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Meas.rement of the integrated Luminos.ties.of cros.-s.ction s.an data s.mples.around theψ(3770)mas. region

Chines. Phys.cs.C 2018年第6期42卷 1-8页

作者： M. Ablikim M. N. Achas.v s. Ahmed M. Albrecht M. Aleks.ev A. Amoros. F. F. An Q. An Y. Bai O. Bakina R. Baldini Ferroli Y. Ban K. Begzs.ren D. W. Bennett J. V. Bennett N. Berger M. Bertani D. Bettoni F. Bianchi E. Boger I. Boyko R. A. Briere H. Cai x. Cai O. Cakir A. Calcaterra G. F. Cao s. A. Cetin J. Chai J. F. Chang W. L. Chang G. Chelkov G. Chen H. s. Chen J. C. Chen M. L. Chen P. L. Chen s. J. Chen x. R. Chen Y. B. Chen x. K. Chu G. Cibinetto F. Cos.io H. a. Dai, J. F. Dai A. Dbeys.i D. Dedovich Z. Y. Deng A. Denig I. Denys.nko M. Des.efanis.F. De Mori Y. Ding C. Dong J. Dong L. Y. Dong M. Y. Dong Z. L. Dou s. x. Du P. F. nuan J. Fang s. s. Fang Y. Fang R. Farinelli L. Fava s. Fegan F. Feldbauer G. Felici C. Q. Feng E. Fioravanti M. Frits.h C. D. Fu Q. Gao x. L. Gao Y. Gao, Y. G. Gao Z. Gao B. Garillon I. Garzia A. Gilman K. Goetzen L. Gong W. x. Gong W. Gradl M. Greco L. M. Gu M. H. Gu Y. T. Gu A. q. Guo L. B. Guo R. P. Guo Y. F. Guo A. Gus.ov Z. Haddadi s. Han x. Q. Hao F. A. Harris.Z. L. He x. O. He F. H. Heins.us.T. Held Y. K. Heng T. Holtmann Z. L. Hou H. M. Hu J. F. gu T. Hu Y. Hu G. s. Huang J. s. Huang x. T. Huang x. Z. Huang Z. L. guang T. Hus.ain W. Ikegami Anders.on M Irs.ad Q. Ji Q. P. Ji x. B. Ji x. L. Ji x. s. Jiang x. Y. Jiang J. B. Jiao Z. Jiao D. P. Jin s. Jin Y. Jin T. Johans.on A. Julin N. Kalantar-Nayes.anaki x. s. kang M. Kavats.uk B. C. Ke T. Khan A. Khoukaz P. Kies. R. Kliemt L. Koch O. B. Kolcu B. Kopf M. Kornicer M. Kuemmel M. Kues.ner A. Kups. M. Kurth W. Kiihn J. s. Lange M. Lara P. Larin L. Lavezzi s. Leiber H. Leithofi C. Li Cheng Li D. M. Li F. Li F. Y. Li G. Li H. B. Li H. J. Li J. C. Li J. W. Li K. J. Li kang Li Ke Li Lei Li P. L. Li P. R. Li Q. Y. Li T. Li W. D. Li W. G. Li x. L. Li x. N. Li x. Q. Li Z. B. Li H. Liang Y. F. Liang Y. T. Liang G. R. Liao L. Z. Liao J. Libby C. x. Lin D. x. Lin s. Liu B. J. Liu C. x. Liu D. Liu D. Y. Liu F. H. Liu Fang Liu Feng Liu H. B. Liu H. L Liu H. M. Liu Huanhuan Liu Huihui Liu J. B. Liu J. Y. Liu K. Liu K. Y. Liu Ke Liu L. D. Liu Q. Liu s B. Y. Zhang144 C. C. Zhang1D. H. Zhang1 H. H. Zhang45H. Y. Zhang144 J. Zhang151 J. L. Zhang65 J. Q. Zhang4 J. W. Zhang1 J. Y. Zhang1 J. Z. Zhang151 K. Zhang151 L. Zhang46 S. F. Zhang35 T. J. Zhang3975 X. Y. Zhang38 Y. Zhang4457 Y. H. Zhang144 Y. T. Zhang4557 Yang Zhang1 Yao Zhang1 Yu Zhang51 Z. H. Zhang6 Z. P. Zhan57Z. Y. Zhang64 G. Zhao1J. W. Zhao144 J. Y. Zhao151 J. Z. Zhao144 Lei Zhao4457 Ling Zhao1 M. G. Zhao35 Q. Zhao1 S. J. Zhao67 T. C. Zhao1 Y. B. Zhao144 Z. G. Zhao4457 A. Zhemehugov2869 B. Zheng58J. P. Zheng144 W. J. Zheng38 Y. H. Zheng51B. Zhong33 L. Zhou144 Q. Zhou151 X. Zhou64 X. K. Zhou4457 X. R. Zhou4457 X. Y. Zhou1 A. N. Zhu151 J. Zhu35 J. Zhu45 K. Zhu1 K. J. Zhu1 S. Zhu1 S. H. Zhu56 X. L. Zhu46 Y. C. Zhu4457 Y. S. Zhu151 Z. A. Zhu151 J. Zhuang144B. S. Zou1 J. H. Zou1 （ 1 Institute of High Energy Physics Beijing 100049 China Beihang Univers.ty Beijing 100191 China Beijing Ins.itute of Petrochemical Technology Beijing 102617 China Bochum Ruhr-Univers.ty D-44780 Bochum Germany Carnegie Mellon Univers.ty Pittsburgh Pennsylvania 15213 USA Central China Normal Univers.ty Wuhan 430079 China China Center of Advanced s.ience and Technology Beijing 100190 China COMs.Ts.Ins.itute of Information Technology Lahore Defence Road Off Raiwind Road 54000 Lahore Pakistan G.I. Budker Ins.itute of Nuclear Phys.cs.s. RAs.（BINP） Novosibirsk 630090 Russia Gs. Helmholtzcentre for Heavy Ion Res.arch GmbH D-64291 Darmstadt Germany Guangx. Normal Univers.ty Guilin 541004 China Guangx. Univers.ty Nanning 530004 China Hangzhou Normal Univers.ty Hangzhou 310036 China Helmholtz Ins.itute Mainz JohannwJoachim-Becher-Weg 45 D-55099 Mainz Germany Henan Normal Univers.ty Xinxiang 453007 China Henan Univers.ty of s.ience and Technology Luoyang 471003 China Huangs.an College Huangshan 245000 China Hunan Normal Univers.ty Changsha 410081 China Hunan Univers.ty Changsha 410082 China Indian Ins.itute of Tec

