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Pathological findings following radical prostatectomy in patients who are candidates for active surveillance： impact of varying PSA levels

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Asian Journal of Andrology 2011年第6期13卷 838-841页

作者： Dong Il Kang Thomas L. Jang Jeongyun Jeong Eun Young Choi Kelly Johnson Dong Hyeon Lee wun-jae kim Isaac Yi kim Section of Urologic Oncology and Dean and Betty Gallo Prostate Cancer The Cancer Institute of New Jersey Robert Wood Johnson Medical School New Brunswick NJ 08903 USA Department of Urology Inje University Medical School Busan 614-735 Korea Department of Urology Ewha Womans University Seoul 158-710 Korea Department of Urology Chungbuk National University College of Medicine Cheongju 361-711 Korea

Active surveillance is an acceptable treatment option in men with a low-risk prostate cancer. In the present study, we have retrospectively reviewed the outcomes of 509 men who fit the criteria for active surveillance but selected radical prostatectomy. Then, the impact of varying prostate-specific antigen （PSA） levels on the risk of upstaging and upgrading in these patients was assessed. Pathological characteristics of patients who fulfilled the inclusion criteria under three active surveillance criteria--those of the University of California-San Francisco, the National Cancer Institute and the European Association of Urology--were examined. The proportion of men who were deemed candidates for active surveillance but were subsequently upstaged or upgraded was determined. Of 509 patients, 186 （36.5%）, 132 （25.9%） and 88 （17.3%） men fulfilled the active surveillance criteria, respectively. Upgrading （Gleason scores 7-10） ranged from 32.8% to 38.6%, while upstaging （≥ pT3） ranged from 10.2% to 12.5%, depending on the three active surveillance criteria. After a median follow-up of 24 months, three patients developed a biochemical recurrence. When the impact of varying PSA levels was examined using a test for trend analysis in the context of PSA for each protocol, rates of upstaging were lower in men with PSA 〈4 ng m1-1. However, there was no impact of varying PSA levels on upgrading. In conclusion, commonly used active surveillance protocols carry the risks of upgrading and upstaging. More reliable and accurate markers are needed to better stratify the risks of men who are appropriate candidates for active surveillance.

关键词： prostatectomy prostate-specific antigen prostatic neoplasm risk

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Genetic variation of the PSCA gene(rs2294008) is not associated with the risk of prostate cancer

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The Journal of Biomedical Research 2017年第3期31卷 226-231页

作者： II-Seok Lee Sung Pil Seo Yun Sok Ha Pildu Jeong Ho Won Kang Won Tae kim Yong-June kim Seok Joong Yun Sang Cheol Lee wun-jae kim Department of Urology Chungbuk National University College of Medicine Department of Urology School of MedicineKyungpook National University

Prostate stem cell antigen（PSCA） is a cell-membrane glycoprotein consisting of 123 amino acids and highly expressed in the prostate,but there have been few reports on the relationship between rs2294008 of PSCA and prostate cancer in the ***,we evaluated the association between rs2294008 and the risk of prostate cancer.A total of 240 prostate cancer patients and 306 controls（patients with benign prostatic hyperplasia） were *** analysis of rs2294008 of PSCA was performed using *** regression analysis was performed according to the genotype of PSCA *** found that CT and TT genotypes were associated with an insignificant risk of prostate cancer compared with the CC genotype（P= 0.627 and 0.397,respectively）.In addition,there was no significant difference in rs2294008 according to clinicopathological parameters,such as age,Gleason score,prostate-specific antigen（PSA）,stage,and metastasis in prostate cancer（P 〉 0.05 for each）.Age,Gleason score,PSA,pathologic stage,and metastasis did not modify the association between PSCA and the risk of prostate cancer（each P 〉 0.05 for each）.Taken together,the genetic polymorphism of PSCA rs2294008 was not associated with the risk of prostate *** results suggest that rs2294008 may not play a role in prostate carcinogenesis.

关键词： prostatic neoplasms polymorphism genetic risk prostate polymorphism single nucleotide

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Krill oil ameliorates benign prostatic hyperplasia by regulating G1-phase cell cycle arrest and altering signaling pathways and benign prostatic hyperplasia-associated markers

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Food Science and Human Wellness 2024年第6期13卷 3311-3324页

作者： Hoon kim Jongyeob kim Byungdoo Hwang Sang Yong Park Ji-Yeon Shin Eun Byeol Go jae Sil kim Youngjin Roh Soon Chul Myung Seok-Joong Yun Yung Hyun Choi wun-jae kim Sung-Kwon Moon Department of Food and Nutrition Chung-Ang UniversityAnseong 17546Republic of Korea SD Biotechnologies Seoul 07793Republic of Korea Department of Urology College of MedicineChung-Ang UniversitySeoul 06974Republic of Korea Department of Urology Chungbuk National UniversityChungbuk 361-763Republic of Korea Department of Biochemistry College of Oriental MedicineDongeui UniversityBusan 47340Republic of Korea Institute of Urotech CheongjuChungcheongbuk-do 361-763Republic of Korea

Krill oil(KO)exhibits various biological activities,such as anti-inflammatory and antitumor ***,the inhibitory effects of benign prostatic hyperplasia(BPH)in vitro and in vivo have not yet been *** study investigated the anti-BPH effects of KO extracted by an enzymatic hydrolysis *** treatment inhibited the proliferation of WMPY-1 and BPH-1 cells by induction of G0/G1 phase arrest through the modulation of positive and negative regulators in both prostate cell *** treatment stimulated phosphorylation of c-Jun N-terminal kinase(JNK)and p38 *** addition,KO changed the expression of BPH-related markers(5α-reductase,androgen receptor,FGF,Bcl-2,and Bax)and the activity of the proliferation-mediated NF-κB binding ***-induced levels of proliferation-mediated molecules of prostate cells were attenuated in the presence of siRNA-specific p-38(si-p38)and JNK(si-JNK).Furthermore,the administration of KO alleviated prostate size and weight and the cell layer thickness of prostate glands in a testosterone enanthate-induced BPH rat *** treatment altered the level of dihydrotestosterone in serum and the expression levels of BPH-related markers in prostate ***,KO-mediated inhibition of prostatic growth was validated by histological *** results suggest that KO has an inhibitory effect on BPH in prostate cells in vitro and in ***,KO might be a potential prophylactic or therapeutic agent for patients with BPH.

关键词： Proliferation G0/G1-phase cell cycle NF-κB Dihydrotestosterone

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Locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of colon

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Chinese Journal of Cancer Research 2013年第6期25卷 777-780页

作者： Ok-Jun Lee Seok-Joong Yun wun-jae kim Song-Yi Choi Ho-Chang Lee Hyung-Geun Song Sung-Nam Lim Ki-Hyeong Lee Seung-Taik kim Hye-Suk Han Department of Pathology College of MedicineChungbuk National University Department of Urology College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University

Apocrine carcinoma is a rare malignant adnexal neoplasm. The differential diagnosis between apocrine carcinoma and cutaneous metastasis is often difficult. Here, we report a case of locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of the colon. A 75-year-old man with a history of surgical resection due to sigmoid colon cancer and penile metastasis two years prior to this study presented with a nodule at the left penile base. He underwent a wide local resection of the penile mass under a suggested preoperative diagnosis of extra-mammary Paget＇s disease （EMPD） associated with previous sigmoid colon cancer. However, the previously and currently resected penile masses were identified as primary apocrine carcinoma upon hematoxylin and eosin （H＆E） staining and immunohistochemical staining. Although the incidence is extremely rare, both clinicians and pathologists should be alert to the possibility of synchronous double primary apocrine carcinoma in cancer patients with malignant cutaneous lesions.

关键词： Apocrine glands carcinoma colon cancer penis

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Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： jae-Hong kim Ruqayya Afridi Il-Sung Jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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THE ENERGY CONSERVATIONS AND LOWER BOUNDS FOR POSSIBLE SINGULAR SOLUTIONS TO THE 3D INCOMPRESSIBLE MHD EQUATIONS

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Acta Mathematica Scientia 2020年第1期40卷 237-244页

作者： jae-Myoung kim Department of Mathematics Education Andong National University AndongRepublic of Korea

In this note,we give a new proof to the energy conservation for the weak solutions of the incompressible 3D MHD ***,we give the lower bounds for possible singular solutions to the incompressible 3D MHD equations.

关键词： MHD equation lower bounds incompressible

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LOCAL REGULARITY CRITERIA OF A SUITABLE WEAK SOLUTION TO MHD EQUATIONS

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Acta Mathematica Scientia 2017年第4期37卷 1033-1047页

作者： jae-Myoung kim Department of Mathematical Sciences Seoul National UniversitySeoul 08826Republic of Korea

We present a regularity condition of a suitable weak solution to the MHD equations in three dimensional space with slip boundary conditions for a velocity and magnetic vector fields. More precisely, we prove a suitable weak solution are HSlder continuous near boundary provided that the scaled mixed Lx,t^p,q-norm of the velocity vector field with 3/p ＋ 2/q 〈 2, 2 〈 q 〈 ∞ is sufficiently small near the boundary. Also, we will investigate that for this 3 2〈3 solution U ∈ Lx,t^p,q with 1 〈 3＋p ＋2/q＋≤3/2, 3 〈 p 〈 ∞, the Hausdorff dimension of its singular set is no greater than max{p, q}（3/q＋2/q- 1）.

关键词： local regularity criteria suitable weak solution MHD equations

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LOCAL EXISTENCE AND BLOW-UP CRITERION OF 3D IDEAL MAGNETOHYDRODYNAMICS EQUATIONS

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Acta Mathematica Scientia 2018年第6期38卷 1759-1766页

作者： jae-Myoung kim Center for Mathematical Analysis & Computation Yonsei University

We investigate the local existence of smooth solutions of a 3D ideal magneto-hydrodynamics （MHD） equations in a bounded domain and give a blow-up criteria to thisequations with respect to vorticists.

关键词： ideal magnetohydrodynamics equations blow-up criterion bounded domain

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Suppression of laser-induced choroidal neovascularization by intravitreal injection of tristetraprolin

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 952-958页

作者： Yong wun Cho Yong Seop Han In Young Chung Seong jae kim Seong Wook Seo Ji Myong Yoo Jong Moon Park Department of Ophthalmology Gyeongsang National University School of Medicine Gyeongsang Institute of Health Science Gyeongsang National University

AIM: To examine the effect of intravitreal adenoviral vector-mediated tristetraprolin(Ad-TTP) on VEGF m RNA expression in a rat model of laser-induced choroidal ***: Ad-TTP was prepared using a commercial kit. Retinal laser-induced photocoagulation(10 spots per eye) was performed on rats in this experimental choroidal neovascularization(CNV) model. Rats were divided into four groups: control(single intravitreal injection of balanced salt solution, n =10), laser-induced CNV(photocoagulation only, n =20), laser-induced CNV plus Ad-TTP injection(photocoagulation plus a single intravitreal Ad-TTP injection, n =20) and Ad-TTP injection only(n =10). Changes in choroidal morphology were evaluated in ten rats in the laser only and the laser plus Ad-TTP groups. Two weeks after laser injury, the size of CNV was calculated by perfusion with high-molecular-weight fluorescein isothiocyanate(FITC)-dextran. VEGF m RNA expression in retina-choroid tissue from ten rats in each group was measured by reverse transcription polymerase chain reaction(RT-PCR). RESULTS: Two weeks after treatment, the area of laser-induced CNV was reduced by approximately 60% in the rats given the Ad-TTP injection compared with that in the laser-only group. There was a tendency toward decreased VEGF m RNA expression in the Ad-TTP injection ***: A single intravitreal injection of Ad-TTP significantly suppressed CNV size in this experimental laser-induced CNV model. Ad-TTP injection also decreased VEGF m RNA expression compared with that inthe laser-induced CNV group. The present study is meaningful as the first study to investigate the effect of tristetraprolin delivered via intravitreal injection.

关键词： laser-induced choroidal neovascularization tristetraprolin adenoviral vectors

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Supercritical water oxidation for the destruction of toxic organic wastewaters:A review

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Journal of Environmental Sciences 2007年第5期19卷 513-522页

作者： VERIANSYAH Bambang kim jae-Duck Supercritical Fluid Research Laboratory Korea Institute of Science and Technology (KIST)-Department of Green Process and System EngineeringUniversity of Science and Technology (UST)39-1 Hawolgok-dongSeoungbuk-guSeoul 136-791Korea

The destruction of toxic organic wastewaters from munitions demilitarization and complex industrial chemical clearly becomes an overwhelming problem if left to conventional treatment processes. Two options, incineration and supercritical water oxidation （SCWO）, exist for the complete destruction of toxic organic wastewaters. Incinerator has associated problems such as very high cost and public resentment; on the other hand, SCWO has proved to be a very promising method for the treatment of many different wastewaters with extremely efficient organic waste destruction 99.99% with none of the emissions associated with incineration. In this review, the concepts of SCWO, result and present perspectives of application, and industrial status of SCWO are critically examined and discussed.

关键词： supercritical water oxidation toxic wastewater treatment SCWO industrial status

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