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Hypothalamic circuits and aging:keeping the circadian clock updated

Neural Regeneration Research 2024年第9期19卷 1919-1928页

作者： Rosa vázquez-Lizarraga Lucia Mendoza-viveros Carolina cid-Castro Sareni Ruiz-Montoya Erick Carreño-vázquez Ricardo Orozco-Solis Instituto Nacional de Medicina Genómica(INMEGEN) México CityMéxico Centro de Investigacíon sobre el Envejecimiento Centro de Investigacíon y de Estudios Avanzados(CIE-CINVESTAV)México CityMéxico Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México UNAMMéxico CityMéxico

Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of life.Studies on aged animal models have unveiled a progressive discoordination at multiple regulatory levels,including transcriptional,translational,and post-translational processes,resulting from cellular stress and circadian derangements.The circadian clock emerges as a key regulator,sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes,such as stem-cell function,cellular stress responses,and inter-tissue communication,which become disrupted during aging.Given the crucial role of hypothalamic circuits in regulating organismal physiology,metabolic control,sleep homeostasis,and circadian rhythms,and their dependence on these processes,strategies aimed at enhancing hypothalamic and circadian function,including pharmacological and non-pharmacological approaches,offer systemic benefits for healthy aging.Intranasal brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions,like the hypothalamus,while reducing side effects associated with systemic drug delivery,thereby presenting new therapeutic possibilities for diverse age-related conditions.

关键词： aging astrocytes cellular stress responses circadian clock hypothalamus intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis

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Deadwood position matters:Diversity and biomass of saproxylic beetles in a temperate beech forest

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Forest Ecosystems 2024年第1期11卷 120-130页

作者： vaclav Zumr Oto Nakladal Josef Gallo JiríRemes Faculty of Forestry and Wood Sciences Czech University of Life Sciences PragueKamýck a 129Praha 6-Suchdol16500Czech Republic

Deadwood plays a key role for biodiversity in forests.A significant number of beetles from this group are currently listed as endangered in the Red List.In addition to other management recommendations,there have been recent efforts to enrich stands with dead wood to promote biodiversity.An important parameter for forestry enterprises is the optimization of these interventions.The study investigated the abundance,species richness,gamma diversity,conservation value and biomass of saproxylic beetles in natural forests using window traps.A total of 89traps were used for saproxylic beetle monitoring,of which 29 were placed on lying logs,30 on snags and 30 as controls in forest stand space.A total of 35,011 beetles were recorded in 564 species(61 families).Notably,20,515 of these belong to saproxylic beetles(59%)in 311 species(55%),with 62 classified as Red-List species(20%).In the group of'all saproxylic beetles',the results indicate that a diversity and y diversity(q=0)remain consistent across various deadwood types,whileβdiversity showed significant differences.Significant differences were found in the Red-List species group,where a diversity and y diversity differed,with higher values observed in snags.Rarefaction based total species richness of site was estimated to be 391 species,including 74 Red-Listed species.Comparing the sample coverage of the studied stand categories showed that all saproxylic species exhibit a pronounced preference for inhabiting areas featuring lying logs.Conversely,Red-List species mainly inhabit snags,withβdiversity being more similar to snags and forest stand space.Notably,both the conservation value(weighted average by conservation status)and beetle biomass are significantly highest in snags,whereas stand space shows the lowest values across all measured saproxylic beetle indices.Furthermore,the use of traps set on the poles in forest stand space resulted in an underestimation of the actual stand richness by 20%-25%.Our results support the conclusion that snags are indispensable featur

关键词： Snags Coleoptera Fagus sylvatica Unmanaged forests Red-list Coarse woody debris

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Single atom Cu-N-C catalysts for the electro-reduction of CO_(2) to CO assessed by rotating ring-disc electrode

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Journal of Energy Chemistry 2024年第1期88卷 169-182,I0004页

