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Dendritic nanomedicine enhances chemoimmunotherapy by disturbing metabolism of cancer-associated fibroblasts for deep penetration and activating function of immune cells

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3680-3696页

作者： Yunkun Li Xiaoding Shen Haitao Ding Yuxin Zhang Dayi Pan Liping Su Yahui wu Zaixiang Fang Jie Zhoua Qiyong Gong Kui Luo department of Radiology Huaxi MR Research Center(HMRRC)Frontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Functional and Molecular Imaging Key Laboratory of Sichuan Province and Research Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610041China department of Radiology West China Xiamen Hospital of Sichuan UniversityXiamen 361021China

Inefficient drug penetration hurdled by the stroma in the tumor tissue leads to a diminished therapeutic effect for drugs and a reduced infiltration level of immune ***,we constructed a PEGylated dendritic epirubicin(Epi)prodrug(Epi-P4D)to regulate the metabolism of cancer-associated fibroblasts(CAFs),thus enhancing Epi penetration into both multicellular tumor spheroids(MTSs)and tumor tissues in mouse colon cancer(CT26),mouse breast cancer(4T1)and human breast cancer(MDA-MB-231)*** cytotoxicity against CT26 MTSs and remarkable antitumor efficacy of Epi-P4D were ascribed to reduced fibronectin,α-SMA,and collagen ***,thinning of the tumor tissue stroma and efficient eradication of tumor cells promoted the immunogenic cell death effect for dendritic cell(DC)maturation and subsequent immune activation,including elevating the CD4^(+)T cell population,reducing CD4^(+)and CD8^(+)T cell hyperactivation and exhaustion,and amplifying the natural killer(NK)cell proportion and effectively activating *** a result,this dendritic nanomedicine thinned the stroma of tumor tissues to enhance drug penetration and facilitate immune cell infiltration for elevated antitumor efficacy.

关键词： Dendritic prodrug Enhanced penetration Metabolic intervention Cancer-associated fibroblasts Immunogenic cell death Chemotherapy Immunotherapy Immune microenvironment reconstitution

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Expression of SSTR in different types of human thyroid carcinoma

Expression of SSTR in different types of human thyroid carci...

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首届全国分子核医学暨分子影像学学术交流会

作者： Pan Weimin, wu Hua,Su Xinhui. department of. Nuclear Medicine and PET Center, The First Hospital of xiamen, Fujian Medical university, xiamen 361003, china

Purpose To study the expression of SSTR2 (subtype 2 of somatostatin receptor) and other types of SSTR(somatostatin receptor) in thyroid tumor tissue and the adjacent tissue using hybridization in situ. Method A series of oligonucleotide probes for all kinds of SSTR and oligonucleotide probes especially for SSTR2 were designed according to the gene structure of SSTR. (Fig 1 & Fig 2) . It is known that SSTR2 has the strongest affinity for Tc-99m-Octreotid and Tc-99m-RC-160 among the five subtypes. Therefore we used oligonucleotide detector specially for SSTR2 and that for all subtypes of SSTR. The hybridization in situ was performed among both series of probes and frozen slices of various kinds thyroid tumor. The positive signal strength of mRNA expression, intensity of mRNA and signal strength(-x±S )were obtained based on the gray analysis of Mias image analyzer. T

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Mesenchymal stem cell-derived extracellular vesicles in skin wound healing:roles,opportunities and challenges

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Military Medical Research 2024年第3期11卷 400-429页

作者： Jia-Yi Ding Min-Jiang Chen Ling-Feng wu Gao-Feng Shu Shi-Ji Fang Zhao-Yu Li Xu-Ran Chu Xiao-Kun Li Zhou-Guang Wang Jian-Song Ji Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention Researchthe Fifth Affiliated Hospital of Wenzhou Medical UniversityZhejiangLishui 323000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina Clinical College of the Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000ZhejiangChina department of Overseas Education College Jimei UniversityXiamen 361021FujianChina department of Medicine Ⅱ Internal MedicineCardio-Pulmonary Institute(CPI)Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany Pulmonary and Critical Care Department of Medicine VInternal MedicineInfectious Diseases and Infection ControlUniversities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany

Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or *** such injuries are common to all human groups,they may at times represent a serious socioeconomic ***,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound *** a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell *** based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair *** addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix ***,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma *** the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound *** conclusion,MSCderived EV-based therapies have important application prospects in wound *** we provide a comprehensive overview of their current status,application potential,and associated drawbacks.

