正式且生效的规范性文件,但实践中却被作为一种柔性执法方式在不同程度上运用。考察执法实践发现,约谈手段在反垄断领域呈现多种样态,反映出约谈泛化的现象,并存在延续的倾向。新《反垄断法》第五十五条及配套规章建立了执法约谈制度的基本框架,尽管一定程度上能够规范执法约谈实践,但对部分现实问题缺少足够的制度回应和前瞻,执法约谈的启动条件宽泛、法律后果不明、以纠代罚或以约代罚等问题仍有待解决。规范反垄断执法约谈应当遵循反垄断执法总体谦抑的理念,恪守正当程序的基本原则,在提升反垄断执法主动性和回应性的基础上,协调好同其他执法措施的关系。在基本明确方向后,可以从启动机制、过程控制、事后保障三方面实现反垄断执法约谈的规范化续造。

关键词：反垄断执法执法约谈反垄断谦抑性正当程序柔性执法

A hybrid tracking control strategy for an unmanned underwater vehicle aided with bioinspired neural dynamics

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IET Cyber-Systems and Robotics 2022年第3期4卷 153-162页

作者： Zhe xu tao Yan Simon x.Yang S.Andrew Gadsden School of Engineering University of GuelphGuelphOntarioCanada Department of Mechanical Engineering McMaster UniversityHamiltonOntarioCanada

Tracking control has been a vital research topic in *** paper presents a novel hybrid control strategy for an unmanned underwater vehicle(UUV)based on a bio-inspired neural dynamics *** enhanced backstepping kinematic control strategy is first developed to avoid sharp velocity jumps and provides smooth velocity commands relative to conventional ***,a novel sliding mode control is proposed,which is capable of providing smooth and continuous torque commands free from *** comparative studies,the proposed combined hybrid control strategy has ensured control signal smoothness,which is critical in real‐world applications,especially for a UUV that needs to operate in complex underwater environments.

关键词： backstepping bioinspired neural dynamics sliding mode control unmanned underwater vehicle

Ictal-interictal continuum:a review of recent advancements

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Acta Epileptologica 2020年第1期2卷 101-110页

作者： James x.tao xiaoxiao Qin Qun Wang Department of Neurology The University of Chicago5841 South Maryland Ave.MC2030ChicagoIL 6063U.S.A.. Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingP.R.China. China National Clinical Research Center for Neurological Diseases BeijingP.R.China.

Continuous electroencephalogram(cEEG)has become an indispensable technique in the management of critically ill patients for early detection and treatment of non-convulsive seizures(NCS)and non-convulsive status epilepticus(NCSE).It has also brought about a renaissance in a wide range of rhythmic and periodic patterns with heterogeneous frequency and *** patterns share the rhythmic and sharp appearances of electrographic seizures,but often lack the necessary frequency,spatiotemporal evolution and clinical accompaniments to meet the definitive criteria for ictal *** may be associated with cerebral metabolic crisis and neuronal injury,therefore not clearly interictal either,but lie along an intervening spectrum referred to as ictal-interictal continuum(IIC).Generally speaking,rhythmic and periodic patterns are categorized as interictal patterns when occurring at a rate of2.5 Hz with spatiotemporal *** such,IIC commonly includes the rhythmic and periodic patterns occurring at a rate of 1–2.5 Hz without spatiotemporal evolution and clinical *** there are no evidence-based guidelines on when and if to treat patients with IIC patterns,and particularly how aggressively to treat,presenting a challenging electrophysiological and clinical *** practice,a diagnostic trial with preferably a non-sedative anti-seizure medication(ASM)can be considered with the end point being both clinical and electrographic *** available and necessary,correlation of IIC with biomarkers of neuronal injury,such as neuronal specific enolase(NSE),neuroimaging,depth electrode recording,cerebral microdialysis and oxygen measurement,can be assessed for the consideration of ASM *** we review the recent advancements in their clinical significance,risk stratification and treatment algorithm.

关键词： periodic discharges Critical care Continuous EEG Ictal-interictal continuum Nonconvulsive seizures

Numerical study of high-lift hydrofoil near free surface at moderate Froude number

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Journal of Hydrodynamics 2020年第1期32卷 44-53页

作者： tao xing Konstantin I.Matveev Miles p.Wheeler Department of Mechanical Engineering The University of IdahoMoscowIdahoUSA School of Mechanical and Materials Engineering Washingion State UniversityPullmanWashingtonUSA

Shallow hydrofoils are known to produce lower lift in normal operating conditions in comparison with deep ***,the maximum lift capability of shallow hydrofoils at moderate speeds,which is important for transitional regimes of hydrofoil boats,is studied *** this work,two-dimensional flow around a high-lift hydrofoil at a moderate Froude number is numerically simulated in a broad range attack angles up to the stall occurrence in both single-phase fluid and in the vicinity of free *** is found that nearly the same maximum lift coefficient can be produced by the shallow foil in the modeled condition as by the deep foil,but much higher attack angle is required near the free surface,which also results in larger ***,it is shown that higher Reynolds numbers lead to higher lift coefficients,especially at large attack angles.