作者： S.Pérez-Rodríguez M.Gutiérrez-Roa C.Giménez-Rubio D.Ríos-Ruiz P.Arévalo-cid M.v.Martínez-Huerta A.Zitolo M.J.Lázaro D.Sebastián Instituto de Carboquímica(CSIC) Miguel Luesma Castán 450018 ZaragozaSpain Instituto de Catálisis y Petroleoquímica(CSIC) Marie Curie 228049 MadridSpain Synchrotron SOLEIL L’Orme des MerisiersDépartementale 12891190France

The electrochemical CO_(2) reduction reaction(CO_(2)RR) to controllable chemicals is considered as a promising pathway to store intermittent renewable energy. Herein, a set of catalysts based on copper-nitrogendoped carbon xerogel(Cu-N-C) are successfully developed varying the copper amount and the nature of the copper precursor, for the efficient CO_(2)RR. The electrocatalytic performance of Cu-N-C materials is assessed by a rotating ring-disc electrode(RRDE), technique still rarely explored for CO_(2)RR. For comparison, products are also characterized by online gas chromatography in a H-cell. The as-synthesized Cu-NC catalysts are found to be active and highly CO selective at low overpotentials(from -0.6 to -0.8 v vs.RHE) in 0.1 M KHCO_(3), while H_(2) from the competitive water reduction appears at larger overpotentials(-0.9 v vs. RHE). The optimum copper acetate-derived catalyst containing Cu-N_(4) moieties exhibits a CO_(2)-to-CO turnover frequency of 997 h^(-1) at -0.9 v vs. RHE with a H_(2)/CO ratio of 1.8. These results demonstrate that RRDE configuration can be used as a feasible approach for identifying electrolysis products from CO_(2)RR.

关键词： Cu-N-C Carbon xerogel Rotating ring disc electrode Carbon dioxide reduction reaction Carbon monoxide

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First finding of coesite in the eclogitic continental crust of the Sesia Zone, Italian Western Alps

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National Science Review 2023年第5期10卷 108-108页

作者： Giorgio v.dal Piaz Accademia Nazionale dei Lincei

The Western Alps provide classic examples of eclogite facies subduction metamorphism widely preserved in Adriaand Europe-derived continental nappes and interposed ophiolitic units derived from the suture of the Piedmo...

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Haplotype-resolved and chromosome-scale genomes provide insights into co-adaptation between the Amur tiger and Amur leopard

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Zoological Research 2024年第3期45卷 464-467页

作者： Hai-Meng Li Bo-Yang Liu Min-Hui Shi Le Zhang Shang-Chen Yang Sunil Kumar Sahu Liang-Yu Cui Shan-Lin Liu Nicolas Dussex Yue Ma Dan Liu Wei-Yao Kong Hao-Rong Lu Yue Zhao Love dalén Huan Liu Tian-Ming Lan Guang-Shun Jiang Yan-Chun xu College of Wildlife and Protected Area Northeast Forestry UniversityHarbinHeilongjiang 150040China State Key Laboratory of Agricultural Genomics BGI ResearchShenzhenGuangdong 518083China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China College of Life Sciences Zhejiang UniversityHangzhouZhejiang 310058China BGI Research WuhanHubei 430074China Department of Entomology College of Plant ProtectionChina Agricultural UniversityBeijing 100193China Centre for Palaeogenetics Svante Arrhenius väg 20CStockholm 10691Sweden Department of Zoology Stockholm UniversityStockholm 10691Sweden Department of Bioinformatics and Genetics Swedish Museum of Natural HistoryStockholm 10691Sweden Heilongjiang Siberian Tiger Park HarbinHeilongjiang 150000China Jinlin Provincial Academy of Forestry Science ChangchunJilin 130033China China National GeneBank BGI ResearchShenzhenGuangdong 518120China Guangdong Provincial Key Laboratory of Genome Read and Write BGI ResearchShenzhenGuangdong 518083China BGI Life Science Joint Research Center Northeast Forestry UniversityHarbinHeilongjiang 150040China Feline Research Center of National Forestry and Grassland Administration College of Wildlife and Protected AreaNortheast Forestry UniversityHarbinHeilongjiang 150040China National Forestry and Grassland Administration Research Center of Engineering Technology for Wildlife Conservation and Utilization HarbinHeilongjiang 150040China

