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Paleomagnetic constraints on Paleogene-Neogene rotation and paleo-stress in the northern Qaidam Basin

Science China Earth Sciences 2022年第12期65卷 2385-2404页

作者： Ling SUN Junliang JI Bingshuai LI Xingbo LI Wujun WU Kexin ZHANG Hubei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China School of Earth Sciences East China University of TechnologyNanchang 330013China Jiangsu Oilfield Company SinopecYangzhou 225009China Research Institute of Petroleum Exploration and Development-Northwest PetroChinaLanzhou 730020China Institute of Geological Survey China University of GeosciencesWuhan 430074China

Knowing the rotation and paleo-stress history in Qaidam Basin is a fundamental parameter to quantify the mechanism of intracontinental deformation in Tibetan Plateau.However,few studies have been conducted on tectonic rotation and stress evolution over long timescales in the Qaidam Basin.Here,we report new magnetic declination and the anisotropy of magnetic susceptibility(AMS)from a~52–7 Ma sequence of fluvial and lacustrine sediments in the Dahonggou(DHG)section in the northern Qaidam Basin.The magnetic declination revealed that the northern Qaidam Basin underwent a clockwise rotation 25.1°±8.6°during~33–17 Ma,followed by a counterclockwise rotation 16.9°±6.8°during~17–13.5 Ma.The AMS results showed that the“earliest deformation”fabrics were interrupted by the“pencil structure”fabrics in the intervals of~52–45 and~21–15 Ma.The interruption,synchronous with the marked deceleration of the India-Asia convergence rate,indicates pulse of strong tectonic compressive stress.In addition,the AMS results documented a transition in stress direction from S-N to SW-NE at~15 Ma,suggesting a kinematic shift in the northeastern TP.Our constraints on the rotation and stress from the northern Qaidam Basin support the two-stage evolution of the Altyn Tagh Fault(ATF).The fast-rate slip motion on the ATF during the early Oligocene caused the clockwise rotation in the northern Qaidam Basin;the second stage with enhanced thrusting since the middle Miocene caused extensive crustal shortening and dispersive NW-trending folds and faults in the Qaidam Basin and the northeastern TP.

关键词： Tectonic rotation Stress Anisotropy of magnetic susceptibility Paleo-Neogene Northern Qaidam Basin Tibetan Plateau

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Nanozyme-activating prodrug therapies:A review

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Chinese Chemical Letters 2024年第2期35卷 138-150页

作者： Yudong wu wujun Chen Chao Wang Dongming Xing The Affiliated Hospital of Qingdao University Qingdao UniversityQingdao 266071China School of Life Sciences Tsinghua UniversityBeijing 100084China

Enzyme prodrug therapies(EPTs)have been intensively explored as attractive approaches to selective activation of systemically administered benign prodrugs by the exogenous enzymes or enzymes expressed at the desired target site,thus achieving localized,site-specific therapeutic effect.Many effective strategies(e.g.,antibody-,viral-,gene-,as well as polymer-directed EPT)have been developed for enzyme localization to locally activate systemically administered benign prodrugs.Nevertheless,intrinsic limitations(e.g.,complex intracellular environment and catalyst instability)make the practical application of EPT strategies a task that presents itself as highly challenging.As a promising alternative to natural enzyme,nanozyme has attracted substantial attention since its discovery in 2007,mainly due to the advantages of robust catalytic activity,high stability,low cost,and facile synthesis.Recently,nanozyme-activated prodrug strategies bring a new opportunity for targeted therapy,referred to as nanozyme-activating prodrug therapies.This review focuses on recently reported nanozyme-activated prodrug strategies,aiming to provide some new insights into the potential applications in site-specific drug synthesis.

