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香砂六君子汤合除痰解毒中药对Lewis肺癌小鼠免疫逃逸的影响

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中国实验方剂学杂志 2024年第7期30卷 78-86页

作者：杨倩王淑美冯诗函詹雪夏琳涛吴明星中医药防治代谢性疾病重庆市重点实验室重庆400016 重庆医科大学中医药学院重庆400016

目的:观察香砂六君子汤合除痰解毒中药对Lewis肺癌小鼠免疫逃逸的作用及机制。方法:取60只SPF级C57BL/6J雄鼠,于右侧腋中线皮下注射Lewis细胞悬液0.2 m L(含细胞数2×10^(6)个/m L),接种7 d后,将造模成功的小鼠随机分为模型组、顺铂组... 详细信息

目的:观察香砂六君子汤合除痰解毒中药对Lewis肺癌小鼠免疫逃逸的作用及机制。方法:取60只SPF级C57BL/6J雄鼠,于右侧腋中线皮下注射Lewis细胞悬液0.2 m L(含细胞数2×10^(6)个/m L),接种7 d后,将造模成功的小鼠随机分为模型组、顺铂组、香砂六君子汤低、中、高剂量组、联合组,每组10只。香砂六君子汤低、中、高剂量组分别灌胃17.88、35.75、71.50 g·kg^(-1)香砂六君子汤加减溶液,1次/d,顺铂腹腔注射小鼠用量换算为5 mg·kg^(-1),2次/周,各组均连续干预14 d,每2 d测量肿瘤体积。治疗结束后称取各组小鼠肿瘤质量并计算抑瘤率;苏木素-伊红(HE)染色观察各组肿瘤的形态学特征;实时荧光定量聚合酶链式反应(Real-time PCR)检测各组肿瘤组织中自然杀伤(NK)细胞杀伤受体2(NKG2D)、核糖核酸输出因子-1(RAE-1)、γ干扰素(IFN-γ)mRNA含量;免疫组化法(IHC)、蛋白免疫印迹法(Western blot)检测各组肿瘤RAE-1、NKG2D、IFN-γ表达;Western blot检测各组小鼠肿瘤中IL-6、JAK2、p-JAK2、STAT3、p-STAT3及脾脏组织中NKG2D、RAE-1蛋白含量。结果:与模型组比较,香砂六君子汤各剂量组肿瘤质量均下降,差异无统计学意义;肿瘤体积均缩小(P<0.05,P<0.01);病理学形态改善;香砂六君子汤中剂量组NKG2D、RAE-1、IFN-γ mRNA含量均升高(P<0.05,P<0.01),肿瘤组织中NKG2D、RAE-1、IFN-γ蛋白表达均升高(P<0.05,P<0.01),p-JAK2、p-STAT3蛋白表达下降(P<0.05,P<0.01);脾脏组织中,香砂六君子汤各剂量组NKG2D、RAE-1蛋白表达均显著升高(P<0.01)。与顺铂组比较,香砂六君子汤中剂量组NKG2D、RAE-1、IFN-γ mRNA含量升高,差异无统计学意义;IHC显示联合组NKG2D、IFN-γ蛋白表达显著升高(P<0.01),Western blot结果表明RAE-1、NKG2D、IFN-γ蛋白表达升高(P<0.05,P<0.01);联合组p-JAK2、p-STAT3蛋白表达下降(P<0.05,P<0.01);脾脏组织中,香砂六君子汤中剂量组、联合组NKG2D、RAE-1蛋白表达显著升高(P<0.01)。结论:香砂六君子汤合除痰解毒中药能够通过上调RAE-1/NKG2D表达,促进NK细胞活化,抑制免疫逃逸,抑制Lewis肺癌小鼠肿瘤生长,其机制可能与下调JAK2/STAT3通路相关。

关键词：香砂六君子汤 Lewis肺癌免疫逃逸 NK细胞杀伤受体2(NKG2D) 核糖核酸输出因子-1(RAE-1)

