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Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients

World Journal of Gastroenterology 2005年第34期11卷 5283-5288页

作者： Chi-Chung Wen Chao A.Hsiung Ih-Jen Su Ann-Lii Cheng Ming-Chih Chang Chao-Jung Tsao Woei-Yao Kao wu-ching uen Chiun Hsu Chih-Hung Hsu Yen-Shen Lu Hwei-Fan Tien Tsu-Yi Chao Li-Tzong Chen Jacqueline Whang-Peng Pei-Jer Chen Division of Biostatics and Bioinformatics National Health Research Institutes Taipei Taiwan China Division of Clinical Research National Health Research Institutes Taipei Taiwan China Department of Oncology National Taiwan University Hospital Taipei Taiwan China Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan China Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China Department of Internal Medicine Chi-Mei Hospital Tainan Taiwan China Department of Internal Medicine Tri-Service General Hospital Taipei Taiwan China Department of Internal Medicine Shin Kong Memorial Hospital Taipei Taiwan China Department of Oncology National Taiwan University Hospital Taipei Taiwan China Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan China Division of Cancer Research National Health Research Institutes Taipei Taiwan China

AIM: To investigate the long-term consequences of chemotherapy-related HBV reactivation in patients with ***: This study was based on the database of published prospective study evaluating HBV reactivation in HBV lymphoma patients during *** liver reserve (DLR) was defined as development of either one of the following conditions during follow-up: (1) newly onset parenchyma liver disease, splenomegaly or ascites without evidence of lymphoma involvement; (2) decrease of the ratio (albumin/globulin ratio) to less than 0.8 or increase of the ratio of INR of prothrombin time to larger than 1.2 without evidence of malnutrition or infection. Liver cirrhosis was diagnosed by imaging ***: A total of 49 patients were included. The median follow-up was 6.2 years (range, 3.9-8.1 years).There were 31 patients with and 18 patients without HBV reactivation. Although there was no difference of overall survival (OS) and chemotherapy response rate between the two groups, DLR developed more frequently in patients with HBV reactivation (48.4% vs 16.7%; P= 0.0342). Among the HBV reactivators, HBV genotype C was associated with a higher risk of developing DLR (P = 0.0768) and liver cirrhosis (P = 0.003). Four of five patients with sustained high titer of HBV DNA and two of three patients with multiple HBV reactivation developed DLR. Further, patients with a sustained high titer of HBV DNA had the shortest OS among the HBV reactivators (P= 0.0000). No patients in the non-HBV reactivation group developed hepatic failure or liver ***: Chemotherapy-related HBV reactivation is associated with the long-term effect of deterioration of hepatic function.

关键词： HBV reactivation Liver function Non-HodgkJn'slymphoma, Chemotherapy

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To Improve Lung Cancer Serum Proteomic Profile Detection Accuracy by TwoStage Training Process

To Improve Lung Cancer Serum Proteomic Profile Detection Acc...

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第九届中国肿瘤学术大会暨第十五届海峡两岸肿瘤学术大会

作者： Pei-Sung Hsu Yu-Shan Wang Su-Chen Huang Yi-Hsien Lin Chih-Chia Chang Yuk-Hwa Tsang Jiunn-Song Jiang Shang-Jyh Kao wu-ching uen Kwan-Hwa Chi

Background:Surface-Enhanced Laser Desorption/ionization Time-of-Flight Mass Spectrometry ProtienChip system(SELDI-TOF-MS)is a frequent used technique for cancer biomarkers *** specificity of biomarkers detected from SELDI can be influenced by coexistent with inflammatory *** study aimed to increase the detection accuracy by a two-stage analysis ***:Serums from 118 lung cancer patients,72 healthy individuals and 31 inflammatory disease patients were divided into training group and testing group randomly by 3:2 *** stage training method use SELDI profiles analysis to form a decision making tree to directly distinguish lung cancer patients from all the serum in the training *** twostage analysis is to increase the steps of partitioning analysis from distinguishing the healthy people and non-healthy patients(1st-stage)and then differentiating cancer patients from inflammatory disease patients(2nd-stage)to minimize the influence of inflammation.A decision tree by combination of this two-stage training process was validated in the test *** the test group,one stage method has 87.2%sensitivity,37.5%specificity and 64.4%*** two-stage method has lower sensitivity(>70,1%),but higher specificity(80%)and accuracy(74.7%)with statistically *** predominately expressed protein peak at 11480 Da was the primary splitter regardless one-stage or two-stage *** peak was most likely to be SAA(Serum Amyloid A)with average m/z countered around this *** significance of this important primary splitter was further confirmed by ELISA ***:The inflammatory disease severely interfere the detection accuracy of lung cancer by SELDI *** a two-stage training process will improve the specificity and accuracy in detection of lung cancer.

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Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells

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World Journal of Gastroenterology 2005年第20期11卷 3040-3045页

作者： Kuo-ching Yang Yih-Huei uen Fat-Moon Suk Yu-Chih Liang Ying-Jan Wang Yuan-Soon Ho I-Hsuan Li Shyr-Yi Lin Department of Internal Medicine Shin Kong wu Ho-Su Memorial Hospital Taipei Taiwan Department of Internal Medicine Taipei Medical University Taipei Taiwan China Department of Surgery Chi-Mei Foundational Medical Center Yung-Kane City Tainan Taiwan China Department of Internal Medicine Taipei Medical University Hospital Taipei Taiwan China School of Medical Technology Taipei Medical University Taipei Taiwan China Department of Environmental and Occupational Health National Cheng Kung University Medical College TainanTaiwan China Department of Internal Medicine School of Medicine Taipei Medical University Taipei Taiwan China Department of Internal Medicine School of Medicine and Department of Internal Medicine Taipei Medical University Hospital Taipei Medical University Taipei Taiwan China

AIM: To explore both the in vitro and in vivo effects of denbinobin against colon cancer cells and clarify its underlying signal pathways. METHODS: We used COLO 205 cancer cell lines and nude mice xenograft model to study the in vitro and in vivo anti-cancer effects of denbinobin. RESULTS: Denbinobin at concentration of 10-20 μmol/L dose-dependently suppressed COLO 205 cell proliferation by MTT test. Flow cytometry analysis and DNA fragmentation assay revealed that 10-20 μmol/L denbinobin treatment induced COLO 205 cells apoptosis. Western blot analysis showed that caspases 3,8,9 and Bid protein were activated by denbinobin treatment to COLO 205 cells accompanied with cytochrome c and apoptosis-inducing factor (AIF) translocation. Pretreatment of MEK 1 inhibitor (U10126), but not p38 inhibitor (SB203580) and JNK inhibitor (SP600125), reversed denbinobin-induced caspase 8, 9 and Bid activation in COLO 205 cells suggesting that extracellular signal-regulated kinase were involved in the denbinobin-induced apoptosis in COLO 205 cells. Significant regression of tumor up to 68% was further demonstrated in vivo by treating nude mice bearing COLO 205 tumor xenografts with denbinobin 50 mg/kg intraperitoneally. CONCLUSION: Our findings suggest that denbinobin could inhibit colon cancer growth both in vitro and in vivo. Activation of extrinsic and intrinsic apoptotic pathways and AIF were involved in the denbinobin-induced COLO 205 cell apoptosis.

关键词： Denbinobin Colon cancer Nude mice Apoptosis ERK pathway

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The Quantification and Reporting of Negawatt-Hours with Flexible Energy Conservation Measure Verification Software (ECM-Tool)

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Open Journal of Energy Efficiency 2019年第4期8卷 179-201页

作者： Filip Milojkovic Fernando Zuniga Arash Zandi Knuth Posern Erol uen smartB Energy Management GmbH Hardenbergstr. 9A Berlin Germany

In order to promote digital innovations in the field of energy use and monitoring in all end customer sectors, the Federal Ministry for Economic Affairs and Energy (BMWi) has launched the “Pilotprogramm Einsparzähler” in 2016. The program promotes the development of digital platforms following the “Efficiency First” principle, focusing not on individual projects but on the establishment of a business model. smartB successfully applied for subsidies for the development of a software tool, the architecture of which is the content of this open source paper. The tool applies a multivariate regression-model to model a given system’s energy consumption (significant energy uses or SEUs), adjusted to relevant external factors (e.g. weather) and given output levels or product properties. Thereby comparing energy consumption before and after an energy conservation measure (ECM), the tool allows for a quantification and verification of achieved energy savings as laid out in international standards for energy management (ISO, 2014). Achieved energy savings induced by an ECM and energy efficiency improvements cannot be measured directly. We use the term “negawatt-hour”, defined as a unit of energy saved as a direct result of energy conservation measures. International norms provide accepted standards to derive quantified savings in negawatt-hours from a qualified comparison between consumption before and after an ECM, as presented at the beginning of the paper.

关键词： Energy Efficiency Energy Savings Energy Consumption Regression

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Constitutive Overexpression of Bcl-2, Survivin and ER Stress Chaperone GRP-78 Confers Intrinsic Radioresistance in Human Hepatocellular Carcinoma Cells: Insight into the Mechanistic Pathways Involved

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Journal of Cancer Therapy 2013年第2期4卷 399-407页

作者： Chih-Hsiung wu Yih-Huei uen Chun-Te Ho Ya-Ting Tseng Tsan-Zon Liu Jeng-Fong Chiou Stephen Wan Leung Cancer Center and Department of Radiation Oncology Taipei Medical University and Hospital Taipei Chinese Taipei Department of General Surgery Chi-Mei Foundation Medical Center Tainan Chinese Taipei Department of Radiology and Nuclear Medicine Yuan’s General Hospital Kaohsiung Chinese Taipei Department of Surgery Taipei Medical University-Shuang Ho Hospital Taipei Chinese Taipei Graduate Institute of Medical Biotechnology Chang-Gung University Gueishan Chinese Taipei Graduate Institute of Medical Sciences Taipei Medical University Taipei Chinese Taipei

We present evidence here that abundantly expressed b-catenin-triggered NF-kB-dependent upregulation of inducible nitric oxide synthase(iNOS) found in hepatoma Mahlavu cells (RT-resistant variant designated as RR-Mal), but not in Hep 3B cells (RT-sensitive variant designated as RS-3B) is a key element contribrting to the radioresisitance through the activation of two prominent radioprotective pathways. First, high iNOS expression found in RR-Mal, but not in RS-3B cells was found to perturb calcium homeostasis that triggered ER stress response leading to the overproduction of ER chaperone GRP-78 via robust generation of cleaved ATF-6a (50 kDa) subunits and their nuclear translocation. Meanwhile, both abundantly expressed NF-κB and COX-2 found in RR-Mal cells could also provoke an increased production of PGE2 resulting in robust production of Bcl-2. Interestingly, when RR-Mal cells were treated with PDTC (a NF-κB inhibitor) or celecoxib (a COX-2 inhibitor), a concentration-dependent downregulation of Bcl-2 could be demonstrated implying that Bcl-2 overexpression was indeed mediated through NF-κB/Cox-2/PGE2 pathway. Importantly, we also unveiled that siRNA-mediated silencing of survivin in RR-Mal cells could result in a concomitant downregulation of GRP-78 due to a severe inhibition of ATF-6a (50 kDa) expression. Taken together, our data demonstrate that constitutively overexpressed b-catenin/NF-κB/iNOS and NF-κB/COX-2/PGE2 pathways that overproducing GRP-78, survivin and Bcl-2 expressions are responsible for radioresistance acquisition in RR-Mal cells. Thus, both pathways could be served as potential targets for overcoming radioresistance.

关键词： Radioresistance Hepatoma Cells Inducible Nitric Oxide Synthase Bcl-2 Survivin GRP-78

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不同年龄、性别和身体发育的学生体力作业能力

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中国校医 1993年第6期7卷 89-92页

作者： B.A.A uen.u 刘宝林

儿童在学校内学习期间经受各种各样负荷的作用,需要按统一标准最充分反映他们机体功能状况确定适宜的卫生学负荷量。在这方面,反映人的身体潜力、他们的心脏呼吸和肌肉系统状况的体力作业能力（CPPC）测定具有重要意义。按世界卫生组织... 详细信息

儿童在学校内学习期间经受各种各样负荷的作用,需要按统一标准最充分反映他们机体功能状况确定适宜的卫生学负荷量。在这方面,反映人的身体潜力、他们的心脏呼吸和肌肉系统状况的体力作业能力（CPPC）测定具有重要意义。按世界卫生组织推荐方法借助于PWC170测验和根据需氧的供给量的大小——最大耗氧量（MnK）评价CPPC。在普通教育的学校没有系统地从事运动的学生中,CPPC研究的很少。

关键词：儿童少年卫生体力作业能力学生

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猕猴桃皮渣中水溶性膳食纤维的提取方法对比及其性质测定

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中国食品添加剂 2024年第6期35卷 108-116页

作者：刘声鹏李乐怡张佳曼蔡文倩李浩莹陈云吴小勇伍芳芳广东药科大学食品科学学院中山528458

本文采用超声辅助酸法(Ultrasonic-assisted Acid,UAC)、超声辅助碱法(Ultrasonic-assisted Alkali,UAL)、超声辅助酶法(Ultrasound-assisted Enzyme,uen)、剪切乳化辅助酶法(Shear Emulsification-assisted Enzyme,SEN)分别从猕猴桃皮渣中提取水溶性膳食纤维(Soluble Dietary Fiber,SDF)。通过提取率、基本成分含量、傅里叶红外光谱(FT-IR)、扫描电镜(SEM)、粒径、流变特性等各项指标对其特性进行对比分析。结果表明:四种SDF均拥有典型的多糖红外光谱特征,且均为假塑性非牛顿流体。其中,uen法拥有最高的提取率(31.17%±0.5%)、总糖含量(84.11%±3.66%)以及还原糖含量(17.80%±0.45%)。此外,该方法在提取过程中能较好的保护SDF的结构,且拥有最小的粒径和PDI,性质上更加稳定。综上所述,uen法更具备绿色、环保的特征,能在一定程度上保护SDF结构的同时提高提取率。

