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Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway

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Chinese journal of Integrative Medicine 2024年第6期30卷 515-524页

作者： CAO liu-jing liU li-ya CHEN You-qin HAN Yu-ying WEI li-hui YAO Meng-ying FANG Yi WU Mei-zhu CHENG Ying Thomas j.Sferra liU Hui-xin li li PENG jun SHEN A-ling Clinical Research Institute the Second Affiliated Hospital&Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine in Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Pediatrics Case Western Reserve University School of MedicineUH Rainbow Babies and Children’s HospitalClevelandOH44106USA Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Health Management Fujian Provincial HospitalShengli Clinical College of Fujian Medical UniversityFuzhou000000China

ObjectiveTo explore the regulatory effect of Pien Tze Huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) *** polymerase chain reaction was performed to determine mRNA levels of PNO1, TP53, and CDKN1A. Western blotting was performed to determine protein levels of PNO1, p53, and p21. HCT-8 cells were transduced with a lentivirus over-expressing PNO1. Colony formation assay was used to detect cell survival in PNO1 overexpression of HCT-8 cells after PZH treatment. Cell-cycle distribution, cell viability and cell apoptosis were performed to identify the effect of PNO1 overexpression on cell proliferation and apoptosis of HCT-8 cells after PZH treatment. xenograft BALB/c nude mice bearing HCT116 cells transduced with sh-PNO1 or sh-Ctrl lentivirus were evaluated. Western blot assay was performed to detect PNO1, p53, p21 and PCNA expression in tumor sections. Terminal deoxynucleotidyl transferase dUTP nick end labling (TUNEL) assay was used to determine the apoptotic cells in *** treatment decreased cell viability, down-regulated PNO1 expression, and up-regulated p53 and p21 expressions in HCT-8 cells (Pxpression attenuated the effects of PZH treatment, including the expression of p53 and p21, cell growth, cell viability, cell cycle arrest and cell apoptosis in vitro (Pliminated the effects of PZH treatment on tumor growth, inhibiting cell proliferation inhibition and apoptosis induction in vivo (Pliferative effect is at least in part by regulating the expression of PNO1 and its downstream targets p53 and p21.

关键词： colorectal cancer Pien Tze Huang Chinese medicine partner of NOB1 proliferation p53/p21 pathway

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis x.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai x.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin j.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.j.Chen S.L.Chen S.M.Chen T.Chen x.R.Chen x.T.Chen Y.B.Chen Y.Q.Chen Z.j.Chen Z.Y.Chen S.K.Choi x.Chu G.Cibinetto F.Cossio j.j.Cui H.L.Dai j.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.x.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng j.H.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu j.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding x.x.Ding Y.Ding Y.Ding j.Dong L.Y.Dong M.Y.Dong x.Dong M.C.Du S.x.Du Z.H.Duan P.Egorov Y.H.Fan j.Fang jA.Gilman K.Goetzen L.Gong W.x.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.j.Guo R.P.Guo Y.P.Guo A.Guskov j.Gutierrez K.L.Han T.T.Han x.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou x.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu j.F.Hu T.Hu Y.Hu G.S.Huang K.x.Huang L.Q.Huang x.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad j.jackson S.janchiv j.H.jeong Q.ji Q.P.ji W.ji x.B.ji x.L.ji Y.Y.ji x.Q.jia Z.K.jia D.jiang H.B.jiang P.C.jiang S.S.jiang T.j.jiang x.S.jiang Y.jiang j.B.jiao j.K.jiao Z.jiao S.jin Y.jin M.Q.jing x.M.jing T.johansson S.Kabana N.Kalantar-Nayestanaki x.L.Kang x.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner x.Kui A.Kupsc W.K\"uhn j.j.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.li C.li C.H.li Cheng li D.M.li F.li G.li H.li H.B.li H.j.li H.N.li Hui li j.R.li j.S.li K.li L.j.li L.K.li Lei li M.H.li P.R.li Q.M.li Q.x.li R.li S.x.li T.li W.D.li W.G.li x.li x.H.li x.L.li x.Y.li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

