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sTCF conceptual design report (Volume 1): Phy.ics & detector

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Frontiers of phy.ics 2024年第1期19卷 1-154页

作者： M.Achasov x.C.Ai L.P.An R.Aliberti Q.An x.Z.bai y.bai O.bakina A.barny.kov V.blinov V.bobrovnikov D.bodrov A.bogomy.gkov A.bondar I.boy.o Z.h.b. F.M.Cai h.Cai J.J.Cao Q.h.Cao x.Cao Z.Cao Q.Chang k.T.Chao D.y.Chen h.Chen h.x.Chen J.F.Chen k.Chen L.L.Chen P.Chen s.L.Chen s.M.Chen s.Chen s.P.Chen W.Chen x.Chen x.F.Chen x.R.Chen y.Chen y.Q.Chen h.y.Cheng J.Cheng s.Cheng T.G.Cheng J.P.Dai L.y.Dai x.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.y.Dong W.h.Dong V.Druzhinin D.s.Du y.J.Du Z.G.Du L.M.Duan D.Epifanov y.L.Fan s.s.Fang Z.J.Fang G.Fedotovich C.Q.Feng x.Feng y.T.Feng J.L.Fu J.Gao y.N.Gao P.s.Ge C.Q.Geng L.s.Geng A.Gilman L.gong T.gong b.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.k.Guo J.C.Guo J.Guo y.P.Guo Z.h.Guo A.Guskov k.L.han L.han M.han x.Q.hao J.b.he s.Q.he x.G.he y.L.he Z.b.he Z.x.heng b.L.hou T.J.hou y.R.hou C.y.hu h.M.hu k.hu R.J.hu W.h.hu x.h.hu y.C.hu J.hua G.s.huang J.s.huang M.huang Q.y.huang W.Q.huang x.T.huang x.J.huang y.b.huang y.s.huang N.hüsken V.Ivanov Q.P.Ji J.J.Jia s.Jia Z.k.Jia h.b.jiang J.jiang s.Z.jiang J.b.Jiao Z.Jiao h.J.Jing x.L.kang x.s.k.ng b.C.ke M.kenzie A.khoukaz I.koop E.kravchenko A.kuzmin y.Lei E.Levichev C.h.Li C.Li D.y.Li F.Li G.Li G.Li h.b.Li h.Li h.N.Li h.J.Li h.L.Li J.M.Li J.Li L.Li L.Li L.y.Li N.Li P.R.Li R.h.Li s.Li T.Li W.J.Li x.Li x.h.Li x.Q.Li x.h.Li y.Li y.y.Li Z.J.Li h.Liang J.h.Liang y.T.Liang G.R.Liao L.Z.Liao y.Liao C.x.Lin D.x.Lin x.s.Lin b.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu h.b.Liu J.Liu J.J.Liu J.b.Liu k.Liu k.y.Liu k.Liu L.Liu Q.Liu s.b.Liu T.Liu x.Liu y.W.Liu y.Liu y.L.Liu Z.Q.Liu Z.y.Liu Z.W.Liu I.Logashenko y.Long C.G.Lu J.x.Lu N.Lu Q.F.Lü y.Lu y.Lu Z.Lu P.Lukin F.J.Luo T.Luo x.F.Luo y.h.Luo h.J.Ly. x.R.Ly. J.P.Ma P.Ma y.Ma y.M.Ma F.Maas s.Malde D.Matvienko Z.x.Meng R.Mitchell A.Nefediev y.Nefedov s.L.Olsen Q.Ouy.ng P.Pakhlov G.Pakhlova x.Pan y.Pan E.Passemar y.P.Pei h.P.Peng L.Peng x.y.Peng x.J.Peng k.Peters s.Pivovarov E.Py.ta b.b.Qi y.Q.Qi W.b.Qian y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin x.s.Qin T.L.Qiu J.Rademacker C.F.Redmer h.y.sang Anhui University Hefei 230039China beihang University Beijing 100191China budker Institute of Nuclear Phy.ics Novosibirsk 630090Russia CAs.k.y.Laboratory.of Theoretical Phy.ics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central south University Changsha 410083China China University.of Geosciences Wuhan 430074China China University.of Mining and Technology Xuzhou 221116China École Poly.echnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University.Frankfurt D-60325 Frankfurt am MainGermany Guangx. Normal University Guilin 541004China Guangx. Uninversity Nanning 530004China hangzhou Institute for Advanced study UCASHangzhou 310024China h.b.i Normal University Shijiazhuang 050024China h.b.i University Baoding 071002China hefei University.of Technology Hefei 230601China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China high Energy.Phy.ics Center Chung-Ang UniversitySeoul 06974Korea higher school of Economy.11 Pokrovsky.bulvar Moscow 109028Russia huangshan University Huangshan 245000China h.b.i University.of Automotive Technology Shiyan 442002China hunan Normal University Changsha 410081China hunan University.of science and Technology Xiangtan 411201China hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced science Facilities Shenzhen 518107China Institute of high Energy.Phy.ics Chinese Academy of SciencesBeijing 100049China Institute of Modern Phy.ics Chinese Academy of SciencesLanzhou 730000China Institute of Phy.ics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Phy.ics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility.sTCF)is an electron–positron collider proposed by.the Chinese particle phy.ics *** is designed to operate in a center-of-mass energy.range from 2 to 7 GeV with a peak luminosity.of 0.5×10^(35) cm^(–2)·s^(–1) or *** sTCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory.the bEPCII,providing a unique platform for ex.loring the asy.metry.of matter-antimatter(charge-parity.violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for ex.tic hadrons and phy.ics bey.nd the standard *** sTCF project in China is under development with an ex.ensive R&D *** document presents the phy.ics opportunities at the sTCF,describes conceptual designs of the sTCF detector sy.tem,and discusses future plans for detector R&D and phy.ics case studies.

关键词： electron–positron collider tau-charm region high luminosity sTCF detector conceptual design

Optical coherence tomography.angiography.metrics in different stages of diabetic macular edema

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Ey. and Vision 2024年第3期10卷 13-20页

作者： Ruy. han Ruowen gong Wei Liu Gezhi x. Ey. Institute and Department of Ophthalmology Eye and ENT Hospital of Fudan University83 Fenyang RoadShanghai200031People’s Republic of China key.Laboratory.of Visual Impairment and Restoration Fudan UniversityShanghaiPeople’s Republic of China key.Laboratory.of My.pia(Fudan University. Chinese Academy of Medical SciencesNational Health CommissionShanghaiPeople’s Republic of China

background To investigate the optical coherence tomography.angiography.OCTA)characteristics of diabetic macular edema(DME)at different *** This study.was a cross-sectional *** diagnosed with DME were *** was classified into early.advanced,and severe *** vessel density.VD)in the superficial vascular plex.s(sVP),deep vascular plex.s(DVP)and foveal avascular zone(FAZ)parameters,including FAZ area,FAZ perimeter,acircularity.index.and foveal VD in a 300-μm-wide region around the FAZ(FD-300),were calculated by.the AngioVue software.A multivariate generalized estimating equation was used to evaluate the associations between visual acuity.and OCTA *** Ninety.two ey.s from 74 patients with DME were included in this *** to early.P=0.006)and advanced DME(P=0.003),the acircularity.index.was higher in severe *** whole and parafoveal VD in the DVP decreased in ey.s with severe DME compared to early.DME(P=0.018,P=0.005,respectively.and advanced DME(P=0.035,P=0.012,respectively..In the multivariate generalized estimating equation,DME severity.FAZ area and foveal thickness were positively.associated with worse visual acuity.P=0.001,P=0.007 and P=0.001,respectively..Conclusion Compared to early.and advanced DME,severe DME showed increased irregularity.in the FAZ and more ex.ensive vessel damage in the *** severity.level of DME,larger FAZ area,and increased foveal thickness could be risk factors for poor visual *** registration The protocol was published in the Chinese Clinical Trial Registry.ChiCTR2000033082).

关键词： Optical coherence tomography.angiography Diabetic macular edema Vessel density Acircularity.index

MDGA2 Constrains Glutamatergic Inputs selectively.onto CA1 Py.amidal Neurons to Optimize Neural Circuits for Plasticity.Memory.and social behavior

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Neuroscience bulletin 2024年第7期40卷 887-904页

作者： x.ehui Wang Donghui Lin Jie jiang y.hua Liu x.ny.n Dong Jianchen Fan Lifen gong Weida shen Linghui Zeng Tonghui x. kewen jiang steven A.Connor y.cheng x.e school of Life sciences Nanchang UniversityNanchang330031China Department of Neurology Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of biology York University4700 Keele StreetTorontoON M3J 1P3Canada key.Laboratory.of Novel Targets and Drug study.for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhou 310015China

sy.apse organizers are essential for the development,transmission,and plasticity.of *** as rare sy.apse suppressors,the MAM domain containing gly.osy.phosphatidy.inositol anchor(MDGA)proteins contributes to sy.apse organization by.inh.b.ting the formation of the sy.aptogenic neuroligin-neurex.n complex.A previous analy.is of MDGA2 mice lacking a single copy.of Mdga2 revealed upregulated glutamatergic sy.apses and behaviors consistent with ***,MDGA2 is ex.ressed in diverse cell ty.es and is localized to both ex.itatory.and inh.b.tory.*** the network versus cell-specific effects of MDGA2 loss-of-function requires a cell-ty.e and brain region-selective *** address this,we generated mice harboring a conditional knockout of Mdga2 restricted to CA1 py.amidal *** we report that MDGA2 suppresses the density.and function of ex.itatory.sy.apses selectively.on py.amidal neurons in the mature *** deletion of Mdga2 in CA1 py.amidal neurons of adult mice upregulated miniature and spontaneous ex.itatory.postsy.aptic potentials,vesicular glutamate transporter 1 intensity.and neuronal *** effects were limited to glutamatergic sy.apses as no changes were detected in miniature and spontaneous inh.b.tory.postsy.aptic potential properties or vesicular GAbA transporter ***,evoked basal sy.aptic transmission and AMPAR receptor currents were enhanced at glutamatergic *** a behavioral level,memory.appeared to be compromised in Mdga2 ckO mice as both novel object recognition and contex.ual fear conditioning performance were impaired,consistent with deficits in long-term potentiation in the CA3-CA1 *** affiliation,a behavioral analog of social deficits in autism,was similarly.*** results demonstrate that MDGA2 confines the properties of ex.itatory.sy.apses to CA1 neurons in mature hippocampal circuits,thereby.optimizing this network for plasticity.c

关键词： MDGA2 CA1 py.amidal neurons Glutamatergic inputs sy.aptic plasticity Memory social behaviors Autism sy.apse organizers

Frequent recombination in Cy.oglossus abbreviatus(Pleuronectiformes:Cy.oglossidae)ribosomal 18s rDNA

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Acta Oceanologica sinica 2024年第8期43卷 98-103页

作者： Li gong Tingqi jiang bilin hu kaix.n Wang Nannan Zhang Zengliang Miao National Engineering Laboratory.of Marine Germplasm Resources Ex.loration and Utilization Zhejiang Ocean UniversityZhoushan 316022China Marine science and Technology.College Zhejiang Ocean UniversityZhoushan 316022China