关键词：猕猴桃皮渣水溶性膳食纤维性质测定结构表征

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短暂心肌缺血患者脉搏波速增加

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世界核心医学期刊文摘（心脏病学分册） 2007年第2期3卷 56-57页

作者： Baulmann J. Homsi R. uen S. 孙志军 University of Bonn Medizinische Poliklinik Division of Hypertension and Vascular MedicineWilhelmstraβe 35-37 D-53111 Bonn Germany.Dr

目的:最近研究显示短暂心肌缺血患者的平均脉压较高。脉压的增高可能是动脉硬化加重的重要后果。本研究旨在证实短暂心肌缺血患者的动脉硬化程度是否发生改变(该类患者的心血管疾病风险增高),并研究了动脉硬化和波反射是否为短暂心肌缺... 详细信息

目的:最近研究显示短暂心肌缺血患者的平均脉压较高。脉压的增高可能是动脉硬化加重的重要后果。本研究旨在证实短暂心肌缺血患者的动脉硬化程度是否发生改变(该类患者的心血管疾病风险增高),并研究了动脉硬化和波反射是否为短暂心肌缺血的最佳预测因素。

关键词：心肌缺血患者平均脉压平均动脉压最佳预测心血管疾病波反射触发式

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维生素E琥珀酸酯诱导白血病细胞凋亡的信号传导机制探讨

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广东医学 2006年第10期27卷 1435-1437页

作者：肖浩文叶建锋高宁广州军区广州总医院血液科广州510010 南方医科大学热带军队卫生学系广州510515

目的观察维生素E琥珀酸酯(VES)对人白血病Raji细胞的Bcl-2基因蛋白家族及JNK信号通路的作用,探讨VES诱导白血病细胞凋亡的信号传导网络调控的分子生物学机制。方法应用免疫细胞化学方法、Western免疫印迹法等技术方法,体外观察VES对Raj... 详细信息

目的观察维生素E琥珀酸酯(VES)对人白血病Raji细胞的Bcl-2基因蛋白家族及JNK信号通路的作用,探讨VES诱导白血病细胞凋亡的信号传导网络调控的分子生物学机制。方法应用免疫细胞化学方法、Western免疫印迹法等技术方法,体外观察VES对Raji细胞的作用。结果VES作用后,细胞内磷酸化型JNK蛋白于6 h开始增高,12 h达到高峰,并持续24 h,而非磷酸化型JNK蛋白表达无显著变化。VES作用24 h后,细胞内Bcl-2蛋白表达下降,Bax蛋白表达增加。结论VES是JNK的激活因子,活化的JNK可能进一步通过打破促凋亡因子Bax蛋白与抗凋亡因子Bcl-2蛋白之间的平衡而启动细胞凋亡的级联反应,导致细胞凋亡。

关键词：维生素E琥珀酸酯 Raji细胞 JNK Bcl-2 Bax

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DS80C400ROM分析及在嵌入式智能网桥中应用

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辽宁工程技术大学学报（自然科学版） 2008年第6期27卷 885-888页

作者：韩进李会平李斌薛庆军山东科技大学信息科学与工程学院山东青岛266510 上海大学机电工程与自动化学院上海200072

基于DS80C400在嵌入式智能网桥中的应用,分析了DS80C400在硬件设计中的基本要求,给出了嵌入式智能网桥的硬件方案,研究了DS80C400独特且功能强大的ROM函数,其中包括网络协议栈、内存管理、进程调度等模块的初始化加载:内置TINI OS实时... 详细信息

基于DS80C400在嵌入式智能网桥中的应用,分析了DS80C400在硬件设计中的基本要求,给出了嵌入式智能网桥的硬件方案,研究了DS80C400独特且功能强大的ROM函数,其中包括网络协议栈、内存管理、进程调度等模块的初始化加载:内置TINI OS实时操作系统的任务创建、挂起和删除;格式化数据输入输出及文件系统库函数,并给出了基于SOCKET嵌入式WEB实现方式、基于文件系统及指针数组方式内嵌网页的实现方法以及其核心划分实时任务,实现DS80C400嵌入式智能网桥的任务同步与调度的软件实施方案。实际应用证明,基于DS80C400开发嵌入式网络系统的设计达到了实际工程需求的技术指标,大大提高了开发效率,系统运行稳定。

关键词： DS80C400 ROM内核嵌入式智能网桥

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