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Research in Astronomy and Astrophysics 2023年第9期23卷 66-78页

作者： Z.x.Ling x.J.Sun c.Zhang S.L.Sun G.Jin S.N.Zhang x.F.Zhang J.B.chang F.S.chen Y.F.chen Z.W.cheng W.Fu Y.x.Han H.Li J.F.Li Y.Li Z.D.Li P.R.Liu Y.H.Lv x.H.Ma Y.J.Tang c.B.Wang R.J.xie Y.L.xue A.L.Yan Q.Zhang c.Y.Bao H.B.cai H.Q.cheng c.Z.cui Y.F.Dai D.W.Fan H.B.Hu J.W.Hu M.H.Huang Z.Q.Jia c.c.Jin D.Y.Li J.Q.Li H.Y.Liu M.J.Liu Y.Liu H.W.Pan Y.L.Qiu M.Sugizaki H.Sun W.x.Wang Y.L.Wang Q.Y.Wu x.P.xu Y.F.xu H.N.Yang x.Yang B.Zhang M.Zhang W.D.Zhang Z.Zhang D.H.Zhao x.Q.cong B.W.Jiang L.H.Li x.B.Qiu J.N.Sun D.T.Su J.Wang c.Wu Z.xu x.M.Yang S.K.Zhang Z.Zhang N.Zhang Y.F.zhu H.Y.Ban x.Z.Bi Z.M.cai W.chen x.chen Y.H.chen Y.cui x.L.Duan Z.G Feng Y.Gao J.W.He T.He J.J.Huang F.Li J.S.Li T.J.Li T.T.Li H.Q.Liu L.Liu R.Liu S.Liu N.Meng Q.Shi A.T.Sun Y.M.Wang Y.B.Wang H.c.Wu D.x xu Y.Q Yang Y.Yang x.S.Yu K.x.Zhang Y.L.Zhang Y.H.Zhang Y.T.Zhang H.Zhou x.c.zhu J.S.cheng L.Qin L.Wang Q.L.Wang M.Bai R.L.Gao Z.Ji Y.R.Liu F.L.Ma Y.J.Shi J.Su Y.Y.Tan J.Z.Tong H.T.xu c.B.xue G.F.xue W.Yuan National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China North Night Vision Technology co. LTDNanjing 211106China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Science and Technology on Low-Light-Level Night Vision Laboratory Xi'an 710065China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201204China Institute of Electrical Engineering Chinese Academy of ScienceBeijing 100190China National Space Science center Chinese Academy of ScienceBeijing 100190China

The Lobster Eye Imager for Astronomy(LEIA),a pathfinder of the Wide-field x-ray Telescope of the Einstein Probe mission,was successfully launched onboard the SATech-01 satellite of the chinese Academy of Sciences on2022 July *** this paper,we introduce the design and on-ground test results of the LEIA *** stateof-the-art Micro-Pore Optics(MPO),a wide field of view of 346 square degrees(18.6°×18.6°)of the x-ray imager is *** optical assembly composed of 36 MPO chips is used to focus incident x-ray photons,and four large-format complementary metal-oxide semiconductor(cMOS)sensors,each of size 6 cm×6 cm,are used as the focal plane *** instrument has an angular resolution of 4’-8’(in terms of FWHM)for the central focal spot of the point-spread function,and an effective area of 2-3 cm^(2) at 1 keV in essentially all the directions within the field of *** detection passband is 0.5-4 keV in soft x-rays and the sensitivity is2-3×10^(-11) erg s^(-1) cm^(-2)(about 1 millicrab)with a 1000 s *** total weight of LEIA is 56 kg and the power is 85 *** satellite,with a design lifetime of 2 yr,operates in a Sun-synchronous orbit of 500 km with an orbital period of 95 *** is paving the way for future missions by verifying in flight the technologies of both novel focusing imaging optics and cMOS sensors for x-ray observation,and by optimizing the working setups of the instrumental *** addition,LEIA is able to carry out scientific observations to find new transients and to monitor known sources in the soft x-ray band,albeit with limited useful observing time available.

关键词： instrumentation detectors-space vehicles instruments-telescopes-x-rays genera

Planning and control of cOP-Switch-Based Planar Biped Walking

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Journal of Bionic Engineering 2011年第1期8卷 33-48页

作者： x. Luo W. Li c. zhu School of Mechanical Engineering Southeast University Nanjing 210018 P. R. China Department of Systems Life Engineering Maebashi Institute of Technology Gunma Prefecture 371-0816 Japan

Efficient walking is one of the main goals of researches on biped robots. A feasible way is to translate the understanding from human walking into robot walking, for example, an artificial control approach on a human like walking structure. In this paper, a walking pattern based on center of Pressure （cOP） switched and modeled after human walking is introduced firstly. Then, a parameterization method for the proposed walking gait is presented. In view of the complication, a multi-space planning method which divides the whole planning task into three sub-spaces, including simplified model space, work space and joint space, is proposed. Furthermore, a finite-state-based control method is also developed to implement the proposed walking pattern. The state switches of this method are driven by sensor events. For convincing verification, a 2D simulation system with a 9-1ink planar biped robot is developed. The simulation results exhibit an efficient walking gait.

关键词： biped walking bio-inspired cOP switch control multi-space planning simulation

Netrin-1 signaling pathway mechanisms in neurodegenerative diseases

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Neural Regeneration Research 2025年第4期20卷 960-972页

作者： Kedong zhu Hualong Wang Keqiang Ye Guiqin chen Zhaohui Zhang Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurology The First Hospital of Hebei Medical UniversityBrain Aging and Cognitive Neuroscience Laboratory of Heibei ProvinceShijiazhuangHebei ProvinceChina Faculty of Life and Health Sciences Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal *** profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic *** amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of *** findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative *** a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.

关键词： Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways Netrin-1 neurodegenerative diseases neuron survival Parkinson’s disease UNc5c

Fatigue Behavior of HDPE composite Reinforced with Silane Modified TiO_2

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Journal of Materials Science & Technology 2011年第7期27卷 659-667页

作者： c.x. Dong S.J. zhu Mineo Mizuno Masami Hashimoto Department of Intelligent Mechanical Engineering Fukuoka Institute of Technology Fukuoka 811-0295 Japan Nanomaterials Laboratory Beihua University Jilin 132013 China Japan Fine ceramics center Nagoya 456-8587 Japan

The composite of high density polyethylene reinforced with silane-modified TiO2 particles （silane-TiO2/HDPE） is a potential bone substitute biomaterial. The structure, bioactivity, and mechanical properties of silane-TiO2/HDPE are analogous to those of natural bone, correspondingly. In order to investigate the effect of silane connection and saline solution on fatigue behaviors, flexural fatigue tests with this composite were carried out in both air and saline solution. Saline solution was found to have different effect on fatigue life. In saline solution, the fatigue life could be improved at stress levels lower than 30 MPa, while the fatigue life could be reduced at stress levels higher than 30 MPa. After analyzing the fracture morphologies, different failure mechanisms were proposed, and the important role of silane connection in the composite during the fatigue process was discussed. Silane connection cannot only support the loading stress but also hinder the failure process under loading effectively. For dry specimens, no interfacial failure between the filler and matrix was found. For wet specimens, it is inferred that the synergetic effect of saline solution and high concentrated stress at high stress level could easily destroy the silane connection, which accelerated the fracture process, whereas the synergetic effect of saline solution and silane connection at low stress level could promote the formation of more microcracks on sample surface, which hindered the final fracture.

关键词： Fatigue composites Polymers Fracture Interfaces

A mini review： Shape memory polymers for biomedica applications

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Frontiers of chemical Science and Engineering 2017年第2期11卷 143-153页

作者： Kaojin Wang Satu Strandman x. x. zhu Departement de chimie Universite de Montreal Montreal QC H3C 3J7 Canada

Shape memory polymers （SMPs） are smart materials that can change their shape in a pre-defined manner under a stimulus. The shape memory functionality has gained considerable interest for biomedical applications, which require materials that are biocompatible and sometimes biodegradable. There is a need for SMPs that are prepared from renewable sources to be used as substitutes for conventional SMPs. In this paper, advances in SMPs based on synthetic monomers and bio-compounds are discussed. Materials designed for biomedical applica- tions are highlighted.

关键词： shape memory polymer biodegradability biocompatibility biomedical application bile acids

STUDY ON PROPERTIES OF PULSE ELEcTRODEPOSITED RE-Ni-W-P-Sic cOMPOSITE cOATINGS

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Acta Metallurgica Sinica(English Letters) 2007年第2期20卷 111-116页

作者： Z.c. Guo x.Y. zhu R.D. xu Faculty of Materials and Metallurgical Engineering Kunming University of Science and Technology Kunming 650093 China

The effects of pulse frequency f and duty cycle r on the deposition rate, composition, morphology, and hardness of pulse electrodeposited RE （rare earth）-Ni-W-P-Sic composite coatings have been studied. The results indicate that pulse current can improve the deposition rate of RE-Ni-W-P-Sic composite coatings; W, P, and Sic contents in the coating decrease with the increase of pulse frequency and reach the lowest value at f = 33Hz, whereas the RE content in the composite coatings increases with the increase of pulse frequency. Sic content decreases with the increase of duty cycle, W content reaches the lowest value, and P content reaches the highest value at r = 0.4; pulse current and RE can lead to smaller size of the crystalline grains; however, the effects of different pulse frequency and duty cycle on the morphologies of RE-Ni-W-P-Sic composite coatings are not obvious. The hardness of RE-Ni-W-P-Sic composite coatings is the highest when the duty cycle is at 0.6 and 0.8 and pulse frequency is at 50Hz. At the same pulse frequency, the hardness of RE-Ni-W-P-Sic composite coatings at r= 0.8 is higher than that at r= 0.6.

关键词： frequency duty cycle electrodeposition RE-Ni-W-P-Sic composite coating

Regulation of lysosomal ion homeostasis by channels and transporters

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Science china(Life Sciences) 2016年第8期59卷 777-791页

作者： Jian xiong Michael x.zhu Department of Integrative Biology and Pharmacology Mc Govern Medical School Program of Cell and Regulatory Biology Graduate School of Biomedical Sciences The University of Texas Health Science Center at Houston

Lysosomes are the major organelles that carry out degradation functions. They integrate and digest materials compartmental- ized by endocytosis, phagocytosis or autophagy. In addition to more than 60 hydrolases residing in the lysosomes, there are also ion channels and transporters that mediate the flux or transport of H＋, ca2＋, Na＋, K＋, and c1- across the lysosomal mem- branes. Defects in ionic exchange can lead to abnormal lysosome morphology, defective vesicle trafficking, impaired autoph- agy, and diseases such as neurodegeneration and lysosomal storage disorders. The latter are characterized by incomplete lyso- somal digestion and accumulation of toxic materials inside enlarged intracellular vacuoles. In addition to degradation, recent studies have revealed the roles of lysosomes in metabolic pathways through kinases such as mechanistic target of rapamycin （mTOR） and transcriptional regulation through calcium signaling molecules such as transcription factor EB （TFEB） and cal- cineurin. Owing to the development of new approaches including genetically encoded fluorescence probes and whole endoly- sosomal patch clamp recording techniques, studies on lysosomal ion channels have made remarkable progress in recent years. In this review, we will focus on the current knowledge of lysosome-resident ion channels and transporters, discuss their roles in maintaining lysosomal function, and evaluate how their dysfunction can result in disease.

关键词： lysosomal storage disease(LSD) ion homeostasis calcium lysosome acidification

Assembly of Highly Ordered 2D Arrays of Silver-PNIPAM Hybrid Microgels

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chinese Journal of Polymer Science 2017年第10期35卷 1212-1221页

作者： Jun-ying Weng zhuo Tang 关英 x.x.zhu 张拥军 Key Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal chemical Biology The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300071 China Department of chemistry Universite de Montreal C. P. 6128 Succursale Centre-ville Montreal QC H3C 3J7 Canada

A strategy was developed for the synthesis of highly ordered 2D arrays of Ag-PNIPAM hybrid microgel. The highly ordered 2D arrays of PNIPAM microgel were prepared by dispersing PNIPAM microgel on a charge-reversible substrate. The microgel spheres self-assembled into a 3D colloidal crystal, and the first 111 plane was fixed in situ onto the substrate as a result of spontaneous charge reversal of the substrate, leaving a high-quality 2D array of PNIPAM microgel. Ag nanoparticles were then synthesized in situ inside the microgel spheres by introduction of Ag＋ ions into the microgel spheres and reduction with sodium borohydride. The resulting 2D arrays are highly ordered. The inter-particle distance in the array can be tuned. In addition, the method allows the synthesis of large size arrays and the use of nonplanar substrate.

关键词： bonding conductive triazine intermolecular Hydrogen PEDOT responsive glycol polyethylene compressive

constructing Donor–Acceptor‑Linked cOFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang Ma conghui Zhang Yongxin Yang Shuyuan Yu Haiye zhu Yongjiang Sun Hong Guo School of Materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China Yunnan Yuntianhua co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(cOFs)based on intramolecular charge transfer *** other reported cOFbased solid-state electrolyte,the developed concept with D–A-linked cOFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in cOF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5c)than substituted c-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery