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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-Ning Yu hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

含孔洞CoCrNiFeCu高熵合金纳米压入的分子动力学模拟

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原子与分子物理学报 2025年第3期42卷 141-148页

作者：史银花施琴江苏联合职业技术学院镇江分院镇江212016

高熵合金具有优异的力学性能、耐磨耐蚀耐高温等性能,成为未来最有发展潜力的新型材料之一.因此,本文通过分子动力学模拟的方法探究了孔洞对CoCrNiFeCu高熵合金模型纳米压痕力学性能和位错演化的影响.结果表明,屈服点、载荷、杨氏模量... 详细信息

高熵合金具有优异的力学性能、耐磨耐蚀耐高温等性能,成为未来最有发展潜力的新型材料之一.因此,本文通过分子动力学模拟的方法探究了孔洞对CoCrNiFeCu高熵合金模型纳米压痕力学性能和位错演化的影响.结果表明,屈服点、载荷、杨氏模量和硬度等力学参数随着孔洞深度D的增加呈现先增加后稳定的趋势.孔洞的存在显著影响了位错形核的位置,随着孔洞深度的增加,初始位错优先在孔洞与表面之间形成,随后集中在模型表面形成,且位错环由平面圆环状转变为“翼状”.在孔洞深度较小时(D<40A),位错环沿(110)面水平扩展,随着孔洞深度的增加,位错环开始向下扩展.此外,在压痕深度为30?时,位错密度随着孔洞深度的增加逐渐增加.

关键词： CoCrNiFeCu 分子动力学纳米压入力学性能位错演变

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Erosion Resistance Behaviours of H13 Steel to Molten ADC12 Alloy

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材料热处理学报 2004年第5期25卷 239-243页

作者： MINYong-an XULuo-ping wuxiao-chun LILin WANGRong SchoolofmaterialsscienceandEngineering ShanghaiUniversityShanghaiChina

H13 hot work steel samples and surface water vapor oxidized H13 samples were immersed into molten ADC 12 alloy under static resting or dynamic rotating conditions. Weigh-losing method was used to discover the influences of temperature, time and surface conditions on the erosion resistance of H13 steel. The interfaces between the steel and the molten alloy were studied with optical microscopy to compare the different erosion resistance behaviours. The results show that the composite layer outside of the compounds layers changes obviously with increasing temperature, lasting time or sample movement. The better erosion resistance of H13 steel can be endowed with the oxide films, which would gradually decrease along with the dissolve of the films.

关键词：抗腐蚀性氧化薄膜热锻模具钢铝合金

Inflammation-based Glasgow prognostic score as an independent prognostic factor in patients with angioimmunoblastic T-cell lymphoma

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Chinese Medical Journal 2021年第5期134卷 579-581页

作者： Guan-Jun Chen Zhi-Jun wuxiao Yang Liang Chun Li Bi-Bo Fu hua Wang Department of Hematological Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Department of Hematologic Oncology The First Affiliated HospitalHainan Medical UniversityHaikouHainan 570102China

Angioimmunoblastic T-cell lymphoma(AITL)is an aggressive form of peripheral T-cell lymphoma(PIT)associated with poor *** is characterized by lymph node enlargement,B symptoms(unexplained recurrent fevers(often above 38℃),night sweats,and unexplained weight loss of more than 10%within 6 months),polyclonal hypergammaglobulinemia,and autoimmune hemolysis.[1] C-reactive protein(CRP)synthesized by hepatocytes is an acute-phase protein and an important marker of systemic *** CRP level is not only an independent prognostic factor in Hodgkin lymphoma but also an important independent predictor of AITL.

关键词： lymphoma Glasgow blastic

可控核聚变技术的生成:能源约束、能源伦理与能源革命

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中国矿业大学学报（社会科学版） 2025年第1期27卷 112-127页

作者：杨华同济大学人文学院、科研管理部

由于传统能源使用的困境和气候变化的威胁,人类社会加大了寻求有效解决能源危机的努力。但是,光伏、风电等新能源和新一代核裂变能源由于各自的技术及资源风险,有着极大的不确定性,难以成为能源转型的核心角色。可控核聚变技术经过了几... 详细信息

由于传统能源使用的困境和气候变化的威胁,人类社会加大了寻求有效解决能源危机的努力。但是,光伏、风电等新能源和新一代核裂变能源由于各自的技术及资源风险,有着极大的不确定性,难以成为能源转型的核心角色。可控核聚变技术经过了几十年的发展,虽然目前仍面临诸多困难,但业已取得若干阶段性成功,已经看到实现技术突破的曙光。可控核聚变技术能量密度高,资源广泛易得,拥有安全性、永续性和环境友好性等诸多潜在益处,是破解人类发展能源瓶颈的颠覆性技术。不过,科学技术是一把双刃剑,可控核聚变技术在力图解决能源供给问题的同时,也可能带来一系列新问题,比如引发新一轮能源技术竞赛、产生新的能源霸权等。由于能源在人类生存与发展中的基础性地位,从能源伦理的角度对可控核聚变技术产生的影响与风险进行前瞻性研判和哲学反思是至关重要的。可控核聚变的成功将动摇“能源的稀缺性原则”,挑战现有能源现实主义,部分消解能源生态末日论的核心观点,将对传统能源哲学产生革命性影响。

关键词：可控核聚变聚变能源能源哲学能源伦理技术创新

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu Yi-hua Wang Yi-Xin Liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

基于英语学习活动观的初中英语多模态阅读教学实践——以Unit 13 Section B 2b Rethink,Reuse,Recycle!为例

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英语教师 2025年第1期 121-125页

作者：杨桦广东省东莞市可园中学广东东莞523000

阐述指向英语学习活动观的英语多模态阅读教学的内涵和特点。以人教版新目标初中《英语》九年级Unit 13 Section B 2b Rethink,Reuse,Recycle!为例,探索在英语学习活动观的基础上,如何以梳理阅读主题线索、实现多项技能整合、构建关联... 详细信息

阐述指向英语学习活动观的英语多模态阅读教学的内涵和特点。以人教版新目标初中《英语》九年级Unit 13 Section B 2b Rethink,Reuse,Recycle!为例,探索在英语学习活动观的基础上,如何以梳理阅读主题线索、实现多项技能整合、构建关联意识、进行情境模拟迁移和收集数据评估为手段,开展一系列综合性、关联性、实用性的多模态阅读教学,以提升学生的英语学科核心素养,真正达到学科育人的教学目标。

关键词：英语学习活动观初中英语多模态阅读教学

小儿豉翘清热颗粒联合利巴韦林治疗小儿疱疹性咽峡炎临床效果观察

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罕少疾病杂志 2025年第1期32卷 47-48,51页

作者：邵华郑州大学附属儿童医院河南省儿童医院郑州儿童医院药学部河南郑州450000

目的分析对小儿疱疹性咽峡炎患儿实施利巴韦林、小儿豉翘清热颗粒联合治疗的效果和价值。方法收集本院在2021年6月至2023年3月期间就诊的75例小儿疱疹性咽峡炎患儿的临床资料,使用电脑随机分组原则对75例患儿进行分组,其中参照组(37例... 详细信息

目的分析对小儿疱疹性咽峡炎患儿实施利巴韦林、小儿豉翘清热颗粒联合治疗的效果和价值。方法收集本院在2021年6月至2023年3月期间就诊的75例小儿疱疹性咽峡炎患儿的临床资料,使用电脑随机分组原则对75例患儿进行分组,其中参照组(37例)患儿实施利巴韦林治疗,治疗组(38例)患儿加用小儿豉翘清热颗粒干预,对比两组小儿的治疗效果。结果治疗组患儿治疗后的症状缓解时间短于参照组患儿(P<0.05),差异具有统计学意义;治疗组干预后的白细胞计数、C反应蛋白、降钙素原低于参照组(P<0.05),差异具有统计学意义;治疗组患儿的IgG、IgA、治疗优良率高于参照组患儿(P<0.05),差异具有统计学意义。结论儿科治疗小儿疱疹性咽峡炎中使用小儿豉翘清热颗粒联合利巴韦林治疗的效果十分显著,不仅能在短时间内缓解患儿的症状,还能纠正机体炎症状态,缩短患儿的病程时间,改善患儿预后。

关键词：小儿疱疹性咽峡炎利巴韦林小儿豉翘清热颗粒治疗优良率

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Distribution and Virulence Diversity of Phytophthora sojae in China

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Agricultural Sciences in China 2004年第2期3卷 116-123页

作者： ZHUZhen-dong WANGhua-bo WANGXiao-ming CHANGRu-zhen wuxiao-fei InstituteofCropGermplasmResources ChineseAcademyofAgriculturalSciencesBeijing100081P.R.China

By investigating occurrence of Phytophthora root rot in fields and isolating *** fromdiseased plants and soils, the distribution of *** in China was surveyed. In addition tonortheast region, *** existed in huanghe-huaihe basin and Yangtze basin too. Eighty- threeisolates of *** isolated from different areas were identified on virulence using 13differential soybean cultivars, abundant virulence diversity was found in ***. The greaterdiversity in virulence of *** was in isolates from soil than from plants. And the greatestvirulence diversity of *** was found in Yangtze basin.

关键词： Soybean Phytophthora sojae Phytophthora root rot Virulence diversity