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Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1807-1820页

作者： Jianing LIU Jinqiang LI ying wu School of Aerospace Engineering Xi’an Jiaotong UniversityXi’an 710049China College of Aerospace and Civil Engineering Harbin Engineering UniversityHarbin 150001China

Several types of acoustic metamaterials composed of resonant units have been developed to achieve low-frequency *** most of these structures,bandgaps are determined by their geometric configurations and material *** paper presents a frequency-displacement feedback control method for vibration suppression in a sandwich-like acoustic metamaterial *** band structure is theoretically derived using the Hamilton principle and validated by comparing the theoretical calculation results with the finite element simulation *** this method,the feedback voltage is related to the displacement of a resonator and the excitation *** applying a feedback voltage on the piezoelectric fiber-reinforced composite(PFRC)layers attached to a cantilever-mass resonator,the natural frequency of the resonator can be *** ensures that the bandgap moves in a frequency-dependent manner to keep the excitation frequency within the *** on this frequency-displacement feedback control strategy,the bandgap of the metamaterial plate can be effectively adjusted,and the vibration of the metamaterial plate can be significantly suppressed.

关键词： acoustic metamaterial Hamilton principle electromechanical coupling vibration control local resonance

Gene therapy for monogenic disorders: challenges, strategies, and perspectives

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Journal of Genetics and Genomics 2024年第2期51卷 133-143页

作者： Yi Zhang Zhi-ying wu Department of Medical Genetics and Center for Rare Diseases Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Key Laboratory of Medical Neurobiology of Zhejiang Province HangzhouZhejiang 310009China

Monogenic disorders refer to a group of human diseases caused by mutations in single genes. While disease-modifying therapies have offered some relief from symptoms and delayed progression for some monogenic diseases, most of these diseases still lack effective treatments. In recent decades, gene therapy has emerged as a promising therapeutic strategy for genetic disorders. Researchers have developed various gene manipulation tools and gene delivery systems to treat monogenic diseases. Despite this progress, concerns about inefficient delivery, persistent expression, immunogenicity, toxicity, capacity limitation, genomic integration, and limited tissue specificity still need to be addressed. This review gives an overview of commonly used gene therapy and delivery tools, along with the challenges they face and potential strategies to counter them.

关键词： Gene therapy Monogenic diseases Geneediting Genedelivery Challenges

Stretchable and self-healing conductive fibers from hierarchical silver nanowires-assembled network

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Nano Research 2024年第2期17卷 763-770页

作者： ying-ying wu Hong Chen Fan Zhang Pan Guo Haili Qin Huai-Ping Cong Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China

Conductive fibers(CFs)with features of high conductivity,stretchability,self-healability,and electromechanical stability are key components of the increasingly popular wearable ***,since the lack of structural design of conductive network and interfacial interaction between soft polymer and conductive additives,it is still hard to enable CFs to meet above ***,we describe a facial drawing method from a hydrogel reservoir which is remolded into ultrathin and stretchable CFs with excellent multi-responsive *** hydrogel reservoir was fabricated in synergy of an ice-templating method and in situ polymerization using the assembled framework as a *** on the effective fabrication mechanism,the diameter of CFs could be well-tuned from 90 to 400μm by adjusting the dipping depth of the glass rod,accompanied with conductivity increased from 0.75 to 2.5 S/*** the hierarchical network structure was well maintained in the CFs,professional performances have been proved on the stretchability and electromechanical *** presence of massive hydrogen bonding and Ag–S bond enabled the CFs with excellent self-healability under the conditions of contact,electric field,and near infrared light,***,the CFs with high sensing property could be integrated into an advanced textile sensor through an effective healing-induced integration strategy,demonstrating its great potentials as superior two-dimensional(2D)electronic skins.

关键词： conductive fibers self-assembled silver nanowires Ag–S coordination self-healing flexible sensors

Chinese patients with adult onset leukodystrophy caused by CST3 variants

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Journal of Genetics and Genomics 2024年第7期51卷 778-780页

作者： Yi Zhang Zhi-ying wu Department of Medical Genetics and Center for Rare Diseases Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical TranslationSecond Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Nanhu Brain-computer Interface Institute HangzhouZhejiang 314050China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China MOE Frontier Science Center for Brain Science and Brain-machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang 310012China

Leukodystrophies represent a group of cerebral white matter disorders that mainly affect axon-glia *** disorders are clinically diverse and display significant genetic *** is challenging to differentiate hereditary leukodystrophies,particularly those that present in adulthood,from acquired leukodystrophies and other genetic disorders,such as multiple sclerosis(MS)or hereditary spastic paraplegia(HSP)(Wei et al.,2021).Over the past few decades,a series of causative genes associated with leukodystrophies have been identified(Kohler et al.,2018).Nevertheless,a significant proportion of patients still lack a precise molecular diagnosis.

关键词： al. patients Kohler

Strong Limit Theorems for Weighted Sums under the Sub-linear Expectations

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 862-874页

作者： Feng-xiang FENG Ding-cheng WANG Qun-ying wu Hai-wu HUANG School of Mathematics and Statistics Guilin University of TechnologyGuilin 541004China School of Mathematical Science University of Electronic Science and Technology of ChinaChengdu 611731China School of Science Guilin University of Aerospace TechnologyGuilin 541004China

In this article,we study strong limit theorems for weighted sums of extended negatively dependent random variables under the sub-linear *** establish general strong law and complete convergence theorems for weighted sums of extended negatively dependent random variables under the sub-linear *** results of strong limit theorems are more general than some related results previously obtained by Thrum(1987),Li et al.(1995)and wu(2010)in classical probability space.

关键词： sub-linear expectation complete convergence complete moment convergence the maximal weighted sums

Paroxysmal Kinesigenic Dyskinesia:Genetics and Pathophysiological Mechanisms

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Neuroscience Bulletin 2024年第7期40卷 952-962页

作者： Jiao-Jiao Xu Hong-Fu Li Zhi-ying wu Department of Medical Genetics and Center for Rare Diseases The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Neurology in the Second Affiliated Hospital Key Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310009China

Paroxysmal kinesigenic dyskinesia(PKD),the most common type of paroxysmal movement disorder,is characterized by sudden and brief attacks of choreoathetosis or dystonia triggered by sudden voluntary *** is mainly caused by mutations in the PRRT2 or TMEM151A *** exact pathophysiological mechanisms of PKD remain unclear,although the function of PRRT2 protein has been well characterized in the last *** on abnormal ion channels and disturbed synaptic transmission in the absence of PRRT2,PKD may be channelopathy or synaptopathy,or *** addition,the cerebellum is regarded as the key pathogenic *** depolarization in the cerebellum is tightly associated with dyskinetic ***,in PKD,other than the cerebellum,the role of the cerebrum including the cortex and thalamus needs to be further investigated.

关键词： Paroxysmal kinesigenic dyskinesia PRRT2 TMEM151A Genetics Pathophysiological mechanisms

Nonreciprocal generation of Schrodinger cat state induced by topology

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 23-30页

作者： Zi-Hao Li Li-Li Zheng ying wu Xin-You Lü School of Physics and Institute for Quantum Science and Engineering Huazhong University of Science and Technologyand Wuhan Institute of Quantum TechnologyWuhan 430074China Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education Jianghan UniversityWuhan 430074China

The Schrodinger cat state produced differently in two directions is anticipated to be a critical quantum resource in quantum information *** exploring the interplay between quantum nonreciprocity and topology in a one-dimensional microcavity array,we obtain the Schrodinger cat state(a pure quantum state)in a chosen direction at the edge cavity,whereas a classical state in the other *** nonreciprocal generation of the cat state originates from the topologically protected chiralitymode excitation in the nontrivial phase,but in the trivial phase,the nonreciprocal generation of cat state ***,our proposal is switchable by tuning the parameters so that a topological phase transition ***,the obtained cat state has nonreciprocal high fidelity,nonclassicality,and quantum coherence,which are sufficient to be used in various one-way quantum technologies,e.g.,invisible quantum sensing,noise-tolerant quantum computing,and chiral quantum *** work provides a general approach to control quantum nonreciprocities with the topological effect,which substantially broadens the fields of nonreciprocal photonics and topological physics.

