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Cancer Communications 2021年第3期41卷 279-283页

作者： wu-tong ju Ying Liu Li-zhen Wang Jiang Li Guo-xing Ren Jian Sun Wen-yong Tu Yong-jie Hu tong Ji Wen-jun Yang jun Li Yue He Yan-an Wang Chen-ping Zhang Lai-ping Zhong Zhi-yuan Zhang Department of Oral and Maxillofacial-Head and Neck Oncology Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai 200011P.R.China National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of StomatologyShanghai 200011P.R.China Department of Oral Pathology Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai 200011P.R.China

Dear Editor,Induction chemotherapy has been utilized for decades in locally advanced head and neck squamous cell carcinoma(HNSCC).The docetaxel,cisplatin,5-fluorouracil(TPF)regimen is the most recommended induction chemotherapy regimen forHNSCC and oral squamous cell carcinoma(OSCC)[1].However,our initial phase Ⅲ trial failed to demonstrate a significant survival benefit of TPF induction chemotherapy in patients with locally advanced OSCC[2].

关键词： chemotherapy cisplatin regimen

BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu Mao-ju Tang Man Luo Xiao-wu Zhong Qiang Ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

Dermatitis bullosa caused by the immune checkpoint inhibitor camrelizumab:A case report

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World Journal of Clinical Cases 2025年第8期13卷 15-21页

作者： Yuan-Jing Jiang Lu wu Xiao Yang Yu Pu Bing-Jie Ning Na Peng Xiao-ju Zhu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Since the advent of the 20th century,alongside the progression of medical science and technological advancements,immunotherapy has emerged as a pivotal thera-peutic approach for tumor patients subsequent to undergoing radiotherapy and ***(camrelizumab),a flagship drug in the realm of immuno-therapy,functions as a monoclonal antibody specifically targeting the progra-mmed death protein 1(PD-1).This drug engages with the human PD-1 receptor,effectively inhibiting the PD-1/programmed death ligand 1 signaling *** inhibition results in the restoration of T cell activity and the induction of an anti-tumour ***,it is noteworthy that such interference could lead to immune-related adverse events resembling autoimmune *** grow-ing availability and clinical use of immune checkpoint inhibitors have raised sig-nificant clinical concerns regarding their *** instances of immune-related adverse reactions and the associated management strategies have been extensively *** identification and diagnosis,coupled with multidi-sciplinary consultation and the prompt administration of immunosuppressants,can effectively address severe immune-related adverse *** SUMMARY Arimab(camrelizumab),a monoclonal antibody targeting programmed death protein 1(PD-1),disrupts the PD-1/programmed death ligand 1(PD-L1)inter-action,reactivating T cell function and triggering anti-tumor ***,this disruption may trigger immune-mediated adverse events akin to autoim-mune *** 2.8%of such events manifest as immune-related dermatologic reactions,with 0.7%classified as grade 3,which are infrequently ***,this study describes a case of grade 3 bullous dermatitis occur-ring 15 days after initiating camrelizumab *** patient,a 67-year-old male with oesophageal squamous cell carcinoma,received camrelizumab plus paclitaxel alongside chemotherapy and radiotherapy in early ***

关键词： Camrelizumab Anti-programmed cell death protein-1 blockade Skin-related adverse events Immune-related dermatitis Case report

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri H.juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Comprehensive comparison of small-scale natural gas liquefaction processes using brazed plate heat exchangers

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Frontiers in Energy 2020年第4期14卷 683-698页

作者： Jitan wu Yonglin ju Institute of Refrigeration and Cryogenics Shanghai Jiao Tong UniversityShanghai 200240China

