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Feasibility of macromolecular structure experiments operating at the 3W1 beamline of BSRF in the parasitic mode

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Beijing Synchrotron Radiation Facility 2001年第2期 231-235,页

作者： x.ju D.C.xian BeijingSynchrotronRadiationFac.InstituteofHighEnergyPhysics ChineseAcademyofSciencesYuquanRoadBeijing100039People’sRepublicofChina

Parameters for the 3W1 source at BSRF were determined in both the dedicated and parasitic mode and their suitability for protein crystallography beamline at BSRF were *** is discussed that the physics motivation and the design of the 3W1 is compared with similar experimental stations at the Brazilian Light Sourec(1.37Gev) and Max-II in Sweden(1.5GeV).The photon flux from the 3W1 sourcd is about 2×10^11 photon/smA in the wavelength range of 2.0-0.9A in parasitic mode and 50-80 times higher in the dedicated *** the dedicated and parasitic modes are suitable for macromolecular structure experiments.2001 Elsevier Science *** rights reserved.

关键词： BSRF 北京同步辐射装置蛋白质生物化学结构分析结晶学

An experimental apparatur for EDxD of high pressure specimens using synchrotron radiation at BSRF

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Beijing Synchrotron Radiation Facility 2001年第2期 176-179,页

作者： Y.H.Jing Y.Yang x.ju JingLiu R.Z.Che J.Zhao BSRF InstituteofHighEnergyPhysicsChineseAcademyofSciencesYupquanRoadBeijing100039People’sRepublicofchina InstituteofPhysics ChineseAcademyofSciencesBeijing100080People’sRepublicofChina

A high pressure energy dispersive x-ray diffraction apparatus on 3W1A bearmline,at BSRF,is described.A ten-Poles permanent magnetic wiggler provided white x-ray *** extreme high pressure up to 115GPa has been obtained by a modified Mao-Bell diamond anvil cell.A motorized loading system with strain sensor can finely control the pressure *** in situ experimental procedures are *** applications are also presented.2001 Elsevier Science *** rights reserved.

关键词： BSRF 北京同步辐射装置 x射线衍射高压发光性质 EDxD 能量弥散x射线探测器实验方法

ExAFS and SAxS studies for local structure of Hf,Sc and Ti doped ZrCo alloy

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EXAFS and SAXS studies for local structure of Hf,Sc and Ti d...

第九届全国氢能学术会议

作者： Y.Qi~1,x.ju~1,C.B.Wan~1,J.Qiu~1,Y.xin~1,S.M.Wang~2,x.P.Liu~2,L.J.Jiang~2 ~1 University of Science and technology Beijing,China ~2General Research Institute for Nonferrous Metals,China

＜正＞An inter-metallic compound ZrCo was proposed as an alternative of uranium for recovery, storage and supply of tritium and is obtaining increasing attention for applications to fusion reactor fuel *** possesses s...

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Synchrotron xAFS and SAxS studies of Ti-V-Cr hydrogen absorbing alloy

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Synchrotron XAFS and SAXS studies of Ti-V-Cr hydrogen absorb...

第九届全国氢能学术会议

作者： x.ju~1,C.B.Wan~1,Y.Qi~1,J.Qiu~1,Y xin~1,Y.Gao~1,S.M.Wang~2,x.P.Liu~2,L.J.Jiang~2 ~1 University of Science and technology Beijing,China ~2 General Research Institute for Nonferrous Metals,China

＜正＞Vanadium-based alloys with BCC structure had high hydrogen storage capacities,good kinetics,and absorb/desorb hydrogen at room ***-based solid solution alloys were widely concerned especially for V-Ti-Cr alloys....

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Investigation of Defects Induced by Helium and Hydrogen Implantation in CLAM Steel by a Slow Positron Beam

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Investigation of Defects Induced by Helium and Hydrogen Impl...

9th International Conference on Computer Simulation of Radiation Effects in Solids

作者： J.Qiu~1 Y.xin~1 x.ju~(1*) L.P.Guo~2 B.Y.Wang~3 Y.R.Zhong~3 Q.Y.Huang~4 Y.C.Wu~4 1 Department of Physics University of Science and Technology Beijing Beijing 100083 China 2 Accelerator Laboratory School of Physics Wuhan University Wuhan Hubei 430072 China 3 Key Laboratory of Nuclear Analysis Techniques Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China 4 Institute of Plasma Physics Chinese Academy of Sciences Hefei Anhui 230031 China

＜正＞The Reduced Activation Ferritic/Martensitic（RAFM） steel is considered as the primary candidate of structural material for both the ITER and the first fusion plant, and widely studied in the *** China Low Activ... 详细信息

关键词： CLAM Steel Ion Implantation Slow Positron Beam

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri H.juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Status and Strategy of Fusion Materials Development in China

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Status and Strategy of Fusion Materials Development in China

第十二届反应堆数值计算与粒子输运学术会议

作者： Q.Y.Huang~1 Y.C.Wu~1 J.G.Li~1 F.R.Wan~2 J.L.Chen~1 G.N.Luo~1 x.Liu~3 J,M,Chen~3 Z.Y.xu~3 x.G.Zhou~4 x.ju~2 Y.Y.Shan~5 J.N.Yu~6 S.Y.Zhu~6 P.Y.Zhang~6 J.F.Yang~7 x.J.Chen~8 S.M.Dong~9 (1.Institute of Plasma Physics,Chinese Academy of Sciences,Hefei,Anhui,230031,China 2.University of Science and Technology Beijing,Beijing 100083,China 3.Southwestern Institute of Physics,Chengdu,Sichuan,610041,China 4 National University of Defense Technology,Changsha,Hunan,410073,China 5.Institute of Metal Research,Chinese Academy of Sciences,Shenyang,Liaoning,110016,China 6.China Institute of Atomic Energy,Beijing,102413,China 7.xi’an Jiaotong University,xi’an,Shanxi,710049,China 8 China Academy of Engineering Physics,Mianyang,Sichuan,621900,China 9.Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shahghai,200050,China)

The liquid metal and solid ceramic pebble breeder blankets have become the most promising blankets for ITER-TBMs or DEMO reactors in China and the world due to their potential advantages. In recent years the corresponding research work on fusion reactor materials are mainly focus on structural materials,plasma facing materials and the functional materials for the blanket such as breeder, coating and flow channel insert *** push work on fusion materials and then for the successful application of fusion *** R&D on those materials in the two kinds of blankets is being carried out widely in China,including fabrication and manufacturing techniques,physical/mechanical properties assessment before and after irradiation,joining techniques for structural materials, compatibility evaluation,and the development and verification of the criteria for fusion material *** progress on main R&D activities of fusion reactor materials in China is introduced and prospected in the paper.

关键词： Fusion reactor Blanket Materials R&D

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei xu Zi-Chun Yuan xiao Liu Mao-ju Tang Man Luo xiao-Wu Zhong Qiang Ma xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2Ax,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2Ax protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins