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In situ Hydrothermal Ox.dation of Ternary FeCoNi Alloy electrode for Overall Water Splitting

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energy & environmental Materials 2024年第2期7卷 161-170页

作者： Yuwei Chen Lix.a Yang Chao Li Yuqiu wu x.ao Lν Hairen Wang Jun'e Qu Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science and EngineeringHubei UniversityWuhan 430062China Faculty of Material science and Chemistry China University of GeosciencesWuhan 430074China

ex.loring noble metal-free catalyst materials for high efficient electrochemical water splitting to produce hydrogen is strongly desired for renewable energy *** this article,a novel bifunctional catalytic electrode of insitu-grown type for alkaline water splitting based on FeCoNi alloy substrate has been successfully prepared via a facile one-step hydrothermal ox.dation route in an alkaline hydrogen perox.de *** shows that the matrix.alloy with the atom ratio 4∶3∶3 of Fe∶Co∶Ni can obtain the best catalytic performance when hydrothermally treated at 180℃for 18 h in the solution containing 1.8 M hydrogen perox.de and 3.6 M sodium *** as-prepared Fe_(0.4)Co_(0.3)Ni_(0.3)-1.8 electrode ex.ibits small overpotentials of only 184 and 175 mV at electrolysis current density of 10 mA cm^(-2)for alkaline OeR and HeR processes,*** overall water splitting at electrolysis current density of 10 mA cm^(-2)can be stably delivered at a low cell voltage of 1.62 *** characteristics including the large specific surface area,the high surface nickel content,the abundant catalyst species,the balanced distribution between bivalent and trivalent metal ions,and the strong binding of in-situ naturally growed catalytic layer to matrix.are responsible for the prominent catalytic performance of the Fe_(0.4)Co_(0.3)Ni_(0.3)-1.8 electrode,which can act as a possible replacement for ex.ensive noble metal-based materials.

关键词： alkaline water electrolysis bifunctional electrocatalyst FeCoNi alloy hydrothermal ox.dation in-situ growing

Animal models of hepatitis e infection: Advances and challenges

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 171-180页

作者： Ze x.ang x.ang-Lin He Chuan-wu Zhu Jia-Jia Yang Lan Huang Chun Jiang Jian wu Chinese Consortium for the Study of Hepatitis e(CCSHe) Zhejiang University School of Medicine Hangzhou 310030China Department of Infectious Diseases The Fifth People’s Hospital of SuzhouSuzhou 215007China Department of Infection Management The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China 不详

Hepatitis e virus(HeV)is one of the leading causes of acute viral hepatitis *** most of HeV infections are asymptomatic,some patients will develop the symptoms,especially pregnant women,the elderly,and patients with preex.sting liver diseases,who often ex.erience anorex.a,nausea,vom-iting,malaise,abdominal pain,and *** infection may become chronic in immunosuppressed *** addition,HeV infection can also cause several ex.rahepatic *** ex.sts in a wide range of hosts in nature and can be transmitted across ***,animals susceptible to HeV can be used as *** establishment of animal models is of great significance for studying HeV transmission,clinical symptoms,ex.rahepatic manifestations,and therapeutic strategies,which will help us understand the pathogenesis,prevention,and treatment of hepatitis *** review summarized the animal models of HeV,including pigs,monkeys,rabbits,mice,rats,and other *** each animal species,we provided a concise summary of the HeV genotypes that they can be infected with,the cross-species transmission pathways,as well as their role in studying ex.rahepatic manifestations,prevention,and treatment of HeV *** advantages and disadvantages of these animal models were also *** review offers new perspectives to enhance the current understanding of the research landscape surrounding HeV animal models.

关键词： Hepatitis e virus Animal models Pathogenesis Prevention Treatment

The Functional Redundancy of Neddylation e2s and e3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： Di wu Yi Sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation e2-e3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx. caused inflammation disorders with different *** these e2s or e3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Fox.3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Fox.3^(Cre);Rbx.^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation e2s or e3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx.&Sag double-null than Rbx.-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx. for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double e3-null than with double e2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 e3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Fox.3 inflammation markedly

Rational surface charge engineering of haloalkane dehalogenase for boosting the enzymatic performance in organic solvent solutions

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Chinese Journal of Chemical engineering 2024年第1期65卷 276-285页

作者： Yin wu Yan Sun Department of Biochemical engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Biocatalysis in organic solvents(OSs)has numerous important applications,but native enzymes in OSs often ex.ibit limited catalytic ***,we proposed a computation-aided surface charge engineering strategy to improve the catalytic performance of haloalkane dehalogenase DhaA in OSs based on the energetic analysis of substrate binding to the DhaA *** variants with enhanced OS resistance were obtained by replacing negative charged residues on the surface with positive charged residue(Arg).Particularly,a four-substitution variant e16R/e93R/e121R/e257R ex.ibited the best catalytic performance(five-fold improvement in OS resistance and seven-fold half-life increase in 40%(vol)dimethylsulfox.de).As a result,the overall catalytic performance of the variant could be at least 26 times higher than the wild-type *** spectroscopy and molecular dynamics simulation studies revealed that the residue substitution mainly enhanced OS resistance from four aspects:(a)improved the overall structural stability,(b)increased the hydrophobicity of the local microenvironment around the catalytic triad,(c)enriched the hydrophobic substrate around the enzyme molecule,and(d)lowered the contact frequency between OS molecules and the catalytic *** findings validate that computationaided surface charge engineering is an effective and ingenious rational strategy for tailoring enzyme performance in OSs.

关键词： Surface charge engineering Organic solvent resistance Molecular dynamics simulation Haloalkane dehalogenase

OsbZIP53 Negatively Regulates Immunity Response by Involving in Reactive Ox.gen Species and Salicylic Acid Metabolism in Rice

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Rice science 2024年第2期31卷 190-202,I0022-I0028页

作者： wu Lijuan HAN Cong WANG Huimei He Yuchang LIN Hai WANG Lei CHeN Chen e Zhiguo State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China Jiangsu Key Laboratory of Crop Genetics and Physiology/Key Laboratory of Plant Functional Genomics of the Ministry of education/Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Agricultural College of Yangzhou UniversityYangzhou 225009China

The basic region/leucine zipper(bZIP)transcription factors play important roles in plant development and responses to abiotic and biotic ***53 regulates resistance to Magnaporthe oryzae in rice by analyzing APIP5-RNAi transgenic *** further investigate the biological functions of OsbZIP53,we generated osbzip53 mutants using CRISPR/Cas9 editing and also constructed OsbZIP53 over-ex.ression transgenic *** analysis of phenotypical,physiological,and transcriptional data showed that knocking-out OsbZIP53 not only improved disease resistance by inducing a hypersensitivity response in plants,but also regulated the immune response through the salicylic acid ***,disrupting OsbZIP53 increased H2O2 accumulation by promoting reactive ox.gen species generation through up-regulation of several respiratory burst ox.dase homologs(Osrboh genes)and weakened H2O2 degradation by directly targeting *** addition,the growth of osbzip53 mutants was seriously impaired,while OsbZIP53 over-ex.ression lines displayed a similar phenotype to the wild type,suggesting that OsbZIP53 has a balancing effect on rice immune response and growth.

关键词： OsbZIP53 hypersensitive response reactive ox.gen species metabolism rice immunity salicylic acid transcription factor

Review of Networked Microgrid Protection:Architectures,Challenges,Solutions,and Future Trends

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CSee Journal of Power and energy Systems 2024年第2期10卷 448-467页

作者： Jorge de la Cruz Ying wu John e.Candelo-Becerra Juan C.Vasquez Josep M.Guerrero Center for Research on Microgrids(CROM) Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de Minas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Center for Research on Microgrids at UPC(UPC CROM) Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICReA Pg.Lluis Companys 2308010 BarcelonaSpain Center for Research on Microgrids at AAU(AAU CROM) AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

