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Determination of median levels of the free beta subunit of human chorionic gonadotropin in women from China's mainland using a new time-resolved fluoroimmunoassay

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Determination of median levels of the free beta subunit of h...

Effect of Post-weld Heat Treatment on the Microstructure and Mechanical Properties of 2.25Cr-1Mo-0.25V Ultra-Thick Steel Plate

广东省遗传学会第九届代表大会暨学术研讨会

作者： Tang YP wu ys Yin AH Xu WW Yuan PH Li M Prenatal Diagnosis Centre Guangdong Women and Children Hospital

Background:The free beta subunit of human chorionic gonadotropin(free beta-hCG) is an important serum marker for biochemical *** weekly median value varies with *** of the fluorometers for lanthanide chelates are designed for the detection of signals from europium(Eu(3+)) chelates ***:We developed a two-site,one-step assay using two monoclonal antibodies(MAbs) against free beta subunit and beta subunit with Eu(3+) chelates as *** the present assay,we evaluated 24,634 normal serum samples in Chinese pregnant women during 8-20 weeks of ***:The detection limit using this assay was <0.05 ng/*** within-run and between-run imprecision was <6.0%and 7.0%using control *** beta-hCG concentrations measured using the current assay in 999 maternal serum samples correlated well with those obtained by samarium(Sm(3+))-labeled DELFIA free hCGbeta assay(r=0.987).The medians for 8-20 weeks for maternal serum free beta-hCG were higher in the women from China’s mainland compared to reports from other ***:The present assay is suitable for use in biochemical screening of women in China’s *** study on the median concentrations of free beta-hCG will help establish reference values that are specific for ethnic populations from the Chinese *** will be useful for studying the importance of ethnic factors in biochemical screening.

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 1104-1114页

作者： Yanyang wu Zongye Ding Wenquan Lu Jingchao Hou Qiaodan Hu Jianguo Li Shanghai Key Laboratory of Materials Laser Processing and Modification School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai200444China School of Mechatronic Engineering and Automation Foshan UniversityFoshan528225GuangdongChina wuYang Iron and Steel Wugang450000HenanChina

Ensuring the homogeneous and excellent mechanical properties of 2.25Cr-1Mo-0.25V ultra-thick steel plate is the key to the production of hydrogenation reactor ***,it is required to understand the heterogeneity of microstructures and properties of ultra-thick plate after heat *** this work,the effect of post-weld heat treatment(PWHT)on the strength,plasticity,toughness and microstructures of the 193-mm-thick steel plate was investigated,and the formation mechanism of heterogeneity was *** PWHT decreased the room-and high-temperature yield strength(ys)and ultimate tensile strength(UTS)of the steel plate after normalizing and tempering(NT),while the room-and high-temperature ys and UTS decreased from the surface to the center of 193-mm-thick steel *** was attributed to the enhanced decomposition of martensite-austenite(M-A)constituents and coarsening of grains and precipitated carbides.

关键词： Cr-Mo steel Ultra-thick steel plate Microstructure Mechanical properties Heterogeneity

Liposomalα-cyperone targeting bone resorption surfaces suppresses osteoclast differentiation and osteoporosis progression via the PI3K/Akt axis

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Nano Research 2024年第4期17卷 2949-2959页

作者： Lin Yang Xueying An Wang Gong Wenshu wu Bin Liu Xiaoyan Shao Yansi Xian Rui Peng Baosheng Guo Qing Jiang Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic SurgeryNanjing Drum Tower Hospital Clinical College of Nanjing Medical University321 Zhongshan RoadNanjing 210008China Branch of National Clinical Research Center for Orthopedics Sports Medicine and RehabilitationNanjing 210008China State Key Laboratory of Pharmaceutical Biotechnology Medical SchoolNanjing University&Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China

Osteoporosis is a metabolic dysregulation of bone that occurs mainly in postmenopausal women,and the hyperfunction of osteoclasts is the primary contributor to postmenopausal ***,the development of effective therapeutic drugs and precise delivery systems remains a challenge in the field of anti-absorption ***,we reported theα-cyperone(α-CYP)for anti-osteoporosis and developed a liposome-based nano-drug delivery system ofα-CYP,that specifically targets the bone resorption ***,we found that theα-CYP,one of the major sesquiterpenes of Cyperus rotundus L.,attenuated the progression of osteoporosis in ovariectomized(OVX)mice and down-regulated the expression of phosphorylated proteins of phosphoinositide 3-kinase(PI3K)and protein kinase B(Akt),causing down-regulation of osteoclast-related genes/proteins and curbing osteoclast ***,α-CYP reversed the activation of osteoclastic differentiation and enhanced osteoporosis-related proteins expression caused by PI3K/Akt agonist(ys-49).More importantly,we adopted the osteoclastic resorption surface targeting peptide Asp8 and constructed the liposome(lipαC@Asp8)to deliverα-CYP to osteoclasts and confirmed its anti-osteoporosis effect and enhanced osteoclast inhibition by blocking PI3K/Akt *** conclusion,this study demonstrated thatα-CYP inhibits osteoclast differentiation and osteoporosis development by silencing PI3K/Akt pathway,and the liposome targeting delivery systems loaded withα-CYP might provide a novel and effective strategy to treat osteoporosis.

关键词： osteoporosis α-cyperone osteoclast phosphoinositide 3-kinase/protein kinase B(PI3K/Akt) liposome

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直立式混凝土落地声屏障振动放大效应

振动．测试与诊断 2024年第2期44卷 337-344,412,413页

作者：刘必灯宋瑞祥邬玉斌吴琼吴瑞北京市科学技术研究院城市安全与环境科学研究所北京100054

以普速铁路路侧落地安装直立式混凝土声屏障为研究对象,利用原位试验方法研究了列车运行下屏障板水平及竖向加速度时程和频谱特征,结合悬臂板理论模态分析了屏障板相对其基础的振动放大效应及机理。结果表明,钢轨-轨枕-道床-声屏障基础... 详细信息

以普速铁路路侧落地安装直立式混凝土声屏障为研究对象,利用原位试验方法研究了列车运行下屏障板水平及竖向加速度时程和频谱特征,结合悬臂板理论模态分析了屏障板相对其基础的振动放大效应及机理。结果表明,钢轨-轨枕-道床-声屏障基础振动递减,屏障板较其基础加速度平均放大2倍,振级平均增大6 dB,道床和基础竖向振动卓越频率为63.5 Hz,水平向放大显著频段为6~8 Hz和40~50 Hz,竖向放大显著频率为63.5 Hz和160 Hz。理论模态分析显示,屏障板水平向前2阶自振频率为7 Hz和46 Hz,竖向1阶自振频率为170 Hz,说明水平放大效应与其前2阶自振频率相关,竖向放大效应与其1阶自振频率和基础激励频率相关。将屏障板振动响应估算简化为地基土-声屏障动力相互作用耦合振动模型,以考虑其受地基激励强迫振动和自由振动双重影响是合理可行的。

关键词：落地声屏障振动放大效应地基土-声屏障动力相互作用加速度时程和频谱特征原位试验普速铁路

Islet separation and islet cell culture in vitro from human embryo-pancreas

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World Journal of Gastroenterology 1999年第5期5卷 458-460页

作者： Yuan Z wu GY He ys Shao CM Zhan Y Kunming Med Coll Dept Histol & Embryol Kunming 650031 Yunnan Province Peoples R China First Affiliated Hosp Kunming Med Coll Dept Nucl Med Kunming 650032 Yunnan Province Peoples R China Kunming Med Coll Dept Biol Kunming 650031 Yunnan Province Peoples R China

INTRODUCTIONDiabetes mellitus is the most common disease and its death rate ranks the 8th in the world. Up to now, its incidence has a tendency to increase[1]. Since disorder of sugar metabolism might result in microvascular degeneration and injury of important human organs, it will endanger human health seriously. In 1969, Younszai first reported the method that could decrease diabetes symptoms by islet tissue transplantation. In 1981, our country began to treat diabetes type Ⅰ by transplanting cultured islet tissues. In our study, we digested the pieces of pancreas with collagenase and made morphological observation on islet cells cultured for 3d, 5d, 7d, 9d and 13d respectively, and the contents of insulin and C-peptide in the supernatant were detected by radioimmunoassay. The experimental model of rabbit diabetes was established, and certain curative effect was achieved in the treatment of experimental diabetes in rats.

关键词： cell culture islet cell islets of langerhans transplantetion pancreas/ embryology

Morphological disruption and visual tuning alterations in the primary visual cortex in glaucoma(DBA/2J)mice

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Neural Regeneration Research 2024年第1期19卷 220-225页

作者： Yin Yang Zhaoxi Yang Maoxia Lv Ang Jia Junjun Li Baitao Liao Jing’an Chen Zhengzheng wu Yi Shi Yang Xia Dezhong Yao Ke Chen Department of Ophthalmology Sichuan Provincial People’s HospitalMedical SchoolUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for NeuroInformationSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Research Unit of NeuroInformation Chinese Academy of Medical SciencesChengduSichuan ProvinceChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical CollegeBeijingChina Health Management Center Sichuan Provincial Key Laboratory for Human Disease Gene StudySichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuan ProvinceChina School of Electrical Engineering Zhengzhou UniversityZhengzhouHenan ProvinceChina

Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the ***,it is not yet clear how the primary visual cortex(V1)is altered in *** study used DBA/2J mice as a model for spontaneous secondary *** aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J *** conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band *** morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue ***-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were *** with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial *** r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J *** findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual *** findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse *** study might offer some innovative perspectives regarding the treatment of glaucoma.

关键词： DBA/2J degeneration gamma band oscillations glaucoma primary visual cortex(V1) retina single-unit recording tuning curve

Effect of thermo-mechanical treatment on microstructure and mechanical properties of wire-arc additively manufactured Al-Cu alloy

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Journal of Central South University 2024年第7期31卷 2181-2193页

作者： ZHANG Tao QIN Zhen-yang GONG Hai wu Yun-xin CHEN Xin Light Alloy Research Institute Central South UniversityChangsha 410083China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China Welding and Additive Manufacturing Centre Cranfield UniversityBedfordMK430ALUK

Wire-arc additive manufacture(WAAM)has great potential for manufacturing of Al-Cu ***,inferior mechanical properties of WAAM deposited material restrict its industrial ***-layer cold rolling and thermo-mechanical heat treatment(T8)with pre-stretching deformation between solution and aging treatment were adopted in this *** effects on hardness,mechanical properties and microstructure were analyzed and compared to the conventional heat treatment(T6).The results show that cold rolling increases the hardness and strengths,which further increase with T8 *** ultimate tensile strength(UTS)of 513 MPa and yield stress(ys)of 413 MPa can be obtained in the inter-layer cold-rolled sample with T8 treatment,which is much higher than that in the as-deposited *** cold-rolled samples show higher elongation than that of as-deposited ones due to significant elimination of porosity in cold rolling;while both the T6 and T8 treatments decrease the *** cold rolling and pre-stretching deformation both contribute to the formation of dense and dispersive precipitatedθ′phases,which inhibits the dislocation movement and enhances the strengths;as a result,T8 treatment shows better strengthening effect than the T6 *** strengthening mechanism was analyzed and it was mainly related to work hardening and precipitation strengthening.

关键词： wire-arc additive manufacture inter-layer cold rolling thermal-mechanical treatment microstructure mechanical properties strengthening mechanism

地铁沿线高层住宅建筑室内振动与结构噪声的相关性分析

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铁道科学与工程学报 2024年第8期21卷 3445-3454页

作者：曾钦娥宋瑞祥吴丹邬玉斌何蕾北京市科学技术研究院城市安全与环境科学研究所北京100054

结构噪声是引起地铁临近住宅建筑居民烦恼的最直接原因,结构噪声与室内楼板振动之间相关性是进行地铁临近住宅建筑室内结构噪声预测及控制的关键问题。以某地铁邻近某高层住宅为研究对象,通过多点同步测试获得4个不同大小房间的楼板垂... 详细信息

结构噪声是引起地铁临近住宅建筑居民烦恼的最直接原因,结构噪声与室内楼板振动之间相关性是进行地铁临近住宅建筑室内结构噪声预测及控制的关键问题。以某地铁邻近某高层住宅为研究对象,通过多点同步测试获得4个不同大小房间的楼板垂向加速度及室内结构噪声,分析楼板垂向加速度、声压的频率特性及两者之间的相干性,对比分析不同房间振动噪声的卓越频段及其相干频段的差异性,结合数值仿真方法,揭示不同房间加速度-声压相干性的差异原因,同时,利用不同列车通过时振动离散性特点对室内结构噪声典型1/3频带处的加速度级与声压级进行线性拟合优化,分析两者的相关性及其与房间特性之间的关联性。研究结果表明,楼板振动加速度卓越频段、噪声卓越频段均随房间大小改变而显著变化,4个房间的声压峰值频率分别为49、40和50、49、65 Hz,且振动卓越频段与噪声卓越频段之间非完全重叠;房间振动与噪声的相干频段与振动的卓越频段部分重叠,与噪声的卓越频段基本不重叠,受声腔简正模式的影响,在噪声峰值频率处的相干性较低,相干系数均小于0.5;受房间简正模式的影响,不同尺寸房间4个典型1/3频带处(40、50、63和100 Hz)楼板垂向加速度级与声压级的修正量变化范围为12.0~34.9 dB,对结构噪声的预测建议按房间尺寸及频带进行分类处理。研究成果可为地铁临近住宅建筑室内结构噪声的预测提供参考。

关键词：地铁住宅建筑振动结构噪声相关性

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon