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原发性肝细胞癌中cyclin D1基因表达与P16及CDK4蛋白表达的关系

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世界华人消化杂志 2000年第3期8卷 307-309页

作者：孙宝华王涛武忠弼阮幼冰杨木兰同济医科大学实验医学研究中心超微病理研究室湖北省武汉市430030 武汉市四医院同济医科大学附属普爱医院内科湖北省武汉市430033

目的研究cyclin D1基因在原发性肝细胞癌中的表达,并探讨其与P16及CDK4蛋白表达的关系。方法用原位杂交检测cyclin D1基因mRNA表达,免疫组化检测Cyclin D1蛋白表达。结果 6例(14.3％)HCC可检测到cyclin D1基因过表达,5例属Ⅲ—Ⅳ级,... 详细信息

目的研究cyclin D1基因在原发性肝细胞癌中的表达,并探讨其与P16及CDK4蛋白表达的关系。方法用原位杂交检测cyclin D1基因mRNA表达,免疫组化检测Cyclin D1蛋白表达。结果 6例(14.3％)HCC可检测到cyclin D1基因过表达,5例属Ⅲ—Ⅳ级,1例属Ⅱ级。6例HCC均有CDK4蛋白表达,其中3例为P16蛋白阳性。结论 ①cyclin D1表达增加只在小部分恶性程度高的HCC中起作用,可能与肿瘤侵袭有关。②在HCC中,cyclin D1基因过表达和(或)P16蛋白丢失均起重要作用。

关键词：肝肿瘤肝细胞癌 cyclinD1基因基因表达

Treatment of invasive giant prolactinomas involving the cavemous sinus with Bromocriptine:Results of long-term follow-up

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Treatment of invasive giant prolactinomas involving the cave...

Asymmetric Meerwein-Ponndorf-Verley reduction catalyzed by a new type of chiral binaphthol-samarium complex

中国医师协会神经外科医师分会首届全国代表大会

作者： Zhe Bao wu Chun Jiang Yu Zhi Peng Su Qi Chuan Zhuge Jin Sen wu Wei Ming Zheng Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, People'' s Republic of China (wu zb, Su ZP, Zhuge QC, wu JS, Zheng WM) and Department of Neurosurgery, Fu Xing Hospital, Capital University of Medical Science, Bei Jing 100038, People'' s Republic of China (Yu CJ)

＜正＞Objective To observe the long- term clinical outcomes in a group of patients with invasive giant prolactinomas （IGPs） involving the cavernous sinus treated with bromocriptine. Methods Data from 20 patients with IGPs treated in our institutions during a period from July, 1997 to June, 2004 were retrospectively reviewed. The criteria utilized included: （1） tumor diameter ＞ 4 cm, invasion of the cavernous sinus by tumor, corresponding to grade III - IV according to the classification of Knosp;（2） serum prolactin level ＞ 200 ng/ml;（3） clinical signs of hyperprolactinemia and mass effect. Among the 20 patients who met the criteria: 6 patients had undergone unsuccessful transcranial or transsphenoidal microsurgery prior to bromocriptine treatment and 14 patients initially received bromocriptine as primary treatment. Eleven of the 20 had received adjuvant radiotherapy. Results After an average follow- up period of 37. 3 months, the clinical symptoms of all patients had improved by different degrees. Tumor volume on MRI was decreased on average by 93. 3 %;in 11 patients, the tumors had almost completely disappeared, and in the other 9 patients, residual tumor involved the cavernous sinus. Visual symptoms improved in 13 of the patients who presented with visual loss. Eight patients had normal PRL level. The postoperative prolactin level was more than 200ng/ml in 7 patients. During the course of drug administration, CSF leakage occurred in one patient, who subsequently underwent transsphenoidal surgery. No cases of apoplexy occurred during bromocriptine treatment. Conclusion Dopamine agonist medications are effective as first- line therapy for IGPs, because they can significantly shrink tumor volume and control the PRL level. Tumor mass vanishes in some patients after bromocriptine treatment, and for other patients, with localized residual tumor, stereotaxic radiosurgery is an option so that unnecessary surgery can be avoided. Radiotherapy does not reliably result in tumor

关键词： Giant prolactinoma Invasiveness Bromocriptine Cavernous sinus

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Chinese Journal of Chemistry 1996年第6期14卷 561-564页

作者： Ding, zb Cheng, KJ wu, SH FUDAN UNIV DEPT CHEMSHANGHAI 200433PEOPLES R CHINA

A new type of chiral 1,1'-binaphthol(BINOL) derived samarium complex, prepared from (R)- or (S)-BINOL and SmCl3, serves as an enantioselective catalyst for the Meerwein-Ponndorf-Verley (MPV) reduction in the presence of Molecular Sieves 4 Angstrom(MS 4 Angstrom). Moderate enantioselectivity was obtained. Kinetic studies show slight decrease of the enantiomeric excess with the conversion.