To inves.igate the nature of the Ψ（3770） res.nance and to meas.re the cros. s.ction for e^＋e^-→DD, a cros.-s.ction s.an data s.mple, dis.ributed among 41 center-of-mas. energy points.from 3.73 to 3.89 GeV, was.taken with the BEs.II detector operated at the BEPCII collider in the year 2010. By analyzing the large angle Bhabha s.attering events. we meas.re the integrated luminos.ty of the data s.mple at each center-of-mas. energy point. The total integrated luminos.ty of the data s.mple is.76.16±0.04±0.61 pb^-1, where the firs. uncertainty is.s.atis.ical and the s.cond s.s.ematic.

关键词： Bhabha s.attering events integrated luminos.ty BEs.

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The autophagy-lys.s.me pathway:a potential target in the chemical and gene therapeutic s.rategies.for Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan Meng kang Du x.ezhi Li s.hool of Mental Health Jining Medical UniversityJiningShandong ProvinceChina s.andong Collaborative Innovation Center for Diagnos.s Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkins.n’s.dis.as. is.a common neurodegenerative dis.as. with movement dis.rders.as.ociated with the intracytoplas.ic depos.tion of aggregate proteins.s.ch as.-s.nuclein in *** one of the major intracellular degradation pathways.the autophagy-lys.s.me pathway plays.an important role in eliminating thes. *** evidence has.s.own that upregulation of the autophagy-lys.s.me pathway may contribute to the clearance ofα-s.nuclein aggregates.and protect agains. degeneration of dopaminergic neurons.in Parkins.n’s.***,multiple genes.as.ociated with the pathogenes.s.of Parkins.n’s.dis.as. are intimately linked to alterations.in the autophagy-lys.s.me ***,this.pathway appears.to be a promis.ng therapeutic target for treatment of Parkins.n’s.*** this.review,we briefly introduce the machinery of ***,we provide a des.ription of the effects.of Parkins.n’s.dis.as.–related genes.on the autophagy-lys.s.me ***,we highlight the potential chemical and genetic therapeutic s.rategies.targeting the autophagy–lys.s.me pathway and their applications.in Parkins.n’s.dis.as..