关键词： Enzyme prodrug therapy Nanozyme Prodrug activation Chemotherapy Drug synthesis

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Advances and challenges in using nirmatrelvir and its derivatives against SARS-CoV-2 infection

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Journal of Pharmaceutical Analysis 2023年第3期13卷 255-261页

作者： wujun Chen Bing Liang Xiaolin wu Ling Li Chao Wang Dongming Xing Cancer Institute Department of OrthopedicsThe Affiliated Hospital of Qingdao UniversityQingdaoShandong266071China Qingdao Cancer Institute Qingdao UniversityQingdaoShandong266071China Department of Pharmacy The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiGuangdong519000China School of Life Sciences Tsinghua UniversityBeijing100084China

On December 22,2021,the United States Food and Drug Administration approved the first main protease inhibitor,i.e.,oral antiviral nirmatrelvir(PF-07321332)/ritonavir(Paxlovid),for the treatment of early severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Nirmatrelvir inhibits SARSCoV-2 infection,but high doses or long-term treatment may cause embryonic developmental toxicity and changes in host gene expression.The chiral structure of nirmatrelvir plays a key role in its antiviral activity.Ritonavir boosts the efficacy of nirmatrelvir by inactivating cytochrome P4503A4 expression and occupying the plasma protein binding sites.Multidrug resistance protein 1 inhibitors may increase the efficacy of nirmatrelvir.However,Paxlovid has many contraindications.Some patients treated with Paxlovid experience a second round of coronavirus disease 2019(COVID-19)symptoms soon after recovery.Interestingly,the antiviral activity of nirmatrelvir metabolites,such as compounds 12e18,is similar to or higher than that of nirmatrelvir.Herein,we review the advances and challenges in using nirmatrelvir and its derivatives with the aim of providing knowledge for drug developers and physicians in the fight against COVID-19.

关键词： Nirmatrelvir Pharmacology Pharmacokinetics Toxicology Derivatives COVID-19

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Conversion Margins for the Major Uses of Agricultural Land and Their Variations in Shandong Province, China

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Chinese Journal of Population,Resources and Environment 2011年第1期9卷 55-62页

作者： Wang Xingjie Gu Shuzhong Zhang Xinhua wu Hong Zhou Hong Wen wujun Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Institute of Resources and Environmental Polices Development Research Center of the State Council Beijing 100010 China Research Center for Sustainable Development of Shandong Province Jinan Shandong 250014 China

It is of practical significance for the decision-making on country food security and farmland protection to analyze the conversion margins for the major uses of agricultural land and their variations. Based on the panel data of wheat, corn, vegetable, fruit, and forests productions from 520 investigated farmer households of 13 investigated villages in Shandong Province from 2003 to 2009, and using Cobb-Douglas production function, the revenue conversion margins can be obtained separately, between different grain-crops (wheat, corn) and different non-grain crops (vegetable, fruit, forests), and the conversion relationship between growing grain( wheat, corn) and going out for non-farm work. The results show that from 2003 to 2009, growing wheat and corn are more economically and reasonably for farmers, compared with growing vegetable, but growing wheat and corn are becoming less economically and less reasonably day by day, compared with planting forests. Moreover, the conversion margin between wheat and fruit shows obvious scissors difference. Just from 2007, farmers' growing fruit became economically and reasonably, but until 2009, compared with going out to work after abandoning farm8land, growing wheat had no economic rationality. From 2003 to 2009, farmers' growing corn is more profitable than growing fruit and going out for non-farm work after abandoning farmland. The subsidies for wheat and corn have increased farmers' comparative income from food production remarkably, but the subsidies cannot change the general tendency that farmers transform food (wheat, corn) production into non-food (especially forests) production. The revenue difference between growing wheat, corn and vegetable and growing fruit and forests is being pulled ceaselessly bigger, and the tendency that farmers transform wheat, corn and vegetable growing lands into fruit and forests growing lands has become increasingly apparent.

关键词：山东省用途空间蔬菜种植农民收入农地中国国家粮食安全

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巧用海媒直播促进中外民心相通——重庆国际传播中心“重庆@国际友城”海外直播案例分析

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公共外交季刊 2022年第2期 85-90,129页

作者：赵吾君陈冬艳吴晓重庆国际传播中心

新冠肺炎疫情的出现,给国际人文交流带来了新的挑战,重庆国际传播中心对此进行了积极的探索,实践出以海外直播促进国际人文交流的路径:发起“重庆@国际友城”活动,在海外社交媒体平台上,邀请重庆的国际城市进行双城联合直播,为中国与海... 详细信息

新冠肺炎疫情的出现,给国际人文交流带来了新的挑战,重庆国际传播中心对此进行了积极的探索,实践出以海外直播促进国际人文交流的路径:发起“重庆@国际友城”活动,在海外社交媒体平台上,邀请重庆的国际城市进行双城联合直播,为中国与海外网友搭建起一座“友谊云桥”。通过活用平台与工具、团结知华友华人士以及创造共同话语空间等方式,突破疫情阻隔,促进民心相通,“重庆@国际友城”活动的成功举办对我国同其他国家进行国际人文交流具有重要的借鉴作用和启发意义。

关键词：话语空间人文交流民心相通案例分析直播新的挑战海外社交媒体成功举办

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页岩气储层总孔隙度与有效孔隙度测量及测井评价——以四川盆地龙马溪组页岩气储层为例

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石油与天然气地质 2017年第3期38卷 602-609页

作者：李军武清钊路菁金武军中国石化石油勘探开发研究院北京100083 页岩油气富集机理与有效开发国家重点实验室北京100083

在地层束缚水条件下,对页岩气储层有效孔隙度理解及测量方法尚无统一标准,由此造成同一样品的孔隙度测量结果显著差异,给储层评价带来困难。对来自四川盆地龙马溪组页岩气储层的平行岩心样品分别依据GRI和SY/T 5336—2006标准进行总孔... 详细信息

在地层束缚水条件下,对页岩气储层有效孔隙度理解及测量方法尚无统一标准,由此造成同一样品的孔隙度测量结果显著差异,给储层评价带来困难。对来自四川盆地龙马溪组页岩气储层的平行岩心样品分别依据GRI和SY/T 5336—2006标准进行总孔隙度和有效孔隙度测量,并配套进行岩矿组分、粘土组分和有机碳含量(TOC)测量。通过实验数据分析认为,页岩气储层总孔隙度和有效孔隙度测量结果两者相差1~3倍,造成差异的根本原因是对与粘土有关的束缚水体积不同的处理方式;页岩气储层中充气孔隙度与TOC呈高度正相关关系,相关系数达到0.9以上,表明有机孔隙是页岩气储层中有效孔隙的主要贡献者;束缚水孔隙与粘土矿物含量呈现良好正相关关系,表明与粘土有关的微细孔隙被束缚水占据,为无效孔隙。基于上述认识,构建了有效孔隙定量关系。同时,基于干粘土体积模型建立了总孔隙度评价方法,利用测井资料确定了实际地层的总孔隙度和有效孔隙度。应用表明,测井评价结果与不同实验室测定的总孔隙度和有效孔隙度吻合较好。

关键词：总孔隙度有效孔隙度测井页岩气龙马溪组四川盆地

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多糖类抗血栓药物舒洛地特与低分子肝素的多方位比较分析

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中国药事 2023年第7期37卷 817-824页

作者：吴朝阳李湛军董武军中国食品药品检定研究院北京102629 国家药品监督管理局药品审评中心北京100022

目的:舒洛地特与低分子肝素都是多糖类抗血栓药物,多方位比较二者的异同,对监管提出建议。方法:从构效关系入手,探讨质控基本要求,对作用机理、临床应用、不良反应等多方位进行全面梳理并比较二者的抗凝、抗血栓强度及临床应用价值。结... 详细信息

目的:舒洛地特与低分子肝素都是多糖类抗血栓药物,多方位比较二者的异同,对监管提出建议。方法:从构效关系入手,探讨质控基本要求,对作用机理、临床应用、不良反应等多方位进行全面梳理并比较二者的抗凝、抗血栓强度及临床应用价值。结果与结论:舒洛地特与低分子肝素作为抗血栓药物,二者抗血栓作用相当,抗凝作用舒洛地特比低分子肝素强,并且无出血风险。由于多组分多糖类药物质量控制难度较大,本文提出对原料药和制剂的监管需要从起始物料源头开始,参照生物类似药进行生产全过程质量控制,以保证多糖类药物的质量稳定、安全有效。

关键词：舒洛地特低分子肝素抗凝抗血栓质量控制

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舒洛地特老药新用在治疗新型冠状病毒肺炎中的作用

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世界临床药物 2023年第8期44卷 865-870,890页

作者：吴朝阳李湛军董武军中国食品药品检定研究院北京102629 国家药品监督管理局药品审评中心北京100022

舒洛地特(sulodexide)作为抗血栓药物有超过50年的临床用药历史。该文主要综述舒洛地特保护血管内皮、抗血栓和抗炎的作用机制及其临床应用,探讨舒洛地特在新型冠状病毒肺炎(corona virus disease 2019,COVID-19)治疗中的作用和理论依据... 详细信息

舒洛地特(sulodexide)作为抗血栓药物有超过50年的临床用药历史。该文主要综述舒洛地特保护血管内皮、抗血栓和抗炎的作用机制及其临床应用,探讨舒洛地特在新型冠状病毒肺炎(corona virus disease 2019,COVID-19)治疗中的作用和理论依据,并对其用于COVID-19临床研究的初步结果作总结。舒洛地特已被国际血栓和止血学会纳入最新治疗COVID-19指南,由于其具有保护血管内皮、抗炎等独特药理作用和优势,故在抗击COVID-19中发挥重要作用。

关键词：舒洛地特糖萼血管内皮抗炎抗血栓新型冠状病毒肺炎

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基于Kinect深度图像的三维重建

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微型机与应用 2016年第5期35卷 54-57页

作者：李务军吴斌西南科技大学信息工程学院四川绵阳621000

随着机器视觉理论的发展和硬件技术的进步,三维重建在生产、生活中的应用越来越广泛,基于Kinect传感器的三维重建得到广泛的应用。针对于现有的Kinect传感器获得的深度图像深度信息丢失的问题,提出了一种新的基于均值滤波的方法对深度... 详细信息

随着机器视觉理论的发展和硬件技术的进步,三维重建在生产、生活中的应用越来越广泛,基于Kinect传感器的三维重建得到广泛的应用。针对于现有的Kinect传感器获得的深度图像深度信息丢失的问题,提出了一种新的基于均值滤波的方法对深度图像进行去噪,并对深度图像进行预处理,获取三维点云,用迭代最近点(Iterative Closest Point,ICP)算法完成点云的精确配准,从而得到配准后物体表面三维点云,并完成物体的三维重建。

关键词： Kinect传感器点云配准 ICP算法三维重建

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Flavonoids from Leaves of Heritiera littoralis D.

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Journal of Chinese Pharmaceutical Sciences 2004年第3期13卷 214-216页

作者： TIANYan wujun ZHANGSi GuangdongKeyLaboratoryofMarineMateriaMedica SouthChinaSeaInstituteofOceanologyChineseAcademyofSciencesCuangzhou510301China

The mangrove plant Heritiera littoralis D. (Sterculi-aceae) is widely distributed in southeastern Asia and traditionally used as a fish, arrowhead, and spearhead poison. It has also been used as a folk medicine to treat hematuria and diarrhea for a long history in China. Past investigations on the chemical constituents of this plant have yielded four triterpenes, five sesquiterpenes, a

关键词：银叶素类黄铜树叶血尿

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