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Journal of Traditional Chinese Medicine 2024年第3期44卷 478-488页

作者： chu Mengzhen WANG Yu LIN Zhijian Lyu Jintao ZHANG Xiaomeng ZHANG Bing Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 102488China

OBJECTIVE: To explore the pharmacodynamic effects and potential mechanisms of Shuangling extract against ulcerative colitis(UC). METHODS: The bioinformatics method was used to predict the active ingredients and action targets of Shuangling extract against UC in mice. And the biological experiments such as serum biochemical indexes and histopathological staining were used to verify the pharmacological effect and mechanism of Shuangling extract against UC in mice. RESULTS: The Shuangling extract reduced the levels of seruminterleukin-1β(IL-1β), tumor necrosis factor-α(TNF-N), interleukin-6(IL-6) and other inflammatory factors in UC mice and inhibited the inflammatory response. AKT Serine/threonine Kinase 1 and IL-6 may be the main targets of the anti-UC action of Shuangling extract, and the TNF signaling pathway, Forkhead box O signaling pathway and T-cell receptor signaling pathway may be the main signaling pathways. CONCLUSION: The Shuangling extract could inhibit the inflammatory response induced by UC and regulate intestinal immune function through multiple targets and multiple channels, which provided a new option and theoretical basis for anti-UC.

关键词： colitis ulcerative pharmacodynamic study network pharmacology molecular docking simulation Shuangling extract

Real-Time Co-optimization of Gear Shifting and Engine Torque for Predictive Cruise Control of Heavy-Duty Trucks

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 294-317页

作者： Hongqing chu Xiaoxiang Na Huan Liu Yuhai Wang Zhuo Yang Lin Zhang Hong Chen School of Automotive Studies Tongji UniversityShanghaiChina Department of Engineering University of CambridgeCambridgeUK State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchunChina Qingdao Automotive Research Institute Jilin UniversityQingdaoChina Dongfeng Commercial Vehicle Technology Center Dongfeng Motor CorporationWuhanChina

Fuel consumption is one of the main concerns for heavy-duty *** cruise control(PCC)provides an intriguing opportunity to reduce fuel consumption by using the upcoming road *** this study,a real-time implementable PCC,which simultaneously optimizes engine torque and gear shifting,is proposed for heavy-duty *** minimize fuel consumption,the problem of the PCC is formulated as a nonlinear model predictive control(MPC),in which the upcoming road elevation information is *** the solution of the nonlinear MPC is time consuming;thus,a real-time implementable solver is developed based on Pontryagin’s maximum principle and indirect shooting *** programming(DP)algorithm,as a global optimization algorithm,is used as a performance benchmark for the proposed ***,hardware-in-the-loop and real-truck experiments are conducted to verify the performance of the proposed *** results demonstrate that the MPC-based solution performs nearly as well as the DP-based solution,with less than 1%deviation for testing ***,the proposed co-optimization controller is implementable in a real-truck,and the proposed MPC-based PCC algorithm achieves a fuel-saving rate of 7.9%without compromising the truck’s travel time.

关键词： Heavy-duty truck Predictive cruise control Model predictive control Pontryagin’s maximum principle Real-truck implementation

Solid-state NMR studies of proteins in condensed phases

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Magnetic Resonance Letters 2024年第3期4卷 1-10页

作者： Jiani Xiang Xialian Wu Angelo L.chu Junxia Lu Key Laboratory of Industrial Fermentation(Ministry of Education) School of Life and Health SciencesHubei University of TechnologyWuhan430068China Interdisciplinary Institute of NMR and Molecular Sciences School of Chemistry and Chemical EngineeringThe State Key Laboratory of Refractories and MetallurgyWuhan University of Science and TechnologyWuhan430081China Thomas Jefferson High School for Science and Technology 6560 Braddock RdAlexandriaVA22312USA

Some proteins perform their biological functions by changing their material states through liquid-liquid phase *** phase separation,the protein condenses into a concentrated liquid phase and sometimes into a gel phase,changing its dynamic properties and intermolecular interactions,thereby regulating cellular *** the biological significance of this phenomenon has been widely recognized by researchers,there is still a lack of a comprehensive understanding of the structural and dynamic properties of the protein in the condensed *** this phase,molecules usually contain domains with varied dynamic properties and undergo intermediate *** angle spinning(MAS)solid-state NMR(SSNMR)experiments are very powerful in studying rigid protein polymers such as *** incorporation of solution-like experiments into SSNMR and the development of J-coupling based MAS SSNMR techniques extend its ability to study partially mobile segments of proteins in a condensed liquid or gel phase which are not visible by solution NMR or dipolar-coupling based ***,it has been applied in studying protein condensation and has provided very important information that is hard to obtain by other techniques.