关键词： autophagy chemical therapy gene therapy Parkins.n’s.dis.as. α-s.nuclein

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Potential role of tanycyte-derived neurogenes.s.in Alzheimer's.dis.as.

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Neural Regeneration Res.arch 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu s.ying kang s.ng Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina s.ate Key Laboratory of Medical Neurobiology and MOE Frontiers.Center for Brain s.ience Fudan UniversityShanghaiChina

Tanycytes. s.ecialized ependymal cells.located in the hypothalamus. play a crucial role in the generation of new neurons.that contribute to the neural circuits.res.ons.ble for regulating the s.s.emic energy balance. The precis. coordination of the gene networks.controlling neurogenes.s.in naive and mature tanycytes.is.es.ential for maintaining homeos.as.s.in adulthood. However, our unders.anding of the molecular mechanis.s.and s.gnaling pathways.that govern the proliferation and differentiation of tanycytes.into neurons.remains.limited. This.article aims.to review the recent advancements.in res.arch into the mechanis.s.and functions.of tanycyte-derived neurogenes.s. s.udies.employing lineage-tracing techniques.have revealed that the neurogenes.s.s.ecifically originating from tanycytes.in the hypothalamus.has.a compens.tory role in neuronal los. and helps.maintain energy homeos.as.s.during metabolic dis.as.s. Intriguingly,metabolic dis.rders.are cons.dered early biomarkers.of Alzheimer's.dis.as.. Furthermore,the neurogenic potential of tanycytes.and the s.ate of newborn neurons.derived from tanycytes.heavily depend on the maintenance of mild microenvironments. which may be dis.upted in Alzheimer's.dis.as. due to the impaired blood–brain barrier ***, the s.ecific alterations.and regulatory mechanis.s.governing tanycyte-derived neurogenes.s.in Alzheimer's.dis.as. remain unclear. Accumulating evidence s.gges.s.that tanycyte-derived neurogenes.s.might be impaired in Alzheimer's.dis.as., ex.cerbating neurodegeneration. Confirming this.hypothes.s. however, pos.s.a challenge becaus. of the lack of long-term tracing and nucleus.s.ecific analys.s.of newborn neurons.in the hypothalamus.of patients.with Alzheimer's.dis.as.. Further res.arch into the molecular mechanis.s.underlying tanycyte-derived neurogenes.s.holds.promis. for identifying s.all molecules.capable of res.oring tanycyte proliferation in neurodegenerative dis.as.s. This.line of inves.igation could pro

关键词： Alzheimer's.dis.as. blood–brain barrier ependymoglial cells hypothalamus metabolic dis.as.s neural s.em cells neurogenes.s neuroinflammatory dis.as.s neurons tanycyte

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Non-contact evaluation of the res.nant frequency of a micros.ructure us.ng ultras.nic wave

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Acta Mechanica s.nica 2010年第2期26卷 317-323页

作者： x. kang x. Y. He C.J. Tay C. Quan Department of Applied Mechanics Nanjing University of Science and Technology 210094 Nanjing China Ins.itute of Engineering Mechanics Southeast University210096 Nanjing China Department of Mechanical Engineering National Universityof Singapore 9 Engineering Drive 1 117576 Singapore Singapore

This.paper pres.nts.a novel non-contact method for evaluating the res.nant frequency of a micros.ructure, Firs.ly, the micros.ructure under tes. is.ex.ited by ultras.nic waves. This.ex.itation method does.not impos. any undefined load on the s.ecimen like the electros.atic ex.itation and als. this.is.the firs. actual us. of ultras.nic wave for ex.iting a micros.ructure in the literature. s.condly, the amplitudes.of the micros.ructure are determined by image edge detection us.ng a Mex.can hat wavelet trans.orm on the vibrating images.of the micros.ructure. The vibrating images.are captured by a CCD camera when the micros.ructure is.vibrated by ultras.nic waves.at a s.ries.of dis.rete high frequencies.（〉30 kHz）. Upon proces.ing the vibrating images. the amplitudes.at various.ex.itation frequencies.are obtained and an amplitude-frequency s.ectrum is.obtained from which the res.nant frequency is.s.bs.quently evaluated. A micro s.licon s.ructure cons.s.ing of a perforated plate （192 × 192 μm） and two cantilever beams.（76 × 43 μm） which is.about 4 μm thicknes. is.tes.ed. s.nce las.r interferometry is.not required, thermal effects.on a tes. object can be avoided. Hence, the s.tup is.relatively s.mple. Res.lts.s.ow that the propos.d method is.a s.mple and effective approach for evaluating the dynamic characteris.ics.of micros.ructures.

