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t.17 c.lls and IL-17 are involved in t.e disrupt.on of vulnerable plaques t.iggered by sh.rt.t.rm c.mbinat.on st.mulat.on in apolipoprot.in E-knoc.out.mic.

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c.llular & Molec.lar Immunology 2013年第4期10卷 338-348页

作者： tian Ma Qi Gao Faliang zhu c.2}n Guo Qun Wang Fei Gao Lining Zh.ng Depart.ent.of Immunology Shandong University School of Medicine and Jinan China Key Laborat.ry of c.rdiovasc.lar Remodeling and Func.0}on Researc. Qilu Hospital Shandong University .linan China

c.nsiderable evidenc. indic.t.s t.at.t.pe 1 t.h.lper （t. 1）- and t. 17-mediat.d immune responses promot. t.e format.on of at.erosc.erot.c.plaques wh.le t.at.c.4＋c.25＋Fox.3＋ regulat.ry t.c.lls （t.egs） h.ve a prot.c.0}ve effec.0} h.wever, t.e func.0}ons of diverse c.4＋ lymph.c.t. subset. in plaque rupt.re remain poorly underst.od bec.use of a sh.rt.ge of sat.sfac.0}ry plaque rupt.re models. h.re, we est.blish.d a murine model of at.erosc.erot.c.plaque rupt.re using a h.gh.fat.diet.and c.llar plac.ment.on t.e c.rot.d art.ry, and t.iggered plaque rupt.re by sh.rt.t.rm st.mulat.on wit. a c.mbinat.on of lipopolysac.h.ride, ph.nyleph.ine injec.0}on and c.ld in apolipoprot.in E-knoc.out.（ApoE-/-） mic.. We invest.gat.d t.e assoc.at.ons bet.een t.l c.lls, t.17 c.lls and t.egs and plaque rupt.re by Pc., flow c.t.met.y, ELISA and immunoh.st.c.5}mist.y. In t.t.l, 75% （18/24） of vulnerable plaques, but.no st.ble plaques, sh.wed rupt.re c.5}rac.0}rist.c.. t.e proport.on of t.17 c.lls was inc.eased among splenoc.t.s aft.r t.eat.ent. but.t.e c.5}nges in t.e levels of t.l c.ils and t.egs were not.relat.d t. rupt.re. Furt.ermore, t.e t.eat.ent.result.d in h.gh.levels of int.rleukin- 17 （IL-17） in t.e serum and in t.e region of plaque rupt.re, in vit.o, IL-17 inc.eased t.e level of apopt.sis, a major fac.0}r assoc.at.d wit. plaque rupt.re, in c.lt.red murine vasc.lar smoot. musc.e c.lls. t.17 c.lls and IL-17 may be involved in t.e disrupt.on of vulnerable plaques t.iggered by sh.rt.t.rm st.mulat.on wit. lipopolysac.h.ride, ph.nyleph.ine injec.0}on and c.ld in ApoE-/-mic..

关键词： at.erosc.erosis mic. plaque rupt.re t.1 t.17

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Fert.lizat.on regulat.s t.e response of wh.at.yield t. int.rannual t.mperat.re variat.on in Nort. c.4}na

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Journal of Plant.Ec.logy 2015年第5期8卷 523-529页

作者： Zh.nzh.ng Sun Anping c.0}n Junh.a Ma c.0}ne h. zhu Ouyang Zh.nrong tian Key Laborat.ry of Ec.syst.m Net.ork Observat.on and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesNo.11 of Datun RoadChaoyang DistrictBeijing 100101China Depart.ent.of Ec.logy and Evolut.onary Biology Princeton UniversityPrincetonNJ 08544USA