关键词： Schr?dinger cat state nonreciprocity topology

Configuring single-layer MXene nanosheet onto natural wood fiber via C-Ti-C covalent bonds for high-stability Li-S batteries

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Journal of Energy Chemistry 2024年第8期95卷 701-711,I0016页

作者： Yangyang Chen Yu Liao ying wu Lei Li Zhen Zhang Sha Luo Yiqiang wu Yan Qing College of Materials Science and Technology Central South University of Forestry and TechnologyChangsha 410004HunanChina

Lithium-sulfur batteries(LSBs)are considered promising candidates for next-generation battery technologies owing to their outstanding theoretical energy density and ***,the low conductivity and polysulfide shuttling effect of S cathodes severely hamper the practical performance of ***,in situ-generated single layer MXene nanosheet/hierarchical porous carbonized wood fiber(MX/PCWF)composites are prepared via a nonhazardous eutectic activation strategy coupled with pyrolysis-induced gas *** unique architecture,wherein single layer MXene nanosheets are constructed on carbonized wood fiber walls,ensures rapid polysulfide conversion and continuous electron transfer for redox *** C-Ti-C bonds formed between MXene and PCWF can considerably expedite the conversion of polysulfides,effectively suppressing the shuttle *** impressive capacity of 1301.1 m A h g^(-1)at 0.5 C accompanied by remarkable stability is attained with the MX/PCWF host,as evidenced by the capacity maintenance of 722.6 m A h g^(-1)after 500 ***,the MX/PCWF/S cathode can still deliver a high capacity of 886.8 m A h g^(-1)at a high S loading of 5.6 mg cm^(-2).The construction of two-dimensional MXenes on natural wood fiber walls offers a competitive edge over S-based cathode materials and demonstrates a novel strategy for developing high-performance batteries.

关键词： Lithium-sulfur batteries S cathodes MXene nanosheets Wood fiber C-Ti-C bonds

Risk factors for the prognosis of colon cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3738-3740页

作者： Chu-ying wu Kai Ye Department of Gastrointestinal Surgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

A study on clinical outcomes and prognostic factors in T4N0M0 colon cancer patients after R0 resection revealed that ileostomy,T stage,right hemicolectomy,irregular follow-up,and CA199 level were independent risk factors affecting overall survival.T4-stage cancer invades the entire thickness of the intestinal tract,increasing the difficulty of treatment and the risk of recurrence,and requires a combination of chemotherapy,immunotherapy,and targeted therapy to control the spread of cancer *** prognosis of right hemicolectomy is significantly worse than that of left hemicolectomy,and right hemicolectomy is an independent risk factor for a poor *** age,histopathological type,and lymph node metastasis are also risk factors for colon cancer.

关键词： Risk factor Prognosis Colon cancer Tumour stage Right hemicolectomy

Mars exploration——In situ K-Ar dating of jarosite

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Science China Earth Sciences 2024年第3期67卷 641-656页

作者： Jing YANG Dewen ZHENG ying wu Hong CHEN Li YANG Bin ZHANG Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesInstitute of GeomechanicsChinese Academy of Geological SciencesBeijing 100081China State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing 100029China Institute of Earth Sciences China University of GeosciencesBeijing 100083China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029Chin

To accurately determine the chronological framework of climatic variations recorded by various Martian terrains, the absolute ages of Martian events and cratering rate need to be constrained by either in situ dating or returned samples. In situ K-Ar dating is currently a more plausible dating technique as compared with sample return. Jarosite(KFe_(3)[SO_(4)]_(2)[OH]_(6)) is the only confirmed K sulfate mineral that is widely present on Mars, as indicated by in situ detection, orbital remote sensing, and meteorite studies. Jarosite can be used for precise K-Ar and (40)Ar/(39)Ar dating. The preservation of jarosite on Mars provides information about the nature and duration of aqueous processes on the Martian surface. Different ages of Martian jarosite represent the key to constraining the transition from Martian surface water activity to arid climatic conditions. This paper summarizes recent advances in our knowledge of the spatial distribution of Martian jarosite, its mineralogical properties and stability on Mars, the Ar diffusion kinetics of jarosite, and the current status of in situ K-Ar dating. Moreover, we examine the key scientific issues to be addressed for in situ K-Ar dating of jarosite and Martian sample return missions, and discuss future research directions.

关键词： Mars Jarosite In situ K-Ar dating Ar diffusion Stability