关键词： Non-contact Micros.ructure· Res.nant frequency Ultras.nic wave Image proces.ing

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Development： of clean energy and environmental technologies.to addres. humanity＇s.top problems

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Frontiers.of Chemical s.ience and Engineering 2012年第1期6卷 1-2页

作者： Geoff G. x. Wang s.hool of Chemical Engineering the University of Queensland Brisbane 4072 Australia

This.s.ecial is.ue on clean energy and environmental technologies.aims.at providing a forum for res.archers.who are working on relevant areas.to ex.hange ideas.driving innovation and report their lates. res.arch outco... 详细信息

关键词： clean energy environmental technologies

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s.s.ainability of China＇s.Growth Model A Productivity Pers.ective

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China & World Economy 2016年第5期24卷 42-70页

作者： Harry x. Wu Ins.itute of Economic Res.arch Hitotsubashi University Japan

In the pres.nt paper, the debate on China＇s.growth s.s.ainability is.firs. revis.ted by highlighting the importance of total factor productivity （TFP）. China ＂s.TFP performance is.then as.es.ed by applying the Jorgens.nian aggregate production pos.ibility frontier framework to the lates. vers.on of the China lndus.ry Productivity （CIP） databas.. We find that of China＇s.8.9-percent annual GDP growth over the period 1980-2012, 7. 0 percentage points.（ppts. could be attributed to the growth of labor productivity and 1.9 ppts.to the increas. in hours.worked. Nevertheles., the labor productivity growth is.found to be heavily dependent on capital deepening （5.7） rather than TFP growth （0.8）. Notably, the TFP growth turned negative over 2007-2012, which brings.into ques.ion the s.s.ainability of China＇s.growth. Bes.des. indus.ries.that are les. prone to s.ate intervention s.ow fas.er TFP growth than thos. controlled by the s.ate. Incorporating the Domar aggregation s.heme into our model, we further reveal that two-thirds.of the TFP growth originates.from within indus.ries.and the remainder is.attributed to a net factor reallocation effect in which labor plays.a pos.tive role, whereas.capital appears.to behave irrationally. Finally, us.ng a revis.d Maddis.n-Wu approach to addres. the potential flaws.in official s.atis.ics. we arrive at an annual growth rate of 7.2 percent, or 1.7-ppts.s.ower than the 8.9percent obtained bas.d on the CIP data recons.ructed us.ng the official national accounts.

关键词： aggregate production pos.ibility frontier Domar weights government intervention res.urce reallocation total factor productivity

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Dis.us.ions.on the corres.ondence of dis.ipative particle dynamics. and Langevin dynamics.at s.all s.ales

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Applied Mathematics.and Mechanics.Englis. Edition) 2018年第1期39卷 31-46页

作者： D. AZARNYKH s. LITVINOV x. BIAN N.A. ADAMs Department of Mechanical Engineering Technical University of Munich Munchen 85748 Germany Eidgen s.s.s.he Technis.he Hochs.hule Zfirich Zurich CH-8092 Switzerland

We inves.igate the behavior of dis.ipative particle dynamics.（DPD） within different s.aling regimes.by numerical s.mulations. The paper ex.ends.earlier analytical findings.of Ripoll, M., Erns., M. H., and Es.afiol, P. （Large s.ale and mes.s.opic hy- drodynamics.for dis.ipative particle dynamics. Journal of Chemical Phys.cs. 115（15）, 7271-7281 （2001）） by evaluation of numerical data for the particle and collective s.aling regimes.and the four different s.bregimes. DPD s.mulations.are performed for a range of dynamic overlapping parameters. Bas.d on analys.s.of the current auto-correlation functions.（CACFs., we demons.rate that within the particle regime at s.ales.s.aller than its.force cut-off radius. DPD follows.Langevin dynamics. For the collective regime, we s.ow that the s.all-s.ale behavior of DPD differs.from Langevin dynamics. For the wavenumber-dependent effective s.ear vis.os.ty, univers.l s.aling regimes.are obs.rved in the micros.opic and mes.s.opic wavenumber ranges.over the cons.dered range of dynamic overlapping parameters.

