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Effects of the aqueous extract of Schizandra chinensis fruit on ethanol withdrawal-induced anxiety in rats

Chinese Medical Journal 2014年第10期127卷 1935-1940页

作者： wu yiyan Zhao Zhenglin Yang Yupeng Yang Xudong Eun Young Jang Nathan D Schilaty David M Hedges Sang Chan Kim Il Je Cho Zhao Rongjie Department of Pharmacology Mudanjiang Medical University Mudanjiang Heilongjiang 157011 China Fourth Affiliated Hospital of Harbin Medical University HarbinHeilongjiang 150001 China Brigham Young University Provo Utah 84602 USA Research Center for Biomedical Resource of Oriental Medicine Daegu Haany University Daegu 706-828 South Korea

Background We previously demonstrated that the aqueous extract of the Schizandra chinensis fruit （AESC） ameliorated Cd-induced depletion of monoamine neurotransmitters in the brain through antioxidant activity.In the present study,we investigated the effect of AESC on anxiety-like behavior and the levels of norepinephrine and 3-methoxy-4-hydroxyphenylglycol （a metabolite of norepinephrine） in different brain regions during ethanol withdrawal in rats.Methods Male Sprague-Dawley rats were treated with 3 g/kg of ethanol （20％,w/v） or saline by daily intraperitoneal injection for 28 days followed by three days of withdrawal.During withdrawal,rats were given AESC （100 mg.kg 1.d-1 or 300 mg.kg 1·d1,P.O.） once a day for three days.Thirty minutes after the final dose of AESC,the anxiogenic response was evaluated using an elevated plus maze,and the plasma corticosterone levels were examined by radioimmunoassay.Meanwhile,the concentrations of norepinephrine and 3-methoxy-4-hydroxy-phenylglycol in the hypothalamic paraventricular nucleus and hippocampus were also measured by high performance liquid chromatography.Results Rats undergoing ethanol withdrawal exhibited substantial anxiety-like behavior,which was characterized by both the decrease in time spent in the open arms of the elevated plus maze and the increased level of corticosterone secretion,which were greatly attenuated by doses of AESC in a dose-dependent manner.The high performance liquid chromatography analysis revealed that ethanol withdrawal significantly increased norepinephrine and 3-methoxy-4-hydroxy-phenylglycol levels in the hypothalamic paraventricular nucleus,while not significantly altering them in the hippocampus.Similar to the results from the elevated plus maze test,the AESC significantly inhibited the elevation of norepinephrine and its metabolite in the hypothalamic paraventricular nucleus in a dose-dependent manner.Conclusions These results suggest that AESC attenuates anxiety-like behavior induced by ethanol withdrawal through modulation of the h

关键词： Schizandra chinensis fruit ethanol withdrawal anxiety norepinephrine hypothalamic paraventricular nucleus hippocampus

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Knockdown of neuronal DAF-15/Raptor promotes healthy aging in C.elegans

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Journal of Genetics and Genomics 2024年第5期51卷 507-516页

作者： Xiao Zang Qi Wang Hanxin Zhang yiyan Zhang Zi Wang Zixing wu Di Chen Model Animal Research Center of Medical School Nanjing UniversityNanjingJiangsu 210061China Zhejiang University-University of Edinburgh Institute School of MedicineZhejiang UniversityHainingZhejiang 314400China Department of Colorectal Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310058China

The highly conserved target of rapamycin(TOR)pathway plays an important role in aging across species.Previous studies have established that inhibition of the TOR complex 1(TORC1)significantly extends lifespan in Caenorhabditis elegans.However,it has not been clear whether TORC1 perturbation affects aging in a spatiotemporal manner.Here,we apply the auxin-inducible degradation tool to knock down endogenous DAF-15,the C.elegans ortholog of regulatory associated protein of TOR(Raptor),to characterize its roles in aging.Global or tissue-specific inhibition of DAF-15 during development results in various growth defects,whereas neuron-specific knockdown of DAF-15 during adulthood significantly extends lifespan and healthspan.The neuronal DAF-15 deficiency-induced longevity requires the intestinal activities of DAF-16/FOXO and PHA-4/FOXA transcription factors,as well as the AAK-2/AMP-activated protein kinaseαcatalytic subunit.Transcriptome profiling reveals that the neuronal DAF-15 knockdown promotes the expression of genes involved in protection.These findings define the tissue-specific roles of TORC1 in healthy aging and highlight the importance of neuronal modulation of aging.