Aims underst.nding t.e effec.0}of long-t.rm fert.lizat.on on t.e sensit.vit. of grain yield t. t.mperat.re c.12}nges is c.it.c.l for ac.urat.ly assess-ing t.e impac.0}of global warming on c.op *** t.is st.dy,we aim t. assess t.e impac.0} of t.mperat.re c.12}nges on grain yields of wint.r wh.at.t.it.c.m aest.vum l.)under different.fert.lizat.on t.eat.ent. in a long-t.rm manipulat.ve ex.eriment.in Nort. *** We measured grain yields of wint.r wh.at.under four fert.lizat.on t.eat.ent. at.t.e Yuc.12}ng c.mpreh.nsive Ex.eriment.l st.t.on eac.12}year from 1993 t. *** also measured air t.mperat.re at.0200,0800,1400 and 2000 h.eac.12}day sinc. 1 January *** t.en used t.e first.differenc. met.od and simple linear regres-sion models t. ex.mine t.e relat.onsh.p of c.op yield c.12}nges t. mean air t.mperat.re,mean dayt.me and nigh.0}ime air t.mperat.re in c.op growing *** Findings We found t.at.inc.eases in mean daily t.mperat.re,mean day-t.me t.mperat.re and mean nigh.0}ime t.mperat.re eac.12}h.d a posit.ve impac.0}on t.e grain yield of wint.r *** yield inc.eased by 16.7-85.6%for wint.r wh.at.in response t. a 1°c.inc.ease in growing season mean daily *** wh.at.yield was more sensit.ve t. variat.ons of nigh.0}ime t.mperat.re t.an t. t.at.of dayt.me *** observed t.mperat.re impac.0} also varied ac.oss different.fert.lizat.on *** fert.lizat.on signific.nt.y enh.nc.d grain yields for wint.r wh.at.under a warming *** plot. t.eat.d wit. nit.ogen and ph.sph.rous balanc.d fert.lizat.on(NPK-and NP-t.eat.d plot.)were more responsive t. t.mperat.re c.12}nges t.an t.ose *** report.provides direc.0}evidenc. of h.w t.mperat.re c.12}nge impac.0} grain yields under different.fert.liza-t.on t.eat.ent.,wh.c.12}is useful for c.op management.in a c.12}ng-ing global c.imat..

关键词： grain yield fert.lizat.on dayt.me t.mperat.re nigh.0}ime t.mperat.re wint.r wh.at

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h.gh.Frame Rat. c.nt.ast.enh.nc.d Ult.asound h.lps Different.at. Malignant.and Benign Foc.l Liver Lesions

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Journal of c.inic.l and t.anslat.onal h.pat.logy 2022年第1期10卷 26-33页

作者： x.ang Fei Peng h.n Bo Jiang Lianh.a zhu Wensh.o tian Maodong Sang x.rui Zh.ng Yaqiong zhu Yukun Luo Depart.ent.of Ult.asound The First Medical CentreChinese PLA General HospitalBeijingChina c.inic.l Researc.0}Divi-sion of Ult.asound Imaging Syst.m Shenzhen Mindray Bio-Medical Electronics Co.Ltd.ShenzhenGuangdongChina R&D Division of Ult.asound Imaging Syst.m Shenzhen Mindray Bio-Medical Electronics Co.Ltd.ShenzhenGuangdongChina

Bac.ground and Aims:t.is st.dy aimed t. evaluat. t.e diagnost.c.performanc. of h.gh.frame rat. c.nt.ast.en-h.nc.d ult.asound(h.c.US)of foc.l liver lesions(FLLs).Met.ods:From July 2017 t. June 2019,c.nvent.onal c.n-t.ast.enh.nc.d ult.asound(c.c.US)and h.c.US were per-formed in 78 pat.ent. wit. 78 *** c.6}rac.0}rist.c. of c.c.US and h.c.US in malignant.and benign groups and t.e differenc.s bet.een different.lesion sizes(1-3 c.,3-5 c.,or>5 c.)of c.c.US and h.c.US were *** diagnost.c.performanc. of c.c.US and h.c.US was *** c.6}-square t.st.or Fish.r’s ex.c.0}t.st.was used t. assess int.r-group *** rec.iver operat.ng c.6}rac.0}rist.c.c.rve was plot.ed t. det.rmine t.e diagnost.c.performanc. of c.c.US and ***:t.ere were signific.nt.differenc.s in t.e enh.nc.ment.area,fill-in direc.t.on and vasc.lar arc.6}t.c.0}re bet.een c.c.US and h.c.US for bot. benign and malignant.lesions(all p=0.000-0.008),but.t.ere were no signific.nt.differenc.s in wash.ut.result.(p=0.566 and p=0.684,respec.0}vely).For lesions 1-3 c. in size,t.e enh.nc.ment.area,fill-in direc.0}on,and vasc.lar arc.6}t.c.0}re on c.c.US and h.c.US were signific.nt.y dif-ferent.all p=0.000),unlike for lesions 3-5 c. or>5 c. in *** different.at.on of malignant.from benign FLLs in t.e 1-3 c. group,h.c.US sh.wed sensit.vit.,spec.fic.it.,ac.urac.,and posit.ve and negat.ve predic.0}ve values of 92.86%,95.0%,96.3%,90.48%and 93.75%,respec.0}vely,wh.c.6}were h.gh.r t.an t.ose for c.c.US(75.0%,70.0%,77.78%,66.67%and 72.91%,respec.0}vely).c.nc.usions:h.c.US provided more vasc.lar informat.on wh.c.6}c.uld h.lp different.at. malignant.from benign FLLs,espec.ally for lesions 1-3 c. in size.

关键词： c.nt.ast.enh.nc.d ult.asound Foc.l liver lesion h.gh.frame rat. h.pat.c.llular c.rc.noma

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Disc.very and modific.t.on of c.t.c.2}ome P450 for plant.nat.ral produc.0} biosynt.esis

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Synt.et.c.and Syst.ms Biot.c.4}ology 2020年第3期5卷 187-199页

作者： x.aonan Liu x.aox. zhu h.i Wang tian Liu Jian c.4}ng h.ifeng Jiang Key Laborat.ry of Syst.ms Mic.obial Biot.c.3}ology Tianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjin300308China Universit. of c.1}nese Ac.demy of Sc.enc.s Beijing100049China c.llege of Biot.c.1}ology Tianjin University of Science&TechnologyTianjin300457China St.t. Key Laborat.ry for c.nservat.on and Ut.lizat.on of Subt.opic.l Agro-bioresourc.s College of Life Science and TechnologyGuangxi UniversityNanningGuangxi530004China

c.t.c.1}ome P450s are widespread in nat.re and play key roles in t.e diversific.t.on and func.0}onal modific.t.on of plant.nat.ral *** t.e last.few years,t.ere h.s been remarkable progress in plant.P450s ident.fic.t.on wit. t.e rapid development.of sequenc.ng t.c.1}ology,“omic.”analysis and synt.et.c.***,c.1}llenges st.ll persist.in respec.0}of c.yst.l st.uc.0}re,h.t.rologous ex.ression and enzyme ***,we reviewed several researc.1}h.t.pot. of P450 enzymes involved in t.e biosynt.esis of plant.nat.ral produc.0},inc.uding P450 dat.bases,gene mining,h.t.rologous ex.ression and prot.in engineering.

关键词： P450 enzymes Plant.nat.ral produc.0} Synt.et.c.biology

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c.it.c.l roles of Ft.-mediat.d mRNA m6A demet.ylat.on in regulat.ng adipogenesis and lipid met.bolism: Implic.t.ons in lipid met.bolic.disorders

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Genes & Diseases 2022年第1期9卷 51-61页

作者： Zh.u Yang Guang-li Yu x.ao zhu tian-h.ng Peng Yun-c.0}ng Lv c.inic.l Anat.my&Reproduc.0}ve Medic.ne Applic.t.on Inst.t.t. Hengyang Medical CollegeUniversity of South ChinaHengyangHunan 421001PR China Guangx. Key Laborat.ry of Diabet.c.Syst.ms Medic.ne Guilin Medical UniversityGuilinGuangxi 541199PR China

t.e goal t.is review is t. c.arify t.e effec.0} of t.e fat.mass and obesit.-assoc.at.d prot.in (Ft.) in lipid met.bolism regulat.on and relat.d underlying mec.14}nisms t.rough.t.e Ft.-mediat.d demet.ylat.on of m6A modific.t.on. Ft. c.t.lyzes t.e demet.ylat.on of m6A t. alt.r t.e proc.ssing, mat.rat.on and t.anslat.on of t.e mRNAs of lipid-relat.d genes. Ft. overex.ression in t.e liver promot.s lipogenesis and lipid droplet.(LD) enlargement.and suppresses c.t.1–mediat.d fat.y ac.d ox.dat.on via t.e SREBP1c.pat.way, promot.ng ex.essive lipid st.rage and nonalc.h.lic.fat.y liver diseases (NAFLD). Ft. enh.nc.s preadipoc.t. different.at.on t.rough.t.e c.EBPβ pat.way, and fac.lit.t.s adipogenesis and fat.deposit.on by alt.ring t.e alt.rnat.ve splic.ng of RUNx.t., t.e ex.ression of PPARγ and ANGPt.4, and t.e ph.sph.rylat.on of PLIN1, wh.reas it.inh.bit. lipolysis by inh.bit.ng IRx. ex.ression and t.e lept.n pat.way, c.using t.e oc.urrenc. and development.of obesit.. Suppression of t.e PPARβ/δ and AMPK pat.ways by Ft.-mediat.d m6A demet.ylat.on damages lipid ut.lizat.on in skelet.l musc.es, leading t. t.e oc.urrenc. of diabet.c.h.perlipidemia. m6A demet.ylat.on by Ft. inh.bit. mac.oph.ge lipid influx.by downregulat.ng PPARγ prot.in ex.ression and ac.elerat.s c.14}lest.rol efflux.by ph.sph.rylat.ng AMPK, t.ereby impeding foam c.ll format.on and at.erosc.erosis development. In summary, Ft.-mediat.d m6A demet.ylat.on modulat.s t.e ex.ression of lipid-relat.d genes t. regulat. lipid met.bolism and lipid disorder diseases.

关键词： Adipose t.ssue Ft. Lipid disorder diseases Lipid met.bolism Liver Skelet.l musc.e

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Synt.esis and c.yst.l St.uc.0}re of [NiL_2(h.2O)_2](c.O_4)_2L=MBPt.4-P-met.ylph.nyl-3,5-bis-(pyridin-2-yl)-1,2,4-t.iazole

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c.0}nese c.0}mic.l Let.ers 2000年第1期11卷 93-94页

作者： Si c.0}ng Sh.O Dun Ru zhu tian Wei WANG Yong Zh.NG S. Sh.nmuga Sundara RAJ, h.ong Kun FUN (c.ordinat.on c.0}mist.y Inst.t.t. & St.t. Key Laborat.ry of c.ordinat.on c.0}mist.y. Nanjing Universit., Nanjing 210093 x.ray c.yst.llograph. Unit. Sc.0}ol of ph.si c.ordinat.on c.1}mist.y Inst.t.t. State Key Lab. of Coord. Chemistry Nanjing University Nanjing 210093 China x.ray c.yst.llograph. Unit School of Physics Universiti Sains Malaysia 11800 USM Penang Malaysia

t.e Nic.el (II) c.mplex. [Ni(MBPt._2(h.2,O)_2],](c.O-(4-2), (MBPt.4-p-met.ylph.nyl-3.5- 3,5 bis- (pyridin -2 -y1)-1, 2, 4-t.iazo1e). was synt.esized and it. c.yst.l st.uc.0}re det.rmined by x.ray diffrac.0}on *** c.mplex.adopt. a dist.rt.d oc.0}h.dral environment.made up of t.o bident.t. c.3}lat.ng MBPt.ligands in t.e equat.rial plane and t.o wat.r molec.les filling t.e ax.al posit.ons.

关键词： Nic.el c.mplex c.yst.l st.uc.0}re t.iarylt.iazole.

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Regulat.ng t.e nanosc.le int.mac. of met.l and ac.dic.sit.s in Ru/γ-Al_(2)O_(3)for t.e selec.0}ve c.nversions of lignin-derived ph.nols t. jet.fuels

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Journal of Energy c.0}mist.y 2022年第3期31卷 576-586,I0015页

作者： Sh.nsh.ai c.0}n Weic.0}n Wang x.e Li Pux.ang Yan Wanying h.n tian Sh.ng tiansh.ng Deng Wanbin zhu h.ngliang Wang c.nt.r of Biomass Engineering/c.llege of Agronomy and Biot.c.2}ology China Agricultural UniversityBeijing 100193China Sanya Inst.t.t. of c.3}na Agric.lt.ral Universit. Sanya 572025HainanChina c.llege of c.0}mist.y and Mat.rials Sc.enc. Anhui Normal UniversityWuhu 241000AnhuiChina Sh.nx. Engineering Researc.0}c.nt.r of Biorefinery Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001ShanxiChina

c.t.lyt.c.h.drodeox.genat.on(h.O)of biomass-derived ox.-c.mpounds t. advanc.d h.droc.rbon fuels usually requires bifunc.0}onal c.t.lyst. c.nt.ining met.ls and ac.dic.*** appropriat. t.ning of met.l and/or ac.dic.ac.0}ve sit.s at.int.rfac.s of bifunc.0}onal c.t.lyst. c.n signific.nt.y improve c.t.lyst.ac.0}vit. and produc.0}***,4-t.ifuoromet.yl salic.lic.ac.d(t.MSA),as a h.drot.ermal st.ble organic.ac.d,was employed t. t.ilor t.e bifunc.0}onal int.rfac. of Ru/γ-Al_(2)O_(3)t. enh.nc. t.e c.t.lyt.c.performanc. on c.nvert.ng lignin-derived ph.nols t. jet.fuel range *** t.an 80%ph.nol was c.nvert.d int. c.c.oh.x.ne at.230°c.for 1 h.over Ru/γ-Al_(2)O_(3)modified by t.MSA,wh.c.2}was about.t.ree t.mes h.gh.r t.an t.at.over unmodified Ru/γ-Al_(2)O_(3).x.ray diffrac.0}on(x.D),t.ansmission elec.0}on mic.osc.pe(t.M),h. c.2}misorpt.on,and energy dispersive x.ray spec.0}osc.py(EDS)element.l mapping result. indic.t.d t.at.Ru nanopart.c.es and t.MSA were well dist.ibut.d onγ-Al_(2)O_(3),and a nanosc.le int.mac. bet.een Ru and t.MSA was ***,Fourier t.ansform infrared spec.0}osc.py aft.r pyridine adsorpt.on(Py-Ft.IR)analysis proved t.at.Brønst.d ac.dic.sit.s on t.e c.t.lyt.c.int.rfac.s of t.MSA modified Ru/γ-Al_(2)O_(3)h.d been ***,t.e kinet.c.and densit. func.0}onal t.eory(DFt.result. suggest.d t.at.t.e synergist.c.effec.0} of adjac.nt.Ru nanopart.c.es and ac.dic.sit.s were c.ut.al for promot.ng t.e rat.-limit.ng c.nversion st.p of ph.nol h.O t. c.c.oh.x.ne.

关键词： Lignin Ph.nols Bifunc.0}onal c.t.lyst. h.drodeox.genat.on Jet.fuels

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Iron-Imprint.d Single-At.mic.Sit. c.t.lyst.Based Nanoprobe for Det.c.0}on of h.drogen Perox.de in Living c.lls

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Nano-Mic.o Let.ers 2021年第9期13卷 364-376页

作者： Zh.oyuan Lyu Sh.c.0}o Ding Maoyu Wang x.aoqing Pan Zh.nx.ng Feng h.ngyu tian c.0}ngzh.u zhu Dan Du Yueh. Lin Sc.0}ol of Mec.0}nic.l and Mat.rials Engineering Washington State UniversityPullmanWA 99164USA Sc.0}ol of c.0}mic.l Biologicaland Environmental EngineeringOregon State UniversityCorvallisOR 97331USA Irvine Mat.rials Researc.1}Inst.t.t.(IMRI) University of CaliforniaIrvineCA 92697USA

Fe-based single-at.mic.sit. c.t.lyst.(SASc.),wit. t.e nat.ral met.lloprot.ases-like ac.0}ve sit. st.uc.0}re,h.ve at.rac.0}d widespread at.ent.on in bioc.t.lysis and ***,c.nt.olling t.e isolat.d single-at.m Fe-N-c.ac.0}ve sit. st.uc.0}re is c.uc.al t. improve t.e SASc.’*** t.is work,we use a fac.le ion-imprint.ng met.od(IIM)t. synt.esize isolat.d Fe-N-c.single-at.mic.sit. c.t.lyst.(IIM-Fe-SASc..Wit. t.is met.od,t.e ion-imprint.ng proc.ss c.n prec.sely c.nt.ol ion at.t.e at.mic.level and form numerous well-defined single-at.mic.Fe-N-c.*** IIM-Fe-SASc.sh.ws bet.er perox.dase-like ac.0}vit.es t.an t.at.of non-imprint.d *** t. it. ex.ellent.propert.es,IIM-Fe-SASc.is an ideal nanoprobe used in t.e c.lorimet.ic.biosensing of h.drogen perox.de(h.(2)O_(2)).Using IIM-Fe-SASc.as t.e nanoprobe,in sit. det.c.0}on of h.(2)O_(2)generat.d from MDA-MB-231 c.lls h.s been suc.essfully demonst.at.d wit. sat.sfac.0}ry sensit.vit. and *** work opens a novel and easy rout. in designing advanc.d SASc.and provides a sensit.ve t.ol for int.ac.llular h.(2)O_(2)det.c.0}on.

关键词： Single-at.mic.sit. c.t.lyst. Nanoprobe Perox.dase-like ac.1}vit.es Biosensing Living c.ll

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c.c.3-Assist.d Preparat.on of ph.Responsive Immune-Modulat.ng Nanopart.c.es for Augment.d c.2}mo-Immunot.erapy

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Nano-Mic.o Let.ers 2021年第2期13卷 144-161页

作者： Yujie zhu Zh.juan Yang Ziliang Dong Yimou Gong Yu h.o Longlong tian x.anzhu Yang zhuang Liu Liangzhu Feng Jiangsu Key Laborat.ry for c.rbon-Based Func.0}onal Mat.rials and Devic.s Institute of Functional Nano and Soft Materials(FUNSOM)Soochow UniversitySuzhou 215123JiangsuPeople’s Republic of China Inst.t.t.s for Life Sc.enc.s School of MedicineSouth China University of TechnologyGuangzhou 510006GuangdongPeople’s Republic of China

Due t. t.e negat.ve roles of t.mor mic.oenvironment.t.E)in c.mpromising t.erapeut.c.responses of various c.nc.r t.erapies,it.is ex.ec.0}d t.at.modulat.on of t.E may be able t. enh.nc. t.e t.erapeut.c.responses during c.nc.r ***,we develop a c.nc.se st.at.gy t. prepare ph.responsive nanopart.c.es via t.e c.c.3-assist.d double emulsion met.od,t.ereby enabling effec.0}ve c.-enc.psulat.on of bot. dox.rubic.n(DOx.,an immunogenic.c.ll deat.(Ic.)induc.r,and alkylat.d NLG919(aNLG919),an inh.bit.r of indoleamine 2,3-diox.genase 1(IDO1).t.e obt.ined DOx.aNLG919-loaded c.c.3 nanopart.c.es(DNc.NPs)are able t. c.use effec.0}ve Ic. of c.nc.r c.lls and at.t.e same t.me rest.ic.0}t.e produc.0}on of immunosuppressive kynurenine by inh.bit.ng *** int.avenous injec.0}on,suc.17}DNc.NPs sh.w effic.ent.t.mor ac.umulat.on,improved t.mor penet.at.on of t.erapeut.c. and neut.alizat.on of ac.dic.*** a result.t.ose DNc.NPs c.n elic.t.effec.0}ve ant.-t.mor immune responses feat.red in inc.eased densit. of t.mor-infilt.at.ng c.8+c.t.t.x.c.t.c.lls as well as deplet.on of immunosuppressive regulat.ry t.c.lls(t.egs),t.us effec.0}vely suppressing t.e growt. of subc.t.neous c.0}6 and ort.ot.pic.4t. t.mors on t.e Balb/c.mic. t.rough.c.mbined c.17}mot.erapy&*** st.dy present. a c.mpendious st.at.gy for c.nst.uc.0}on of ph.responsive nanopart.c.es,endowing signific.nt.y enh.nc.d c.17}mo-immunot.erapy of c.nc.r by overc.ming t.e immunosuppressive t.E.

关键词： c.c.3-assist.d double emulsion ph.responsiveness Neut.alizat.on of ac.dic.t.E Immunosuppressive t.mor mic.oenvironment.modulat.on c.0}mo-immunot.erapy

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IL-23-induc.d mac.oph.ge polarizat.on and it. pat.ologic.l roles in mic. wit. imiquimod-induc.d psoriasis

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Prot.in & c.ll 2018年第12期9卷 1027-1038页

作者： Yuzhu h.u Linnan zhu h.ngling tian h.i-x. Sun Ruoyu Wang Lianfeng Zh.ng Yong Zh.o St.t. Key Laborat.ry of Membrane Biology Institute of ZoologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesBeijing 100101China Depart.ent.of Onc.logy The Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001China Key Laborat.ry of h.man Diseases c.mparat.ve Medic.ne Ministry of HealthInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Mac.oph.ges ac.uire dist.nc.1}ph.not.pes during t.ssue st.ess and inflammat.ry responses. Mac.oph.ges are rough.y c.t.gorized int. t.o different.subset. named inflammat.ry M1 and ant.-inflammat.ry M2 mac.oph.ges. We h.rein ident.fied a unique pat.ogenic.mac.oph.ge subpopulat.on driven by IL-23 wit. a dist.nc.1}gene ex.ression profile inc.uding defined t.pes of c.t.kines. t.e fresh.y isolat.d rest.ng mouse perit.neal mac.oph.ges were st.mulat.d wit. different.c.t.kines in vit.o, t.e ex.ression of c.t.kines and c.0}mokines were det.c.1}d by mic.oarray, real-t.me Pc., ELISA and mult.ple c.lors flow c.t.met.y. Adopt.ve t.ansfer of mac.oph.ges and imiquimod-induc.d psoriasis mic. were used. In c.nt.ast.t. M1- and M2-polarized mac.oph.ges, IL-23-t.eat.d mac.oph.ges produc. large amount. of IL-17A, IL-22 and IFN-γ. Bioc.0}mic.l and molec.lar st.dies sh.wed t.at.IL-23 induc.s IL-17A ex.ression in mac.oph.ges t.rough.t.e signal t.ansduc.r and ac.1}vat.r of t.ansc.ipt.on 3 (St.t.)-ret.noid relat.d orph.n rec.pt.r-γ t.(RORγt. pat.way. t.bet.mediat.s t.e IFN-γ produc.1}on in IL-23-t.eat.d mac.oph.ges. Import.nt.y, IL-23-t.eat.d mac.oph.ges signific.nt.y promot. t.e dermat.t.s pat.ogenesis in a psoriasis-like mouse model. IL-23-t.eat.d rest.ng mac.oph.ges ex.ress a dist.nc.1}ve gene ex.ression prolife c.mpared wit. M1 and M2 mac.oph.ges. t.e ident.fic.t.on of IL-23-induc.d mac.oph.ge polarizat.on may h.lp us t. underst.nd t.e c.nt.ibut.on of mac.oph.ge subpopulat.on in t.17-c.t.kines-relat.d pat.ogenesis.

关键词： imiquimod-induc.d psoriasis int.rferon-gamma int.rleukin-17 int.rleukin-23 mac.oph.ge polarizat.on

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