关键词： asymmetric synthesis reduction samarium reagent

Smart Cellulose‑Based Janus Fabrics with Switchable Liquid Transportation for Personal Moisture and Thermal Management

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Nano-Micro Letters 2025年第1期17卷 333-347页

作者： Jianfeng Xi Yanling Lou Liucheng Meng Chao Deng Youlu Chu Zhaoyang Xu Huining Xiao Weibing wu Jiangsu Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsJiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass MaterialsNanjing Forestry UniversityNanjing 210037People’s Republic of China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering University of New BrunswickFrederictonNB E3B 5A3Canada Macromolecular Chemistry and Bavarian Polymer Institute University of BayreuthBayreuth 95440Germany

The Janus fabrics designed for personal moisture/thermal regulation have garnered significant attention for their potential to enhance human ***,the development of smart and dynamic fabrics capable of managing personal moisture/thermal comfort in response to changing external environments remains a ***,a smart cellulose-based Janus fabric was designed to dynamically manage personal moisture/*** cotton fabric was grafted with N-isopropylacrylamide to construct a temperature-stimulated transport ***,hydrophobic ethyl cellulose and hydrophilic cellulose nanofiber were sprayed on the bottom and top sides of the fabric to obtain wettability *** fabric exhibits anti-gravity directional liquid transportation from hydrophobic side to hydrophilic side,and can dynamically and continuously control the transportation time in a wide range of 3–66 s as the temperature increases from 10 to 40℃.This smart fabric can quickly dissipate heat at high temperatures,while at low temperatures,it can slow down the heat dissipation rate and prevent the human from becoming too *** addition,the fabric has UV shielding and photodynamic antibacterial properties through depositing graphitic carbon nitride nanosheets on the hydrophilic *** smart fabric offers an innovative approach to maximizing personal comfort in environments with significant temperature variations.

关键词： Directional water transport Cotton fabric Anti-gravity directional liquid transportation Janus wettability

White oak (Quercus fabri Hance) regenerated stump sprouts show few senescence symptoms during 40 years of growth in a natural forest

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Forest Ecosystems 2021年第1期8卷 139-150页

作者： Honggang Sun Sisheng wu Liwen wu Research Institute of Subtropical Forestry Chinese Academy of ForestryHangzhou 311400China

Background:The relationship between physiological age of parental trees and lifespan of clonal offspring is *** oak(Quercus fabri Hance)has a high sprouting capability after harvest,with the regenerated sprouts being typical clonal *** determine whether regenerated sprouts undergo rapid senescence compared with the parent,the senescence levels of 5-,10-,20-and 40-year-old regenerated stump sprouts in a natural forest were *** antioxidative abilities and transcriptomes in these leaves and shoots were ***:Older regenerated sprouts still had robust antioxidative systems,with 40-year-old sprouts having lower peroxidation product levels but similar antioxidative enzyme activity levels compared with 5-year-old *** leaves had greater transcriptional activities in pathways related to cell growth and division than younger ***,older sprouts had some unhealthy characteristics,such as increased base excision repair levels and upregulated phagosome,proteasome and glycerophospholipid metabolism pathways in 40-year-old leaves,which indicates that DNA damage and tissue remodeling occurred more frequently than in younger ***,plant-pathogen interactions and MAPK signals pathways were upregulated in older shoots,which indicates that older shoots suffered from more pathogen-related biotic ***:The 40-year-old sprouts still had the same vitality level as the 5-year-old sprouts,although the former had some unhealthy *** conclude that during their first 40 years of growth,regenerated stump sprouts do not begin to senesce,and that physiological age of parental trees does not significantly affect the lifespan of its clonal offspring.

关键词： Sprout Regeneration Senescence White oak Vegetative propagation

LINEAR CHAOS IN THE QUANTUM HARMONIC OSCILLATOR

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Journal of Systems Science & Complexity 2014年第4期27卷 694-700页

作者： wu Xinxing ZHU Peiyong School of Mathematics University of Electronic Science and Technology of China

In this note,it is proved that for the annihilation operator B of the unforced quantum harmonic oscillator,B^n is mixing and generically 5-chaotic with any 0 < δ < 2 for each positive integer ***,by using the result ... 详细信息

In this note,it is proved that for the annihilation operator B of the unforced quantum harmonic oscillator,B^n is mixing and generically 5-chaotic with any 0 wu X and Zhu P,***.A:***.,2011,44:505101],the authors obtain that the principal measure of B^n is equal to 1 for each positive integer n.

关键词： Annihilation operator Devaney chaos generical 5-chaos mixing principal measure.