关键词： Aging targetof rapamycin DAF-15 DAF-16 C.elegans

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大豆玉米带状复合种植技术初探

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作物研究 2024年第2期38卷 153-156页

作者：喻勇湛厚观李俭梅马雄吴依衍肖冬根汨罗市农业农村局湖南汨罗414400

大豆玉米带状复合种植模式是农业农村部推广的稳玉米、扩大豆的种植模式,目标是在保证玉米基本不减产的基础上,通过间种或套种增收一季大豆。2022—2023年,汨罗市对大豆玉米带状复合种植模式进行试验与示范推广,全市种植面积达2000 hm^(... 详细信息

大豆玉米带状复合种植模式是农业农村部推广的稳玉米、扩大豆的种植模式,目标是在保证玉米基本不减产的基础上,通过间种或套种增收一季大豆。2022—2023年,汨罗市对大豆玉米带状复合种植模式进行试验与示范推广,全市种植面积达2000 hm^(2),玉米平均单产6900 kg/hm^(2),大豆平均单产1740 kg/hm^(2),与单作玉米相比,玉米单产仅减少690 kg/hm^(2),且全市增产大豆约3500 t,2年合计增收2100多万元。重点介绍了大豆玉米带状复合种植模式从整地到收获的全程规范化栽培技术。

关键词：玉米大豆复合种植技术

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干旱荒漠区农田防护林正负效应及其影响机制

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新疆农业科学 2022年第9期59卷 2232-2239页

作者：马彬王帅吴依衍姜艳石河子大学农学院新疆石河子832000

【目的】研究干旱区农田防护林胁地的效应。【方法】选取新疆150团一处南北走向的农田防护林以及西侧的棉田为研究对象,针对农田防护林对棉田的各个胁地因子,对比分析距离农田防护林不同树高(H为农田防护林平均树高15 m)倍数处棉田的气... 详细信息

【目的】研究干旱区农田防护林胁地的效应。【方法】选取新疆150团一处南北走向的农田防护林以及西侧的棉田为研究对象,针对农田防护林对棉田的各个胁地因子,对比分析距离农田防护林不同树高(H为农田防护林平均树高15 m)倍数处棉田的气象、土壤及棉花生长状况等因素的时空变化及分布特征,研究防护林对棉田的胁迫规律、胁迫程度,筛选出农田防护林胁地的主导因子。【结果】150团农田防护林杨树树种发达的根系是构成林带胁地的主要原因;引起农田防护林对棉田胁地的气象因素是光照与土壤含水量,相关系数可达0.972与0.995;造成农田防护林对棉田胁地的主要肥力因素是土壤有机质与全氮,相关系数可达0.980与0.992;农田防护林对棉花前期生长发育状况影响较大,后期胁地症状有所缓解。【结论】农田防护林对棉田土壤有机质及全氮影响较大,在前期通过降低光照强度及土壤含水量影响棉花生长。

关键词：农田防护林棉田气象肥力胁地

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Angle-resolved photoemission study of NbGeSb with non-symmorphic symmetry

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Chinese Physics B 2024年第2期33卷 464-470页

作者：马欢谭宁吴徐传李满王义炎路洪艳夏天龙王善才 Department of Physics Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education)Renmin University of ChinaBeijing 100872China Beijing Key Laboratory of Opto-Electronic Functional Materials&Micro-Nano Devices Renmin University of ChinaBeijing 100872China School of Information Network Security People’s Public Security University of ChinaBeijing 100038China Institute of Physical Science and Information Technology Anhui UniversityHefei 230601China School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China

We investigate the electronic structure of NbGeSb with non-symmorphic symmetry.We employ angle-resolved photoemission spectroscopy(ARPES)to observe and identify the bulk and surface states over the Brillouin zone.By utilizing high-energy photons,we identify the bulk Fermi surface and bulk nodal line along the direction X–R,while the Fermi surface of the surface state is observed by using low-energy photons.We observe the splitting of surface bands away from the high-symmetry point X.The density functional theory calculations on bulk and 1 to 5-layer slab models,as well as spin textures of NbGeSb,verify that the band splitting could be attributed to the Rashba-like spin–orbit coupling caused by space-inversion-symmetry breaking at the surface.These splitted surface bands cross with each other,forming two-dimensional Weyl-like crossings that are protected by mirror symmetry.Our findings provide insights into the two-dimensional topological and symmetry-protected band inversion of surface states.

关键词： non-symmorphic symmetry nodal line splitting of surface bands angle-resolved photoemission spectroscopy

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典型荒漠农田防护林对棉田土壤水盐动态的影响

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新疆农业科学 2021年第6期58卷 1012-1020页

作者：吴依衍马彬姜艳石河子大学农学院新疆石河子832000

【目的】研究典型荒漠农田防护林对棉田土壤水盐动态的影响。【方法】以新疆石河子150团棉田-防护林体系为研究对象,测定0.1H、0.25H、0.5H、1H、2H、3H地段与林地的水盐含量及蒸发量,分析防护林对周围棉田土壤的水盐变化特征。【结果】... 详细信息

【目的】研究典型荒漠农田防护林对棉田土壤水盐动态的影响。【方法】以新疆石河子150团棉田-防护林体系为研究对象,测定0.1H、0.25H、0.5H、1H、2H、3H地段与林地的水盐含量及蒸发量,分析防护林对周围棉田土壤的水盐变化特征。【结果】(1)防护林的浅根系在其0.25H范围内同棉株争夺水分。(2)棉田防护林下的土壤盐分含量明显低于无防护林棉田,0~20 cm的浅层土壤含盐量普遍较低,距离防护林0.5H范围的棉田没有盐渍化现象,该团场棉田地基本维持在无盐渍化或轻度盐渍化的范围;(3)农田防护林的脱盐效果明显,尤其在0.1H处平均脱盐率达到14.38%以上,即距离农田防护林越近,脱盐效果越明显。【结论】林带边缘防护林争水严重,可增加林带的灌溉频率;防护林对林带边缘土壤有着明显的脱盐降盐效果,可防止土壤此生盐渍化的发生。

关键词：荒漠防护林棉田土壤水分土壤盐分

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正念癌症康复训练联合耳穴贴压应用于行化学治疗的肠癌患者的效果

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中西医结合护理（中英文） 2023年第2期9卷 49-52页

作者：武一彦刘昱郭秋月北京中西医结合医院北京100039

目的探讨正念癌症康复训练(MBCR)联合耳穴贴压对行化学治疗(简称“化疗”)的肠癌患者胃肠道不良反应的影响。方法以北京中西医结合医院于2020年1月至2021年10月期间收治的98例行化疗的肠癌患者为研究对象,按随机数字表法分为对照组和观... 详细信息

目的探讨正念癌症康复训练(MBCR)联合耳穴贴压对行化学治疗(简称“化疗”)的肠癌患者胃肠道不良反应的影响。方法以北京中西医结合医院于2020年1月至2021年10月期间收治的98例行化疗的肠癌患者为研究对象,按随机数字表法分为对照组和观察组,各49例。对照组患者接受常规化疗护理,观察组接受MBCR联合耳穴贴压。对比2组的癌因性疲乏、胃肠激素水平和胃肠道不良反应。结果干预4周和8周后,2组的癌症疲乏量表(CFS)各维度得分均比干预前下降,在干预8周的评分均比干预4周更低;观察组均比同期对照组低,对比均存在统计学差异(P均<0.05)。观察组在干预4周和8周后的促胃液素和胃动素水平均比干预前下降,在干预8周的胃动素水平比干预4周更低;对照组在干预8周的促胃液素和胃动素水平均比干预前更低,在干预8周的胃动素水平比干预4周更低;观察组在干预8周后的促胃液素和胃动素水平均比对照组更高,对比均存在统计学差异(P均<0.05)。观察组的胃肠道不良反应发生率均低于对照组(P均<0.05)。结论MBCR联合耳穴贴压能缓解行化疗肠癌患者的癌因性疲乏,有助于调节胃肠激素水平和减少胃肠道不良反应的发生。

关键词：肠癌化学治疗正念癌症康复训练耳穴贴压胃肠激素

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Strong Anisotropic Order Parameters at All-Nitride Ferromagnet/Superconductor Interfaces

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Chinese Physics Letters 2024年第2期41卷 102-111页

作者： Qiao Jin Meng Yang Guozhu Song Nan Zhao Shengru Chen Haitao Hong Ting Cui Dongke Rong Qianying Wang yiyan Fan Chen Ge Can Wang Jiachang Bi Yanwei Cao Liusuo wu Shanmin Wang Kui-Juan Jin Zhi-Gang Cheng Er-Jia Guo Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Physics&Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Department of Physics Southern University of Science and TechnologyShenzhen 518055China Songshan Lake Materials Laboratory Dongguan 523808China Ningbo Institute of Materials Technology&Engineering Chinese Academy of SciencesNingbo 315201China

Proximity effects between superconductors and ferromagnets(SC/FM)hold paramount importance in comprehending the spin competition transpiring at their interfaces.This competition arises from the interplay between Cooper pairs and ferromagnetic exchange interactions.The proximity effects between transition metal nitrides(TMNs)are scarcely investigated due to the formidable challenges of fabricating high-quality SC/FM interfaces.We fabricated heterostructures comprising SC titanium nitride(TiN)and FM iron nitride(Fe_(3)N)with precise chemical compositions and atomically well-defined interfaces.The magnetoresistance of Fe_(3)N/TiN heterostructures shows a distinct magnetic anisotropy and strongly depends on the external perturbations.Moreover,the superconducting transition temperatureT_(C) and critical field of TiN experience notable suppression when proximity to Fe_(3)N.We observe the intriguing competition of interfacial spin orientations near𝑇T_(C)(∼1.25 K).These findings not only add a new materials system for investigating the interplay between superconductor and ferromagnets,but also potentially provide a building block for future research endeavors and applications in the realms of superconducting spintronic devices.

关键词： proximity Superconductor titanium

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Microalgae-material hybrid for enhanced photosynthetic energy conversion:a promising path towards carbon neutrality

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National Science Review 2023年第10期10卷 151-171页

作者： Wei Xiong yiyan Peng Weimin Ma Xurong Xu Yueqi Zhao Jinhui wu Ruikang Tang School of Chemistry and Chemical Engineering Nanchang University College of Life Sciences Shanghai Normal University Department of Chemistry Zhejiang University Qiushi Academy for Advanced Studies Zhejiang University Department of Orthopaedic Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University State Key Laboratory of Pharmaceutical Biotechnology Medical School & School of Life Sciences Nanjing University

