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Correlations of the expression of Cx43,SCffBxW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： Rong-Gang Luan Ming-Da Liu Zi-feng Deng Cong-Lan Lu Mei-Ling Yu Ming-Yu zhang Rong Liu Ran An You-Liang Yao Dong-Bei Guo Yong-xing zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/f-box(SCf)fBxW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCffBxW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCffBxW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCffBxW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCffBxW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(Pxpressions of the above proteins were positively correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCffBxW7,thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCffBxW7 Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

Examining the effect of the aging state on strength and plasticity of wrought aluminum alloys

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Journal of Materials Science & Technology 2022年第27期122卷 54-67页

作者： Z.Qu Z.J.zhang J.x.Yan P.zhang B.S.Gong S.L.Lu Z.f.zhang T.G.Langdon Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Department of Mechanical Engineering University of SouthamptonSouthampton SO171BJUnited Kingdom

A general rule of strength and plasticity was proposed for three typical wrought Al alloys(2xxx,6xxx,and 7xxx)subjected to different aging *** of the work-hardening processes and dislocation configurations in tensile and compressive testing reveal that this general rule arises because there is a common mechanism for these three kinds of wrought alloys whereby the tendency for cross-slip increases monotonously with aging *** analyzing the strain hardening exponent and the stacking fault energy,it is demonstrated that the change in the dislocation slip mode is attributed mainly to the formation of second phases rather than to the matrix ***,a new work-hardening model was proposed for wrought Al alloys containing second phases and this explains the interaction between dislocations and second phases and other relevant experimental *** work is therefore beneficial for quantitatively investigating and optimizing the strength and plasticity of wrought aluminum alloys.

关键词： Wrought aluminum alloy Strength and plasticity Work hardening Dislocation slip mode Second phase

Design and optimization of the composition and mechanical properties for non-equiatomic CoCrNi medium-entropy alloys

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Journal of Materials Science & Technology 2023年第8期139卷 232-244页

作者： J.x.Yan Z.J.zhang P.zhang J.H.Liu H.Yu Q.M.Hu J.B.Yang Z.f.zhang Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering Chongqing Jiaotong UniversityChongqing 400074China chool of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China School of Information Science and Engineering Shenyang University of TechnologyShenyang 111003China

The development of multi-principal element alloys(MPEAs,also called as high-or medium-entropy al-loys,HEAs/MEAs)provides tremendous possibilities for materials ***,designing MPEAs with desirable mechanical properties confronts great challenges due to their vast composition *** this work,we provide an essential criterion to efficiently screen the CoCrNi MEAs with outstanding strength-ductility *** negative Gibbs free energy difference△E_(fCC-BCC)between the face-centered cubic(fCC)and body-centered cubic(BCC)phases,the enhancement of shear modulus G and the decline of stacking fault energy(SfE)γ_(isf)are combined as three requisites to improve the fCC phase stability,yield strength,deformation mechanisms,work-hardening ability and ductility in the *** effects of chemical composition on△E_(fCC-BCC),G andγisf were investigated with the first principles calculations for Co_(x)Cr_(33)Ni_(67-x),Co_(33)Cr_(y)Ni_(67-y)and Co_(z)Cr_(66-z)Ni_(34)(0≤x,y≤67 and 0≤z≤66)*** on the essential criterion and the calculation results,the composition space that displays the neg-ative Gibbs free energy difference△E_(fCC-BCC),highest shear modulus G and lowest SfEγ_(isf)was screened with the target on the combination of high strength and excellent *** this context,the optimal composition space of Co-Cr-Ni alloys was predicted as 60 at.%-67 at.%Co,30 at.%-35 at.%Cr and 0 at.%-6 at.%Ni,which coincides well with the previous experimental evidence for Co_(55)Cr_(40)Ni_(5)*** valid-ity of essential criterion is further proved after systematic comparison with numerous experimental data,which demonstrates that the essential criterion can provide significant guidance for the quick exploitation of strong and ductile MEAs and promote the development and application of MPEAs.

