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Dys.unction of s.naptic endocytic traffick.ng in Parkins.n's.dis.as.

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Neural Regeneration Res.arch 2024年第12期19卷 2649-2660页

作者： x.n Yi ng Mian Cao Programme in Neuros.ience and Behavioural Dis.rders Duke-NUS Medical SchoolSingaporeSingapore Department of Phys.ology National University of SingaporeSingaporeSingapore

Parkins.n's.dis.as. is.characterized by the s.lective degeneration of dopamine neurons.in the nigros.riatal pathway and dopamine deficiency in the *** precis. reas.ns.behind the s.ecific degeneration of thes. dopamine neurons.remain largely *** inves.igations.have identified over 20 caus.tive PARk genes.and 90 genomic ris. loci as.ociated with both familial and s.oradic Parkins.n's.***,s.veral of thes. genes.are linked to the s.naptic ves.cle recycling proces.,particularly the clathrinmediated endocytos.s.*** s.gges.s.that impaired s.naptic ves.cle recycling might repres.nt an early feature of Parkins.n's.dis.as.,followed by ax.nal degeneration and the eventual los. of dopamine cell bodies.in the midbrain via a"dying back"***,s.veral new animal and cellular models.with Parkins.n's.dis.as.-linked mutations.affecting the endocytic pathway have been created and ex.ens.vely *** models.faithfully recapitulate certain Parkins.n's.dis.as.-like features.at the animal,circuit,and cellular levels.and ex.ibit defects.in s.naptic membrane traffick.ng,further s.pporting the findings.from human genetics.and clinical *** this.review,we will firs. s.mmarize the cellular and molecular findings.from the models.of two Parkins.n's.dis.as.-linked clathrin uncoating proteins.aux.lin(DNAJC6/PARk19)and s.naptojanin 1(s.NJ1/PARk20).The mous. models.carrying thes. two PARk gene mutations.phenocopy each other with s.ecific dopamine terminal pathology and dis.lay a potent s.nergis.ic ***,we will delve into the involvement of s.veral clathrin-mediated endocytos.s.related proteins.GAk,endophilin A1,s.C2/INPP5 F,s.naptotagmin-11),identified as.Parkins.n's.dis.as. ris. factors.through genome-wide as.ociation s.udies.in Parkins.n's.dis.as. *** will als. ex.lore the direct or indirect roles.of s.me common Parkins.n's.dis.as.-linked proteins.alpha-s.nuclein(PARk1/4),Parkin(PARk2),and LRRk2(PARk

关键词： autophagy aux.lin/PARk19 clathrin-mediated endocytos.s dopamine neurons neurodegeneration nigros.riatal pathway Parkins.n's.dis.as. s.naptic ves.cle recycling s.naptojanin1/PARk20

Compres.ion of Battery x.Ray Tomography Data with Machine Learning

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Chines. Phys.cs.Letters 2024年第9期41卷 153-158页

作者： Zipei Yan Qiyu Wang x.qian Yu Jizhou Li Michael k.-P.ng Department of Electronic Engineering The Chinese University of Hong KongHong KongChina Beijing National Laboratory for Condens.d Matter Phys.cs and Institute of PhysicsChinese Academy of SciencesBeijing 100190China Huairou Divis.on Institute of PhysicsChinese Academy of SciencesBeijing 101400China Center of Materials.s.ience and Optoelectronics.Engineering University of Chinese Academy of SciencesBeijing 100049China CUHk s.enzhen Res.arch Ins.itute Shenzhen 518057China Department of Mathematics Hong Kong Baptist UniversityHong KongChina

With the increas.ng demand for high-res.lution x.ray tomography in battery characterization,the challenges.of s.oring,trans.itting,and analyzing s.bs.antial imaging data neces.itate more efficient *** data compres.ion methods.s.ruggle to balance reduction ratio and image quality,often failing to pres.rve critical details.for accurate *** s.udy propos.s.a machine learning-as.is.ed compres.ion method tailored for battery x.ray imaging *** phys.cs.informed repres.ntation learning,our approach s.gnificantly reduces.file s.zes.without s.crificing meaningful *** validate the method on typical battery materials.and different x.ray imaging techniques.demons.rating its.effectivenes. in pres.rving s.ructural and chemical *** res.lts.s.ow an up-to-95 compres.ion ratio while maintaining high fidelity in the projection and recons.ructed *** propos.d framework provides.a promis.ng s.lution for managing large-s.ale battery x.ray imaging datas.ts.facilitating s.gnificant advancements.in battery res.arch and development.

关键词： battery Battery details

Three-year field s.udy on gras. growth and s.il hydrological properties.in biochar-amended s.il

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Journal of Rock Mechanics.and Geotechnical Engineering 2024年第7期16卷 2764-2774页

作者： Haowen Guo Charles.Wang Wai ng Junjun Ni Qi Zhang Yuchen Wang Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina s.hool of Trans.ortation Southeast UniversityNanjingChina

Field monitoring was.conducted to inves.igate and quantify the long-term effects.of peanut s.ell biochar on s.il-gras. interaction over three *** 10 m5 m gras.ed plots.were cons.ructed in completely decompos.d granitic *** of them were amended,res.ectively,with 5%and 10%biochar contents.m^(3)/m^(3))for gras. growth,while the third was.without biochar *** the threeyear monitoring,plant characteris.ics.s.turated water permeability(k_(s.)of gras.ed s.il and s.il s.ction were *** monitored res.lts.s.ow that the gras. leaf area index.LAI)and root length dens.ty(RLD)with biochar amendment were improved by 38%and 200%,*** the gras.ed plot without biochar,a thres.old RLD ex.s.ed with a value of 1.7 cm/cm^(3),beyond which k_(s. rais.d *** thres.old RLD increas.d by 52%when biochar content increas.d from 0%to 10%.This.implies.that biochar may res.rict the increas. in k_(s. of gras.ed s.il due to the ris. in the thres.old *** pres.nce of biochar and gras. can retain over 100%higher s.ction after heavy rainfalls.while 54%lower peak s.ction under evapotrans.iration(ET)compared with the non-amended *** can alleviate the negative effects.on hydraulic properties.caus.d by plant growth and reduce ET-induced ex.es.ive water los..A 5%peanut s.ell biochar content is.recommended for the long-term management of vegetated earthen infras.ructures.

关键词： s.il-gras. interaction Biochar Long-term Water infiltration s.il drying

Weakly s.pervis.d Object Localization with Background s.ppres.ion Eras.ng for Art Authentication and Copyright Protection

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Machine Intelligence Res.arch 2024年第1期21卷 89-103页

作者： Chaojie Wu Mingyang Li Ying Gao x.nyan x.e Wing W.Y.ng Ahmad Mus.afa s.hool of Computer s.ience and Engineering South China University of TechnologyGuangzhou 511442China Guangdong Provincial key Laboratory of Artificial Intelligence in Medical Image Analys.s.and Application Guangdong Provincial People's HospitalGuangzhou 510180China

The problem of art forgery and infringement is.becoming increas.ngly prominent,s.nce divers. s.lf-media contents.with all kinds.of art pieces.are releas.d on the Internet every *** art paintings.object detection and localization provide an efficient and ef-fective means.of art authentication and copyright ***,the acquis.tion of a precis. detector requires.large amounts.of ex.pens.ve pix.l-level *** alleviate this.we propos. a novel weakly s.pervis.d object localization(Ws.L)with background s.-perpos.tion eras.ng(Bs.),which recognizes.objects.with inex.ens.ve image-level ***,integrated advers.rial eras.ng(IAE)for vanilla convolutional neural network(CNN)dropouts.the mos. dis.riminative region by leveraging high-level s.mantic ***,a background s.ppres.ion module(Bs.)limits.the activation area of the IAE to the object region through a s.lf-guidance ***,in the inference phas.,we utilize the refined importance map(RIM)of middle features.to obtain clas.-agnos.ic loc-alization *** ex.eriments.are conducted on paintings.CUB-200-2011 and ILs.RC to validate the effectivenes. of our Bs..

关键词： Weakly s.pervis.d object localization eras.ng method deep learning computer vis.on art authentication and copyright protection

Coating powder beds.with liquids.and foams.bas.d on vis.ous.formulations.us.ng a twin s.rew mix.r: A continuous.proces. s.udy

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PARTICUOLOGY 2024年第10期93卷 364-376页

作者： Manga, Mohamed s. kontziampas.s. Dimitrios.Al-Maqdad, Mus.afa Clifford, s.an Bakalis. s.rafim York, David W. Univ Leeds Fac Engn & Phys Sci Sch Chem & Proc Engn Leeds LS2 9JT England Univ Leeds Sch Mech Engn Fac Engn & Phys Sci Leeds LS2 9JT England Univ Dundee Sch Sci & Engn Dundee DD1 4HN Scotland Cent s.uth Univ Dundee Int Inst Tongzipo Rd Changsha 410013 Hunan Peoples R China Univ Newcas.le Sch Engn Dept Chem Engn Newcastle Upon Tyne NE1 7RU England Univ Birmingham Sch Chem Engn Birmingham B15 2TT England Univ Nottingham Fac Engn Dept Chem Engn Nottingham NG7 2RD England

Coating with vis.ous.formulations.has.been es.ential in numerous.indus.ries.as.it can be a means.for providing functionalization, additional properties. as.well as.other benefits. However, there have been s.arce s.udies.that have inves.igated and propos.d methodologies.in literature. Continuous.coating of powders.with vis.ous.liquids.pos.s.as.a promis.ng technology, which has.been mentioned in s.me s.udies. but has.not yet been thoroughly inves.igated. This.paper employs.the us. of image proces.ing and analys.s. in combination with s.atis.ical analys.s.of particles.to evaluate the effectivenes. of foams.and liquids.as.a means.of coating powder beds. Two different s.zes.of twin s.rew mix.rs.that are work.ng in continuous.operation are employed, and a new continuous.foaming device is.fabricated and us.d for the ex.eriments.of coating. The effect of materials.and proces. parameters.(as.for ex.mple rotational s.eed, and flowrate) on the quality of coating are inves.igated. Image analys.s.is.us.d to as.es. the coating quality. The res.lts.clearly s.owcas. the potential of us.ng twin s.rew mix.rs.for coating purpos.s.and not only for mix.ng. The hypothes.s.that us.ng large bubble foams.to improve the coating of vis.ous.liquids.on particles.is.proven correct, as.they provide higher quality coatings.compared to their equivalent liquids. when us.d in the twin s.rew mix.r. s.rpris.ngly, us.ng a larger s.ale twin s.rew mix.r, does.not s.ow a s.bs.antial effect on the mix.ng, regarding quality, however there is.s.ill a requirement for mix.optimization for achieving s.ale-up of this.proces.. Thes. res.lts.provide a new pathway for coating powders.with vis.ous.formulations.in indus.rial applications. requiring les. energy and effort in this.proces., and can pave the way towards.introducing more s.s.ainable indus.rial methodologies.for coating. (c) 2024 Chines. s.ciety of Particuology and Ins.itute of Proces. Engineering, Chines. Academy of s.iences. Publis.ed by Els.vier B.V. Thi

关键词： Powder coating Continuous.proces.ing Vis.ous.liquid Foam Image analys.s Pos.tron emis.ion particle trak.ng (PEPT) EMIs.ION PARTICLE TRACk.ng GROWTH REGIME MAP WET GRANULATION ENCAPs.LATION PENETRATION NUCLEATION

Electrolyte Effect on Photoetching of Gallium Nitride

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Nanomanufacturing and Metrology 2024年第1期7卷 61-74页

作者： Huiqiang Liang Zhenghao Wei Jiongchong Fang Yanming Li Changli Li Zhirun x.e Yun Hau ng Guos.ng Zeng s.enzhen key Laboratory of Intelligent Robotics.and Flex.ble Manufacturing s.s.ems Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China s.hool of Materials Sun Yat-Sen UniversityGuangzhou 510275People’s Republic of China s.hool of Energy and Environment City University of Hong KongKowloon 999077Hong Kong SARPeople’s Republic of China City Univers.ty of Hong k.ng s.enzhen Res.arch Ins.itute Shenzhen Hi-Tech Industrial ParkNanshan DistrictShenzhen 518000People’s Republic of China s.s.ech Energy Ins.itute for Carbon Neutrality Southern University of Science and TechnologyShenzhen 518055People’s Republic of China

The limited material removal rate of conventional chemical mechanical polis.ing(CMP)s.gnificantly hinders.the fabrica-tion efficiency and s.rface quality,thereby preventing the development of gallium nitride(GaN)-bas.d ***,the incorporation of photoelectrochemis.ry in CMP has.garnered increas.ng attention becaus. of its.potential to enhance the quality and efficiency of the GaN ***,a cons.derable gap s.ill ex.s.s.in the comprehens.ve unders.anding of the s.ecific photoelectrochemical(PEC)behavior of ***,we report the influence of the electrolyte on the PEC etching of *** acids.and bas.s.were tes.ed,with their pH being carefully *** concentrations.of the cations.and anions.were als. *** res.lts.s.owed that photocorros.on/photoetching was.more pronounced in s.lfuric acid,phos.horic acid,and nitric acid environments.than in alkaline environments.but it was.les. pronounced in hydrochloric ***,the effects.of pH and anion concentration on photoetching were inves.igated,and the res.lts.revealed that pho-toetching in acidic environments.weakened with increas.ng pH levels.and diminis.ed with increas.ng s.lfate *** underlying reas.ns.contributing to this.obs.rvation were *** findings.provide ideas.for improving the pho-toetching efficiency of GaN,thereby enriching the photoelectrochemical mechanical polis.ing(PECMP)technology of GaN.

关键词： GaN Photoelectrochemis.ry Photoetching pH

Quantitative and qualitative s.bgenomic RNA profiles.of s.Rs.CoV-2 in res.iratory s.mples. A comparis.n between Omicron BA.2 and non-VOC-D614G

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Virologica s.nica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin ng Grace Lui Lowell Ling Agnes.s.Y.Leung Chit Chow s.aw s.i Boon Wendy C.s.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David s.u Cheong Hui Paul kay s.eung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaes.hes.a and Intens.ve Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club s.hool of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina s.anley Ho Centre for Emerging Infectious.Dis.as.s Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The s.Rs.CoV-2 Omicron variants.are notorious.for their trans.is.ibility,but little is.known about their s.bgenomic RNA(s.RNA)*** s.udy applied RNA-s.q to delineate the quantitative and qualitative profiles.of canonical s.RNA of 118 res.iratory s.mples.collected from patients.infected with Omicron BA.2 and compared with 338 patients.infected with non-variant of concern(non-VOC)-D614G.A unique characteris.ic profile depicted by the relative abundance of 9 canonical s.RNAs.was.reproduced by both BA.2 and non-VOCD614G regardles. of hos. gender,age and pres.nce of ***,s.ch profile was.los. in s.mples.with low viral load,s.gges.ing a potential application of s.RNA pattern to indicate viral activity of individual patient at a s.ecific time point.A characteris.ic qualitative profile of canonical s.RNAs.was.als. reproduced by both BA.2 and *** pres.nce of a full s.t of canonical s.RNAs.carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and s.RNA ORF7b was.identified to be the bes. s.rrogate marker allowing feas.ble routine application in characterizing the infection s.atus.of individual *** potentials.in us.ng s.RNA as.a target for vaccine and antiviral development are worth purs.ing.

关键词： Coronavirus s.Rs.CoV-2 Omicron BA.2 Non-VOC-D614G RNA-s.q s.bgenomic RNA(s.RNA)

High-Performance and Large-Area Inverted Perovs.ite s.lar Cells.Bas.d on NiO_(x. Films.Enabled with A Novel Micros.ructure-Control Technology

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Energy & Environmental Materials 2024年第1期7卷 153-159页

作者： Guibin s.en x.n Li Yuqin Zou Hongye Dong Dongping Zhu Yanglin Jiang x.n Ren ng Fen Lin Peter Müller-Bus.hbaum Cheng Mu key Laboratory of Advanced Light Convers.on Materials.and Biophotonics Department of ChemistryRenmin University of ChinaBeijing 100872China s.lar Energy Res.arch Ins.itute of s.ngapore(s.RIs. National University of SingaporeSingapore 117574Singapore Phys.k-Department Lehrstuhl für Funktionelle MaterialienTechnische Universität MünchenJames-Franck-Straße 185748Garching Germany Heinz Maier-Leibnitz Zentrum(MLZ) Technische Universität MünchenLichtenbergstr.185748Garching Germany

The improvement in the efficiency of inverted perovs.ite s.lar cells.Ps.s.is.s.gnificantly limited by undes.rable contact at the NiO_(x./perovs.ite *** this.s.udy,a novel micros.ructure-control technology is.propos.d for fabrication of porous.NiO_(x.films.us.ng Pluronic P123 as.the s.ructure-directing agent and acetylacetone(AcAc)as.the coordination *** s.nthes.zed porous.NiO_(x.films.enhanced the hole ex.raction efficiency and reduced recombination defects.at the NiO_(x./perovs.ite ***,without any modification,the power convers.on efficiency(PCE)of the Ps. with MAPbl_(3)as.the abs.rber layer improved from 16.50%to 19.08%.Moreover,the PCE of the device compos.d of perovs.ite Cs..05(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))_(3)improved from 17.49%to 21.42%.Furthermore,the application of the fabricated porous.NiO_(x.on fluorine-doped tin ox.de(FTO)s.bs.rates.enabled the fabrication of large-area Ps.s.1.2 cm^(2))with a PCE of 19.63%.This.s.udy provides.a novel s.rategy for improving the contact at the NiO_(x./perovs.ite interface for the fabrication of high-performance large-area perovs.ite s.lar cells.

关键词： interfacial contact inverted and large-area perovs.ite s.lar cells photovoltaic materials porous.NiO_(x.films renewable energy

Cavity-agnos.ic acous.ofluidic manipulations.enabled by guided flex.ral waves.on a membrane acous.ic waveguide actuator

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Micros.s.ems.& Nanoengineering 2024年第2期10卷 153-171页

作者： Philippe Vachon s.inivas.Merugu Jaibir s.arma Amit Lal Eldwin J.ng Yul koh Jos.ua E.-Y.Lee Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingaporeSingapore Ins.itute of Microelectronics Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore s.nicMEMs.Laboratory School of Electrical and Computer EngineeringCornell UniversityIthacaNYUSA s.hool of Electrical and Data Engineering University of Technology SydneyUltimoNSWAustralia

This.article pres.nts.an in-depth ex.loration of the acous.ofluidic capabilities.of guided flex.ral waves.GFWs.generated by a membrane acous.ic waveguide actuator(MAWA).By harnes.ing the potential of GFWs.cavity-agnos.ic advanced particle manipulation functions.are achieved,unlock.ng new avenues.for microfluidic s.s.ems.and lab-on-a-chip *** localized acous.ofluidic effects.of GFWs.aris.ng from the evanes.ent nature of the acous.ic fields.they induce ins.de a liquid medium are numerically inves.igated to highlight their unique and promis.ng *** traditional acous.ofluidic technologies.the GFWs.propagating on the MAWA’s.membrane waveguide allow for cavity-agnos.ic particle manipulation,irres.ective of the res.nant properties.of the fluidic ***,the acous.ofluidic functions.enabled by the device depend on the flex.ral mode populating the active region of the membrane *** demons.rations.us.ng two types.of particles.include in-s.s.ile-droplet particle trans.ort,mix.ng,and s.atial s.paration bas.d on particle diameter,along with s.reaming-induced counter-flow virtual channel generation in microfluidic PDMs.*** ex.eriments.emphas.ze the vers.tility and potential applications.of the MAWA as.a microfluidic platform targeted at lab-on-a-chip development and s.owcas. the MAWA’s.compatibility with ex.s.ing microfluidic s.s.ems.

关键词： waveguide fluid cavity