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Construction of a multidimensional plane network-on-chip architecture based on the hypercube structure

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Progress in Natural Science:Materials International 2009年第5期19卷 635-641页

作者： chang wu, yubai li, Qicong Peng, song chai, Zhongming Yang DSP Lab, School of Communication and Information Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China DSP Lab School of Communication and Information Engineering University of Electronic Science and Technology of China Chengdu 610054 China

In current network-on-chip (NOC) studies and in practical applications, the mesh structure is the most widely used and deeply researched structure. However, the hypercube structure is more symmetrical and regular than the mesh or torus structures. This paper compares the network characteristics of these three direct topologies and proposes a method to compress the hypercube into a plane structure. This structure, which has the multidimensional property based on the hypercube, is called the multidimensional plane (MDP) NOC. The compression process is divided into two steps: the transformation of router denotations and the connection of channels. Then, SystemC is used to implement the MDP NOC and it is compared with the mesh and torus NOCs in terms of four aspects of performance, including average latency time, normalization throughput, energy consumption and area cost.

关键词： NOC Hypercube Dimension SystemC Simulation

Synthesis and acaricidal activity of strobilurin-pyrimidine derivatives

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Chinese Chemical Letters 2014年第1期25卷 137-140页

作者： Bao-Shan chai chang-ling liu Hui-Chao li Shao-wu liu Ying Xu Yu-Quan song Jun-Biao chang College of Chemistry and Molecular Engineering Zhengzhou University State Key Laboratory of the Discovery and Development of Novel Pesticide Shenyang Research Institute of Chemical Industry Co.Ltd.

Pyriminostrobin, a new acaricide, was discovered in our previous studies. Because introducing fluorine into organic compounds can increase bioactivity, pyriminostrobin was modified as a series of strobilurin-pyrimidine derivatives for biological screening. The compounds were characterized by 1H NMR, MS and elemental analysis. Preliminary bioassays demonstrated that compounds 7e and 7i exhibited significant control against Tetranychus cinnabarinus （Boisd.） at 0.625 mg L^-1, and their acaricidal potencies were higher than pyriminostrobin in a greenhouse. The relationship between structure and acaricidal activity was also studied.

关键词： Strobilurin-pyrimidine Acaricidal activity Intermediate derivatization method Pyriminostrohin

Plasma exosomal hsa_circ_0079439 as a novel biomarker for early detection of gastric cancer

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World Journal of Gastroenterology 2023年第22期29卷 3482-3496页

作者： Xiao li Yan-li lin Jia-Kang Shao Xiao-Jie wu Xiang li He Yao Fa-liang Shi Long-song li Wen-Gang Zhang Zheng-Yao chang Ning-li chai You-liang Wang En-Qiang linghu Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Medical School of Chinese PLA Beijing 100853China Beijing Institute of Biotechnology Beijing 100071China

BACKGROUND Due to the poor prognosis of gastric cancer(GC),early detection methods are urgently *** exosomal circular RNAs(circRNAs)have been suggested as novel biomarkers for *** To identify a novel biomarker for early detection of *** Healthy donors(HDs)and GC patients diagnosed by pathology were *** GC patients and three HDs were selected for exosomal whole-transcriptome RNA *** expression profiles of circRNAs were analyzed by bioinformatics methods and validated by droplet digital polymerase chain *** expression levels and area under receiver operating characteristic curve values of plasma exosomal circRNAs and standard serum biomarkers were used to compare their diagnostic *** There were 303 participants,including 240 GC patients and 63 HDs,involved in the *** expression levels of exosomal hsa_circ_0079439 were significantly higher in GC patients than in HDs(P<0.0001).However,the levels of standard serum biomarkers were similar between the two *** area under the curve value of exosomal hsa_circ_0079439 was higher than those of standard biomarkers,including carcinoembryonic antigen,carbohydrate antigen(CA)19-9,CA72-4,alpha-fetoprotein,and CA125(0.8595 vs 0.5862,0.5660,0.5360,0.5082,and 0.5018,respectively).The expression levels of exosomal hsa_circ_0079439 were significantly decreased after treatment(P<0.05).Moreover,the expression levels of exosomal hsa_circ_0079439 were obviously higher in early GC(EGC)patients than in HDs(P<0.0001).CONCLUSION Our results suggest that plasma exosomal hsa_circ_0079439 is upregulated in GC ***,the levels of exosomal hsa_circ_0079439 could distinguish EGC and advanced GC patients from ***,plasma exosomal hsa_circ_0079439 might be a potential biomarker for the diagnosis of GC during both the early and late stages.

