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THE SUN THE LION:EARLIEST HYMN TO THE SUN FROM EBLA AND ABU-SALABIKH (2600-2500)

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Journal of Ancient Civilizations 2007年 75-90页

作者： wu yuhong, ihac, Northeast Normal University, Changchun

A hymn that praises the Sun god belongs to the earliest literature work of Mesopotamian civilization and it expressed a hearty praise of the absolute being, the Sun, the god of brightness of the ancient Akkadian peopl... 详细信息

关键词： THE SUN THE LION IAS down

ETYMOLOGY OF AKKADIAN MONTH OF AYYARU AND SUMERIAN ITI-GUD-SI～S

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Journal of Ancient Civilizations 2007年 69-73页

作者： wu yuhong, ihac, Northeast Normal University, Changchun

1. Ayyaru in the Gula Hymn of Bullutsa-rabi Lines 178-187 of the Gula Hymn of Bullutsa-rabi1 is about the function of Ninlil. Prof. Lambert did not translate the sentence of sa i-na a-a-re-e hi-ta-ku in line 183, because the meaning of a-a-re-e is difficult. CAD S p 150 (mistakes Nin-karrak for Ninlil) thinks that a-a-re-e is aru A from Sumerian a-ra,

关键词： ITI

Multi-view Feature Learning for the Over-penalty in Adversarial Domain Adaptation

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Data Intelligence 2024年第1期6卷 183-200页

作者： yuhong Zhang Jianqing wu Qi Zhang Xuegang Hu School of Computer and Information Engineering Hefei University of TechnologyHefei 230601China Key Laboratory of Knowledge Engineering with Big Data(Hefei University of Technology) The Ministry of Education of ChinaHefei 230009China

Domain adaptation aims to transfer knowledge from the labeled source domain to an unlabeled target domain that follows a similar but different ***,adversarial-based methods have achieved remarkable success due to the excellent performance of domain-invariant feature presentation ***,the adversarial methods learn the transferability at the expense of the discriminability in feature representation,leading to low generalization to the target *** this end,we propose a Multi-view Feature Learning method for the Over-penalty in Adversarial Domain ***,multi-view representation learning is proposed to enrich the discriminative information contained in domain-invariant feature representation,which will counter the over-penalty for discriminability in adversarial ***,the class distribution in the intra-domain is proposed to replace that in the inter-domain to capture more discriminative information in the learning of transferrable *** experiments show that our method can improve the discriminability while maintaining transferability and exceeds the most advanced methods in the domain adaptation benchmark datasets.

关键词： domain adaptation adversarial learning multi-view learning

Simple and effective:Superlubricity behaviour of the G-quadruplex hydrogel with high selectivity for K+ions based on the ocular environment

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Friction 2024年第11期12卷 2548-2562页

作者： Hongdong WANG Jian wu Kunpeng WANG Yunjuan SU Xiacong ZHANG yuhong LIU Jianhua ZHANG School of Mechatronic Engineering and Automation and Key Laboratory of Advanced Display and System Application Ministry of EducationShanghai UniversityShanghai 200444China State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China Department of Polymer Materials School of Materials Science and EngineeringShanghai UniversityShanghai 200444China

Hydrogels have been the subject of significant research in the field of friction due to their exceptional lubricating *** this study,the G-quadruplex hydrogel with high selectivity for K+ions was formed by introducing a mixture of G,2-formylphenylboronic acid,and polyethylene glycol diamine into simulated artificial tears solution with high transparency,and an ultra-low coefficient of friction(COF)of about 0.004 was obtained based on the simulated ocular environment,thus achieving macroscopic *** friction pairs simulating the ocular environment,to assess the frictional performance of the G-quadruplex hydrogel as both a lubricant and a friction pair based on the simulated ocular environment,we conducted experiments considering various factors such as concentration,sliding speed,and *** these experiments,it was found that superlubricity was achieved when the G-quadruplex hydrogel was applied as lubricant or friction *** effect was attributed to the three-dimensional network structure and hydrophilicity of the hydrogel,which facilitated the formation of a highly bearing and flowing hydration layer,promoting macroscopic *** to the G-quadruplex hydrogel with low concentration,the high concentration hydrogel(75 mM)exhibited increased mechanical strength and robustness in *** with biocompatibility experiments,our synthesized G-quadruplex hydrogel has excellent biocompatibility and offers a novel approach to achieve superlubricity in ocular drug delivery.

关键词： superlubricity ocular environment G-quadruplex hydrogel bio-compatibility

Preparation of norovirus GII loop mediated isothermal amplification freeze-drying microsphere reagents and its application in an on-site integrated rapid detection platform

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Chinese Chemical Letters 2024年第9期35卷 262-265页

作者： Yanqi wu yuhong Guan Peilin Huang Hui Chen Liping Bai Zhihong Jiang State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China Shenzhen LemnisCare Medical Technology Co. Ltd.Shenzhen 518107China Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of TechnologyZhuzhou 412077China

Norovirus is an infectious disease that can cause non-bacterial gastroenteritis,which has a low infectious dose,rapid onset,and strong transmission ability;therefore,rapid and sensitive detection is essential to reduce the transmission of *** the study,a norovirus GII loop-mediated isothermal amplification assay was developed and prepared into freeze-drying microspheres,and a closed-cassette-based,integrated,reagent-ambient storage,on-site instant detection platform for norovirus GII was constructed using a commercial,fully automated nucleic acid analyzer with integrated magnetic bearing based nuclear acid extraction and nucleic acid detection,with a sensitivity of 10 copies/μL,with no cross-reactivity with other 5 *** 28 simulated samples,the integrated assay platform was consistent with the experimental results of reverse transcription-quantitative polymerase chain reaction(RT-qPCR)assays after conventional laboratory nucleic acid *** entire process can be finished in about 1 h,which is ideal for immediate rapid detection.

关键词： Freeze-dried microspheres Point-of-care testing Loop-mediated isothermal amplification Norovirus GII Integrated testing

Short lifespan and ‘prime period’ of carbon sequestration call for multi-ages in dryland tree plantations

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Forest Ecosystems 2024年第5期11卷 670-676页

作者： Chongyang Xu Xiuchen wu yuhong Tian Liang Shi Yang Qi Jingjing Zhang Hongyan Liu College of Urban and Environmental Sciences and MOE Laboratory for Earth Surface Processes Peking UniversityBeijing100871China College of Resources Science and Technology Beijing Normal UniversityBeijing100875China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing100101China College of JunCao Science and Ecology Fujian Agriculture and Forestry UniversityFuzhou350002China

Enhancing forest cover is important for effective climate change *** suggest that drylands are promising areas for expanding forests,but conflicts arise with increased forest area and water *** tree mortality in drylands raises concerns about carbon sequestration potential in tree *** Chinese dryland tree plantations as an example,we compared their growth with natural *** results suggested plantation trees grew 1.6–2.1 times faster in juvenile phases,significantly shortening time to maturity(13.5 vs.30 years)compared to natural forests,potentially stemming from simple plantation age *** from natural forests,74%of trees in plantations faced growth decline,indicating a short“prime period”for carbon sequestration and even a short ***,a negative relationship between evapotranspiration and tree growth was observed in tree plantations since maturity,leading to high sensitivities of trees to vapor pressure deficit and soil ***,this was not observed in natural *** address this,we suggest afforestation in drylands should consider complex age structures,ensuring a longer prime period for carbon sequestration and life expectancy in tree plantations.

关键词： Tree growth Drylands Tree plantations Carbon sequestration Lifespan

Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signalling

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1441-1456页

作者： Xin Zhuo Yue wu Xiujuan Fu Jianbin Li Yuxin Xiang Xiaoyu Liang Canquan Mao yuhong Jiang Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Excessive and uncontrollable inflammatory responses in alveoli can dramatically exacerbate pulmonary disease progressions through vigorous cytokine releases,immune cell infiltration and protease-driven tissue *** is an urgent need to explore potential drug strategies for mitigating lung ***-activated receptor 2(PAR2)as a vital molecular target principally participates in various inflammatory diseases via intracellular signal ***,it has been rarely reported about the role of PAR2 in lung *** study applied CRISPR-Cas9 system encoding Cas9 and sg RNA(p Cas9-PAR2)for PAR2 knockout and fabricated an anionic human serum albuminbased nanoparticles to deliver p Cas9-PAR2 with superior inflammation-targeting efficiency and stability(TAP/p Cas9-PAR2).TAP/p Cas9-PAR2 robustly facilitated p Cas9-PAR2 to enter and transfect inflammatory cells,eliciting precise gene editing of PAR2 in vitro and in ***,PAR2 deficiency by TAP/p Cas9-PAR2 effectively and safely promoted macrophage polarization,suppressed proinflammatory cytokine releases and alleviated acute lung inflammation,uncovering a novel value of *** also revealed that PAR2-mediated pulmonary inflammation prevented by TAP/p Cas9-PAR2was mainly dependent on ERK-mediated NLRP3/IL-1β and NO/i NOS ***,this work indicated PAR2 as a novel target for lung inflammation and provided a potential nanodrug strategy for PAR2 deficiency in treating inflammatory diseases.