关键词： Mesenchymal stem cell(MSC) Extracellular vesicles(EVs) Wound repair Engineered nanoparticles

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Elucidating ligand effects in rhodium(Ⅲ)-catalyzed arene-alkene coupling reactions

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Chinese Chemical Letters 2024年第5期35卷 130-134页

作者： Kongchuan wu Dandan Lu Jianbin Lin Ting-Bin Wen Wei Hao Kai Tan Hui-Jun Zhang department of Chemistry College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China

Rhodium(Ⅲ)-catalyzed C-H couplings of arenes with alkenes are among the most powerful methods for C-C bond *** these transformations,subtle manipulation of ancillary ligands can lead to dramatic changes in reactivity and ***,detailed mechanistic studies concerning the ligand effects are *** this study,we investigated the origin of ligand-controlled product-selectivity in rhodium(Ⅲ)-catalyzed C-H couplings of arenes with alkenes,using a series of well-defined[CpXRhⅢ]complexes that feature electronically or sterically distinct Cp^(X)(Cp(η^(5)-C_(5)H_(5)),Cp^(CF3)(η^(5)-C_(5)Me_(4)CF_(3))and Cp^(∗)(η^(5)-C_(5)Me_(5)))ligands.A combination of experimental and theoretical investigations showed that(i)rhodium hydride species containing the electron rich Cp^(∗)ligand can undergo reinsertion of the alkene,thereby allowing rhodium-walking,(ii)rhodium hydride species involving the electron-deficient Cp or Cp^(CF3) ligands prefer reductive elimination rather than alkene *** findings offer valuable insights on future rational catalyst design for selective arene-alkene cross coupling reactions.

关键词： Organometallics Transition metal catalysis Arene-alkene coupling β-H elimination Rhodium hydride

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SYNTHESIS, STRUCTURE AND SOME PHYSICAL PROPERTIES OF 2-METHYL-4-NITROPYRIDINE-1-OXIDE

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结构化学 1987年第1期 20-24页

作者： Li Songxian Liu Shixiong wu Wenshi department of Chemistry,Fuzhou university Shi Dashuang Hu Shengzhi department of Chemistry, xiamen university

INTRODUCTION. Some relationship have been discovered among frequency doubling effect, moleculer electronic structure, and molecular orientation in some organic crystals by Li Songxian et al. This paper reports synthes... 详细信息

关键词： POM SYNTHESIS STRUCTURE AND SOME PHYSICAL PROPERTIES OF 2-METHYL-4-NITROPYRIDINE-1-OXIDE

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GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling

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Oncology Research 2024年第2期32卷 361-371页

作者： TINGTING LI WEI ZHONG LIU YANG ZHIYU ZHAO LI WANG CONG LIU WANYUN LI HAIYAN LV SHENGYU WANG JIANGHUA YAN TING wu GANG SONG FANGHONG LUO Cancer Research Center School of MedicineXiamen UniversityXiamen361000China department of Pharmacy Xiamen Mental Health CenterXiamen Xianyue HospitalXiamen361000China

The high mortality rate associated with gastric cancer(GC)has resulted in an urgent need to identify novel therapeutic targets for *** study aimed to investigate whether GAIP interacting protein,C terminus 1(GIPC1)represents a therapeutic target and its regulating mechanism in ***1 expression was elevated in GC tissues,liver metastasis tissues,and lymph node ***1 knockdown or GIPC1 blocking peptide blocked the platelet-derived growth factor receptor(PDGFR)/PI3K/AKT signaling pathway,and inhibited the proliferation and migration of GC ***,GIPC1 overexpression markedly activated the PDGFR/PI3K/AKT signaling pathway,and promoted GC cell proliferation and ***,platelet-derived growth factor subunit BB(PDGF-BB)cytokines and the AKT inhibitor attenuated the effect of differential GIPC1 ***,GIPC1 silencing decreased tumor growth and migration in BALB/c nude mice,while GIPC1 overexpression had contrasting *** together,our findings suggest that GIPC1 functions as an oncogene in GC and plays a central role in regulating cell proliferation and migration via the PDGFR/PI3K/AKT signaling pathway.

关键词： GIPC1 PDGFR Gastric cancer Proliferation Migration

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Fluorescent Core-shell Silica Nanoparticles as Functionable Precursors:Towards Multicolor and Multifunctional Nanoprobes

Fluorescent Core-shell Silica Nanoparticles as Functionable ...