Photosynthetic energy conversion for high-energy chemicals generation is one of the most viable solutions in the quest for sustainable energy towards carbon neutrality.Microalgae are fascinating photosynthetic organisms,which can directly convert solar energy into chemical energy and electrical energy.However,microalgal photosynthetic energy has not yet been applied on a large scale due to the limitation of their own characteristics.Researchers have been inspired to couple microalgae with synthetic materials via biomimetic assembly and the resulting microalgae-material hybrids have become more robust and even perform new functions.In the past decade,great progress has been made in microalgae-material hybrids,such as photosynthetic carbon dioxide fixation,photosynthetic hydrogen production,photo electrochemical energy conversion and even biochemical energy conversion for biomedical therapy.The microalgae-material hybrid offers opportunities to promote artificially enhanced photosynthesis research and synchronously inspires investigation of biotic-abiotic interface manipulation.This review summarizes current construction methods of microalgae-material hybrids and highlights their implication in energy and health.Moreover,we discuss the current problems and future challenges for microalgae-material hybrids and the outlook for their development and applications.This review will provide inspiration for the rational design of the microalgae-based semi-natural biohybrid and further promote the disciplinary fusion of material science and biological science.

关键词： microalgae–material hybrid photosynthesis cell–material interaction energy conversion carbon neutrality

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刺五加精制多糖对尼古丁诱导的学习记忆障碍小鼠的影响

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实用临床医药杂志 2023年第22期27卷 67-70,76页

作者：邹婷刘友昊高晓岩邓代千吴宜艳牡丹江医学院黑龙江牡丹江157011 牡丹江医学院附属红旗医院黑龙江牡丹江157011

目的观察刺五加精制多糖(ASPS)对尼古丁诱导的学习记忆障碍小鼠的影响。方法选取6周龄小鼠96只,雌雄各半,将其分为2批进行动物试验,即水迷宫试验和新物体识别试验。每批按小鼠体质量随机分为6组:空白组、模型组、阳性药物组、ASPS高剂... 详细信息

目的观察刺五加精制多糖(ASPS)对尼古丁诱导的学习记忆障碍小鼠的影响。方法选取6周龄小鼠96只,雌雄各半,将其分为2批进行动物试验,即水迷宫试验和新物体识别试验。每批按小鼠体质量随机分为6组:空白组、模型组、阳性药物组、ASPS高剂量组、ASPS中剂量组、ASPS低剂量组。除空白组外,其余5组连续7 d每天皮下注射尼古丁0.5 mg/kg,制备尼古丁记忆障碍模型。第7天注射尼古丁24 h后,阳性药物组灌胃吡拉西坦800 mg/kg,ASPS高剂量组、ASPS中剂量组、ASPS低剂量组连续7 d分别灌胃ASPS 270、90、30 mg/kg。通过水迷宫试验和新物体识别试验分别检测小鼠的学习记忆能力。测试结束后,检测血清中超氧化物歧化酶(SOD)活性和海马组织中五羟色胺(5-HT)含量。结果新物体识别试验结果显示,ASPS高、中、低剂量组辨别指数高于模型组,差异有统计学意义(P<0.01或P<0.05)。水迷宫试验结果显示,与模型组比较,ASPS高、中剂量组小鼠空间搜索试验中找到平台的时间缩短,差异有统计学意义(P<0.05);定位航行试验中,ASPS高剂量组小鼠平台进入次数多于模型组,差异有统计学意义(P<0.05);ASPS高、中剂量组小鼠Ⅲ象限路程比例高于模型组,差异有统计学意义(P<0.05)。ASPS高、中、低剂量组SOD活性高于模型组,差异有统计学意义(P<0.01);小鼠海马组织含量测定显示,ASPS高、中剂量组小鼠5-HT含量高于模型组,差异有统计学意义(P<0.01或P<0.05)。结论ASPS能显著提高尼古丁戒断小鼠的学习记忆能力,减轻海马神经递质的损伤,调节体内氧化应激能力,其机制可能与提高机体抗氧化能力、调节海马神经递质水平有关。

关键词：刺五加精制多糖学习记忆抗氧化作用神经递质超氧化物歧化酶五羟色胺

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