关键词： Medium-entropy alloys first-principles calculations Phase stability Stacking-fault energy Strength Ductility

Enhanced mechanical performance of grain boundary precipitation-hardened high-entropy alloys via a phase transformation at grain boundaries

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Journal of Materials Science & Technology 2021年第27期86卷 271-284页

作者： Y.L.Qi L.Zhao x.Sun H.x.Zong x.D.Ding f.Jiang H.L.zhang Y.K.Wu L.He f.Liu S.B.Jin G.Sha J.Sun State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710049China Analytical&Testing Center Northwestern Polytechnical UniversityXi’an710072China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China

Grain-boundary(GB)precipitation has a significant adverse effect on plasticity of alloys,which easily leads to catastrophic intergranular failure in safety-critical applications under high external ***,we report a novel strategy that uses the local stress concentration induced by GB precipitates as a driving force to trigger phase transformation of preset non-equiatomic high-entropy solid-solution phase at *** in situ deformation-induced phase transformation at GBs introduces a well-known effect:transformation-induced plasticity(TRIP),which enables an exceptional elongation to fracture(above 38%)at a high strength(above 1.5 GPa)in a GB precipitation-hardened high-entropy alloy(HEA).The present strategy in terms of"local stress concentration-induced phase transformations at GBs"may provide a fundamental approach by taking advantage of(rather than avoiding)the GB precipitation to gain a superior combination of high strength and high ductility in HEAs.

关键词： Non-equiatomic Grain-boundary precipitation High-entropy alloys Ductility Transformation-induced plasticity

An approach to extracting information of residential areas from Beijing-1 image based on Gabor texture segmentation

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International Journal of Digital Earth 2009年第2期2卷 186-193页

作者： J.Gong x.Yang f.Su Y.Du D.zhang School of Remote Sensing and Information Engineering Wuhan UniversityWuhanChina State key Lab of Resources and Environment Information System CASBeijingChina

According to the features of high-resolution panchromatic imagery of Beijing-1 small satellite,an approach to extracting information of residential areas is proposed in this paper based on Gabor texture *** algorithm extracts the features in different directions and different scales by building the Gabor filter,uses cluster analysis of multiple features to segment the image,and performs the fusion processing based on morphological scale *** solves the problems in image processing resulting from low contrast between remote sensing objects and background,the blurring of image edges and high *** has the benefits of direction selection and frequency selection with strong self-adaptive *** experiments prove the effectiveness of the approach for extracting information of residential areas from Beijing-1 high-resolution imagery.

关键词： Gabor filter texture segmentation Beijing-1 small satellite image processing

THE REINfORCING MECHANISM Of TiB2 IN TiB2/A357 COMPOSITE

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Acta Metallurgica Sinica(English Letters) 2003年第5期16卷 375-378页

作者： B.Yu Y.J.zhang Z.x.Zhao~ f.x.Zhao: Q.K.Cai C.S.Liu ShenyangResearchInstituteoffoundry TheChineseAcademyofMachinerySciencesShenyang110022China EastChinaUniversityofScienceandTechnology Shanghai200237China SchoolofMaterials&Metallurgy NortheasternUniversityShenyang110004China

Mechanical properties were tested for in situ TiB2/A357 composite fabricated by LSM (mixed salts reaction) method. Micro structures of as cast and plastic deformed TiB2/A357 were investigated. The results show that there is a low misfit between (200) Al and (101)TiB2 with [011]//Al [101]TiB2. There is a change from fully dendritic structure of the α-Al of A357 to a rosette-type structure of TiB2/A357. Significant increases in proof stress and Young's modulus can be obtained at low TiB2 additions. There exist dislocation loops around neighboring TiB2 particles with about 0.1μm in diameter and dislocation multiplication near TiB2 particles.