Design and selection of advanced protection schemes have become essential for reliable and secure operation of networked *** protection schemes that allow correct operation of microgrids have been proposed for individual systems in different topologies and ***,protection schemes for networked microgrids are still in devel-opment,and further research is required to design and operate advanced protection in interconnected *** of these microgrids in different nodes with various intercon-nection technologies increases fault occurrence and complicates protection *** paper aims to point out challenges in developing protection for networked microgrids,potential solutions,and research areas that need to be addressed for their ***,this article presents a systematic analysis of different microgrid clusters proposed since 2016,including several architectures of networked microgrids,operation modes,components,and utilization of renewable sources,which have not been widely ex.lored in previous review ***,the paper presents a discussion on protection systems currently available for microgrid clusters,current challenges,and solutions that have been proposed for these ***,it discusses the trend of protection schemes in networked microgrids and presents some conclusions related to ***—Adaptive eprotection,microgrid cluster,microgrid,multiple microgrid,networked microgrid,real-time simulation,smart grid.

关键词： Adaptive eprotection microgrid cluster microgrid multiple microgrid networked microgrid real-time simulation smart grid

Ultrafast optical modulation of the fluorescence from a single-photon emitter in silicon carbide

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Photonics Research 2024年第5期12卷 941-946页

作者： MeNGTING He YUJING CAO JUNJIe LIN ZHIPING JU BOTAO wu e wu State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China Photon Technology(Zhejiang)Co. Ltd.Jiaxing 314100China National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200000China Department of Physics and Shanghai Key Laboratory for Magnetic Resonance East China Normal UniversityShanghai 200241China Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal UniversityChongqing 401120China Collaborative Innovation Center of ex.reme Optics Shanxi UniversityTaiyuan 030006China

The quest for the room-temperature optical transistor based on nonlinearities in single atoms or molecules is attracting a lot of *** this work,a single-photon emitter in cubic silicon carbide is verified that can operate as an optical switch at room temperature under pulsed green laser illumination with a near-infrared pulsed laser as the control *** demonstrated an ultrafast and reversible optical modulation with a high photoluminescence intensity suppression ratio up to 97.9%and a response time as short as 287.9±5.7 *** current development provides insights for high-precision and ultrafast optical switches,with possibilities for integration with emerging electronic installations to realize more intelligent photoelectric integrated devices.

关键词： emitter carbide photon

Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotox.city through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2e1

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Food Science and Human Wellness 2024年第2期13卷 932-945页

作者： Si Zou Yetao Gong x.ujie Li Yanbin wu Jinzhong wu Jianguo wu Ka-Hing Wong College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Research Institute for Future Food The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHong Kong 999077China

Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with ox.dative *** SeNPs with lower tox.city and higher biocompatibility could bring better therapeutic activity and clinical application ***,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex.funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced ox.dative injure in HepG2 cells and C57BL/6J mouse *** elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also *** results showed that PTR-SeNPs could significantly ameliorate APAP-induced ox.dative injury as evidenced by a range of biochemical analysis,histopathological ex.mination and immunoblotting ***-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 ***,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2e1 inhibition,restoring the mitochondrial ***,the protective effect of PTR-SeNPs against APAP induced hepatotox.city was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective *** a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.

关键词： PTR-SeNPs(polysaccharide-proteincomplex.functionalized selenium nanoparticles) Acetaminophen-induced hepatotox.city Nuclear factor erythroid 2-related factor 2 Cytochrome P450 enzyme 2e1 Mitochondria

Generation of macroscopic entanglement in ensemble systems based on silicon vacancy centers

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Chinese Physics B 2024年第9期33卷 308-315页

作者： Jian-Zhuang wu Ying x. Bo-Ya Li Lian-e Lu Yong-Hong Ma School of Science Inner Mongolia University of Science and TechnologyBaotou 014010China

entanglement in macroscopic systems,as a fundamental quantum resource,has been utilized to propel the advancement of quantum technology and probe the boundary between the quantum and classical *** study focuses on a unique hybrid quantum system comprising of an ensemble of silicon vacancy(SiV)centers coupled to phononic waveguides in diamond via strain *** employing two sets of time-dependent,non-overlapping driving fields,we investigate the generation process and dynamic properties of macroscopic quantum entanglement,providing fresh insights into the behavior of such hybrid quantum ***,it paves the way for new possibilities in utilizing quantum entanglement as an information carrier in quantum information processing and quantum communication.

关键词： quantum entanglement silicon vacancy centers diamond waveguide