关键词： Protease-activated receptor 2(PAR2) CRISPR-Cas9 Gene editing Inflammation Acute lung inflammation NLRP3 Nanoparticles Drug delivery

Fucoidan protects against LPS-induced mastitis and enhances the integrity of blood-milk barrier by activating AMPK/Nrf2 and autophagy

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Food Science and Human Wellness 2024年

作者： Xiaoben Liang yuhong Chen Zhijie Zheng Yonghui Zheng Haichong wu Longyan University & Fujian Provincial Key Laboratory for Prevention and Control of Animal Infectious Diseases and Biotechnology College of Animal Sciences and Veterinary Medicine， Guangxi University Department of Veterinary Medicine， College of Animal Sciences， Zhejiang University

Mastitis often occurs during women’s lactation period， causing great psychological and physical pain to women. Fucoidan， a sulfated polysaccharide obtained from brown algae， has much broader biological properties. However， the roles of fucoidan in lipopolysaccharides (LPS)-induced mastitis are still undiscovered. The present study was aimed to evaluate the influences of fucoidan on LPS-induced mouse mastitis and investigate its possible mechanisms. The expression profiles of fucoidan acting on mastitis were analyzed by Network pharmacology. Additionally， mechanism experiments verified the mechanism of fucoidan on mastitis. The results of in vivo study displayed that the treatment of fucoidan to LPS-stimulated mouse mastitis decreased the inflammatory damage， proinflammatory cytokines level and repaired the completeness of blood-milk barrier. In the study of mouse mammary epithelial cells， fucoidan suppressed the secretion of reactive oxygen species (ROS)and enhanced the activity of antioxidant enzymes. Molecular experiments suggested that fucoidan promoted Nrf2 nuclear import and autophagy via activating the AMPK signaling pathway. The above results indicated that in mastitis， fucoidan promoted Nrf2 nuclear import and autophagy via activating the AMPK signaling pathway， thereby suppressing oxidative stress and inflammatory injury to the mammary glands and protecting the blood-milk barrier.

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Krill oil attenuates obesity-induced skeletal muscle atrophy in mice

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Food Science and Human Wellness 2024年

作者： Mengqing Zhou yuhong Yang Yan Zheng Zijian wu Chen Chen Qijian Liang Yu Yang Hao wu Xin Guo Lei Du School of Food Science and Engineering， Qilu University of Technology (Shandong Academy of Sciences) School of Public Health， Cheeloo College of Medicine， Shandong University Research Center of Translational Medicine， Jinan Central Hospital， Shandong University

Obesity is associated with skeletal muscle mass loss and physical dysfunction. Krill oil (KO) has been shown to be beneficial in human health. However， the effect of KO on obesity-induced skeletal muscle atrophy is still unclear. In this study， the male C57BL/6J mice were fed a high-fat diet (HFD) for 12 weeks to induce obesity， and then were intragastric administration with 400 mg/kg bw KO for an additional 6 weeks. The results showed that KO treatment reduced body weight， fat accumulation and serum pro-inflammatory cytokines in HFD-induced obese mice. Importantly， KO treatment attenuated skeletal muscle atrophy in HFD-fed mice， as evidenced by preserving skeletal muscle mass， average myofiber cross-sectional area and grip strength. KO administration also mitigated obesity-induced ectopic lipid deposition and inflammatory response in skeletal muscle. Additionally， KO treatment inhibited the transcriptional activities of nuclear factor-kappa B (NF-κB) p65 and forkhead box O 3a (FoxO3a)， and then down-regulated muscle atrophy F-box (MAFbx) and muscle-specific RING finger protein 1 (MuRF1) protein levels in skeletal muscle from HFD-fed mice. KO administration also improved obesity-induced impaired muscle protein synthesis via activating PI3K/Akt pathway. Furthermore， KO treatment enhanced muscle mitochondrial biogenesis in HFD-induced obese mice via activating PGC-1α pathway. Collectively， KO might be developed as a potential nutritional supplement for the prevention and treatment of obesity-induced skeletal muscle atrophy.

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