The brazed plate heat exchanger(BPHE)has some advantages over the plate-fin heat exchanger(PFHE)when used in natural gas liquefaction processes,such as the convenient installation and transportation,as well as the high tolerance of carbon dioxide(CO2)***,the BPHEs with only two channels cannot be applied directly in the conventional liquefaction processes which are designed for multi-stream heat ***,the liquefaction processes using BPHEs are different from the conventional PFHE *** this paper,four different liquefaction processes using BPHEs are optimized and comprehensively compared under respective optimal *** processes are compared with respect to energy consumption,economic performance,and *** genetic algorithm(GA)is applied as the optimization method and the total revenue requirement(TRR)method is adopted in the economic *** results show that the modified single mixed refrigerant(MSMR)process with part of the refrigerant flowing back to the compressor at low temperatures has the lowest specific energy consumption but the worst robustness of the four *** MSMR with fully utilization of cold capacity of the refrigerant shows a satisfying robustness and the best economic *** research in this paper is helpful for the application of BPHEs in natural gas liquefaction processes.

关键词： liquefied natural gas brazed plate heat exchanger energy consumption economic performance robustness

Quantitative Investigation of Tomographic Effects in Abnormal Regions of Complex Structures

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Engineering 2021年第7期7卷 1011-1022页

作者： Longjun Dong Xiaojie tong ju Ma School of Resources and Safety Engineering Central South UniversityChangsha 410083China

The detection of abnormal regions in complex structures is one of the most challenging targets for underground space *** or artificial geologic variations reduce the effectiveness of conventional exploration *** the emergence of real-time monitoring,seismic wave velocity tomography allows the detection and imaging of abnormal regions to be accurate,intuitive,and *** tomographic results are affected by multiple factors in practical small-scale applications,it is necessary to quantitatively investigate those *** adopted an improved three-dimensional(3D)tomography method combining passive acoustic emission acquisition and active ultrasonic *** varying individual parameters(i.e.,prior model,sensor configuration,ray coverage,event distributions,and event location errors),37 comparative tests were *** quantitative impact of different factors was *** experiments showed that the method could effectively adapt to complex *** optimal input parameters based on quantization results can significantly improve the detection reliability in abnormal regions.

关键词： Detection of abnormal regions Tomographic effects Wave velocity Ray path

Effect of Ti content on microstructure and properties of TixZrVNb refractory high-entropy alloys

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International Journal of Minerals,Metallurgy and Materials 2020年第10期27卷 1318-1325页

作者： Tian-dang Huang Shi-yu wu Hui Jiang Yi-ping Lu tong-min Wang Ting-ju Li Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China College of Mechanical and Electronic Engineering Shandong University of Science and TechnologyQingdao 266590China

This study aimed to investigate the microstructure and mechanical properties of TixZrVNb(x=1,1.5,2)refractory high-entropy alloys at room and elevated *** TiZrVNb alloy consisted of the body-centered cubic(bcc)matrix with a small amount of V2Zr *** Ti1.5ZrVNb and Ti2ZrVNb alloys exhibited a single-phase bcc *** room temperature,the tensile ductility of the as-cast alloys increased from 3.5%to 12.3%with the increase in the Ti *** TixZrVNb alloys exhibited high yield strength at 600°C,and the ultimate yield strength was more than 900 *** occurred at 800°C,but the ultimate yield strength could still exceed 200 ***,the TixZrVNb alloys displayed low densities but high specific yield strengths(SYSs).The lowest density of TixZrVNb alloys was only 6.12 g/cm^3,but the SYS could reach about 180 MPa·cm^3·g^−1,which is better than those of most reported high-entropy alloys(HEAs).

关键词： high-entropy alloys mechanical properties low density elevated temperature

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Adult-onset Still's disease evolving with multiple organ failure and death:A case report and review of the literature

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World Journal of Clinical Cases 2021年第4期9卷 886-897页

作者： Zhong-Bin Han ju wu Jing Liu He-Ming Li Kai Guo tong Sun Department of Surgery Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001Liaoning ProvinceChina Department of ICU Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001Liaoning ProvinceChina Department of Oncology Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001Liaoning ProvinceChina Department of Surgery Second People's Hospital of Jinzhong CityJinzhong 030600Shanxin ProvinceChina

BACKGROUND Adult-onset Still’s disease(AOSD)is a rare systemic inflammatory disease,which is characterized by daily fever and arthritis,with an evanescent rash and neutrophilic *** date,there has been no definite laboratory or imaging test available for diagnosing AOSD;the diagnosis is one of exclusion,which can be very *** particular,AOSD patients may experience different complications affecting their clinical picture,management,and *** treatment of AOSD remains largely empirical and involves therapeutic *** SUMMARY We report the case of a 36-year-old woman who presented with fever,red rash,arthralgia,and sore *** serum ferritin level and white blood cell count were markedly elevated,and the first diagnosis 22 years prior was"juvenile rheumatoid arthritis of systemic type".The patient was treated with prednisone,sulfasalazine,methotrexate,and *** remission of her symptoms,the patient stopped taking the medications,and the disease ***,the patient was diagnosed with adult-onset Still's *** occurred several times due to self-medication withdrawal,and an interleukin-6 antagonist(tocilizumab/Actemra)was administered to control the ***,she was hospitalized because an incision did not heal,and the patient suddenly developed high fever and diarrhea during *** patient's disease progressed violently and quickly developed into macrophage activation syndrome,disseminated intravascular coagulation,shock,and multiple organ *** patient had sudden cardiac arrest,and she died despite emergency rescue *** AOSD patients need regular follow-up in the long-term treatment process,and must press formulary standard medication,and do not voluntarily withdraw or reduce the *** it may cause disease back-and-forth or serious lifethreatening ***,strict management of trauma,infections,tumors,and other diseases may contribute

关键词： Adult-onset Still's disease Macrophage activation syndrome Disseminated intravascular coagulopathy Multiple organ failure Death Case report

Self-assembly of InAs quantum dots on GaAs（O01） by molecular beam epitaxy

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Frontiers of physics 2015年第1期10卷 7-58页

作者： ju wu Peng Jin Key Laboratory of Semiconductor Materials Science and Beijing Key Laboratory ofLow-dimensional Semiconductor Materials and Devices Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 China

Currently, the nature of self-assembly of three-dimensional epitaxial islands or quantum dots （QDs） in a lattice-mismatched heteroepitaxial growth system, such as InAs/GaAs（001） and Ge/Si（001） as fabricated by molecular beam epitaxy （MBE）, is still puzzling. The purpose of this article is to discuss how the self-assembly of InAs QDs in MBE InAs/GaAs（001） should be properly understood in atomic scale. First, the conventional kinetic theories that have traditionally been used to interpret QD self-assembly in heteroepitaxial growth with a significant lattice mismatch are reviewed briefly by examining the literature of the past two decades. Second, based on their own experimental data, the authors point out that InAs QD self-assembly can proceed in distinctly different kinetic ways depending on the growth conditions and so cannot be framed within a universal kinetic theory, and, furthermore, that the process may be transient, or the time required for a QD to grow to maturity may be significantly short, which is obviously inconsistent with conventional kinetic the- ories. Third, the authors point out that, in all of these conventional theories, two well-established experimental observations have been overlooked： i） A large number of ＂floating＂ indium atoms are present on the growing surface in MBE InAs/GaAs（001）; ii） an elastically strained InAs film on the GaAs（001） substrate should be mechanically unstable. These two well-established experimental facts may be highly relevant and should be taken into account in interpreting InAs QD formation. Finally, the authors speculate that the formation of an InAs QD is more likely to be a collective event involving a large number of both indium and arsenic atoms simultaneously or, alternatively, a morphological/structural transformation in which a single atomic InAs sheet is transformed into a three-dimensional InAs island, accompanied by the rehybridization from the sp2-bonded to sp3- bonded atomic configuration of both indium an

关键词： molecular beam epitaxy InAs quantum dots