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Urinary metabolic profiles during Helicobacter pylori eradication in chronic gastritis

World Journal of Clinical Cases 2024年第5期12卷 951-965页

作者： Wen-Ting An Yu-xia Hao Hong-xia li xing-kang Wu Department of Pharmacy Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Department of Gastroenterology Shanxi Provincial People's HospitalTaiyuan 030012Shanxi ProvinceChina Department of Oncology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is a major risk factor for chronic gastritis,affecting approximately half of the global *** eradication is a popular treatment method for ***-positive chronic gastritis,but its mecha-nism remains *** metabolomics has been used to elucidate the mechanisms of gastric disease ***,no clinical study has been conducted on urinary metabolomics of chronic *** To elucidate the urinary metabolic profiles during *** eradication in patients with chronic *** We applied lC–MS-based metabolomics and network pharmacology to in-vestigate the relationships between urinary metabolites and ***-positive chronic gastritis via a clinical follow-up *** Our study revealed the different urinary metabolic profiles of ***-positive chronic gastritis before and after *** *** metabolites regulated by *** eradication therapy include cis-aconitic acid,isocitric acid,citric acid,l-tyrosine,l-phenylalanine,l-tryptophan,and hippuric acid,which were involved in four metabolic pathways:(1)Phenylalanine metabolism;(2)phenylalanine,tyrosine,and tryptophan biosynthesis;(3)citrate cycle;and(4)glyoxylate and dicarboxylate *** metabolomics and network pharmacology revealed that MPO,COMT,TPO,TH,EPx,CMA1,DDC,TPH1,and lPO were the key proteins involved in the biological progress of *** eradication in chronic *** Our research provides a new perspective for exploring the significance of urinary metabolites in evaluating the treatment and prognosis of ***-positive chronic gastritis patients.

关键词： lC-MS metabolomics chronic gastritis Helicobacter pylori urinary metabolites

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Turán number of Berge linear forests in uniform hypergraphs

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Frontiers of Mathematics in China 2024年第1期19卷 25-35页

作者： liying kang Jiawei HUANG Yisai xUE Zhiwei WU Department of Mathematics Shanghai UniversityShanghai 200444China

let F be a graph and H be a *** say that H contains a Berge-F If there exists a bijectionψ:E(F)→E(H)such that for Ve E E(F),e C(e),and the Turan number of Berge-F is defined to be the maximum number of edges in an r-uniform hypergraph of order n that is Berge-F-free,denoted by ex,(n,Berge-F).A linear forest is a graph whose connected components are all paths or isolated *** ln,k be the family of all linear forests of n vertices with k *** this paper,Turan number of Berge-ln,in an r-uniform hypergraph is *** r≥k+1 and 3≤r≤l[]=1,we determine 2 the exact value of ex,(n,Berge-ln,)*** K-1≤r≤k,we 2 determine the upper bound of ex,(n,Berge-ln,).

关键词： Uniform hypergraph Berge hypergraph linear forest Turán number

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Utilization of biomarkers for the prognostic prediction of cardiac arrest survivors using a multi-modal approach

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World Journal of Emergency Medicine 2024年第2期15卷 131-134页

作者： Changshin kang Yeonho You Jung Soo Park Byeong Kwon Park Jae Kwang lee Byung Kook lee Department of Emergency Medicine College of MedicineChungnam National UniversityDaejeon 35015Republic of Korea Department of Emergency Medicine Chungnam National University HospitalDaejoen 35015Republic of Korea Department of Emergency Medicine Konyang University HospitalCollege of MedicineDaejeon 35015Republic of Korea Department of Emergency Medicine Chonnam National University Medical SchoolChonnam National University HospitalGwangju 61469Republic of Korea

International guidelines for post-cardiac arrest care recommend using multi-modal strategies to avoid the withdrawal of life-sustaining therapy(WlST)in patients with the potential for neurological recovery.[1]However,a clear methodology for multi-modal approaches has yet to be ***-specific enolase(NSE)is currently the only recommended biomarker,and the European Resuscitation Council(ERC)and the European SocietyofIntensiveCareMedicine(ESICM)have proposed a cutoff value of 60μg/l at 48 and/or 72 h after the return of spontaneous circulation(ROSC)as a multimodal prognostic tool for predicting poor neurological outcomes.

关键词： cardiac modal return

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Efficacy of chemotherapy containing bevacizumab in patients with metastatic colorectal cancer according to programmed cell death ligand 1

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3521-3528页

作者： Shin Woo kang Sung Hee lim Min-Ji Kim Jeeyun lee Young Suk Park Ho Yeong lim Won Ki kang Seung Tae Kim Division of Hematology Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Samsung Biomedical Research Institute Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Bevacizumab,an anti-vascular endothelial growth factor(VEGF)monoclonal antibody,inhibits angiogenesis and reduces tumor *** VEGF-C,lactate dehydrogenase,and inflammatory markers have been reported as predictive markers related to bevacizumab *** cell death ligand 1(PD-l1)could act upon VEGF receptor 2 to induce cancer cell angiogenesis and *** To investigate the efficacy of bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer(CRC)according to the expression of *** This analysis included CRC patients who received bevacizumab plus FOlFOx or FOlFIRI as first-line therapy between June 24,2014 and February 28,2022,at Samsung Medical Center(Seoul,South Korea).Analysis of patient data included evaluation of PD-l1 expression by the combined positive score(CPS).We analyzed the efficacy of bevacizumab according to PD-l1 expression status in patients with *** A total of 124 patients was included in this *** all patients were treated with bevacizumab plus FOlFIRI or FOlFOx as the first-line *** 77%of patients received FOlFOx,23%received FOlFIRI as backbone first-line *** numbers of patients with a PD-l1 CPS of 1 or more,5 or more,or 10 or more were 105(85%),64(52%),and 32(26%),*** results showed no significant difference in progression-free survival(PFS)and overall survival(OS)with bevacizumab treatment between patients with PDl1 CPS less than 1 and those with PD-l1 CPS of 1 or more(PD-l1l1≥1%;PFS:P=0.93,OS:P=0.33),between patients with PD-l1 CPS less than 5 and of 5 or more(PD-l1l1≥5%;PFS:P=0.409,OS:P=0.746),and between patients with PD-l1 CPS less than 10 and of 10 or more(PD-l1l1≥10%;PFS:P=0.529,OS:P=0.568).CONClUSION Chemotherapy containing bevacizumab can be considered as first-line therapy in metastatic CRC irrespective of PD-l1 expression.

关键词： Bevacizumab Colorectal cancer Programmed cell death ligand 1 expression First-line chemotherapy Metastatic colorectal cancer

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Effects of interleukin-10 treated macrophages on bone marrow mesenchymal stem cells via signal transducer and activator of transcription 3 pathway

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World Journal of Stem Cells 2024年第5期16卷 560-574页

作者： Meng-Hao lyu Ce Bian Yi-Ping Dou kang Gao Jun-Ji xu Pan Ma Department of Periodontics School of StomatologyCapital Medical UniversityBeijing 100050China Department of Orthodontics School of StomatologyCapital Medical UniversityBeijing 100050China Department of Dental Implantology School of StomatologyCapital Medical UniversityBeijing 100050China Beijing Key laboratory of Tooth Regeneration and Function Reconstruction School of StomatologyCapital Medical UniversityBeijing 100050China Beijing laboratory of Oral Health Capital Medical UniversityBeijing 100050China

BACKGROUND Alveolar bone defects caused by inflammation are an urgent issue in oral implant surgery that must be *** the various phenotypes of macrophages to enhance the inflammatory environment can significantly affect the progression of diseases and tissue engineering repair *** To assess the influence of interleukin-10(Il-10)on the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)following their interaction with macrophages in an inflammatory *** Il-10 modulates the differentiation of peritoneal macrophages in Wistar rats in an inflammatory *** this study,we investigated its impact on the proliferation,migration,and osteogenesis of *** expression levels of signal transducer and activator of transcription 3(STAT3)and its activated form,phos-phorylated-STAT3,were examined in Il-10-stimulated ***,a specific STAT3 signaling inhibitor was used to impede STAT3 signal activation to further investigate the role of STAT3 *** Il-10-stimulated macrophages underwent polarization to the M2 type through substitution,and these M2 macrophages actively facilitated the osteogenic differentiation of ***,STAT3 signaling plays a crucial role in the process by which Il-10 influences ***,Il-10 stimulated the activation of the STAT3 signaling pathway and reduced the macrophage inflammatory response,as evidenced by its diminished impact on the osteogenic differentiation of *** Stimulating macrophages with Il-10 proved effective in improving the inflammatory environment and promoting the osteogenic differentiation of *** Il-10/STAT3 signaling pathway has emerged as a key regulator in the macrophage-mediated control of BMSCs’osteogenic differentiation.

关键词： Macrophages Interleukin-10 Bone marrow mesenchymal stem cells Signal transducer and activator of transcription 3 Inflammatory response

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二维范德华磁体的拓扑自旋结构的研究进展

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Science Bulletin 2024年第11期69卷 1612-1616页

作者：许洪军刘艺舟 Giovanni Finocchio kang lWang 于国强 Beijing National laboratory for Condensed Matter Physics Institute of PhysicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100190China RIKEN Center for Emergent Matter Science(CEMS) Wako 351-0198Japan Department of Mathematical and Computer Sciences Physical Sciences and Earth SciencesUniversity of MessinaMessina 98166Italy Department of Electrical Engineering University of CaliforniaLos Angeles CA 90095USA

The importance of topological spin textures(TSTs), such as skyrmions, merons, hopfions, etc., is due to their static and dynamic properties [1]. They carry a topological number that characterizes the homotopy group Π_(n)(S^(2))(n ∈ Z) and classifies maps from S^(n) to S^(2)(e.g., the skyrmion winding number corresponds to Π_(2)(S^(2))).

关键词：自旋结构 topological homotopy

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Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1257-1282页

作者： Zhao Wang Heng Zhang Zhen Gao Zihao Sang Erik De Clercq Christophe Pannecouque Dongwei kang Peng Zhan xinyong liu Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Rega Institute for Medical Research Laboratory of Virology and ChemotherapyK.U.LeuvenLeuven B-3000Belgium China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province Jinan 250012China Suzhou Research Institute Shandong UniversitySuzhou 215123China

With our continuous endeavors in seeking potent anti-HIV-1 agents,we reported here the discovery,biological characterization,and druggability evaluation of a class of nonnucleoside reverse transcriptase *** fully explore the chemical space of the NNRTI-binding pocket,novel series of dihydrothiopyrano[3,2-d]pyrimidines were developed by employing the structure-based design *** of the derivatives were endowed with prominent antiviral activities against HIV-1 wild-type and resistant strains at nanomolar *** them,compound 23h featuring the aminopiperidine moiety was identified as the most potent inhibitor,with EC50values ranging from 3.43 to 21.4 nmol/***,for the challenging double-mutants F227l+V106A and K103N+Y181C,23h exhibited 2.3-to 14.5-fold more potent activity than the first-line drugs efavirenz and ***,the resistance profiles of 23h achieved remarkable improvement compared to efavirenz and *** binding target of 23h was further confirmed to be HIV-1 reverse *** modeling studies were also performed to elucidate the biological evaluation results and give guidance for the optimization ***,no apparent inhibition of the major CYP450 enzymes and hERG channel was observed for *** importantly,23h was characterized by good pharmacokinetic properties and excellent safety in ***,23h holds great promise as a potential candidate for its effective antiviral efficacy and favorable drug-like profiles.

关键词： HIV-1 Reverse transcriptase Dihydrothiopyrano[3,2-d]pyrimidine Antiviral agent

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透射式GaAs光电阴极性能提高以及结构优化

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物理学报 2024年第3期73卷 266-272页

作者：吕行富容国常本康郭欣王芝南京理工大学电子工程与光电技术学院南京210094 昆明物理研究所昆明650221 西安应用光学研究所西安710065

为了提高透射式GaAs光电阴极性能,将国内与美国ITT公司的透射式GaAs光电阴极量子效率曲线进行对比,可知我国透射式光电阴极积分灵敏度已经达到2130μA/lm,美国ITT达到了2330μA/lm.利用修正后的量子效率、光学性能以及积分灵敏度的理论... 详细信息

为了提高透射式GaAs光电阴极性能,将国内与美国ITT公司的透射式GaAs光电阴极量子效率曲线进行对比,可知我国透射式光电阴极积分灵敏度已经达到2130μA/lm,美国ITT达到了2330μA/lm.利用修正后的量子效率、光学性能以及积分灵敏度的理论模型,分别对两者进行光学结构拟合.结果表明,国内光电阴极在窗口层和发射层的厚度、电子扩散长度以及后界面复合速率等方面均与ITT有一定差距.为了缩短两者的差距,优化阴极结构参数,具体研究了电子扩散长度和发射层厚度对量子效率的影响,结果表明如果均匀掺杂透射式GaAs光电阴极发射层厚度为1.3μm、电子扩散长度为7μm,则积分灵敏度可以达到2800μA/lm以上.

关键词： Ga As光电阴极透射式结构优化光学性能光电发射性能

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Design and parameters optimization of the curved sieve for an air suction jujube harvester

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 132-139页

作者： Shenghe Bai Yanwei Yuan kang Niu liming Zhou Bo Zhao liguo Wei lijing liu xuejun Zhang College of Engineering China Agricultural UniversityBeijing 100083China National Key laboratory of Agricultural Equipment Technology Chinese Academy of Agricultural Mechanization Sciences Group Co.Ltd.Beijing 100083China College of Mechanical and Electrical Engineering Xinjiang Agricultural UniversityUrumqi 830052China

In order to improve the screening performance and cleaning effect of the jujube harvesting machinery cleaning device,a vibrating curved screen device was designed in this *** analyzing the structure mechanism of the curved sieve body,it was obtained that the arc-shaped mesh hole spacing S was 15-25 mm and the curved mesh hole curvature U was 90°-150°.By exploring the movement state and stress of jujube and impurities on the curved sieve body,it was determined that the horizontal spacing l of the curved layer sieve was 30 mm and the vertical spacing H was 45-65 *** the vertical spacing H of the curved layer sieve,the curvature U of the curved mesh hole,and the spacing S of the curved mesh hole as the experimental factors,considering the screening efficiencyαand the impurity contentβof the jujube as the response values,the three-factor three-level quadratic regression orthogonal experiment was designed,establishing the regression mathematical model of each factor and response value,and the multiple target optimization algorithm of Design-expert software was used to optimize various *** results showed that the influence factors on the screening efficiency were in the descending order as:the arc screen spacing,the vertical spacing of the curved layer screen,and the curved screen hole curvature;The significant factors affecting the impurity content of jujube were in the descending order as:the arc screen spacing,the curved screen hole curvature,and the vertical spacing of the curved layer *** experimental results were verified by the optimized combination of parameters:when the vertical spacing H of the curved layer screen was 65 mm,the curved screen hole curvature U was 110°,and the arc screen spacing S was 23 mm,the average screening efficiencyαin the test was 91.09%.The relative error between the experimental verification value and the theoretical optimization value was 1.36%,which was less than 5%.The impurity content of jujubeβin the test w

关键词： jujube harvesting cleaning device curved sieve sieve structure conveying pipe mathematical model

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Emerging strategies and developments in oxygen reduction reaction using high-performance platinum-based electrocatalysts

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Nano Research 2024年第5期17卷 3516-3532页

作者： Asad Ali Aatto laaksonen Guo Huang Shahid Hussain Shuiping luo Wen Chen Pei kang Shen Jinliang Zhu xiaoyan Ji Energy Engineering Division of Energy ScienceLuleåUniversity of Technology97187 LuleåSweden Department of Materials and Environmental Chemistry Arrhenius LaboratoryStockholm UniversitySE-10691 StockholmSweden Center of Advanced Research in Bionanoconjugates and Biopolymers “Petru Poni”Institute of Macromolecular ChemistryIasi 700469Romania State Key laboratory of Materials-Oriented and Chemical Engineering Nanjing Tech UniversityNanjing 211816China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060China School of Resources Environment and MaterialsState Key Laboratory of Processing for Non-ferrous Metal and Featured MaterialsGuangxi UniversityNanning 530004China

The global practical implementation of proton exchange membrane fuel cells(PEMFCs)heavily relies on the advancement of highly effective platinum(Pt)-based electrocatalysts for the oxygen reduction reaction(ORR).To achieve high ORR performance,electrocatalysts with highly accessible reactive surfaces are needed to promote the uncovering of active positions for easy mass *** this critical review,we introduce different approaches for the emerging development of effective ORR electrocatalysts,which offer high activity and *** strategies,including morphological engineering,geometric configuration modification via supporting materials,alloys regulation,core-shell,and confinement engineering of single atom electrocatalysts(SAEs),are discussed in line with the goals and requirements of ORR performance *** review the ongoing development of Pt electrocatalysts based on the syntheses,nanoarchitecture,electrochemical performances,and *** eventually explore the obstacles and research directions on further developing more effective electrocatalysts.

关键词： oxygen reduction reaction(ORR) Pt-based electrocatalysts proton exchange membrane fuel cells(PEMFCs) morphology and alloys strategies single atom electrocatalysts(SAEs)

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