The conventional theory.of concerted evolution has been used to ex.lain the lack of sequence variation in ribosomal RNA(rRNA)genes across diverse eukary.tic ***,recent investigations into rRNA genes in flatfish genome have resulted in controversial *** study.focuses on 18s rRNA genes of the widely.distributed tongue sole,Cy.oglossus abbreviatus(Pleuronectiformes:Cy.oglossidae),aiming to ex.lore sequence *** distinct 18s rDNA sequence ty.es(Ty.e A,b,R1,R2,and R3)were identified,suggesting a departure from concerted evolution.A combination of general criteria and variations in highly.conserved regions were employ.d to detect *** results pinpointed Ty.e A sequences as potential pseudogenes due to significant sequence variations and deviations in secondary.structure within highly.conserved *** ty.es(Ty.e R1,R2,and R3)were identified as recombinants between Ty.e A and b sequences,with simple crossing over and gene conversion as the most likely.recombination *** findings not only.contribute to rRNA pseudogene identification but also shed light on the evolutionary.dy.amics of rRNA genes in teleost genomes.

关键词： ribosomal RNA tongue sole non-concerted evolution pseudogene crossing over gene conversion

Amplitude analy.is of the decay. D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Phy.ics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis x.C.Ai R.Aliberti A.Amoroso Q.An y.bai O.bakina I.balossino y.ban h.-R.bao V.batozskay. k.begzsuren N.berger M.berlowski M.bertani D.bettoni F.bianchi E.bianco A.bortone I.boy.o R.A.briere A.brueggemann h.Cai x.Cai A.Calcaterra G.F.Cao N.Cao s.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.h.Chen Chao Chen G.Chen h.s.Chen M.L.Chen s.J.Chen s.L.Chen s.M.Chen T.Chen x.R.Chen x.T.Chen y.b.Chen y.Q.Chen Z.J.Chen Z.y.Chen s.k.Choi x.Chu G.Cibinetto F.Cossio J.J.Cui h.L.Dai J.P.Dai A.Dbey.si R.E.de boer D.Dedovich C.Q.Deng Z.y.Deng A.Denig I.Deny.enko M.Destefanis F.De Mori b.Fang s.s.Fang W.x.Fang y.Fang y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.h.Feng y.T.Feng k.Fischer M.Fritsch C.D.Fu J.L.Fu y.W.Fu h.Gao y.N.Gao y.ng Gao s.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck b.Ding x.x.Ding y.Ding y.Ding J.Dong L.y.Dong M.y.Dong x.Dong M.C.Du s.x.Du Z.h.Duan P.Egorov y.h.Fan J.Fang JA.Gilman k.Goetzen L.gong W.x.gong W.Gradl s.Gramigna M.Greco M.h.Gu y.T.Gu C.y.Guan Z.L.Guan A.Q.Guo L.b.Guo M.J.Guo R.P.Guo y.P.Guo A.Guskov J.Gutierrez k.L.han T.T.han x.Q.hao F.A.harris.k.k.he k.L.he F.h.heinsius C.h.heinz y.k.heng C.herold T.holtmann P.C.hong G.y.hou x.T.hou y.R.hou Z.L.hou b.y.hu h.M.hu J.F.hu T.hu y.hu G.s.huang k.x.huang L.Q.huang x.T.huang y.P.huang T.hussain F.h\"olzken N.h\"usken N.in der Wiesche M.Irshad J.Jackson s.Janchiv J.h.Jeong Q.Ji Q.P.Ji W.Ji x.b.Ji x.L.Ji y.y.Ji x.Q.Jia Z.k.Jia D.jiang h.b.jiang P.C.jiang s.s.jiang T.J.jiang x.s.jiang y.jiang J.b.Jiao J.k.Jiao Z.Jiao s.Jin y.Jin M.Q.Jing x.M.Jing T.Johansson s.k.bana N.kalantar-Nay.stanaki x.L.kang x.s.k.ng M.kavatsy.k b.C.ke V.khachatry.n A.khoukaz R.kiuchi O.b.kolcu b.kopf M.kuessner x.kui A.kupsc W.k\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.h.Lei h.Leithoff M.Lellmann T.Lenz C.Li C.Li C.h.Li Cheng Li D.M.Li F.Li G.Li h.Li h.b.Li h.J.Li h.N.Li hui Li J.R.Li J.s.Li k.Li L.J.Li L.k.Li Lei Li M.h.Li P.R.Li Q.M.Li Q.x.Li R.Li s.x.Li T.Li W.D.Li W.G.Li x.Li x.h.Li x.L.Li x.y.Li y Institute of high Energy.Phy.ics Chinese Academy of SciencesBeijing 100049China beihang University Beijing 100191China bochum Ruhr-University D-44780 BochumGermany budker Institute of Nuclear Phy.ics sb RAs(bINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central south University Changsha 410083China China Center of Advanced science and Technology Beijing 100190China China University.of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMsATs University.Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GsI helmholtzcentre for heavy.Ion Research Gmbh D-64291 DarmstadtGermany Guangx. Normal University Guilin 541004China Guangx. University Nanning 530004China hangzhou Normal University Hangzhou 310036China h.b.i University Baoding 071002China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China henan University.of science and Technology Luoyang 471003China henan University.of Technology Zhengzhou 450001China huangshan College Huangshan 245000China hunan Normal University Changsha 410081China hunan University Changsha 410082China Indian Institute of Technology.Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Phy.ics Lanzhou 730000China Institute of Phy.ics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity.of 2.93 fb^(−1)taken at the center-of-mass energy.s=3.773 GeV with the bEsIII detector,a joint amplitude analy.is is performed on the decay. D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decay. D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(s)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(sy.t.))%and(68.9±1.5_(stat).±2.4_(sy.t.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(sy.t.))%and(0.951±0.025_(stat.)±0.021_(sy.t.))%,*** amplitude analy.is provides an important model for the binning strategy.in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CkM angleγ(ϕ_(3))via the b^(−)→Dk^(−)decay.