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Atomistic Investigation of Shock-Induced Amorphization within Micro-shear Bands in Hexagonal Close-Packed Titanium

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Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1590-1600页

作者： Z.C.Meng K.G.Wang T.Ali D.li C.G.Bai D.S.xu S.j.li A.H.Feng G.j.Cao j.H.Yao Q.B.Fan H.Wang R.Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Interdisciplinary Centre for Additive Manufacturing(ICAM) School of Materials and ChemistryUniversity of Shanghai for Science and TechnologyShanghai 200093China School of Materials Science and Engineering Tongji UniversityShanghai 201804China Key Laboratory for light-Weight Materials Nanjing Tech UniversityNanjing 210009China National Key Laboratory of Science and Technology on Materials Under Shock and Impact School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401135China

The mechanical response of a single crystal titanium sample against(0001)α surface impact was investigated using molecular dynamics ***,non-uniform plastic deformation was observed in the *** high strain rates,amorphization occurred near the edge of the contact region where severe shear strain induced a large number of stacking faults(SFs)and *** contrast,the central part of the contact region underwent less deformation with significantly fewer ***,instead of amorphization by consuming SFs and dislocations,there was a gradual increase in the density of dislocations and SFs during the process of *** local amorphous regions eventually grew into shear bands.

关键词： Shock compression Amorphization Shear band Titanium Molecular dynamics

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Coordinate-wise monotonic transformations enable privacy-preserving age estimation with 3D face point cloud

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Science China(life Sciences) 2024年第7期67卷 1489-1501页

作者： xinyu Yang Runhan li xindi Yang Yong Zhou Yi liu jing-Dong j.Han School of life Sciences Peking UniversityBeijing 100871China Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology(CQB)Peking UniversityBeijing 100871China Beijing Key Lab of Traffic Data Analysis and Mining School of Computer and Information TechnologyBeijing Jiaotong UniversityBeijing 100044China Clinical Research Institute Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

The human face is a valuable biomarker of aging,but the collection and use of its image raise significant privacy *** we present an approach for facial data masking that preserves age-related features using coordinate-wise monotonic *** first develop a deep learning model that estimates age directly from non-registered face point clouds with high accuracy and *** show that the model learns a highly indistinguishable mapping using faces treated with coordinate-wise monotonic transformations,indicating that the relative positioning of facial information is a low-level biomarker of facial *** visual perception tests and computational3D face verification experiments,we demonstrate that transformed faces are significantly more difficult to perceive for human but not for machines,except when only the face shape information is *** study leads to a facial data protection guideline that has the potential to broaden public access to face datasets with minimized privacy risks.

关键词： face point cloud age estimation face verification privacy coordinate-wise monotonic transformation

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Effect of stress-dependent microannulus aperture on well leakage

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journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 1967-1976页

作者： Meng Meng Luke P.Frash j.William Carey Mohamed Mehana Wenfeng li Bailian Chen Earth and Environmental Sciences Los Alamos National LaboratoryLos AlamosNMUSA

Debonding at the cement-casing interface is recognized as a principal failure mechanism leading to CO_(2) leakage in *** detachment gives rise to a microannulus,which notably possesses greater permeability than undamaged cement,undermining its sealing ***,the permeability of the microannulus is regarded as a uniform value throughout the ***,fundamentally,a microannulus is one type of fracture,and its gap or aperture size is affected by the effective *** this work,we developed a unique experimental *** equipment facilitates the curing of cement inside a steel casing,the formation of a microannulus between the casing and the cement,and the investigation of the fluid flow dynamics along the microannulus under laboratory-replicated in situ *** microannulus was formed by injecting fluid from one end of the setup,and receiving similar amount of fluid on the other end signified the development of the leakage ***,strain gauges affixed to the casing’s external surface yielded key information on the microannulus’s opening and *** observed a noticeable decline in microannulus hydraulic aperture(or permeability)in relation to effective stress and an exponential equation fits their *** findings also indicate a distinct behavior when comparing liquid CO_(2) with ***,it is easier for liquid CO_(2) to create the ***,the hydraulic aperture range for this microannulus(0.7-6 mm)is considerably smaller than that created by water flow(2-17 mm).Finally,we integrated the stressdependent microannulus aperture size into the combined analysis of well mechanical integrity and well *** outcomes consistently demonstrated that when factoring in the stress-dependent aperture sizes,the leakage rates are 3e5 times compared to a fixed aperture *** traditional assumption of a constant aperture significantly underestimates fluid leakage risks.

