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Chinese Journal of Chemical Engineering 2024年第1期65卷 276-285页

作者： yin wu Yan Sun Department of Biochemical Engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Biocatalysis in organic solvents(OSs)has numerous important applications,but native enzymes in OSs often exhibit limited catalytic ***,we proposed a computation-aided surface charge engineering strategy to improve the catalytic performance of haloalkane dehalogenase DhaA in OSs based on the energetic analysis of substrate binding to the DhaA *** variants with enhanced OS resistance were obtained by replacing negative charged residues on the surface with positive charged residue(Arg).Particularly,a four-substitution variant E16R/E93R/E121R/E257R exhibited the best catalytic performance(five-fold improvement in OS resistance and seven-fold half-life increase in 40%(vol)dimethylsulfoxide).As a result,the overall catalytic performance of the variant could be at least 26 times higher than the wild-type *** spectroscopy and molecular dynamics simulation studies revealed that the residue substitution mainly enhanced OS resistance from four aspects:(a)improved the overall structural stability,(b)increased the hydrophobicity of the local microenvironment around the catalytic triad,(c)enriched the hydrophobic substrate around the enzyme molecule,and(d)lowered the contact frequency between OS molecules and the catalytic *** findings validate that computationaided surface charge engineering is an effective and ingenious rational strategy for tailoring enzyme performance in OSs.

关键词： Surface charge engineering Organic solvent resistance Molecular dynamics simulation Haloalkane dehalogenase

Periodic Solutions of Singular Second Order Equations at Resonance

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Acta Mathematica Sinica,English Series 2015年第10期31卷 1599-1610页

作者： yin yin wu Ding Bian QIAN School of Mathematical Sciences Soochow University Department of Fondamental Courses Wuxi Institute of Technology

In this paper, we study the existence of positive periodic solutions for singular second order equations x＂＋ n2/4＋h（x） = p（t）, where h has a singularity at the origin and n is a positive integer. We give an explicit condition to ensure the existence of positive periodic solutions when h is an unbounded perturbation at infinity by using qualitative analysis and topological dezree theory.

关键词： Second order equations singularity periodic solutions resonance unbounded perturba-tions

Bortezomib, dexamethasone plus thalidomide for treatment of newly diagnosed multiple myeloma patients with or without renal impairment

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Chinese Journal of Cancer Research 2013年第2期25卷 155-160页

作者： Guangzhong Yang Wenming Chen yin wu Department of Hematology & Multiple Myeloma Research Center of Beijing Beijing Chaoyang Hospital Affiliated to Capital Medical Universit

Objective： To investigate the efficacy and safety of the treatment of the newly diagnosed multiple myeloma （MM） with or without renal impairment receiving the therapy of bortezomib, dexamethasone plus thalidomide （BTD） regimen in order to analyze the effects of BTD regimen on the prognosis of the MM patients with renal impairment compared with the patients without renal impairment. Methods： Seventy-two newly diagnosed MM patients entered into our study and all the patients belonged to International Stage System （ISS） 3 in which transplantation patients were excluded or the patients refused receiving transplantation therapy. According to the level of serum creatinine （Scr）, the patients were divided into two groups including group 1 （n=42）（Scr 〈2 mg/dL） and group 2 （n=30）（Scr ≥2 mg/dL）. All the patients received the therapy of BTD regimen as induction therapy, and the median treatment time was 5 （range, 2-8） cycles. The outcome was analyzed retrospectively. Results： The overall remission （OR） rates were 81.0% （group 1） and 80.0% （group 2）. There was no statistical difference between the two groups （P〉0.05）. In group 2, 10 patients （33.3%） got renal function reversal, 14 patients （46.7%） got improved renal function and the median time to renal function reversal was 1.4 （range, 0.7-3.0） months. Among 12 patients with hemodialysis at diagnosis, 8 patients got rid of hemodialysis after median 4 cycles of therapy （range, 3-6 cycles）. After a median follow-up period of 16 （range, 2-31） months, 5 patients （11.9%） in group 1 died and 9 patients （30.0%） in group 2 died （P=0.056）. The 2-year estimate of overall survival was 77.3% in group 1 and 63.8% in group 2, respectively （P=0.188）. During a median follow-up time of 13.0 months （range, 2-25 months）, 15 patients （35.7%） in group 1 progressed and 13 patients （43.3%） in group 2 progressed （P=0.513）. The 2-year estimate of response duration was 50.6% in group 1 and 42.1% in group 2, respectively （P=1）. The main toxicities in

