检索结果-南通市图书馆

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu ming-Lei wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

在线全文

学校读者我要写书评

暂无评论

区间值模糊命题逻辑系统的广义恒真式

模糊系统与数学 2001年第2期15卷 21-24页

作者：陆秋君吴望名上海理工大学基础部数学教研室上海200093 上海师范大学数学科学学院上海200234

建立区间值模糊命题逻辑系统 F(∨ ,∧ ,θ⊥ ,c) ,其中 ,aθ⊥ b=(a) c⊥ b,⊥是 I[0 ,1]中的 t-余范 ;讨论系统 F(∨ ,∧ ,θ⊥ ,c)与对应的模糊命题逻辑系统 F(∨ ,∧ ,θ⊥ ,c)在广义恒真式方面的相互关系 ,得到定理 :T... 详细信息

建立区间值模糊命题逻辑系统 F(∨ ,∧ ,θ⊥ ,c) ,其中 ,aθ⊥ b=(a) c⊥ b,⊥是 I[0 ,1]中的 t-余范 ;讨论系统 F(∨ ,∧ ,θ⊥ ,c)与对应的模糊命题逻辑系统 F(∨ ,∧ ,θ⊥ ,c)在广义恒真式方面的相互关系 ,得到定理 :T[0 ,α] (F(∨ ,∧ ,θ⊥ ,c) ) =Tα(F(∨ ,∧ ,θ⊥ ,c) )。

关键词：区间值模糊命题逻辑系统上半同态广义恒真式模糊逻辑下半同态模糊命题逻辑系统

在线全文

学校读者我要写书评

暂无评论

不同形状砂岩的动态力学特性

中南大学学报（自然科学版） 2017年第9期48卷 2441-2448页

作者：谢晓锋陶明吴秋红王泽伟尚雪义刘恺中南大学资源与安全工程学院湖南长沙410083

为研究横截面形状对岩石试样动态力学特性的影响,采用改进后的霍普金森压杆(SHPB)对砂岩圆柱试样、方形试样和厚壁圆筒试样进行冲击试验。研究结果表明:这3种试样的动态强度均随应变率的增大而增大,由于厚壁圆筒试样存在较大自由面,故... 详细信息

为研究横截面形状对岩石试样动态力学特性的影响,采用改进后的霍普金森压杆(SHPB)对砂岩圆柱试样、方形试样和厚壁圆筒试样进行冲击试验。研究结果表明:这3种试样的动态强度均随应变率的增大而增大,由于厚壁圆筒试样存在较大自由面,故其比圆柱试样和方形试样对应变率变化更敏感;横截面形状对岩石变形模量的影响较小,而对峰值应变的影响较大,峰值应变的应变率效应不明显;横截面形状和应变率对试样破坏形式的影响较明显,方形试样棱角处均出现明显的剪切面,应变率越大,试样破碎块度越小。

关键词：岩石力学霍普金森压杆(SHPB) 动态性质形状效应应变率强度

THREE NEW DITERPENOIDS FROM COLEUS FORSKOHLII BRIQ.

在线全文

学校读者我要写书评

暂无评论

THREE NEW DITERPENOIDS FROM COLEUS FORSKOHLII BRIQ.

LOW RATE SPACE-TIME TRELLIS CODES INPOWER LIMITED WIRELESSCOMMUNICATION SYSTEMS

第八届全国中药和天然药物学术研讨会与第五届全国药用植物和植物药学学术研讨会

作者： YAN-WEN LIU, QIAO-RONG YANG, HE-ZHEN wu, XIAO-ming wang, and GUO-AN ZOU (Key Laboratory of Phytochemistry, HuBei College of Traditional Chinese Medicine, 430061, wuhan, China)

Three new diterpenoids, forskolin G(2), forskolin H(3), forskolin I(4), were isolated from the whole plant of the Coleus forkohlii Brig., and their structures were elucidated as 1α,6β-diacetoxy-8,13-epoxylabd-14-en-11-one, la-hydroxy-6p,7p-diacetoxy-8,13-epoxylabd-14-en-11-one, and 1α,9α-dihydroxy-6β,7α-diacetoxy-8,13-epoxylabd-14-en -11-one on the basis of spectral data.

关键词： Coleus forskohlii Brig. Labiatae Diterpenes Forskolin G Forskolin H

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Electronics(China) 2002年第3期19卷 241-247页

作者： wuGang wangHafeng 等 NationalMobileCommunicationsResearchLab SoutheastUniversityNanjing210096 NokiaMobilePhones OuluFinlandPL5090571

Space-time trellis codes can achieve the best tradeoff among bandwidth efficiency, diversity gain, constellation size and trellis complexity. In this paper, some optimum low rate space-time trellis codes are proposed. Performance analysis and simulation show that the low rate space-time trellis codes outperform space-time block codes concatenated with convolutional code at the same bandwidth efficiency, and are more suitable for the power limited wireless communication system.