DEAR EDITOR,Big cats,such as Amur tigers(Panthera tigris altaica)and Amur leopards(P.pardus orientalis),are apex predator and have evolved specialized traits for hunting and carnivory(Moya et al.,2022),thus playing a crucial role in maintaining biodiversity and ecosystem integrity by regulating prey-predator dynamics.However,human-induced pressures,habitat fragmentation,and environmental alterations have restricted these species in small and isolated populations.Currently,all extant big cats are categorized as endangered or threatened according to their conservation status.Amur tigers and Amur leopards share overlapping geographic ranges,habitats,and certain prey species in the forests of Northeast Asia(Jiang et al.,2015).To reduce interspecies conflict,these carnivores exhibit differentiated dietary and temporal niches.Amur tigers predominantly prey on large ungulates,while Amur leopards hunt small to medium-sized animals(Sugimoto et al.,2016).Additionally,they occupy different temporal niches,with tigers being active at night and leopards more active during the day.Despite spatial and temporal niche partitioning,interspecific competition between these two species is inevitable.Tigers,benefiting from their greater size,have a competitive advantage over leopards,which can manifest in occasional leopard predation by tigers and declines in leopard populations with increasing tiger density(Jiang et al.,2015).Tigers also displace leopards from marginal habitats in nature reserves where they coexist.

关键词： habitat Panthera resolved

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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： victor v.Chizhikov Igor Y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in mice.The cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)proteins.The cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;dal-valle-Anton and Borrell,2022).

关键词： epithelium Figure center

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Diversity of click beetles in managed nonnative coniferous and native beech stands: Consequences of changes in the structural and species composition of tree stands in Central Europe

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Forest Ecosystems 2022年第5期9卷 596-605页

作者： václav Zumr Oto Nakladal JiríRemes Tereza Brestovanska váaclav Zumr Czech University of Life Sciences Prague Faculty of Forestry and Wood SciencesKamýcka 129Praha 6Suchdol16500Czech Republic The Silva Tarouca Research Institute for Landscape and Ornamental Gardening Kvetnove namestí391Průhonice25243Czech Republic SC*** Czech Republic

The natural composition of forests has undergone significant changes over recent centuries.A closer-to-natural tree species composition has long been perceived as key to a high biodiversity.We investigated the impact on communities of click beetles(Elateridae)caused by changes in the tree species composition of spruce monocultures compared to reference sites of recently unmanaged natural beech forests.To collect data,passive interception traps were distributed within managed spruce stands of different age classes and natural beech forests of various developmental stages.The beetle species richness was slightly but not significantly higher in the beech forests.The saproxylic species group was significantly more common in the spruce stands,whereas the group of nonsaproxylic species was significantly more abundant in the beech stands.In the commercial stands,the significantly highest species richness was in the clearings(0–10-year-old stands),and at this forest age class,the vast majority of the beetle species occurred in the spruce stands.In the developmental stages of the natural forest,a slightly higher beetle richness was found at the disintegration stage.The study results suggested that different tree species compositions and stand structures affect the communities of click beetles and substantially change their species composition and thus their response to external influences.Therefore,management of stands using diverse silvicultural systems is recommended for creating diverse ecological niches in forests.