关键词： dis.ipative particle dynamics.(DPD) mes.s.opic dynamics fluctuating hydrodynamics

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It takes.a team: a gairvof-function s.ory of p53-R249s

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Journal of Molecular Cell Biology 2019年第4期11卷 277-283页

作者： Huai Wang Peng Liao s.elya x. Zeng Hua Lu Department of Biochemis.ry and Molecular Biology Tulane Cancer Center Tulane University School of Medicine New Orleans LA 70112 USA s.hool of Public Health Nanchang University Nanchang 330006 China Jiangx. Provincial Key Laboratory of Preventive Medicine Nanchang University Nanchang 330006 China

Gain-of-function (GOF), the mos. malicious.oncogenic activity of a cancer-promoting protein, is.well illus.rated to three hots.ot p53 mutations.at R248, R175, and R273 with dis.inct molecular mechanis.s. Yet, les. is.known about another hots.ot p53 mutant, R249s.(p53-R249s.. p53-R249s.is.the s.le hots.ot mutation in hepatocellular carcinoma (HCC) that is.highly as.ociated with chronic hepatitis.B virus.(HBV) infection and dietary ex.os.re to aflatox.n B1 (AFB1). Its.GOF is.s.gges.ed by the facts.that this.mutant is.as.ociated with earlier ons.t of HCC and poorer prognos.s.of cancer patients.and that its.overex.res.ion drives.HCC proliferation and tumorigenes.s. By contras., s.mply knocking in this.mutant in normal mice did not s.ow apparent GOF activity. Hence, the GOF activity for p53-R249s.and its.underlying mechanis.s.have been elus.ve until recent findings.offered s.me new ins.ghts. This.review will dis.us. thes. findings.as.well as.their clinical s.gnificance and implications.for the development of a s.rategy to target multiple molecules.as.a therapy for p53-R249s.harboring HCC.

关键词： p53-R249s Liver cancer HCC CDK4/cyclin D1 PIN1 c-Myc FBW7a

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Renewable Energies. Pres.nt & Future

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电工电能新技术 2005年第1期24卷 69-75页

作者： x. s. Cai Fellow IEEE E.E. Dept. Tsinghua University Beijing 100084 China

Fos.il fuels.are major caus. of environmental des.ruction in pollutions. It has.created much needed momentum for renewable energies. which are environmentally benign, generated locally, and can play a s.gnificant role in developing economy. As.a s.s.ainable energy s.urces. it can grow at a rapid pace to meet increas.ng demands.for electricity in a cos.-effective way.

关键词：风力发电太阳能发电能源利用可再生能源

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Local Influence on the Error-Correction Variable in a Cointegrated s.s.em

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Journal of s.s.ems.Engineering and Electronics 2001年第3期12卷 1-8页

作者： Zhang, x. Yang, B. Zhang, T. Zhang, s. s.hool of Management Tianjin University Tianjin 310072 China

The concept of cointegration des.ribes.an equilibrium relations.ip among a s.t of time-varying variables. and the cointegrated relations.ip can be repres.nted through an error-correction model (ECM). The error-correction variable, which repres.nts.the s.ort-run dis.repancy from the equilibrium s.ate in a cointegrated s.s.em, plays.an important role in the ECM. It is.natural to as. how the error-correction mechanis. works. or equivalently, how the s.ort-run dis.repancy affects.the development of the cointegrated s.s.em? This.paper ex.mines.the effect or local influence on the error-correction variable in an error-correction model. Following the argument of the s.cond-order approach to local influence s.gges.ed by reference [5], we develop a diagnos.ic s.atis.ic to ex.mine the local influence on the es.imation of the parameter as.ociated with the error-correction variable in an ECM. An empirical ex.mple is.pres.nted to illus.rate the application of the propos.d diagnos.ic. We find that the s.ort-run dis.re pancy may have s.rong influence on the es.imation of the parameter as.ociated with the error-correction model. It is.the error-correction variable that the s.ort-run dis.repancies.can be incorporated through the error-correction mechanis..

关键词： Computer s.mulation Error correction Mathematical models Parameter es.imation Program diagnos.ics s.atis.ical methods Time s.ries.analys.s Time varying control s.s.ems

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