关键词： Magic angle spinning(MAS)solid-state NMR(SSNMR) Protein condenses J-coupling based MAS SSNMR Liquid-liquid phase separation

River width and depth as key factors of diurnal activity energy expenditure allocation for wintering Spot-billed Ducks in the Xin'an River Basin

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Avian Research 2024年第1期15卷 116-122页

作者： Chao Yu Xuying Lu Deli Sun Mengnan chu Xueyun Li Qun Li College of Life and Environmental Sciences Huangshan UniversityHuangshan245021China Environment Conservation Research Centre of Xin’an River Basin Huangshan UniversityHuangshan 245021China Department of Resources Conservation Southern Anhui National Wildlife Rescue CenterXiuning 245400China

Rivers are important habitats for wintering ***,they are easily influenced by natural and human *** important approach for waterbirds to adapt to habitats is adjusting the activity time and energy expenditure allocation of diurnal *** compensatory foraging hypothesis predicts that increased energy expenditure leads to longer foraging time,which in turn increases food intake and helps maintain a constant energy ***,it is unclear whether human-disturbed habitats result in increased energy expenditure related to safety or *** this study,the scan sample method was used to observe the diurnal behavior of the wintering Spot-billed Duck(Anas poecilorhyncha) in two rivers in the Xin’an River Basin from October 2021 to March *** allocation of time and energy expenditure for activity in both normal and disturbed environments was *** results showed that foraging accounted for the highest percentage of time and energy ***,foraging decreased in the disturbed environment than that in the normal *** behavior showed the opposite trend,while other behaviors were similar in both *** total diurnal energy expenditure of ducks in the disturbed environment was greater than that in the normal environment,with decreased foraging and resting time percentage and increased behaviors related to immediate safety(swimming and alert) and *** results oppose the compensatory foraging hypothesis in favor of increased *** optimal diurnal energy expenditure model included river width and water depth,which had a positive relationship;an increase in either of these two factors resulted in an increase in energy *** study provides a better understanding of energy allocation strategies underlying the superficial time allocation of wintering waterbirds according to environmental *** these changes can help understand the maximum fitness of wi

关键词： Diurnal behavior activities River factors Time and energy expenditure allocation Wintering Spot-billed Duck Xin’an River Basin

Numerical investigation of geostress influence on the grouting reinforcement effectiveness of tunnel surrounding rock mass in fault fracture zones

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 81-101页

作者： Xiangyu Xu Zhijun Wu Lei Weng Zhaofei chu Quansheng Liu Yuan Zhou The Key Laboratory of Safety for Geotechnical and Structural Engineering of Hubei Province School of Civil EngineeringWuhan UniversityWuhan430072China Wuhan University Shenzhen Research Institute Shenzhen518057China State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan430072China Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhan430071China

Grouting is a widely used approach to reinforce broken surrounding rock mass during the construction of underground tunnels in fault fracture zones,and its reinforcement effectiveness is highly affected by *** this study,a numerical manifold method(NMM)based simulator has been developed to examine the impact of geostress conditions on grouting reinforcement during tunnel *** develop this simulator,a detection technique for identifying slurry migration channels and an improved fluid-solid coupling(FeS)framework,which considers the influence of fracture properties and geostress states,is developed and incorporated into a zero-thickness cohesive element(ZE)based NMM(Co-NMM)for simulating tunnel ***,to simulate coagulation of injected slurry,a bonding repair algorithm is further proposed based on the ZE *** verify the accuracy of the proposed simulator,a series of simulations about slurry migration in single fractures and fracture networks are numerically reproduced,and the results align well with analytical and laboratory test ***,these numerical results show that neglecting the influence of geostress condition can lead to a serious over-estimation of slurry migration range and reinforcement *** validations,a series of simulations about tunnel grouting reinforcement and tunnel excavation in fault fracture zones with varying fracture densities under different geostress conditions are *** on these simula-tions,the influence of geostress conditions and the optimization of grouting schemes are discussed.