关键词： Hydrofoil numerical simulation free surface effect stall

Data-Driven Fault-Tolerant Bipartite Consensus Tracking for Multi-Agent Systems With a Non-Autonomous Leader

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 279-281页

作者： Yan Zhou Guanghui Wen Jialing Zhou tao Yang the Department of Systems Science Southeast University the State Key Laboratory of CNS/ATM Beijing Institute of Technology the Beijing Institute of Technology (Zhuhai) the State Key Laboratory of Synthetical Automation for process Industries Northeastern University

Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur.

关键词：

环黄芪醇促进脊髓损伤小鼠运动功能恢复及皮质神经元再生的相关机制

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中国组织工程研究 2025年第20期29卷 4258-4265页

作者：陶紫晗赛吉拉夫苏州大学苏州医学院骨科研究所江苏省苏州市215031

背景:前期研究证实,环黄芪醇能够促进坐骨神经损伤修复,且环黄芪醇能够激活端粒酶反转录酶进一步参与外周感觉神经元轴突再生的调节。但环黄芪醇是否可以激活皮质神经元轴突再生仍然未知,尤其是环黄芪醇是否参与脊髓损伤修复过程中运动... 详细信息

背景:前期研究证实,环黄芪醇能够促进坐骨神经损伤修复,且环黄芪醇能够激活端粒酶反转录酶进一步参与外周感觉神经元轴突再生的调节。但环黄芪醇是否可以激活皮质神经元轴突再生仍然未知,尤其是环黄芪醇是否参与脊髓损伤修复过程中运动功能的恢复。目的:探究环黄芪醇对小鼠脊髓损伤后运动功能恢复的影响,以及环黄芪醇促进皮质神经元再生的相关机制。方法:①将12只ICR小鼠随机分为溶剂组、环黄芪醇组,每组6只,构建脊髓损伤模型后分别腹腔注射含2%吐温20和5%二甲基亚砜的pBS、环黄芪醇(20 mg/kg),连续给药12周,使用BMS运动功能评分评估小鼠肢体运动功能;②体外培养E14胎鼠大脑皮质神经元,分为二甲基亚砜组与环黄芪醇组,分别用二甲基亚砜、0.5μmol/L环黄芪醇体外培养3 d;③E7孕鼠分为溶剂组与环黄芪醇组,分别腹腔注射含2%吐温20和5%二甲基亚砜的pBS、20 mg/kg环黄芪醇,连续给药7 d,分离出胎鼠大脑皮质,体外培养皮质神经元3 d;④对胎鼠大脑皮质神经元进行Tuj1免疫荧光染色,分析Tuj1阳性细胞的轴突长度,验证环黄芪醇对皮质神经元轴突再生的作用;对胎鼠大脑皮质神经元进行Tuj1、端粒酶反转录酶双标免疫荧光染色,分析环黄芪醇对端粒酶反转录酶表达的影响;蛋白免疫印迹分析胎鼠大脑皮质神经元中端粒酶反转录酶蛋白的相对表达;⑤将6只ICR小鼠随机分为溶剂组、环黄芪醇组,每组3只,构建脊髓损伤模型后分别腹腔注射含2%吐温20和5%二甲基亚砜的pBS和环黄芪醇(20 mg/kg),连续给药7 d,蛋白免疫印迹检测脊髓组织中端粒酶反转录酶蛋白的相对表达。结果与结论:①脊髓损伤后环黄芪醇治疗4,6,8,12周,环黄芪醇组小鼠运动功能评分显著高于溶剂组(ppppppp<0.05)。结果表明,环黄芪醇能够促进皮质神经元轴突生长并改善小鼠脊髓损伤后运动功能,这一现象可能与端粒酶反转录酶的表达升高有关。

关键词：环黄芪醇皮质神经元轴突生长端粒酶反转录酶运动功能脊髓损伤工程化动物模型

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HIGHLY DISpERSED MULTI-WALLED CARBON NANOTUBES IN WATER/ETHANOL AND ITS AppLICATION FOR pVA COMpOSITE

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 389-396页

作者： x.Y.tao J.M.xu F.Liu G.L.xu InstituteofMaterialsphysicsandMicrostructures DepartmentofMaterialsScienceandEngmeeringZhejiangUniversityHangzhou310027China CollegeofElectronicInformation HangzhouDianziUniversityHangzhou310018China

Two carboxylation processes were carried out to modify multi-walled carbon nanot ube bundles (m-MWNTs). The results showed that both of the m-MWNTs could be high ly dispersed in water with the concentration up to 25 and 15mg/mL in ethanol wit hout obvious deposition or conglomeration over 6 months. FTIR, Raman, TGA and TE M characterizations of the m- MWNTs showed that hydroxyl and carboxyl groups hav e been attached with MWNTs, and that the nanotube structure was only damaged a l ittle after modification treatments in mixed acids over 24h. Above prepared nano tube suspensions in water were successfully used as a filler of thermoplastic pV A composite to enhance its electrical conductivity. The results showed that the addition of m-MWNTs greatly improved the conductivity and the threshold of mass fraction was about 5wt%. The results also proved that purification process was n ot needed because of high purity of the raw MWNTs prepared in our group.

关键词： carbon nanotube polyvinylalcohol composite conductivity