关键词： TiB2/Al in situ composite reinforcing mechanism

Data-driven evaluation of fatigue performance of additive manufactured parts using miniature specimens

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Journal of Materials Science & Technology 2019年第6期35卷 1137-1146页

作者： H.Y. Wan G.f. Chen C.P. Li x.B. Qi G.P. zhang Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences 72 Wenhua Road Shenyang 110016 China School of Materials Science and Engineering University of Science and Technology of China Shenyang 110016 China Materials Manufacturing Qualification Group Corporate Technology Siemens Ltd. China Beijing 100102 China State Key Laboratory of Tribology Tsinghua University Beijing J00084 China

This overview firstly introduces the state-of-the-art research progress in length scale-related fatigue performance of conventionally-fabricated metals evaluated by miniature specimens. Some key factors for size effects sensitive to microstructures including the specimen thickness, grain size and a ratio between them are highlighted to summarize some general rules for size effects. Then, ongoing research progress and new challenges in evaluating the fatigue performance of additive manufactured parts controlled by location-specific defects, microstructure heterogeneities as well as mechanical anisotropy using miniature specimen testing technique are discussed and addressed. finally, a potential roadmap to establish a data-driven evaluation platform based on a large number of miniature specimen-based experiment data,theoretical computations and the ’big data’ analysis with machine learning is proposed. It is expected that this overview would provide a novel strategy for the realistic evaluation and fast qualification of fatigue properties of additive manufactured parts we have been facing to.

关键词： Additive manufacturing Miniature specimen fatigue Size effect Location-specific Data analysis

Precipitation of multi-type nano-quasicrystals in a Mg-Zn-Y alloy

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Journal of Magnesium and Alloys 2024年第3期12卷 997-1008页

作者： W.Z.Wang x.Z.Zhou L.f.zhang H.Q.Ye Z.Q.Yang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of ScienceShenyang 110016China Ji Hua Laboratory Foshan 528251China foshan University Foshan 528231China

Mg-6Zn-1Y(at.%)ribbons with strengthening precipitates of multi-type nanoquasicrystals were prepared by melt-spinning followed by aging *** evolution of the rapidly solidified ribbons during isothermal aging was comprehensively studied using various electron microscopy *** new kinds of decagonal quasicrystals were formed in aged ribbons,in addition to precipitation of nanometer icosahedral ***-resolution observations reveal that both decagonal quasicrystals can be modeled by quasiperiodic tiling with decagonal clusters of 2.5 nm in diameter,but overlap of neighboring clusters in both decagonal quasicrystals is different from the Gummelt model observed in other quasicrystals.A shell composed of complex Laves Mg-Zn domains was formed surrounding each decagonal quasicrystal precipitate upon prolonged *** addition,all kinds of nanoprecipitates exhibit excellent structure and size stability at 573 *** findings may have implications for not only fundamental studies about quasicrystals,but also microstructural manipulation of high-performance Mg alloys.

关键词： Quasicrystal Mg alloys Rapid solidification Scanning-transmission electron microscopy.

Three principles for preparing Al wire with high strength and high electrical conductivity

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Journal of Materials Science & Technology 2019年第5期35卷 742-751页

作者： J.P.Hou R.Li Q.Wang H.Y.Yu Z.J.zhang Q.Y.Chen H.Ma x.M.Wu x.W.Li Z.f.zhang Materials fatigue and fracture Division Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China National Quality Supervision & Inspection Center of Electrical Equipment Safety Performance Zhejiang Huadian Equipment Testing Institute Hangzhou 310015 China Electric Power Research Institute of Liaoning Electric Power Co. Ltd. Liaoning Electric Power Co. Ltd. Shenyang 110006 China Department of Materials Physics and Chemistry School of Materials Science and Engineering Key Laboratory for Anisotropy and Texture of Materials Ministry of Education Northeastern University Shenyang 110819 China

The trade-off relation between the strength and the electrical conductivity has been a Iong-standing dilemma in metallic materials. In the study, three key principles, *** grains, sharp texture and nano-scale precipitates, were presented for preparing Al wire with high strength and high electrical conductivity based on the specially designed experiments for breaking the mutually exclusive relation between the strength and the electrical conductivity. The results show that the elongated grains could lead to a higher electrical conductivity in Al wire without sacrificing the strength;while, the sharp texture can efficiently strengthen the Al wire without influencing the electrical conductivity. furthermore, nano-scale precipitates with proper size can simultaneously improve the strength and electrical conductivity of Al alloy wire. Under the guidance of the above three key principles, Al wires with high strength and high conductivity were prepared.

关键词： Al wire Texture Precipitates Strength Electrical conductivity