关键词： Microannulus Leakage assessment Aperture size Triaxial experiment Carbon sequestration

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Advanced Algorithm for Parameters Estimation of Negative Binomial Distribution with High Dimensional Sparse Group Structure

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journal of Systems Science & Complexity 2024年第5期37卷 2173-2195页

作者： li Meiqi jIN Baisuo School of Management University of Science and Technology of ChinaHefei 230000China

Negative binomial regression is a powerful technique for modeling count data,particularly when dealing with ***,estimating the parameters for large-dimensional sparse models is challenging due to the complexity of optimizing the mean and dispersion parameter of the negative binomial *** address this issue,the authors propose a novel approach that employs two iterations of the majorize-minimize(MM)algorithm,one for estimating the dispersion parameter and the other for estimating the mean *** approaches improve the convergence speed and stability of the *** authors also use group penalty for variable selection,which enhances the accuracy and efficiency of the *** proposed method provides an explicit solution,simplifies the iteration process,and maintains good stability while ensuring algorithm ***,the authors apply the proposed algorithm to the zero-inflated model and demonstrate its promising predictive performance on specific data *** research has important implications for count data modeling and analysis in various fields,such as data mining,machine learning,and bioinformatics.

关键词： Group structure majorize-minimize(MM) negative binomial

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Completeness of Induced Cotorsion Pairs in Representation Categories of Rooted Quivers

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2436-2452页

作者： Zhen xing DI li Ping li li liANG Fei xU School of Mathematical Sciences Huaqiao University LCSM (Ministry of Education) School of Mathematics and Statistics Hunan Normal University Department of Mathematics Lanzhou Jiaotong University Gansu Provincial Research Center for Basic Disciplines of Mathematics and Statistics Department of Mathematics Shantou University

This paper focuses on a question raised by Holm and j?rgensen, who asked if the induced cotorsion pairs(Φ（x）, Φ（x）⊥) and(⊥Ψ（Y）, Ψ（Y）) in Rep（Q, A）—the category of all A-valued representations of a quiver Q—are complete whenever（x, Y） is a complete cotorsion pair in an abelian category A satisfying some mild conditions. We give an affirmative answer if the quiver Q is rooted. As an application, we show under certain mild conditions that if a subcategory L, which is not necessarily closed under direct summands, of A is special precovering（resp., preenveloping）, then Φ（L）(resp.,Ψ（L）) is special precovering（resp., preenveloping） in Rep（Q, A）.

关键词： 16G20 18G25 complete cotorsion pair Rooted quiver special precovering (preenveloping) subcategory

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Resistive field generation in intense proton beam interaction with solid targets

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Matter and Radiation at Extremes 2024年第1期9卷 35-43页

作者： W.Q.Wang j.j.Honrubia Y.Yin x.H.Yang F.Q.Shao Department of Physics National University of Defense TechnologyHunanChina ETSI Aeronáutica y del Espacio Universidad Politécnica de MadridMadridSpain Department of Nuclear Science and Technology National University of Defense TechnologyHunanChina

The Brown-Preston-Singleton(BPS)stopping power model is added to our previously developed hybrid code to model ion beam-plasma *** simulations show that both resistive field and ion scattering effects are important for proton beam transport in a solid target,in which they compete with each *** the target is not completely ionized,the self-generated resistive field effect dominates over the ion scattering ***,when the target is completely ionized,this situation is ***,it is found that Ohmic heating is important for higher current densities and materials with high *** energy fraction deposited as Ohmic heating can be as high as 20%-30%.Typical ion divergences with half-angles of about 5°-10°will modify the proton energy deposition substantially and should be taken into account.