Synthesis of La_2MoO_6@MWCNTs composite catalysts as Pt-free counter electrodes for dye-sensitized solar cell

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Journal of Rare Earths 2018年第12期36卷 1278-1283页

作者： Kezhong wu Jiajing Zhao Yuanyuan Xiong Bei Ruan mingxing wu Key Laboratory of Inorganic Nano-materials of Hebei Province Department of Chemistry and Material Science Hebei Normal University

Pt-free counter electrode(CE) composed of La2 MoO(LaO-MoO) was successfully synthesized by simple pyrolysis of lanthanum acetate(CHOLa·xHO) and hexaammonium heptamolybdate tetrahydrate((NH4)6 MoO·4 HO). Furthermore,three proportions composites catalysts of La2 MoO@MWCNTs based on La2 MoOand multiwall carbon nanotubes(MWCNTs) were prepared and characterized as Ptfree catalyst for CE in dye-sensitized solar cells(DSSCs). The morphology and structure of La2 MoO@MWCNTs composites were determined by scanning electron microscopy, transmission electron microscope and X-ray diffraction. The electrochemical performance of La2 MoO@MWCNTs composite catalysts for CEs was determined by photocurrent-voltage measurements, cyclic voltammetry,electrochemical impedance spectroscopy, and Tafel polarization. The power conversion efficiencies of4.68%, 4.87% and 5.06% are obtained for La2 MoO:MWCNTs with the mass ratios of 5:1, 3:1 and 1:1 towards the reduction of I~-to I~-under the same conditions,respectively,which are superior to those of MWCNTs(3,94%) and La2 MoO(1.71%) electrodes. The experimental results reveal that the presence of MWCNTs results in an augmented active catalytic surface area and enhanced charge transfer from CE to the electrolyte.

关键词： Dye-sensitized solar cell Counter electrode Metal composite oxide Composite catalysts Power conversion efficiency Rare earths

The effect of transition metal ions (M^(2+)=Mn^(2+),Ni^(2+),Co^(2+),Cu^(2+)) on the chemical synthesis polyaniline as counter electrodes in dye-sensitized solar cells

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Chinese Journal of Chemical Engineering 2017年第5期25卷 671-675页

作者： Kezhong wu Lei Chen Weizhen Cui Bei Ruan mingxing wu Key Laboratory of Inorganic Nano-materials of Hebei Province Department of Chemistry and Material ScienceHebei Normal University

The effect of transition metal ions(M^(2+)=Mn^(2+),Ni^(2+),Co^(2+),Cu^(2+)) on the chemical synthesis of polyaniline(PANI) used as a platinum-free counter electrode(CE) in dye-sensitized solar cells(DSSCs) was *** was synthesized by co-polymerization of aniline in the presence of different transition metal ions by using potassium dichromate in acidic medium. It was found that the ion doping of PANI showed a certain catalytic activity for the regeneration of traditional iodide/triiodide(I^-/I_3^-) redox couples. The power conversion efficiency(η) of PANI CEs doped with Mn^(2+),Ni^(2+),Co^(2+) (4.41%, 2.36% and 2.10%, respectively) were higher than 1.94%, the value measured for PANI CE without doping. Doping with Cu^(2+)decreased the power conversion efficiency of PANI CE(PANI-Cu^(2+) η = 1.41%). The electrical properties of the PANI, PANI-Ni^(2+), PANI-Co^(2+),PANI-Mn^(2+) and PANI-Cu^(2+) were studied by cyclic voltammetry(CV), impedance(EIS), and Tafel polarization curve. The experimental results confirmed that PANI was affected by the doping of different transition metal ions(M^(2+)=Mn^(2+),Ni^(2+),Co^(2+),Cu^(2+)). These results indicate a potential application of ion doped PANI as counter electrode in cost-effective DSSCs.

