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临床实践中多发性硬化影像：欧洲428个中心广泛调查以及ESNR工作组结论

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国际医学放射学杂志 2023年第6期 753-753页

作者： J.Hodel M.W.Vernooij M.K.Beyer M.Severino x.leclerc 周彤

摘要目的为评估对现有推荐标准的依从性，评价目前多发性硬化（MS）影像学评估的临床实践。方法通过电子邮件向所有会员和附属机构发送一份在线问卷。收集应用MRI

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急性卒中病人3D多回波梯度回波与2D T2~* MR序列动脉血栓检出的对照研究

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国际医学放射学杂志 2014年第3期 299-299页

作者： J.Hodel x.leclerc W.Khaled R.Tamazyan M.Rodallec S.Gerber 唐光健 Department of Radiology H?pital Saint Joseph186rue Raymond LosserandParisFrance

摘要目的比较急性卒中病人多回波梯度回波MR序列[磁敏感加权血管成像(SWAN)]与T2*序列对动脉血栓的检出。方法连续74例急性卒中病人被纳入研究。采用时间

关键词：动脉血栓急性卒中梯度回波 T2 检出 MR 序列

FLAIR序列的血管高信号无法在3D CUBE FLAIR序列上显示

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国际医学放射学杂志 2013年第5期 496-496页

作者： J.Hodel x.leclerc M.Rodallec S.Gerber R.Blanc O.Outteryck 张泳欣 Service de Radiologie Hpital Saint Joseph

摘要目的 FLAIR血管高信号征(FVH)最初描绘于2D液体反转恢复序列(FLAIR)上,是急性缺血性脑卒中病人的一个有用的影像学指标。该项研究的目的是比较3D CUBE FLAIR及2D FLAIR在显示血管高信号征的敏感性是否存在差异。方法 47例可疑脑卒... 详细信息

摘要目的 FLAIR血管高信号征(FVH)最初描绘于2D液体反转恢复序列(FLAIR)上,是急性缺血性脑卒中病人的一个有用的影像学指标。该项研究的目的是比较3D CUBE FLAIR及2D FLAIR在显示血管高信号征的敏感性是否存在差异。方法 47例可疑脑卒中病人在1.5 T及3.0 T MR设备上均行2D FLAIR及3D CUBE FLAIR序列扫描。通过盲法让3名评估员对"FLAIR血管高信号征"进行评价,"FLAIR血管高信号征"定义为大脑动脉内的高信号。对局限性的"FLAIR血管高信号征"、急性脑梗死及动脉狭窄也进行了评估,2D

关键词：高信号 CUBE FLAIR 血管序列

在自发颈动脉夹层中与生物炎症反应相关的动脉周水肿的高分辨MR成像

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国际医学放射学杂志 2009年第6期 598-598页

作者： O.Naggara E.Touzé R.Marsico x.leclerc T.Nguyen J.L.Mas 肖芳 Department of Neuroradiology University of Paris DescartesEA4055INSERM U894Centre Hospitalier Sainte-Anne1rue Cabanis75014 ParisFrance

已有研究表明自发颈动脉夹层(spontaneocervical carotid artery dissection,sCAD)可能由动脉的炎症致。有时出现在sCAD病人的动脉腔壁血肿附近的动脉周水肿(periarterial edema,PAE)可以支持该假说。利用颈部分辨力MRI技术,由3名不了... 详细信息

已有研究表明自发颈动脉夹层(spontaneocervical carotid artery dissection,sCAD)可能由动脉的炎症致。有时出现在sCAD病人的动脉腔壁血肿附近的动脉周水肿(periarterial edema,PAE)可以支持该假说。利用颈部分辨力MRI技术,由3名不了解颈动

关键词：颈动脉夹层 CAD MR 炎症反应动脉水肿

使用动脉自旋标记图皮质投射实现早发型阿尔茨海默病病人脑灌注影像质量优化

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国际医学放射学杂志 2015年第5期 509-509页

作者： S.Verclytte R.Lopes C.Delmaire J.C.Ferre F.Pasquier x.leclerc 李倩 Department of Radiology Hospital Saint-PhilibertRuedu Grand But

摘要目的动脉自旋标记(ASL)作为一个有前景的MRI序列,能够无创检测神经退行性疾病皮质灌注的改变,但在个体水平的应用仍有一定困难。本研究以早发型阿尔茨海默病(EOAD)病人为研究对象,将ASL影像投射到皮质表面,以提高影像质量和直观显... 详细信息

摘要目的动脉自旋标记(ASL)作为一个有前景的MRI序列,能够无创检测神经退行性疾病皮质灌注的改变,但在个体水平的应用仍有一定困难。本研究以早发型阿尔茨海默病(EOAD)病人为研究对象,将ASL影像投射到皮质表面,以提高影像质量和直观显示灌注数据。方法18例来自EOAD治疗中心的病人进行MRI ASL序列扫描。每个检查的

关键词：阿尔茨海默病脑灌注影像质量早发型皮质自旋标记动脉病人

Advanced nonmetastatic hepatocellular carcinoma: curative surgery may be an option