关键词： Species richness Forest management Saproxylic beetles Nonsaproxylic beetles Dead wood Elateridae Canopy openness

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The diameter of beech snags is an important factor for saproxylic beetle richness: Implications for forest management and conservation

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Forest Ecosystems 2023年第5期10卷 635-645页

作者： václav Zumr Oto Nakládal Lukás Bílek JiríRemes Czech University of Life Sciences Prague Faculty of Forestry and Wood SciencesKamýcka 129Praha 6–Suchdol16500Czech Republic

Snags are an important component of beech forests that promote biodiversity.However,their occurrence is completely marginal in managed stands.Creating snags in these stands would greatly enhance biodiversity.We investigated whether snag dimensions were important for saproxylic beetle richness since they were easily transferable parameters to forest management and assessed the presence of other snag microhabitats affecting beetle communities.Data collection was performed using passive flight traps placed on thirty snags in a recent beech reserve.A total of 6706 adults belonging to 231 saproxylic species(53 Red List species,23%)were captured.The results showed that the most important snag parameters were the diameter(thickness)and canopy openness of the surrounding stands.The occurrence of Fomes fomentarius,the volume of snag and decay class 3 were marginally significant in terms of the preference of all saproxylic species.Alpha diversity was reduced by an advanced degree of decay and a surprisingly deep stem cavity.After dividing snag thickness into categories(70 cm DBH),we found that categories with snag diameter greater than 35 cm showed little differences in all saproxylic and Red List species richness and diversity indices and exhibited the highest similarity in beetle communities.Regarding recommendations to forest managers in terms of optimization and simplification of practical procedures,we suggest actively creating high stumps to act as snags greater than 35 cm in DBH diameter to promote biodiversity in beech management stands.

关键词： Deadwood Coleoptera Biodiversity Active management Endangered beetles

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ThMn12-Type Alloys for Permanent Magnets

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Engineering 2020年第2期6卷 141-147页

作者： G.C.Hadjipanayis A.M.Gabay A.M.Schonhobel A.Martin-cid J.M.Barandiaran D.Niarchos Department of Physics and Astronomy University of DelawareNewarkDE 19716USA BCMaterials Leioa 48940Spain NCSR Demokritos Agia Paraskevi 15341Greece

Iron-rich compounds with the tetragonal ThMn12-type structure have the potential to meet current demands for rare-earth-lean permanent magnets with high energy density and operating temperatures of 150-200℃.However,while it is normal for magnet technology to lag behind the development of underlying magnetic material,this gap has always been unusually large for ThMn12-type magnets.The gap has widened further in recent years,as excellent combinations of intrinsic magnetic properties have been obtained in compounds synthesized with a smaller amount of structure-stabilizing elements(e.g.,SmFe11v or Sm0.8Zr0.2Fe9.2Co2.3Ti0.5)or with no such elements(i.e.,SmFe9.6Co2.4 thin films).The search for promising compounds continues-with increasing help coming from theoretical calculations.Unfortunately,progress in the development of magnets beyond polymer-bonded interstitially modified powders remains marginal.The introduction of lanthanum(La)was found to stabilize low-meltingtemperature minority phases in Sm(Fe,Ti)12 alloys,thus allowing for liquid-phase sintering for the first time.The high reactivity of La,however,has apparently undermined the development of coercivity(Hc).A controlled crystallization of the initially suppressed ThMn12-type phase makes"bulk"magnetic hardening possible,not only in Sm-Fe-v alloys(in which it has been known since the 1990s),but also is in La-added(Ce,Sm)(Fe,Ti)12 alloys.The properties of the bulk-hardened alloys,however,remain unsatisfactory.Mechanochemically synthesized(Sm,Zr)(Fe,Si)12 and(Sm,Zr)(Fe,Co,Ti)12 powders may become suitable for sintering into powerful fully dense magnets,although not before a higher degree of anisotropy in both alloys and a higher Hc in the latter alloy have been developed.

关键词： Permanent magnets Rare earths permanent magnets ThMn12 structure

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 Tev with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.v. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja x. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.v. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos v. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.v. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol v.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey v.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta v. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced background.This paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 Tev proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS experiment.Two taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet pseudorapidity.Differences in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 Gev and 2 Tev and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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