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CSPP1 stabiliz.s microtubules by capping both plus and minus ends

Journal of Molecular Cell Biology 2024年第2期16卷 36-46页

作者： z.ikai Wang Wenwen Wang Shuaiyu liu Fengrui Yang x. liu Shasha Hua Lĳuan z.u Aoqing x. Donald LHill Dongmei Wang Kai Jiang Jennifer Lippincott-Schwartz.x.ng liu x.ebiao Yao MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics Center for Advanced Interdisciplinary Science and Biomedicine of IHMUniversity of Science and Technology of China School of Life SciencesHefei 230027China Anhui Key Laboratory for Cellular Dynamics and Chemical Biology Hefei National Research Center for Interdisciplinary Sciences at the MicroscaleHefei 230027China Frontier Science Center for Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhan 430071China Comprehensive Cancer Center University of AlabamaBirminghamAL 35233USA Janelia Research Campus Howard Hughes Medical InstituteAshburnVA 20147USA

Although the dynamic instability of microtubules(MTs)is fundamental to many cellular functions,quiescent MTs with unattached free distal ends are commonly present and play important roles in various events to power cellular ***,how these free MT tips are stabiliz.d remains poorly ***,we report that centrosome and spindle pole protein 1(CSPP1)caps and stabiliz.s both plus and minus ends of static ***-time imaging of laser-ablated MTs in live cells showed deposition of CSPP1 at the newly generated MT ends,whose dynamic instability was concomitantly ***,MT ends in CSPP1-overex.ressing cells were hyper-stabiliz.d,while those in CSPP1-depleted cells were much more *** CSPP1-elicited stabiliz.tion of MTs was demonstrated to be achieved by suppressing intrinsic MT catastrophe and restricting ***,CSPP1-bound MTs were resistant to mitotic centromere-associated kinesin-mediated *** findings delineate a previously uncharacteriz.d CSPP1 activity that integrates MT end capping to orchestrate quiescent MTs.

关键词： CSPP1 microtubule plus end minus end capping

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Spin transport of half-metal Mn_(2)x.(3) with high Curie temperature:An ideal giant magnetoresistance device from electrical and thermal drives

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Frontiers of physics 2024年第4期19卷 125-135页

作者： Bin liu x.aolin z.ang Jingx.an x.ong x.uyang Pang Sheng liu z.x.n Yang Qiang Yu Honggen Li Sicong z.u Jian Wu Hubei Province Key Laboratory of Systems Science in Metallurgical Process The State Key Laboratory for Refractories and MetallurgyCollaborative Innovation Center for Advanced SteelsInternational Research Institute for Steel TechnologyWuhan University of Science and TechnologyWuhan 430081China Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education and School of Physical and Technology Wuhan UniversityWuhan 430072China College of Advanced Interdisciplinary Studies Nanhu Laser LaboratoryNational University of Defense TechnologyChangsha 410073China Department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore i-Lab&Key Laboratory of Nanodevices and Applications&Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and NanoBionicsChinese Academy of SciencesSuzhou 215123China Institute of Optical Science and Technology School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China

Currently,magnetic storage devices are encountering the problem of achieving lightweight and high integration in mobile computing devices during the information *** a result,there is a growing urgency for twodimensional half-metallic materials with a high Curie temperature(TC).This study presents a theoretical investigation of the fundamental electromagnetic properties of the monolayer hex.gonal lattice of Mn_(2)x.(3)(x.S,Se,Te).Additionally,the potential application of Mn_(2)x.(3) as magneto-resistive components is *** three of them fall into the category of ferromagnetic *** particular,the Monte Carlo simulations indicate that the TC of Mn2S3 reachs 381 K,noticeably greater than room *** findings present notable advantages for the application of Mn2S3 in spintronic ***,a prominent spin filtering effect is apparent when employing non-equilibrium Green’s function simulations to ex.mine the transport *** resulting current magnitude is approx.mately 2×10^(4) nA,while the peak gigantic magnetoresistance ex.ibits a substantial value of 8.36×10^(16)%.It is noteworthy that the device demonstrates a substantial spin Seebeck effect when the temperature differential between the electrodes is *** brief,Mn_(2)x.(3) ex.ibits outstanding features as a highTC half-metal,ex.ibiting ex.eptional capabilities in electrical and thermal drives spin ***,it holds great potential for usage in spintronics applications.

关键词： half-metals Mn_(2)x.(3) high Curie temperature electrical and thermal GMR

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Ischemia-reperfusion injury:molecular mechanisms and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 558-596页

作者： Meng z.ang Qian liu Hui Meng Hongx.a Duan x.n liu Jian Wu Fei Gao Shijun Wang Rubin Tan Jinx.ang Yuan The Collaborative Innovation Center Jining Medical UniversityJiningShandong 272067China Clinical Medical College Jining Medical UniversityJiningShandong 272067China Second Clinical Medical College Jining Medical UniversityJiningShandong 272067China Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital and Institutes of Biomedical SciencesFudan UniversityShanghaiChina Institute of z.ology Chinese Academy of SciencesBeijingChina Department of Physiology Basic medical schoolXuzhou Medical UniversityXuzhou 221004China

Ischemia-reperfusion(I/R)injury paradox.cally occurs during reperfusion following ischemia,ex.cerbating the initial tissue *** limited understanding of the intricate mechanisms underlying I/R injury hinders the development of effective therapeutic *** Wnt signaling pathway ex.ibits ex.ensive crosstalk with various other pathways,forming a network system of signaling pathways involved in I/R *** review article elucidates the underlying mechanisms involved in Wnt signaling,as well as the complex.interplay between Wnt and other pathways,including Notch,phosphatidylinositol 3-kinase/protein kinase B,transforming growth factor-β,nuclear factor kappa,bone morphogenetic protein,N-methyl-D-aspartic acid receptor-Ca2+-Activin A,Hippo-Yes-associated protein,toll-like receptor 4/toll-interleukine-1 receptor domain-containing adapter-inducing interferon-β,and hepatocyte growth factor/mesenchymal-epithelial transition *** particular,we delve into their respective contributions to key pathological processes,including apoptosis,the inflammatory response,ox.dative stress,ex.racellular matrix.remodeling,angiogenesis,cell hypertrophy,fibrosis,ferroptosis,neurogenesis,and blood-brain barrier damage during I/R *** comprehensive analysis of the mechanisms involved in Wnt signaling during I/R reveals that activation of the canonical Wnt pathway promotes organ recovery,while activation of the non-canonical Wnt pathways ex.cerbates ***,we ex.lore novel therapeutic approaches based on these mechanistic findings,incorporating evidence from animal ex.eriments,current standards,and clinical *** objective of this review is to provide deeper insights into the roles of Wnt and its crosstalk signaling pathways in I/R-mediated processes and organ dysfunction,to facilitate the development of innovative therapeutic agents for I/R injury.

关键词： therapeutic reperfusion damage

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Fission barriers with the Weiz.?cker-Skyrme mass model

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Chinese Physics C 2024年第9期48卷 164-169页

作者： Ning Wang Min liu Department of Physics Guangxi Normal UniversityGuilin 541004China Guangx. Key Laboratory of Nuclear Physics and Technology Guilin 541004China

Based on the Weiz.acker-Skyrme(WS4)mass model,the fission barriers of nuclei are systematically *** the shell corrections,macroscopic deformation energy,and a phenomenological residual correction,the fission barrier heights for nuclei with z.82 can be well described,with an rms deviation of 0.481 MeV with respect to 71 empirical barrier *** addition to the shell correction at the ground state,the shell correction at the saddle point and its relative value are also important for both deformed and spherical *** fission barriers for nuclei far from theβ-stability line and super-heavy nuclei are also predicted with the proposed approach.

关键词： fission barrier shell correction saddle point macroscopic-microscopic model

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The Role of Renewable Protocatechol Acid in Epox. Coating Modification: Significantly Improved Antibacterial and Adhesive Properties

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Chinese Journal of Polymer Science 2024年第1期42卷 63-72,I0008页

作者： Ming-x.an Chen Jin-Yue Dai Li-Yue z.ang Shuai-Peng Wang Jing-Kai liu Yong-Gang Wu x.n-Wu Ba x.ao-Qing liu School of Chemistry and Materials Science Hebei UniversityBaoding 071000China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Marine Materials and Related Technologies Chinese Academy of SciencesNingbo 315201China

It is of great significance to design epox. coatings with superior antibacterial properties and high adhesive properties, as well as ex.ellent processing, superior durability, and high transparency. However, it is still a challenge because of the common complex.design and synthesis. Herein, the bio-based monomer protocatechuic acid(PCA) was used as raw material, the catechol structure with high bonding and antibacterial properties was introduced into the flex.ble alkane segment of ethylene glycol diglycidyl ether(EGDE) through an efficient, and green method, and it was cured with isophorone diamine(IPDA) to prepare corresponding thermosets. The cured resins ex.ibited ex.ellent allaround qualities, particularly in bonding and antibacterial. When 30% PCA was added to pure epox. resin, the adhesion between substrate and coating increased from 4.40 MPa to 13.60 MPa and the antibacterial rate of coating against E. coli and S. aureus could approach 100%. All of this is due to the fact that the catechol structure present in PCA has the ability to interact with various substrates and alter the permeability of bacterial cell membranes. The architecture of this method offers a fresh approach to dealing with the issues of challenging raw material selection and complex.synthesis techniques.

关键词： Epox. coatings Thermosets Catechol structure Antibacterial High adhesion

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Ex.ernal-Cavity Tunable Laser Using MEMS Technology

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光学学报 2003年第S1期23卷 433-434页

作者： J. z. Hao x. M. z.ang C. Lu A. Q. liu Institute for Infocomm Research Unit 230 Innovation Center Block 2 18 Nanyang Drive Singapore 639798School of Electrical & Electronic Engineering Nanyang Technological University Nanyang Avenue Singapore 639798School of Electrical & Electronic Engineering Nanyang Technological University Nanyang AvenueSingapore 639798 Institute for Infocomm Research Unit 230 Innovation Center Block 2 18 Nanyang Drive Singapore 639798School of Electrical & Electronic Engineering Nanyang Technological University Nanyang Avenue Singapore 639798

This paper introduces a tunable ex.ernal-cavity diode laser using a MEMS vertical mirror fabricated on a silicon-on-insulator (SOI) wafer. This laser has the merits of simple alignment process, easy integration/packag... 详细信息

关键词： MEMS as in on be with Ex.ernal-Cavity Tunable Laser Using MEMS Technology for mode of dBm from

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Single crystal growth and characteriz.tion of 166-type magnetic kagome metals

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Chinese Physics B 2024年第9期33卷 145-150页

作者： Huangyu Wu Jinjin liu Yongkai Li Peng z.u liu Yang Fuhong Chen Deng Hu z.iwei Wang Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic Systems Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Zhuhai 519000China Material Science Center Yangtze Delta Region Academy of Beijing Institute of TechnologyJiaxing 314011China

Kagome magnets were predicted to be a good platform to investigate correlated topology band structure,Chern quantum phase,and geometrical frustration due to their unique lattice *** we reported single crystal growth of 166-type kagome magnetic materials,including HfMn_(6)Sn_(6),z.Mn_(6)Sn_(6),GdMn_(6)Sn_(6)and GdV_(6)Sn_(6),by using the flux.method with Sn as the *** them,HfMn_(6)Sn_(6)and z.Mn_(6)Sn_(6)single crystals were grown for the first time.x.ray diffraction measurements reveal that all four samples crystalliz. in HfFe6Ge6-type hex.gonal structure with space group P6/*** samples show metallic behavior from temperature dependence of resistivity measurements,and the dominant carrier is hole,ex.ept for GdV6Sn6 which is electron *** samples have magnetic order with different transition temperatures,HfMn_(6)Sn_(6),z.Mn_(6)Sn_(6)and GdV_(6)Sn_(6)are antiferromagnetic with TN of 541 K,466 K and 4 K respectively,while GdMn_(6)Sn_(6)is ferrimagnetic with the critical temperature of about 470 *** study will enrich the research platform of magnetic kagome materials and help ex.lore the novel quantum phenomena in these interesting *** dataset of specific crystal structure parameters for HfMn_(6)Sn_(6)are available in Science Data Bank,with the link.

关键词： kagome metal single crystal growth crystal structure physical property

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Atomically dispersed calcium as solid strong base catalyst with high activity and stability

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Green Energy & Environment 2024年第10期9卷 1619-1626页

作者： x.ang-Bin Shao z.i-Wei x.ng Si-Yu liu Ke-x.n Miao Shi-Chao Qi Song-Song Peng x.ao-Qin liu Lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM)College of Chemical EngineeringNanjing Tech University30 South Puzhu Road

Solid strong base catalysts are highly attractive for diverse reactions owing to their advantages of neglectable corrosion,facile separation,and environmental ***,their widespread applications are impeded by basic components aggregation and low *** this work,we fabricate single calcium atoms on graphene （denoted as Ca1/G） by use of a redox.strategy for the first time,producing solid strong base catalyst with high activity and *** precursor Ca（NO3）2is first reduced to CaO at 400℃ by the support graphene,forming CaO/G with conventional basic sites,and the subsequent reduction at 850℃ results in the generation of Ca1/G with atomically dispersed *** characteriz.tions reveal that Ca single atoms are anchored on graphene in tetra-coordination （Ca–C2–N2） where N is in situ doped from Ca（NO3）*** atomically dispersed Ca,along with their anchoring on the support,endow Ca1/G with high activity and stability toward the transesterification reaction of ethylene carbonate with *** turnover frequency value reaches 128.0 h-1on Ca1/G,which is much higher than the traditional counterpart CaO/G and various reported solid strong bases (2.9–46.2 h-1).Moreover,the activity of Ca1/G is well maintained during 5 cycles,while 60% of activity is lost for the conventional analogue CaO/G due to the leaching of Ca.

关键词： Solid strong base Single Ca atoms Heterogeneous catalysts Transesterification Reaction

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A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes

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Protein & Cell 2024年第2期15卷 98-120页

作者： Shanshan Yang Chengyu liu Mengmeng Jiang x.aoqian liu Lingling Geng Yiyuan z.ang Shuhui Sun Kang Wang jian Yin Shuai Ma Si Wang Juan Carlos Iz.isua Belmonte Weiqi z.ang Jing Qu Guang-Hui liu Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China x.anwu Hospital Capital Medical University Beijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Aging Biomarker Consortium Beijing 100101China Altos Labs Inc.San DiegoCA 94022USA

Aging increases the risk ofliver diseases and systemic susceptibility to aging-related ***,cell type-specific changes and the underlying mechanism of liver aging in higher vertebrates remain incompletely ***,we constructed the first single-nucleus transcriptomic landscape of primate liver aging,in which we resolved cell type-specific gene ex.ression fluctuation in hepatocytes across three liver z.nations and detected aberrant cell-cell interactions between hepatocytes and niche *** in-depth dissection of this rich dataset,we identifed impaired lipid metabolism and upregulation of chronic inflammation-related genes prominently associated with declined liver functions during *** particular,hyperactivated sterol regulatory element-binding protein(SREBP)signaling was a hallmark of the aged liver,and consequently,forced activation of SREBP2 in human primary hepatocytes recapitulated in vivo aging phenotypes,manifesting as impaired detox.fication and accelerated cellular *** study ex.ands our knowledge of primate liver aging and informs the development of diagnostics and therapeutic interventions for liver aging and associated diseases.

关键词： single-nucleus RNA sequencing liver hepatocytes aging senescence SREBP2

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Selective photosynthesis of z.olefins through crystalline metal-organic cage-initiated ex.editious cascade reactions

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Carbon Energy 2024年第3期6卷 118-131页

作者： Jia-Ni Lu Yunz. Huang Yuan-Sheng x.a Long-z.ang Dong Lei z.ang Jing-Jing liu Lan-Gui x.e Jiang liu Ya-Qian Lan Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials ScienceJiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsNanjing Normal UniversityNanjingChina School of Chemistry South China Normal UniversityGuangzhouChina

The semi-hydrogenation of alkyne to form z.olefins with high conversion and high selectivity is still a huge challenge in the chemical ***,flammable and ex.losive hydrogen as the common hydrogen source of this reaction increases the cost and danger of industrial ***,we connect the photocatalytic hydrogen evolution reaction and the semihydrogenation reaction of alkynes in series and successfully realiz. the high selective production of z.alkenes using low-cost,safe,and green water as the proton *** the cascade reaction,a series of isomorphic metal–organic cage catalysts(Co_(x.z._(8−x.L_(6),x.0,3,4,5,and 8)are designed and synthesiz.d to improve the yield of the photocatalytic hydrogen *** them,Co_(5)z._(3)L_(6) shows the highest photocatalytic activity,with a H_(2) generation rate of 8.81 mmol g^(−1) h^(−1).Then,Co_(5)z._(3)L_(6) is further applied in the above tandem reaction to efficiently reduce alkynes to z.alkenes under ambient conditions,which can reach high conversion of>98%and high selectivity of>99%,and maintain original catalytic activity after multiple ***“one-pot”tandem reaction can achieve a highly selective and safe stepwise conversion from water into hydrogen into z.olefins under mild reaction conditions.

关键词： alkyne semi-hydrogenation hydrogen evolution reaction metal-organic cages photocatalysis z.olefins

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