关键词： Gastric cancer Exosomes Circular RNA Droplet digital polymerase chain reaction Biomarker

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可设置仲裁优先程度的NOC路由节点设计

电子科技大学学报 2008年第5期37卷 645-648页

作者：武畅李玉柏彭启琮柴松杨中明电子科技大学通信与信息工程学院DSP技术中心成都610054

针对片上网络(NOC)具体应用中各个IP之间出现不同的通信情况的问题,提出了一种可设置仲裁优先程度的NOC路由节点。该节点采用基于Lottery算法的仲裁机制,取代了目前NOC路由节点中广泛采用的轮询调度(RR)仲裁机制,可以根据具体应用的通... 详细信息

针对片上网络(NOC)具体应用中各个IP之间出现不同的通信情况的问题,提出了一种可设置仲裁优先程度的NOC路由节点。该节点采用基于Lottery算法的仲裁机制,取代了目前NOC路由节点中广泛采用的轮询调度(RR)仲裁机制,可以根据具体应用的通信状况来设定仲裁响应的优先程度。在NOC路由节点中,设计了内部TUM(时间单元复用)的传输机制来解决不同输入口竞争同一输出口所带来的节点内部阻塞问题,使得即使在有多个端口竞争同一端口的情况下,路由节点仍然能保证输入的数据包和进入输出缓冲的数据包数量上的一致,大大提高了路由节点的处理性能。

关键词：片上网络路由节点仲裁器优先级仿真

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A/A/O氧化沟流态特性研究及积泥分析

土木建筑与环境工程 2011年第1期33卷 118-123页

作者：李柏林张智刘少武卢昌松柴华王维忠袁相贵重庆大学城市建设与环境工程学院重庆400045 重庆大学三峡库区生态环境教育部重点实验室重庆400045 重庆水务集团股份有限公司重庆400015

为了探求氧化沟内流速分布规律,解决积泥问题并实现系统能量的优化配置,以重庆市某污水处理厂的A/A/O氧化沟为试验平台,根据曝气转盘及水下推流器的不同组合方式设计了3种试验工况,重点对氧化沟外沟大弯段处的流速分布进行了测试及分析... 详细信息

为了探求氧化沟内流速分布规律,解决积泥问题并实现系统能量的优化配置,以重庆市某污水处理厂的A/A/O氧化沟为试验平台,根据曝气转盘及水下推流器的不同组合方式设计了3种试验工况,重点对氧化沟外沟大弯段处的流速分布进行了测试及分析。结果表明:第1沟段下部流速过大容易造成能量浪费,间歇开/停水下推流器可以优化系统的能量配置;第2沟段水力情况复杂,外侧流速高、内侧流速低,形成了明显的滞水区,造成了内侧部分区域积泥;提出了解决积泥问题的措施,即在第2沟段的弯道处加设偏心导流墙、调整水下推流器的位置。

关键词：氧化沟流态积泥节能降耗

杀螨剂嘧螨胺(SYP-11277)的创制经纬

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农药 2011年第5期50卷 325-326,335页

作者：柴宝山刘长令张弘李慧超罗艳梅刘少武宋玉泉沈阳化工研究院有限公司新农药创制与开发国家重点实验室沈阳110021

概述了杀螨剂嘧螨胺(SYP-11277)的创制经纬。首先以取代嘧啶醇为中间体进行衍生化研究,合成了一系列化合物,从而发现了具有杀螨活性的先导化合物1(运用中间体衍生化方法发现先导化合物),然后通过结构修饰发现二次先导化合物2,进一步优... 详细信息

概述了杀螨剂嘧螨胺(SYP-11277)的创制经纬。首先以取代嘧啶醇为中间体进行衍生化研究,合成了一系列化合物,从而发现了具有杀螨活性的先导化合物1(运用中间体衍生化方法发现先导化合物),然后通过结构修饰发现二次先导化合物2,进一步优化研究发现SYP-10913、SYP-11277、SYP-11992、SYP-11993等高活性化合物,最终确定嘧螨胺(SYP-11277)作为候选杀螨剂进行产业化开发。该药剂对红蜘蛛成、若、幼螨均具有很好的防治效果,而且表现了优异的杀卵活性。

关键词：中间体衍生化方法先导发现嘧螨胺杀螨活性杀卵活性

Consensus statement on layout and delivery of automatic external defibrillator in China

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Journal of Hainan Medical University 2020年第15期26卷 18-23页

作者： Yu Cao song Chen Yan-Fen chai Xiao-Hui Chen Yu-Guo Chen Shao-Wen Cheng Wen-Wei Cheng Bang-Han Ding Yang Deng Jie Fu Bang-Jiang Fang Mai-Ying Fan li Gui Ping Gong Wei Guo Shu-Bin Guo liang Huang Ji-Yuan Han Zhong Ji Xian-Fei Ji Xin-Cai Ji Hong-Xu Jin Xin-Jun Jiang Wang-Xiang Jiang Jia-liang liu Xiao-Ran liu Zhi liu Chuan-Zhu Lv Feng Lu Tan-Shi li Xin li Yong li Shang-Lun li Shuang-Ming li Xiao-Gang li Bao-Jun li Pei-wu li Chun-Sheng li Zhi-Jun li chang-Luo li Xiang-Min li Yin-Ping li Zong-Jun Lu Zu-Xun Lu Zhong-Qiu Lu Zhi-Qian Luo Xiao-Xing liao Jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma Qing-Bian Ma lin-Hao Ma Jun-Qi Ma Shi-Nan Nie Jie-Miao Ou-Yang Peng Peng Qiao Pei Shu-Ming Pan Guo-Zhong Qing li-Jie Qin wu-Ying Qiao Fei Shao Wei song Xing-Yue song Zhen-Ju song Rong-Ju Sun De-Ya Shang Du-Juan Sha Gui-Lan Tao Guo-Gang Tian Ying-Ping Tian Jian-Guang Tian Chao-Yang Tong Zi-Ren Tang Meng-Xiong Tang Guo-Ping wu Zhi Wan Tao Wang Xin Wang Peng Wang Zhong Wang Tong Wang Ri-Xing Wang Yi-Xin Wang Xiao-Dan Wang ling wu Wei Wei Hua Xiang Feng Xu Jun Xu Jie Xu Miao-Rong Xie Shuo-Gui Xu Tie Xu Feng Yu Wen Yi li-Shan Yang Shi-Jiao Yan Jin-Jian Yao Shou-Chun Yan Xue-Zhong Yu Xian-Zhi Ye Xian-liang Yan Fu-Bing Zhou Rong-Bin Zhou Ming Zhou Qiang Zhou Jin Zhou Ping Zhou chang-Ju Zhu Hua-Dong Zhu Ji-Hong Zhu Hong Zhang Mao Zhang Hua Zhang Na Zhang Guo-Qiang Zhang Guo-Xiu Zhang Jin-song Zhang Wen-wu Zhang Wen-Zhong Zhang Jian-Feng Zhang Yi-Min Zhu Jun Zeng Yuan Zheng Zhi-Jie Zheng Shen Zhao Yan Zhao Min Zhao Bin Zhao Xiao-Dong Zhao Xiao-Jing Zhao Hong-Ke Zeng Sheng-Qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

关键词： cardiac death respiratory

炎症性肠病患者黏附分子-l、D-乳酸、二胺氧化酶的变化及临床意义

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现代消化及介入诊疗 2013年第5期18卷 273-276页