关键词： Numerical manifold method(NMM) Grouting reinforcement Geostress condition Fault fracture zone Tunnel excavation

An Active Deception Defense Model Based on Address Mutation and Fingerprint Camouflage

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China Communications 2024年第7期21卷 212-223页

作者： Wang Shuo chu Jiang Pei Qingqi Shao Feng Yuan Shuai Zhong Xiaoge State Key Laboratory of Astronautic Dynamics Xi’an Satellite Control CenterXi’an 710043China State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an 710071China Shaanxi Key Laboratory of Blockchain and Secure Computing Xidian UniversityXi’an 710071China

The static and predictable characteristics of cyber systems give attackers an asymmetric advantage in gathering useful information and launching *** reverse this asymmetric advantage,a new defense idea,called Moving Target Defense(MTD),has been proposed to provide additional selectable measures to complement traditional ***,MTD is unable to defeat the sophisticated attacker with fingerprint tracking *** overcome this limitation,we go one step beyond and show that the combination of MTD and Deception-based Cyber Defense(DCD)can achieve higher performance than either of *** particular,we first introduce and formalize a novel attacker model named Scan and Foothold Attack(SFA)based on cyber kill ***,we develop probabilistic models for SFA defenses to provide a deeper analysis of the theoretical effect under different defense *** models quantify attack success probability and the probability that the attacker will be deceived under various conditions,such as the size of address space,and the number of hosts,attack analysis ***,the experimental results show that the actual defense effect of each strategy almost perfectly follows its probabilistic ***,the defense strategy of combining address mutation and fingerprint camouflage can achieve a better defense effect than the single address mutation.

关键词： address mutation deception defense fingerprint camouflage moving target defense probabilistic model

A data-driven approach to RUL prediction of tools

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Advances in Manufacturing 2024年第1期12卷 6-18页

作者： Wei Li Liang-Chi Zhang chu-Han Wu Yan Wang Zhen-Xiang Cui Chao Niu Department of Mechanical Engineering University College LondonLondonWC1E 7JEUK Shenzhen Key Laboratory of Cross-Scale Manufacturing Mechanics Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China SUSTech Institute for Manufacturing Innovation Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen518055GuangdongPeople’s Republic of China School of Mechanical and Manufacturing Engineering The University of New South WalesKensingtonNSW2052Australia Baoshan Iron&Steel Co. Ltd.Shanghai200941People’s Republic of China

An effective and reliable prediction of the remaining useful life(RUL)of a tool is important to a metal forming process because it can significantly reduce unexpected maintenance,avoid machine shutdowns and increase system *** study proposes a new data-driven approach to the RUL prediction for metal forming processes under multiple contact sliding *** data-driven approach took advantage of bidirectional long short-term memory(BLSTM)and convolutional neural networks(CNN).A pre-trained lightweight CNN-based network,WearNet,was re-trained to classify the wear states of workpiece surfaces with a high accuracy,then the classification results were passed into a BLSTM-based regression model as inputs for RUL *** experimental results demonstrated that this approach was able to predict the RUL values with a small error(below 5%)and a low root mean square error(RMSE)(around 1.5),which was more superior and robust than the other state-of-the-art methods.

关键词： Remaining useful life(RUL) Bidirectional long short-term memory(BLSTM) Data-driven approach Metal forming

Alloy strategy to synthesize Pt-early transition metal oxide interfacial catalysts

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Nano Research 2024年第4期17卷 3390-3397页

作者： Shi-Long Xu Hang Nan Wanqun Zhang Yue Lin Sheng-Qi chu Hai-Wei Liang Hefei National Research Center for Physical Sciences at the Microscale Department of ChemistryUniversity of Science and Technology of ChinaHefei 230026China School of Materials and Chemical Engineering Anhui Jianzhu UniversityHefei 230601China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Metal oxide supported metal catalysts show promising catalytic performance in many industry-relevant ***,the enhancement of performance is often limited by the insufficient metal/metal oxide *** this work,we demonstrate a general synthesis of Pt-early transition metal oxide(Pt-MO_(x),M=Ti,Zr,V,and Y)catalysts with rich interfacial sites,which is based on the air-induced surface segregation and oxidation of M in the supported Pt-M alloy *** characterizations verify the dynamic structural response of Pt-M alloy catalysts to air and the formation of Pt-MO_(x) catalysts with abundant interfacial *** prepared Pt-TiO_(x) interfacial catalysts exhibit improved performance in hydrogenation reactions of benzaldehyde,nitrobenzene,styrene,and furfural,as a result of the heterolytic dissociation of H_(2) at Pt-metal oxide interfacial sites.

关键词： Pt-early transition metal oxide interfacial catalyst alloy oxidation strategy interfacial sites hydrogenation reactions heterolytic dissociation

Printable oil-NiO_(X)hole transport layer enables efficient n-i-p perovskite solar cells with a high thermal stability

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Science China Chemistry 2024年第7期67卷 2335-2340页

作者： Yazhou Xu Zhaoyang chu Hongyu Wang Zhi Xing Baojin Fan Xiaotian Hu Yiwang Chen College of Chemistry and Chemical Engineering/Institute of Polymers and Energy Chemistry(IPEC)/Film Energy Chemistry for Jiangxi Provincial Key Laboratory(FEC) Nanchang UniversityNanchang 330031China Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal University Nanchang 330022China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China

Currently,highly efficient n-i-p perovskite solar cells rely on an organic interface layer for high efficiency,especially 2,2',7,7'-tetrakis[N,N-bis(4-methoxyphenyl)ami-no]-9,9′-spirobifluorene(spiro-OMeTAD),but the instability of organic materials in the photothermal field compromises device *** this study,we employ the oleic acid(YS)/oleamine(YA)end-sealing method to achieve uniform dispersion of NiO_(X)nanoparticles,effectively mitigating coagulation resulting from high local concentration and secondary motion ***,the conductivity of the hole transport layer and its energy level alignment with perovskite is enhanced by the additional 2,3,5,6-tetrafluoro-7,7',8,8'-tetracyanodimethyl-p-benzoquinone(F4TCNQ),leading to a remarkable improvement of open-circuit voltage and fill factor,thus the high efficiency of 25.17%and 24.36%on 0.1 and 1.01cm2,***,by realizing an all-inorganic interface layer,an initial efficiency exceeding 90%is maintained even after 2,800 h of heating at 85℃.

关键词： oil-NiO_(X) perovskite solar cells printing technology high efficiency thermal stability

Research on vibration energy harvesting technology of power equipment based on alternating magnet array

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High Voltage 2024年第2期9卷 336-345页

作者： Pinlei Lv Chengyu Fan Aijun Yang Huan Yuan Jifeng chu Mingzhe Rong Xiaohua Wang State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong UniversityXi'anChina State Grid Sichuan Electric Power Research Institute ChengduChina

Vibration with a frequency of 100 Hz is widely distributed in the power equipment,and it can provide a new way to supply energy for sensors by vibration energy *** vibration energy harvesting method based on electromagnetic induction principle was studied through the arrayed structure of magnets and *** magnetic field models were established for four magnet array structures and it was found that the alternating magnet array has the largest magnetic flux and magnetic flux *** on the alternating magnet array,prototypes of energy harvester with vertical and parallel movement mode were *** structural parameter optimisation analysis,two different energy harvesters were fabricated and it was found that the energy harvester with a parallel movement mode has better output *** energy harvester could provide output voltage/current and power of 8.35 V/17.39 mA and 15.13 mW(matched resistance is 200Ω)at an acceleration of 5 m⋅s^(-2).The 100 mF capacitor could be charged to 2.72 V within 300 s,and the final voltage of the capacitor is greater than 3 V,which could sustainably drive commercial wireless temperature/humidity sensors.

关键词： power energy alternating