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Hepatobiliary Surgery and Nutrition 2022年第6期11卷 870-872页

作者： Julie leclerc Ahmet Ayav Service de Chirurgie cancerologique digestive hepato-bilio-pancreatique et colo-rectaleCHRU NancyNancyFrance

In this multicentric retrospective study(1),the authors aimed to compare surgery versus Sorafenib(SOR)for the treatment of advanced nonmetastatic hepatocellular carcinoma(HCC).Data were collected from two Italian regi... 详细信息

关键词： surgery hepatocellular metastatic

A-DA′D-A non-fullerene acceptors for high-performance organic solar cells

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Science China Chemistry 2020年第10期63卷 1352-1366页

作者： Qingya Wei Wei Liu Mario leclerc Jun Yuan Honggang Chen Yingping Zou College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Department of Chemistry Universite LavalQuebec CityQuebec G1V 0A6Canada

Since the world-record power conversion efficiency of 15.7%was achieved for organic solar cells(OSCs)in 2019,the newly developed non-fullerene acceptor(NFA)Y6 with an A-DA′D-A structure(A denotes an electron-accepting moiety,D denotes an electron-donating moiety)has attracted increasing ***,many new A-DA′D-A NFAs have been designed and synthesized,and the A-DA′D-A NFAs have played a significant role in the development of high-performance non-fullerene organic solar cells(NF-OSCs).Compared with the classical A-D-A-type acceptors,A-DA′D-A NFAs contain an electrondeficient core(such as benzothiadiazole(BT),benzotriazole(BTA),quinoxaline(Qx),or their derivatives)in the ladder-type fused rings to fine-tune the energy levels,broaden light absorption and achieve higher electron mobility of the *** review emphasizes the recent progress on these emerging A-DA′D-A(including Y-series)*** synthetic methods of DA′D-fused rings are *** relationships between the chemical structure of the A-DA′D-A NFAs and the photovoltaic performance of the corresponding OSCs are summarized and ***,issues and prospects for further improving photovoltaic performance of the OSCs are also proposed.

关键词： organic solar cells A-DA′D-A non-fullerene acceptors electron-deficient core photovoltaic properties

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Enzymatic debridement shall not modify the global strategy for mass burn events

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Military Medical Research 2023年第4期10卷 554-555页

作者： Nicolas Donat Thomas leclerc Stian Kreken Almeland Burn Treatment Centre Percy Military Teaching Hospital92140 ClamartFrance Val-de-Grâce Military Medical Academy 75005 ParisFrance Norwegian National Burn Center Department of PlasticHand and Reconstructive SurgeryHaukeland University Hospital5021 BergenNorway

We read with interest the letter by Surowiecka et al.[1]about early burn wound excision in mass casualty *** couldn’t agree more with their statement about the benefit of early burn wound ***,we doubt whether applying this strategy to every patient during a mass burn event could be *** note,while there is an undisputed consensus that early burn wound excision is the gold standard of burn care,what‘early’actually means is still *** on the authors,the corresponding time limit typically varies from 24 h to a few days[2,3].

关键词： Enzymatic debridement(ED) Burn care Mass causality Burn surgery

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Colon cancer stemness as a reversible epigenetic state:Implications for anticancer therapies

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World Journal of Stem Cells 2019年第11期11卷 920-936页

作者： Audrey Vincent Aicha Ouelkdite-Oumouchal Mouloud Souidi Julie leclerc Bernadette Neve Isabelle Van Seuningen Lille University Institut National de la Sante et de la Recherche MédicaleCHU LilleUMR-S 1172-Jean-Pierre Aubert Research CenterLille F-59000France Department of Biochemistry and Molecular Biology Lille University HospitalLille F-59000France

The recent discovery of cancer cell plasticity,*** ability to reprogram into cancer stem cells(CSCs)either naturally or under chemotherapy and/or radiotherapy,has changed,once again,the way we consider cancer *** cancer stemness is a reversible epigenetic state rather than a genetic identity,opportunities will arise for therapeutic strategies that remodel epigenetic landscapes of ***,the systematic use of DNA methyltransferase and histone deacetylase inhibitors,alone or in combination,in advanced solid tumors including colorectal cancers,regardless of their molecular subtypes,does not seem to be the best *** this review,we first summarize the knowledge researchers have gathered on the epigenetic signatures of CSCs with the difficulty of isolating rare populations of *** raise questions about the relevant use of currently available epigenetic inhibitors(epidrugs)while the expression of numerous cancer stem cell markers are often repressed by epigenetic *** markers include the three cluster of differentiation CD133,CD44 and CD166 that have been extensively used for the isolation of colon ***,we describe current treatment strategies using epidrugs,and we hypothesize that,using correlation tools comparing associations of relevant CSC markers with chromatin modifier expression,we could identify better candidates for epienzyme targeting.

关键词： Cancer stem cells Colon cancer Epigenetics Chromatin modifying enzymes CD44 CD133 CD166