Few-shot RF fingerprinting recognition for secure satellite remote sensing and image processing

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Science China(Information Sciences) 2023年第8期66卷 277-278页

作者： Di LIN Su HU Weiwei wu Gang wu National Key Laboratory of Science and Technology on Communication University of Electronic Science and Technology of China

We consider the security issues in a satellite remote sensing(SRS) and image processing system. Specifically, we present a novel architecture of a secure SRS image recognition system by using a radio frequency(RF) fingerprint to identify whether a satellite user is authenticated or *** unauthenticated users, we address the method of adding perturbation into their received SRS images,

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Nonlinear modal electromechanical coupling factor for piezoelectric structures containing nonlinearities

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Chinese Journal of Aeronautics 2023年第2期36卷 100-110页

作者： Yaguang wu Yu FAN Lin LI School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Key Laboratory of Aero-engine Structure and Strength Beijing 100191China

Within the linear framework,the Modal Electromechanical Coupling Factor(MEMCF)is an important indicator to quantify the dynamic conversion of mechanical energy and electrical energy of piezoelectric *** is also an important tool to guide the piezoelectric damping design of linear *** aircraft often fly in maneuvers,and the variable working conditions induce drastic changes in the load level on *** and contact nonlinearities of thin-walled structures and joint structures are often *** achieve a good vibration reduction effect covering all working conditions,one cannot directly use linear electromechanical coupling theory to instruct the piezoelectric damping design for nonlinear ***,this paper defines the Nonlinear Modal Electromechanical Coupling Factor(NMEMCF)and proposes the corresponding numerical method for the first time to quantitatively evaluate the electromechanical coupling capability of nonlinear piezoelectric *** candidate definitions of the NMEMCF are given,including two frequency definitions and one energy *** energy definition is the most promising *** is not only applicable to both conservative and dissipative nonlinear structures but also compatible with the linear *** addition,based on the energy formula,the NMEMCF can be obtained by only performing one nonlinear modal analysis in the open-circuit *** analytical findings and the numerical tool are validated against two piezoelectric structures with different types of nonlinearities.A strong correlation among the NMEMCF,geometric parameters,and energy dissipation is *** results confirm that the proposed NMEMCF captures the physics of the electromechanical coupling phenomenon associated with nonlinear piezoelectric structures and can be used as an essential design indicator of piezoelectric damping,especially for variable working conditions.

关键词： Modal electromechanical coupling factor Multiharmonic balance method Nonlinear normal modes Piezoelectric damping Vibration control

Decadal Changes in Interannual Dependence of the Bay of Bengal Summer Monsoon Onset on ENSO Modulated by the Pacific Decadal Oscillation

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Advances in Atmospheric Sciences 2019年第12期36卷 1404-1416页

作者： Xiaofei wu Jiangyu MAO School of Atmospheric Sciences/Plateau Atmosphere and Environment Key Laboratory of Sichuan Province/Joint Laboratory of Climate and Environment Change Chengdu University of Information TechnologyChengdu 610225China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

Interannual variations of the Bay of Bengal summer monsoon (BOBSM) onset in association with El Ni-o-Southern Oscillation (ENSO) are reexamined using NCEP1, JRA-55 and ERA20C atmospheric and Hadley sea surface temperature (SST) reanalysis datasets over the period 1900-2017. Decadal changes exist in the dependence of the BOBSM onset on ENSO, varying with the Pacific Decadal Oscillation (PDO). A higher correlation between the BOBSM onset and ENSO arises during the warm PDO epochs, with distinct late (early) onsets following El Ni-o (La Ni-a) events. In contrast, less significant correlations occur during the cold PDO epochs. The mechanism for the PDO modulating the ENSO-BOBSM onset relationship is through the variations in SST anomaly (SSTA) patterns. During the warm PDO epochs, the superimpositions of the PDO-related and ENSO-related SSTAs lead to the SSTA distribution of an El Ni-o (La Ni-a) event exhibiting significant positive (negative) SSTAs over the tropical central-eastern Pacific and Indian Ocean along with negative (positive) SSTAs, especially over the tropical western Pacific (TWP), forming a strong zonal interoceanic SSTA gradient between the TWP and tropical Indian Ocean. Significant anomalous lower tropospheric easterlies (westerlies) together with upper-tropospheric westerlies (easterlies) are thus induced over the BOB, favoring an abnormally late (early) BOBSM onset. During the cold PDO epochs, however, the superimpositions of PDO-related SSTAs with El Ni-o-related (La Ni-a-related) SSTAs lead to insignificant SSTAs over the TWP and a weak zonal SSTA gradient, without distinct circulation anomalies over the BOB favoring early or late BOBSM onsets.

关键词： decadal change Bay of Bengal summer monsoon onset ENSO Pacific Decadal Oscillation