关键词： bEsIII D^(0)meson decay. amplitude analy.is CP-even fraction

Defect Engineering and Carbon supporting to Achieve Ni‑Doped CoP_(3) with high Cataly.ic Activities for Overall Water splitting

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Nano-Micro Letters 2024年第11期16卷 569-584页

作者： Daowei Zha Ruox.ng Wang shijun Tian Zhong‑Jie jiang Zejun x. Chu Qin x.aoning Tian Zhongqing jiang Department of Phy.ics Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China Department of Materials and Chemical Engineering Ningbo University of TechnologyNingbo 315211People’s Republic of China Guangzhou key.Laboratory.for surface Chemistry.of Energy.Materials Guangdong Engineering and Technology Research Center for Surface Chemistry of Energy MaterialsCollege of Environment and EnergySouth China University of TechnologyGuangzhou 510006People’s Republic of China

This work reports the use of defect engineering and carbon supporting to achieve metal-doped phosphides with high activities and stabilities for the hy.rogen evolution reaction(hER)and the ox.gen evolution reaction(OER)in alkaline ***,the nitrogen-doped carbon nanofiber-supported Ni-doped CoP_(3) with rich P defects(Pv·)on the carbon cloth(p-NiCoP/NCFs@CC)is sy.thesized through a plasma-assisted phosphorization *** p-NiCoP/NCFs@CC is an efficient and stable cataly.t for the hER and the *** only.needs overpotentials of 107 and 306 mV to drive 100 mA cm^(-2) for the hER and the OER,*** cataly.ic activities are higher than those of other cataly.ts reported *** high activities of the p-NiCoP/NCFs@CC mainly.arise from its peculiar structural *** density.functional theory.calculation indicates that the Pv·richness,the Ni doping,and the carbon supporting can optimize the adsorption of the h atoms at the cataly.t surface and promote the strong electronic couplings between the carbon nanofiber-supported p-NiCoP with the surface ox.de lay.r formed during the OER *** gives the p-NiCoP/NCFs@CC with the high activities for the hER and the *** used in alkaline water electroly.ers,the p-NiCoP/NCFs@CC shows the superior activity.and ex.ellent stability.for overall water splitting.

关键词： Plasma Electrocataly.is hy.rogen evolution reaction Ox.gen evolution reaction Water splitting

Icaritin inh.b.ts the progression of urothelial cancer by.suppressing PADI2-mediated neutrophil infiltration and neutrophil ex.racellular trap formation

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Acta Pharmaceutica sinica b 2024年第9期14卷 3916-3930页

作者： Zezhong Mou y.ling Chen Jinzhong hu y.n hu Lujia Zou x.nan Chen shenghua Liu Qiuping y.n Jian gong shuchen Li shanhua Mao Cheny.ng x. haowen jiang Department of Urology Huashan HospitalFudan UniversityShanghai 200040China Fudan Institute of Urology Fudan UniversityShanghai 200040China National Clinical Research Center for Aging and Medicine Fudan UniversityShanghai 200040China

Tumor relapse and metastasis are the major causes of mortality.associated with urothelial *** the tumor microenvironment,negative regulatory.molecules and various immune cell subty.es suppress antitumor *** inflammatory.microenvironment,associated with neutrophils and neutrophil ex.racellular traps(NETs),promotes tumor ***,no drugs are currently.available to specifically.inh.b.t neutrophils and *** this study.we first demonstrated that icaritin(ICT),a Chinese herbal remedy.that is a first-line treatment for advanced and incurable hepatocellular carcinoma,reduces NETs caused by.suicidal NETosis and prevents neutrophil infiltration in the tumor ***,ICT binds to and inh.b.ts the ex.ression of PADI2 in neutrophils,thereby.suppressing PADI2-mediated histone ***,ICT inh.b.ts ROs generation,suppresses the MAPk signaling pathway.and inh.b.ts NET-induced tumor ***,ICT inh.b.ts tumoral PADI2-mediated histone citrullination,which consequently.suppresses the transcription of neutrophil-recruiting genes such as GM-CsF and *** downregulation of IL-6 ex.ression,in turn,forms a regulatory.feedback loop through the JAk2/sTAT3/IL-6 *** a retrospective study.of clinical samples,we found a correlation between neutrophils,NETs,UCa prognosis,and immune *** ICT with immune checkpoint inh.b.tors may.have sy.ergistic *** summary.our study.demonstrated that ICT could be a novel inh.b.tor of NETs and a novel UCa treatment.

关键词： Icaritin Neutrophil Neutrophil ex.racellular trap PADI2 Urothelial cancer

Evidence for particle acceleration approaching PeV energies in the W51 complex

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science bulletin 2024年第18期69卷 2833-2841页

