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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl lászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek xavier Monforte Johannes C.Heinzel Antal nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGCs). However, the use of tnGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGCs and compared the various features of these improved silk^(+) tnGCs with the tubes without holes(silk^(–) tnGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGCs increase the vascular supply of regenerating nerves and facilitate improved ax.n.l.regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Multilevel atomic Ramsey interferometry for precise parameter estimations

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Chinese Physics B 2021年第12期30卷 321-328页

作者： x n Feng l F Wei Guangdong Provincial Key laboratory of Quantum Metrology and Sensing&School of Physics and Astronomy Sun Yat-Sen University(Zhuhai Campus)Zhuhai 519082China Information Quantum Technology laboratory School of Information Science and TechnologySouthwest Jiaotong UniversityChengdu 610031China

Multi-path(or multi-mode)entanglement has been proved to be a useful resource for sub-shot-noise sensitivity of phase estimation,which has aroused much research interest in quantum metrology *** schemes of multi-path interferometers based on optical systems have been put ***,we study a multi-state interferometer with multilevel atoms by projective ***,we investigate its ultimate sensitivity described by quantum Fisher information theory and find that the Cramer-Rao bound can be *** particular,we investigate a specific scheme to improve the sensitivity of magnetometery with a three-state interferometry delivered by a single nitrogen-vacancy(nV)center of diamond with tailor *** impacts of imperfections of the atomic beam-splitter,described by the three-level quantum Fourier transform,on the sensitivity of phase estimation is also discussed.

关键词： quantum metrology multi-path interferometers quantum measurement

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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SUPERPlASTICITY OF A WATER-QUEnCHED AnD TEMPERED 40Cr STEEl

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Acta Metallurgica Sinica(English letters) 2004年第5期17卷 682-688页

作者： x.J.xu G.l.liu l.JShi x.n.Cheng l.Cai SchoolofMechanicalEngineering JiangsuUniversityJiangsu212013China

The superplastic deformation characteristics, of commercial 40Cr (i.e., 5140) steel that was water-quenched only 1 times and subsequent high-temperature tempered, were investigated. The results showed that the 40Cr steel has a fine grain of 10-15μm at room temperature, and exhibits a tensile elongation of 304%, a true flow stress of 89.3MPa and a strain rate sensitivity m-value of 0.227 at the initial strain rate of 1.0×10-3s-1and at the temperature of 750°C. The final fracture is caused by the development of neck. The experimental result of elongation is in good agreement with the theoretically predicated value according to the analytical expression (where ef, m, f, nv and ε is respectively elongation, average strain rate sensitivity, initial geometric defect, average strain hardening sensitivity at constant deformation velocity and average true strain). The fracture surface is intergraular, and superplastic deformation induces an equiaxed and grown grain. Decreasing strain rate increases tensile elongation and strain rate sensitivity m-value. The primary superplastic deformation mechanism is thought to be atom-diffusion-controlled grain boundary sliding.

关键词： superplasticity 40Cr steel quenching medium quenching times Microstructure

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nanostructures and nanoprecipitates induce high strength and high electrical conductivity in a CuCrZr alloy

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Journal of Materials Science & Technology 2020年第13期47卷 18-22页

作者： Z.Y.Zhang l.x.Sun n.R.Tao Shenyang national laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China College of Materials Science and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

The mixed nanostructure mainly consisting of nanotwins and nanograins was obtained in a solid solution CuCrZr alloy by means of dynamic plastic deformation at cryogenic *** subsequent aging treatments,the precipitation of Cr at nanometer scale provided further strengthening and brought substantial recovery of electrical *** aged nanostructured CuCrZr alloy exhibited a high tensile strength of 832MPa and a high electrical conductivity of 71.2%*** details of precipitation tuned by nanotwin boundaries were demonstrated in this *** combined strengthening of nanostructures and nanoprecipitates was discussed.

关键词： CuCrZr alloy nanotwins Precipitation hardening Aging Electrical conductivity

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Healing Process of Casting Pores in a ni-based Superalloy by Hot Isostatic Pressing

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Journal of Materials Science & Technology 2015年第11期31卷 1151-1157页

作者： x.G.Zheng Y.-n.Shi l.H.lou Shenyang national laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Superalloy Division Institute of Metal Research Chinese Academy of Sciences

Hot isostatic pressing （HIP） with a pressure of 180 MPa at a temperature of 1170 ℃ was introduced to an investment cast ni-based superalloy （Mgl） turbocharger blade to explore the healing process of casting pores generated during investment casting. Optical micrograph and scanning electron naicroscopy （SEM） observations indicate that eutectic pores are the main cast defects in the as-cast blade before HIP. These pores normally locate at the solidification front of γ/γ＇ eutectic with a size of a few micrometers to a few tens of micrometers. After HIP for 4 h, most of the pores were closed. Based on phase characteristics, these pores were healed by the formation of γ matrix with finer and irregular-shaped γ＇ precipitates. Healing interface can be easily distinguished by SEM. line scan by using energy dispersive x-ray spectroscopy （EDS） reveals a much higher Ti and Al concentration in the healing interface. It is proposed that solute diffusion toward the casting pores during HIP results in the formation of γ, and the much higher concentration of γ＇-forming elements Al and Ti near the healing interface contributes to the precipitation of γ＇ in the healed region in the succeeding cooling process after HIP.

关键词： Superalloy Hot isostatic pressing (HIP) Healing

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Microstructure of Si Cones Prepared by Ar^+-Sputtering Si/Mo Target

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Journal of Materials Science & Technology 2002年第2期18卷 173-175页

作者： x.l.Ma n.G.Shang 等 ShenyangnationallaboratoryforMaterialsScience InstituteofMetalResearchChineseAcademyofSciencesShenyang110016China CenterofSuper-DiamondandAdvancedFilms&DepartmentofPhysicsand

By Ar+ sputtering onto Si wafers which were surrounded by Mo plates, uniform cones over a large area on the Si surface were formed. Scanning electron microscopic study showed that the cones were formed on the entire surface of the Si wafer. The dimensions of the uniform cones were one micrometer in diameter and 5-6 micrometers high. They were further characterized by means of cross-sectional transmission electron microscopy, with the technique of micro-diffractions. It was found that the cone contained a pure Si regime and a Mo-rich regime. In the binary Mo-Si zone, we identified three distinct areas vertically: (1) domains of Mo-induced Si ordered structures, (2) a small volume of a new Mo3Si2 structural variant, intergrown with the Si ordered structure, and (3) a small amount of pure Mo nanoparticles covering the surface of the cones. The formation of the large and uniform cones may provide a new surface configuration for potential applications in surface science and technology.

关键词： Si cones Ordered structure Mo silicide

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Atomic-scale roles of Zn element in age-hardened AlMgSiZn alloys

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Journal of Materials Science & Technology 2021年第11期70卷 105-112页

作者： n.n.Jiao Y.x.lai S.l.Chen P.Gao J.H.Chen Center for High-Resolution Electron Microscopy College of Materials Science&EngineeringHunan UniversityChangsha410082China Electron Microscopy laboratory and International Center for Quantum Materials School of PhysicsPeking UniversityBeijing100871China

Adding alloying elements to improve the performances or the manufacturing processes of Al-Mg-Si alloys has long been a serious issue in developing advanced automotive aluminum *** Zn element,among those promising ones,has demonstrated positive alloying effects on Al-Mg-Si ***,the atomic-scale roles of Zn in an age-hardened Al-Mg-Si-Zn alloy have not been adequately *** atomic-resolution electron microscopy,here we report the precise locations of Zn elements in all hardening precipitates involved and their alloying mechanism at the atomic scale when alloying the *** results show that Zn atoms enter all the major hardening phases to occupy specific featured atomic sites of the original elements,*** Si1 and Mg2 sites in theβ’-2 phase,and modify their crystal structures,interfacial structures and morphologies in characteristic *** is revealed that for theβ’-phase,Zn atoms occupy unique atomic sites,whereas for other phases,they demonstrate similar behaviors as other additive alloying elements such as Ag and Cu do.

关键词： Al-Mg-Si alloy Zn addition Precipitate Electron microscopy

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Dynamic mechanical properties,deformation and damage mechanisms of eutectic high-entropy alloy AlCoCrFeni_(2.1)under plate impact

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Journal of Materials Science & Technology 2023年第3期134卷 178-188页

作者： S.P.Zhao Z.D.Feng l.x.li x.J.Zhao l.lu S.Chen n.B.Zhang Y.Cai S.n.luo The Peac Institute of Multiscale Sciences ChengduChina Key laboratory of Advanced Technologies of Materials Ministry of EducationSouthwest Jiaotong UniversityChengduChina

Shock compression and spallation of a eutectic high-entropy alloy(HEA)AlCoCrFeni_(2.1)with lamellar structure are investigated via plate impact loading with free-surface velocity *** as-cast and postmortem samples are characterized with transmission electron microscopy,electron back-scatter diffraction and scanning electron *** accurate Hugoniot equation of state is ***-ter shock compression to∼12 GPa,both the l1_(2)and B_(2)phases retain their ordered *** dislocations in the{111}slip planes,stacking faults and deformation twins are found in the l1_(2)phase,along with fewer dislocations in the{110}slip bands in the B(2)***-induced deformation twin-ning within the l1_(2)phase of this HEA is observed as a new deformation mechanism under various load-ing *** spallation,both ductile and brittle damage modes are *** micro voids and cracks prefer to nucleate at the phase boundaries chiefly,then in the B(2)*** similar shock stress,the spall strength of AlCoCrFeni_(2.1)HEA is about 40%higher than those of other reported dual-phase HEAs due to the high stability of its semi-coherent phase boundaries.

关键词： High-entropy alloy Hugoniot Spall damage Microstructure

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CRYSTAllOGRAPHIC AnAlYSIS OF THE lATH MARTEnSITE TRAnSFORMATIOn In Fe-ni-Mn AllOY

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Acta Metallurgica Sinica(English letters) 2004年第6期17卷 862-869页

作者： x.P.lin Y.Dong x.M.Cao Y.Zhang n.J.Gu x.l.Ma DepartmentofMaterialsScienceandTechnology HebeiUniversityofTechnologyTianjin300130ChinaManuscriptreceived18November2003 inrevisedform1June2004

Habit plane rotation of lath martensite transformation in Fe-ni-Mn alloy was predicted by means of Displacement Vector Theory. Its surface relief effect was observed and a math model for the quantitative analysis of habit plane rotation of lath martensite transformation was established by means of atomic force microscopy (AFM). The experiment showed that the largest rotation of habit plane of lath martensite transformation predicted by means of Displacement Vector Theory is 13.50°, and it's incompatible with the concept of invariant plane strain (IPS); surface relief of lath martensite revealed no character of IPS, i.e. it exhibited irregular 'n'-shaped 'surface relief packet', and 'surface relief packet' was composed of layers of several small surface reliefs, the AFM quantitative analysis of habit plane rotation of lath martensite transformation was 11.11°, which was in agreement with the prediction of Displacement Vector Theory (13.50°) and it firmly confirmed the habit plane rotation of lath martensite transformation and the correctness of Displacement Vector Theory.

关键词： atomic force microscope (AFM) surface relief invariant plane strain (IPS) relief angle shear angle

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