作者：钟武装宋卫兵杨键肖丽萍杨明常刘岗谢涣琴蔡敏捷乐德广州军区广州总医院干部病房二科 510100

目的研究炎症性肠病(Inflammatory Bowel Disease,IBD)患者可溶性血清细胞间黏附分子-l(sICAM-1)、血浆D-乳酸、二胺氧化酶(DAO)、白细胞(WBC)的变化及其临床意义。方法将108例IBD患者和60例健康体检者分为观察组和对照组,对两组分别采... 详细信息

目的研究炎症性肠病(Inflammatory Bowel Disease,IBD)患者可溶性血清细胞间黏附分子-l(sICAM-1)、血浆D-乳酸、二胺氧化酶(DAO)、白细胞(WBC)的变化及其临床意义。方法将108例IBD患者和60例健康体检者分为观察组和对照组,对两组分别采用酶联免疫法测定血清sICAM-l,分光光度法检测D-乳酸和DAO水平,常规检查白细胞计数。结果 IBD患者sICAM-1、血浆D-乳酸、DAO、WBC明显高于对照组(P0.05),而治疗后sICAM-l、DAO、D-乳酸水平显著低于治疗前(P<0.01)。结论 sICAM-1,血浆D-乳酸和DAO与病情程度密切相关,sICAM-1可作为IBD患者病情的主要监测指标之一。

关键词：炎症性肠病细胞间黏附分子-l D-乳酸二胺氧化酶

骨蚀再造丸对激素性股骨头坏死大鼠炎症因子的影响

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广州中医药大学学报 2024年第12期41卷 3252-3258页

作者：沈彩红邬国松王建忠郭永昌杨志敏李文茜张瑾柴爽冯小艳郭家巧曹玉举郑州中医骨伤病医院河南省骨坏死研究中医药重点实验室河南省骨伤病中医诊疗工程技术研究中心河南郑州450016 南方医院白云分院广东广州510080 内蒙古医科大学第二附属医院内蒙古呼和浩特010030 河南省骨科医院河南郑州450016

【目的】观察骨蚀再造丸对激素性股骨头坏死的治疗作用及机制。【方法】将雄性SD大鼠随机分为正常组、模型组、仙灵骨葆胶囊组和骨蚀再造丸组。除正常组,其他各组大鼠复制激素性股骨头坏死模型。成功造模后,连续给药6周。取大鼠胸腺和... 详细信息

【目的】观察骨蚀再造丸对激素性股骨头坏死的治疗作用及机制。【方法】将雄性SD大鼠随机分为正常组、模型组、仙灵骨葆胶囊组和骨蚀再造丸组。除正常组,其他各组大鼠复制激素性股骨头坏死模型。成功造模后,连续给药6周。取大鼠胸腺和脾脏计算免疫器官指数,酶联免疫吸附法(EliSA)测定大鼠关节液白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)的含量,苏木素-伊红(HE)染色法测定空骨陷窝率、骨小梁面积比,Micro-CT分析股骨头参数[骨体积分数(BV/TV)、骨小梁数量(Tb.N)、骨小梁厚度(***)、骨小梁分离度(***)],小动物骨骼强度测定仪测定股骨头骨骼强度。【结果】与正常组比较,模型组脾脏、胸腺指数显著下降,关节液IL-1β、TNF-α含量显著增加,空骨陷窝率升高,骨小梁面积比降低,BV/TV、Tb.N、***降低,***升高,股骨头骨骼强度显著降低,差异均有统计学意义(P<0.05或P<0.01);与模型组比较,仙灵骨葆胶囊组和骨蚀再造丸组脾脏、胸腺指数显著升高,关节液IL-1β、TNF-α含量降低,空骨陷窝率显著降低,骨小梁面积比显著升高,BV/TV、Tb.N、***升高,***降低,股骨头骨骼强度显著升高,差异均有统计学意义(P<0.05或P<0.01)。【结论】骨蚀再造丸通过调节细胞免疫,减少炎症因子分泌,进而降低股骨头病理损伤,增强骨骼强度,可有效防止激素性股骨头坏死进一步发展。

关键词：骨蚀再造丸激素性股骨头坏死脏器指数炎症因子大鼠