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第三十五届国际光谱会议

作者： C.L.wu J.Q.Hong X.Q.Guo Y.B.Zhao~* department of Chemistry and the Key Laboratory of Analytical Sciences of the Ministry of Education College of Chemistry and Chemical Engineering xiamen university xiamen 361005 china

＜正＞Rational design of functional nanoparticles has attracted a great deal of attention in multiplex bioanalysis and multifunctional ***,we have proposed a post-encoding concept[1]to the design and preparation of encoding fluorescent probes, which makes the preparation process of multicolor fluorescent spheres rather laborsaving

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Synthesis,properties,and optical applications of noble metal nanoparticle-biomolecule conjugates

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Science Bulletin 2012年第Z1期 240-248页

作者： ZHANG YuJuan1,HUANG Rao1,ZHU XianFang1,2*,WANG LianZhou1,2 & wu ChenXu1 1 china-Australia Joint Laboratory for Functional Nanomaterials and Physics department,xiamen university,xiamen 361005,china 2 ARC Centre of Excellence for Functional Nanomaterials,university of Queensland,St Lucia,Brisbane,Qld 4072,Australia

Noble metal nanoparticles,such as gold or silver nanoparticles and nanorods,exhibit unique photonic,electronic and catalytic *** of noble metal nanoparticles with biomolecules(e.g.,protein and DNA) produces systems that possess numerous applications in catalysis,delivery,therapy,imaging,sensing,constructing nanostructures and controlling the structure of *** this paper,the recent development of noble metal nanoparticle-biomolecule conjugates is reviewed from the following three aspects:(1) synthesis of noble metal nanoparticle-biomolecule systems by electrostatic adsorption,direct chemisorption of thiol derivatives,covalent binding through bifunctional linkers and specific affinity interactions;(2) the photonic properties and bioactivation of noble metal nanoparticle-biomolecule conjugates;and(3) the optical applications of such systems in biosensors,and medical imaging,diagnosis,and *** conjugation of Au and Ag nanoparticles with biomolecules and the most recent optical applications of the resulting systems have been focused on.

关键词： noble metal nanoparticle biomolecule integration

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锌在玻璃碳上的电化学成核机理

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物理化学学报 1985年第4期1卷 357-364页

作者：吴辉煌许书楷周绍民厦门大学化学系物理化学研究所

线性扫描伏安法和电位阶跃法被用来研究氯化钾镀锌溶液中锌在玻璃碳上电结晶的初期阶段。发现锌在该基体上的沉积没有经历UPD过程。在本实验条件下,成熟晶核的生长受溶液中锌离子的扩散所控制,而晶核形成的机理依有无添加剂存在而异。... 详细信息

线性扫描伏安法和电位阶跃法被用来研究氯化钾镀锌溶液中锌在玻璃碳上电结晶的初期阶段。发现锌在该基体上的沉积没有经历UPD过程。在本实验条件下,成熟晶核的生长受溶液中锌离子的扩散所控制,而晶核形成的机理依有无添加剂存在而异。通过分析恒电位暂态,求出锌离子的扩散系数D,以及不同过电位η下的成核速度常数A和晶核数密度N0。A和η的关系表明“原子模型”比经典的成核模型更适合于本研究体系。N0与η的经验关系式由曲线拟合而得。本文着重讨论了过电位和添加剂对成核作用的影响。

关键词：电化学添加剂过电位超电位成核机理玻璃碳伏安图晶核形成电位阶跃线性扫描伏安法数密度成核速度

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Force Field Development for Zinc Protein from QM/MM Force Matching:A Short-Long Effective Function Strategy to Model Zinc Interactions in Metalloproteins

Force Field Development for Zinc Protein from QM/MM Force Ma...

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中国化学会第28届学术年会

作者： Ruibo wu,1,Yingkai Zhang,2 and Zexing Cao3 1School of Pharmaceutical Sciences,Sun Yet-sen university,Guangzhou,511006,china 2department of Chemistry,New York university,New York,10003,United State 3department of Chemistry,xiamen university,xiamen,361005,china

＜正＞Zinc-containing proteins play essential roles in many biological *** are currently over 8000 structure hits for zinc-containing proteins with searching "zinc" in the Protein Data Bank（PDB）,which constitute ～10% of the total structures in ***,modeling the Zn-Ligand coordination interaction in zinc protein is a well-known challenge due to the inherent flexibility feature of zinc coordination

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