关键词： Dye-sensitized solar cell Counter electrode Polyaniline Transition metal ion Power conversion efficiency

A hydrophobic artificial solid-interphase-protective layer with fast self-healable capability for stable lithium metal anodes

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Science China Chemistry 2022年第9期65卷 1817-1821页

作者： Lu Zhou Mengfan Zhao Xinyu Chen Jinming Zhou mingxing wu Na wu Key Laboratory of Inorganic Nanomaterials of Hebei Province College of Chemistry and Material ScienceHebei Normal UniversityShijiazhuang 050024China

Lithium(Li)metal has been considered as one of the most promising anodes for high-energy-density ***,the hyperactivity of metallic Li and its dendrite growth are the major hurdles to its practical ***,a multi-functional solid-interphase-protective layer with excellent waterproof performance and fast self-healing properties was modified on the surface of Li metal to address the above *** the protection of this interface,the metallic Li(denoted as P-Li)exhibited superior electrochemical stability in both Li/Li symmetric cells and full ***,even after being exposed to humid air for 3 h,the LiFePO_(4)||Li full battery with P-Li anodes still showed long-term stability with a transcendental capacity retention of~100% after 100 cycles,revealing a significant advantage to the non-working LiFePO_(4)||Li battery with air-exposed bare Li anodes.

关键词： Li metal anode solid interphase protective layer stable Li plating/stripping self-healable hydrophobic property

Studies of high-efficient and low-cost dye-sensitized solar cells

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Frontiers of Optoelectronics 2011年第1期4卷 103-107页

作者： Qingqing MIAO mingxing wu Wei GUO Tingli MA State Key Laboratory of Fine Chemicals Dalian University of Technology

Dye-sensitized solar cell（DSSC） is a new type of photoelectric device. To commercialize DSSC successfully, it is necessary to further improve the efficiency of energy conversion and reduce its cost. Nitrogen-doped（N-doped） TiO2photoanode, the carbon counter electrode（CE）, and a new type of hybrid photoanode were investigated in this study. The conversion efficiency of the DSSC reached by 10.10% as the DSSC was fabricated with the N-doped photoanode, and this efficiency is much higher than that of the undoped-DSSC with 8.90%; as the low-cost carbon was used as CE, the efficiency of the DSSC was 7.50%, it was as samilar as that of PtCE（7.47%）; the hybrid DSSC with multilayer photoanode by the film-transfer technique achieved a panchromatic response and a superposed short circuit current density(JSC) by using two complementary dyes.

关键词： high-efficiency dye-sensitized solar cell (DSSC) hybrid nitrogen-doped (N-doped) TiO2 carbon counter electrode (CE)

曲线形波形钢腹板剪切屈曲强度的影响参数研究

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广东建材 2024年第5期40卷 107-112页

作者：陈慧敏陈伟罗创涟郭荣幸吴明鑫广州广检建设工程检测中心有限公司广东省建筑物健康监测与安全预警工程技术研究中心办公室陈伟工作室

为了研究曲线形波形钢腹板的抗剪强度随影响参数的变化规律,在验证现有文献中ANSYS有限元模型的基础上,引入影响参数变化,建立了曲线形波形钢腹板的ANSYS有限元模型。研究表明:曲率半径对曲线形波形钢腹板的屈曲模式影响很大,但是其对... 详细信息

为了研究曲线形波形钢腹板的抗剪强度随影响参数的变化规律,在验证现有文献中ANSYS有限元模型的基础上,引入影响参数变化,建立了曲线形波形钢腹板的ANSYS有限元模型。研究表明:曲率半径对曲线形波形钢腹板的屈曲模式影响很大,但是其对抗剪强度的影响几乎可以忽略不计。曲线形波形钢腹板的抗剪强度随腹板厚度增大显著提升,随腹板高度增加显著下降。对于不同型号的波形钢腹板,在曲率半径相同的情况下,1200型曲线波形钢腹板的抗剪强度高于1600型和1000型,其中1000型最差。研究结论可为曲线波形钢腹板桥梁的设计和应用提供参考依据。

关键词：曲线形波形钢腹板剪切屈曲模式剪切屈曲强度影响参数

Geographical features and development models of estuarine cities

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Journal of Geographical Sciences 2024年第1期34卷 25-40页