作者： LhAAsO Collaboration Zhen Cao F.Aharonian Ax.kegu y.x.bai y.W.bao D.bastieri x.J.bi y.J.bi W.bian A.V.bukevich Q.Cao W.y.Cao Zhe Cao J.Chang J.F.Chang A.M.Chen E.s.Chen h.x.Chen Liang Chen Lin Chen Long Chen M.J.Chen M.L.Chen Q.h.Chen s.Chen s.h.Chen s.Z.Chen T.L.Chen y.Chen N.Cheng y.D.Cheng M.y.Cui s.W.Cui x.h.Cui y.D.Cui b.Z.Dai h.L.Dai Z.G.Dai Danzengluobu x.Q.Dong k.k.Duan J.h.Fan y.Z.Fan J.Fang J.h.Fang k.Fang C.F.Feng h.Feng L.Feng s.h.Feng x.T.Feng y.Feng y.L.Feng s.Gabici b.Gao C.D.Gao Q.Gao W.Gao W.k.Gao M.M.Ge L.s.Geng G.Giacinti G.h.gong Q.b.Gou M.h.Gu F.L.Guo x.L.Guo y.Q.Guo y.y.Guo y.A.han M.hasan h.h.he h.N.he J.y.he y.he y.k.hor b.W.hou C.hou x.hou h.b.hu Q.hu s.C.hu D.h.huang T.Q.huang W.J.huang x.T.huang x.y.huang y.huang x.L.Ji h.y.Jia k.Jia k.jiang x.W.jiang Z.J.jiang M.Jin M.M.kang I.karpikov D.kuleshov k.kurinov b.b.Li C.M.Li Cheng Li Cong Li D.Li F.Li h.b.Li h.C.Li Jian Li Jie Li k.Li s.D.Li W.L.Li W.L.Li x.R.Li x.n Li y.Z.Li Zhe Li Zhuo Li E.W.Liang y.F.Liang s.J.Lin b.Liu C.Liu D.Liu D.b.Liu h.Liu h.D.Liu J.Liu J.L.Liu M.y.Liu R.y.Liu s.M.Liu W.Liu y.Liu y.N.Liu Q.Luo y.Luo h.k.Lv b.Q.Ma L.L.Ma x.h.Ma J.R.Mao Z.Min W.Mitthumsiri h.J.Mu y.C.Nan A.Neronov L.J.Ou P.Pattarakijwanich Z.y.Pei J.C.Qi M.y.Qi b.Q.Qiao J.J.Qin A.Raza D.Ruffolo A.sáiz M.saeed D.semikoz L.shao O.shchegolev x.D.sheng F.W.shu h.C.song y..V.stenkin V.stepanov y.su D.x.sun Q.N.sun x.N.sun Z.b.sun J.Takata P.h.T.Tam Q.W.Tang R.Tang Z.b.Tang W.W.Tian C.Wang C.b.Wang G.W.Wang h.G.Wang h.h.Wang J.C.Wang kai Wang kai Wang L.P.Wang L.y.Wang P.h.Wang R.Wang W.Wang x.G.Wang x.y.Wang y.Wang y.D.Wang y.J.Wang Z.h.Wang Z.x.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei y.J.Wei T.Wen C.y.Wu h.R.Wu Q.W.Wu s.Wu x.F.Wu y.s.Wu s.Q.x. J.x.a G.M.x.ang D.x.x.ao G.x.ao y.L.x.n y.x.ng D.R.x.ong Z.x.ong D.L.x. R.F.x. R.x.x. W.L.x. L.x.e D.h.y.n J.Z.y.n T.y.n C.W.y.ng C.y.y.ng F.y.ng F.F.y.ng L.L.y.ng M.J.y.ng R.Z.y.ng W.x.y.ng y.h.y.o Z.G.y.o L.Q.y.n N.y.n x.h.y.u Z.y.y.u y.h.y. Q.y.an h.y.e h.D.Zeng T.x.Zeng W.Zeng M.Zha b.b.Zhang F.Zhang h.Zhang 不详 key.Laboratory.of Particle Astrophy.ics&Ex.erimental Phy.ics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University.of Chinese Academy.of sciences Beijing 100049China TIANFU Cosmic Ray.Research Center ChengduChina Dublin Institute for Advanced studies 31 Fitzwilliam Place2 DublinIreland Max.Planck-Institut for Nuclear Phy.ics P.O.Box 103980Heidelberg 69029Germany school of Phy.ical science and Technology.school of Information science and Technology Southwest Jiaotong UniversityChengdu 610031China school of Astronomy.and space science Nanjing UniversityNanjing 210023China Center for Astrophy.ics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&school of Phy.ics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear Research of Russian Academy.of sciences Moscow 117312Russia h.b.i Normal University Shijiazhuang 050024China University.of science and Technology.of China Hefei 230026China state key.Laboratory.of Particle Detection and Electronics China key.Laboratory.of Dark Matter and space Astronomy.key.Laboratory.of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China key.Laboratory.for Research in Galax.es and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China school of Phy.ics and Astronomy Yunnan UniversityKunming 650091China key.Laboratory.of Cosmic Ray.(Tibet University. Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China school of Phy.ics and Astronomy.Zhuhai)&school of Phy.ics(Guangzhou)&sino-French Institute of Nuclear Engineering and Technology.Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary.science Shandong UniversityQingdao 266237China APC UniversitéParis Cité

Theγ-ray.emission from the W51 complex.is widely.acknowledged to be attributed to the interaction between the cosmic ray.(CRs)accelerated by.the shock of supernova remnant(sNR)W51C and the dense molecular clouds in the adjacent star-forming region,***,the max.mum acceleration capability.of W51C for CRs remains *** on observations conducted with the Large high Altitude Air shower Observatory.LhAAsO),we report a significant detection ofγray. emanating from the W51 complex.with energies from 2 to 200 *** LhAAsO measurements,for the first time,ex.end theγ-ray.emission from the W51 complex.bey.nd 100 TeV and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay.bump"featured data from Fermi-LAT,the broadbandγ-ray.spectrum of the W51 region can be well-characterized by.a simple pp-collision *** observed spectral bending feature suggests an ex.onential cutoff at~400 TeV or a power-law break at~200 TeV in the CR proton spectrum,most likely.providing the first evidence of sNRs serving as CR accelerators approaching the PeV ***,two y.ung star clusters within W51b could also be theoretically.viable to produce the most energeticγray. observed by.*** findings strongly.support the presence of ex.reme CR accelerators within the W51 complex.and provide new insights into the origin of Galactic CRs.

关键词： UhE c-ray Cosmic ray. sNR W51C star clusters

Two-photon live imaging of direct glia-to-neuron conversion in the mouse cortex

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Neural Regeneration Research 2024年第8期19卷 1781-1788页

作者： Zongqin x.ang shu he Rongjie Chen shanggong Liu Minhui Liu Liang x. Jiajun Zheng Zhouquan jiang Long Ma y.ng sun y.ngpeng Qin y. Chen Wen Li x.angy. Wang gong Chen Wenliang Lei Guangdong-hong kong-Macao Institute of CNs Regeneration(GhMICR) Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Neurosurgery The First Affiliated HospitalJinan UniversityGuangzhouGuangdong ProvinceChina Laboratory.for Neuroimmunology.in health and Diseases Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouGuangdong ProvinceChina VIb-kU Leuven Center for brain&Disease Research LeuvenFlemish RegionBelgium

Over the past decade,a growing number of studies have reported transcription factor-based in situ reprogramming that can directly.conve rt endogenous glial cells into functional neurons as an alternative approach for n euro regeneration in the adult mammalian central ne rvous *** r,many.questions remain regarding how a terminally.differentiated glial cell can transform into a delicate neuron that forms part of the intricate brain *** addition,concerns have recently.been raised around the absence of astrocy.e-to-neuron conversion in astrocy.ic lineage-tra cing *** this study.we employ.d repetitive two-photon imaging to continuously.capture the in situ astrocy.e-to-neuron conversion process following ecto pic ex.ression of the neural transcription factor NeuroD1 in both prolife rating reactive astrocy.es and lineage-tra ced astrocy.es in the mouse ***-lapse imaging over several wee ks revealed the ste p-by.step transition from a ty.ical astrocy.e with numero us short,tapered branches to a ty.ical neuro n with a few long neurites and dy.amic growth cones that actively.ex.lored the local *** addition,these lineage-converting cells were able to migrate ra dially.or to ngentially.to relocate to suitable ***,two-photon Ca2+imaging and patch-clamp recordings confirmed that the newly.generated neuro ns ex.0}ted sy.chronous calcium signals,repetitive action potentials,and spontaneous sy.aptic responses,suggesting that they.had made functional sy.aptic connections within local neural *** conclusion,we directly.visualized the step-by.step lineage conversion process from astrocy.es to functional neurons in vivo and unambiguously.demonstrated that adult mammalian brains are highly.plastic with respect to their potential for neuro regeneration and neural circuit reconstruction.

关键词： astrocy.e-to-neuron conversion Ca2+imaging direct lineage conversion glia astrocy.e in vivo reprogramming lineage-tracing mice NeuroD1 neuron two-photon imaging