关键词： interaction beam intense

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A Novel Tensor Decomposition-Based Efficient Detector for Low-Altitude Aerial Objects With Knowledge Distillation Scheme

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IEEE/CAA journal of Automatica Sinica 2024年第2期11卷 487-501页

作者： Nianyin Zeng xinyu li Peishu Wu Han li xin Luo Department of Instrumental and Electrical Engineering Xiamen UniversityXiamen 361005China IEEE College of Computer and Information Science Southwest UniversityChongqing 400715China

Unmanned aerial vehicles(UAVs) have gained significant attention in practical applications, especially the low-altitude aerial(LAA) object detection imposes stringent requirements on recognition accuracy and computational resources. In this paper, the LAA images-oriented tensor decomposition and knowledge distillation-based network(TDKD-Net) is proposed,where the TT-format TD(tensor decomposition) and equalweighted response-based KD(knowledge distillation) methods are designed to minimize redundant parameters while ensuring comparable performance. Moreover, some robust network structures are developed, including the small object detection head and the dual-domain attention mechanism, which enable the model to leverage the learned knowledge from small-scale targets and selectively focus on salient features. Considering the imbalance of bounding box regression samples and the inaccuracy of regression geometric factors, the focal and efficient IoU(intersection of union) loss with optimal transport assignment(F-EIoU-OTA)mechanism is proposed to improve the detection accuracy. The proposed TDKD-Net is comprehensively evaluated through extensive experiments, and the results have demonstrated the effectiveness and superiority of the developed methods in comparison to other advanced detection algorithms, which also present high generalization and strong robustness. As a resource-efficient precise network, the complex detection of small and occluded LAA objects is also well addressed by TDKD-Net, which provides useful insights on handling imbalanced issues and realizing domain adaptation.

关键词： Attention mechanism knowledge distillation(KD) object detection tensor decomposition(TD) unmanned aerial vehicles(UAVs)

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Boosting High-Voltage Practical lithium Metal Batteries with Tailored Additives

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Nano-Micro Letters 2024年第12期16卷 23-41页

作者： jinhai You Qiong Wang Runhong Wei li Deng Yiyang Hu li Niu jingkai Wang xiaomei Zheng junwei li Yao Zhou jun-Tao li College of Energy Xiamen UniversityXiamen 361005People’s Republic of China Magnetism Key Laboratory of Zhejiang Province College of Materials and ChemistryChina Jiliang UniversityHangzhou 310018People’s Republic of China Laboratory for Soft Matter and Biophysics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium State Key Lab of Physical Chemistry of Solid Surface College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005People’s Republic of China Department of Chemical Engineering KU LeuvenCelestijnenlaan 200F3001 LeuvenBelgium College of Chemistry and Chemical Engineering Northwest Normal UniversityLanzhou 730070GansuPeople’s Republic of China

The lithium(li)metal anode is widely regarded as an ideal anode material for high-energy-density ***,uncontrolled li dendrite growth often leads to unfavorable interfaces and low Coulombic efficiency(CE),limiting its broader ***,an ether-based electrolyte(termed FGN-182)is formulated,exhibiting ultra-stable li metal anodes through the incorporation of liFSI and liNO3 as dual *** synergistic effect of the dual salts facilitates the formation of a highly robust SEI film with fast li+transport ***,li||Cu half cells exhibit an average CE reaching up to 99.56%.In particular,pouch cells equipped with high-loading lithium cobalt oxide(LCO,3 mAh cm^(-2))cathodes,ultrathin li chips(25μm),and lean electrolytes(5 g Ah-1)demonstrate outstanding cycling performance,retaining 80%capacity after 125 *** address the gas issue in the cathode under high voltage,cathode additives 1,3,6-tricyanohexane is incorporated with FGN-182;the resulting high-voltage LCO||li(4.4 V)pouch cells can cycle steadily over 93 *** study demonstrates that,even with the use of ether-based electrolytes,it is possible to simultaneously achieve significant improvements in both high li utilization and electrolyte tolerance to high voltage by exploring appropriate functional additives for both the cathode and anode.

关键词： li metal anode li dendrites liNO_(3) 1,3,6-tricyanohexane Pouch cells

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