作者： CHEN mingxing XIAN Yue HUANG Yaohuan SUN Zhigang wu Chengbin Key Laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China College of Resource and Environment University of Chinese Academy of SciencesBejing 100049China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China Zhongke Shandong Dongying Institute of Geography Dongying 257509ShandongChina CAs Engineering Laboratory for Yellow River Delta Modern Agriculture Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China

Cities are the key areas for human beings to achieve sustainable development goals in the *** cities are a special type of coastal city in urgent need of a clear *** paper proposed that estuarine cities are cities developed on the coast where rivers and oceans meet and defined four connotations,including the intersection of rivers and marine water systems,the coordinated development of land and oceans,the location advantages of connecting rivers and seas,and the important fragility of the ecological *** used Hydro SHEDS,OSM,GPW,and urban socioeconomic statistics and selected 50 estuarine cities with large rivers as representatives to summarize the main geographical basis and socioeconomic *** are primarily found in low-altitude,flat regions with average annual temperatures that mainly vary from 10℃to 25℃,relatively abundant precipitation,and extensive biological *** are substantial variations in the socioeconomic features of estuarine *** proposed eight development patterns,including open and inclusive city spirit,high-quality livable cities,high-quality development driven by innovation,integration of internal and external communication with ports and cities,construction of an international financial center,ecological environment protection and restoration,active promotion of cultural tourism,and positive international exchanges.

关键词： estuarine cities great rivers development models sustainability physical geography socioeconomy

Determination of Intraocular Lens Tilt and Decentration Using Simple and Rapid Method

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眼科学报 1998年第1期14卷 13-16页

作者： mingxing wu, Huaming Li, Weirong ChengZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences , Guangzhou 510060, China Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Purpose: To determine the tilt and decentration of implanted intraocular lens (IOL) in vivo one year *** : A retrospective study was performed on 67 eyes by the method introduced by Guy-ton using the third and fourth Purkinje imagesm through undilated pupil. Results : The average decentration of implanted IOL was 0.68 mm, and the average tilt was 6.03°. The result was similar to the histopadiological study in postmortem eyes and the measurement in ***-regression analysis showed there was no relationship between the tilt and decentration and the residual astigmatism ,axial length ,IOL power,etc. Conclusion: The result is similar to the other methods. The method using the third and fourth Purkinje images is simple and easy to perform. It can be used for determining the IOL position through undilated pupil and does not require special apparatus. Eye Science 1998; 14: 13 - 16.

关键词：斜视散视浦肯雅反射晶状体

Effect of Liposome-Encapsulated Total Alkaloid of Harmaline on Rabbit Lens Epithelial Cells:Experimental Study on the Prevention of Posterior Capsule Opacification

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眼科学报 1999年第1期15卷 55-60页

作者： mingxing wu, Huaming Li, Shaozhen Li, Suhua PanZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Science, Guangzhou 510060 , China Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Science Guangzhou 510060 China

Purpose: To investigate whether liposome encapsulated total alkaloid of Harmaline (TAH) as a therapeutic agent is beneficial to prevention of posterior capsular opacifi-cation (PCO).Methods: Liposome-encapsulated TAH was prepared by modified freeze-thawing method. 0. 1ml of liposome-encapsulated TAH (0. 2mg/ml) was injected into the capsular bag during extracapsular lens extraction (ECLE) of each eye in total 10 rabbit eyes. Blank liposome or balance salt solution (BSS) was used as control. Slit-lamp examination and histopathological examination was used to evaluated capsule opacifica-tion. Intraocular pressure (IOP) , density and morphology of corneal endothelia cells, the amplitude and latency of b wave of ERG were ***: The inflammatory response was mild both in TAH treated and the control group. PCO formation occurred in the control group 2 weeks postoperatively, but the posterior capsule was clear in TAH treated eyes. 4 weeks and 8 weeks after operation, PCO occurred both in TAH

关键词：囊状不透明体抑制作用生物碱荚膜哈马灵脂质体晶状体上皮细胞