关键词： Space-time trellis codes Space-time transmit diversity Bandwidth efficiency

Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-Shou Kuo Kuan-Hsun Lin Ying-Yi Chen Yuan-ming Tsai Ti-Hui wu Hsu-Kai Huang Tsai-wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于《天工开物》英译本的科技典籍重译研究

语言与翻译 2017年第2期 64-69页

作者：许明武王烟朦华中科技大学外国语学院武汉430074

1948年至2011年的半个多世纪中,先后出现李乔苹、任以都和孙守全夫妇及大中华文库等《天工开物》英文节译本和全译本。译本各具特色,有力地向世界传播了中国古代科技成就。文章辨析"重译"的名称和内涵,并肯定科技典籍重译的合理性和必... 详细信息

1948年至2011年的半个多世纪中,先后出现李乔苹、任以都和孙守全夫妇及大中华文库等《天工开物》英文节译本和全译本。译本各具特色,有力地向世界传播了中国古代科技成就。文章辨析"重译"的名称和内涵,并肯定科技典籍重译的合理性和必要性。在此基础上,重点以李乔苹英译《天工开物》实践为例,探讨其重译《天工开物》的社会、历史和个人因素。

关键词：《天工开物》重译科技典籍李乔苹

Expression pattern of Anoctamin(Ano) family in heart and role of Ano1 in ischemia-induced arrhythmia

在线全文

学校读者我要写书评

暂无评论

Expression pattern of Anoctamin(Ano) family in heart and rol...

Evaluation of Impact of Pollen Grains from Bt,Bt/CpTITransgenic Cotton and Bt Corn Plants on the Growth andDevelopment of the Mulberry Silkworm,Bombyx moriLinnaeus (Lepidoptera:Bombycidae)

第八届海峡两岸心血管科学研讨会

作者： Zhen Ye,ming-ming wu,Qiushi wang,Dan Zhao,Zhi-Ren Zhang( Departments of Cardiology and Pharmacy,The 2~(nd) Affiliated Hospital of Harbin Medical University Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment,Harbin Medical University Harbin,150086,China

Calcium - activated chloride channels(CaCCs) play a fundamental role in many physiological processes including epithelial secretion,sensory transduction,regulation of neuronal and cardiac excitability, and regulation of vascular ***,the molecular identity of CaCCs remained unclear until Yang et al. revealed that Anoctamin 1(Ano1) is a candidate *** hypothesized that activation of Ano1 contributes to ischemia - induced arrhythmia by shortening action potential duration(APD).To test this hypothesis, we established an infraction model in mice to induce *** real - time RT - PCR and western blot were used to examine the expression pattern and level of Anoctamin *** results indicate that expression pattern of Anos was not altered by ischemia,while Ano1 and Ano6 were strongly upregulated in the ischemic *** then acutely isolated cardiac myocytes to perform whole - cell patch recording with respect to the biophysical properties and pharmacological profile of *** found a Ca-activated chloride current with an anion selectivity sequence of SCN->I->Cl->Glut in both normal and ischemic cardiomyocytes. The density of this current is dependent upon intracellular[Ca].This current exerts outward rectification and voltage-dependent relaxation and it can be blocked by external niflumic ***,the density of this Ca-activated chloride current was increased significantly in cardiomyocytes isolated from infarction hearts compared to that from normal ***,APD was shortened significantly in ischemic cardiomyocytes compared to normal *** together,our results indicate that activation of CaCC(most likely Ano1) contributes to ischemia - induced arrhythmia by shortening APD.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Agricultural Sciences in China 2002年第12期1卷 1334-1343页

作者： LI Wen-dong, YE Gong-yin, wu Kong-ming, wang Xiao-qi and GUO Yu-yuan(Institute of Plant Protection , Chinese Academy of Agricultural Sciences , Beijing 100094 , P. R. China College ofPlant Protection, Shenyang Agricultural University, Shenyang 110161 , P.R.China Institute of AppliedEntomology, Zhejiang University , Hangzhou 310029 , P.R.China) Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing 100094 P.R.China College of Plant Protection Shenyang Agricultural University Shenyang 110161 P.R.China Institute of Applied Entomology Zhejiang University Hangzhou 310029 P.R.China Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing 100094 P.R.China College of Plant Protection Shenyang Agricultural University Shenyang 110161 P.R.China

The S-endotoxin genes of Bacillus thuringiensis (Bt) and proteinase inhibitor (PI) genes are two kinds of genes popularly used for developing transgenic plants resistant to insect pests. To clarify whether there is any risk concerning the effects of pollens from these transgenic crops on non-target insects with economic importance, such as the effects on the growth and development as well as cocoon quality of the silkworm, Bombyx mori Linnaeus, a series of feeding experiments were conducted, using pollens from transgenic cotton or corn containing cry 1Ac, cry1A+CpTI or crylAb genes, compared with pollens from non-transgenic normal cotton and corn as well as the non-pollen treatment. In contrast to the latter ones, pollens from transgenic plants showed no significant adverse effects on larval mortality, cocoon weight, pupa weight, cocoon shell weight, pupation rate, emergence rate and fecundity of the silkworm after neonates were fed with the pollens for 72 h. In addition, no dosage effects of pollens were found. Though the duration of 1st instar larvae was prolonged in the case of feeding with transgenic pollens as compared with those of the non-pollen treatment , but they were not significantly different from those fed with pollens from non-transgenic cotton or corn. Meanwhile, the body weight of the 3rd instar molters fed with transgenic pollens was obviously different from those for non-pollen treatment, and was all significantly heavier than that of the controls. Consequently, it is considered that the adverse effect of pollens from transgenic insect-resistant cotton and corn on the growth and development of the silkworm is negligible.

关键词： Bt/CpTI transgenic cotton Bt transgenic corn Pollen Bombyx mori Growth and development