关键词： Myeloma bortezomib renal impairment

Extent, reasons and consequences of off-labeled and unlicensed drug prescription in hospitalized children: a narrative review

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World Journal of Pediatrics 2021年第4期17卷 341-354页

作者： Wasim Shuib Xin-yin wu Fang Xiao Xiangya School of Public Health Central South UniversityChangsha410078China

Background Off-label and unlicensed prescriptions pose a severe safety concern among the pediatric *** aimed to summarize the up-to-date evidence on the extent,reasons,and consequences of off-label and unlicensed drugs in hospitalized pediatric *** We systematically searched PubMed,EMBASE,SCOPUS,Web of Science and Google Scholar between 1990 and 2020 in which the last search was conducted on 12 February *** included studies with the following inclusion criteria:(1)observational studies in design;(2)target population was hospitalized pediatric patients whether admitted in the intensive care unit or in the general ward;(3)study reporting the prevalence of off-label,unlicensed prescriptions or both;and(4)published in *** A total of 47 studies were eligible for *** proportion of off-label and unlicensed prescriptions ranged from 7.4%to 99.5%and 0.1%to 74.4%,*** most frequent category of off-label prescriptions was prescription outside the age range,with the most commonly reported reason for off-label prescriptions being the lack of information specifically for pediatrics on the drug information *** consequences of off-label and unlicensed prescriptions ranged from minor and bearable skin reactions to debilitating renal failure,risking *** Off-label and unlicensed prescriptions are extensive and require progressively meditative ***,the pediatric population is currently a“therapeutic orphan”.Unless adequate pediatric clinical trials and licensed drugs become available,off-label and unlicensed drug prescription should not entirely be banned but rather promoted in an organized manner.

关键词： Licensed medicines Off-label prescribing Pediatrics Unlicensed prescribing

NUMERICAL SIMULATION OF 1998 RED TIDE OF THE BOHAI SEA

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International Journal of Sediment Research 2002年第3期17卷 175-185页

作者： Yongsheng wu,Zhao-yin WANG Hydraulic Engineering Tsinghua University Beijing 100084 China Hydraulic Engineering Tsinghua University Beijing 100084 China

Algal bloom, known as red tide, has occurred frequently in the Bohai Sea in recent decades causing great economic losses to fisheries as well as having significant adverse impact on the environment. A 3-D Eco-Hydraulic model is developed to simulate the explosive propagation of diatom and dinoflagellate as a function of the concentration of various nutrients, river inflow, tide, temperature, wind, sunshine and rainfall. The model is intended to answer the questions of how the 1998 Bohai Sea red tide occurred, and to investigate how environmental factors, such as temperature, wind, rainfall, solar radiance, sea currents and nutrients, affect the algal bloom process. The parameters employed in the model are calibrated with the data collected in the periods 1982-1983 and 1992-1993. Results from the model indicate that eutrophication of the seawater is the basic condition for algal bloom, and that the 1998 red tide was triggered by the abnormal warm weather in August and September.

关键词： Algal bloom Eco-hydrodynamic model Bohai Sea Red tide Eutrophication

Structural Adjustment Approaches and Policy Design of the Chinese Economy： A Comparison Between New and Old Structural Economics

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Fudan Journal of the Humanities and Social Sciences 2017年第4期10卷 431-454页

作者： yin wu School of Economics Southwestern University of Finance and Economics Liulin Campus No.555 Liutai Avenue Wenjiang District Chengdu 611130 China

The structural adjustment of China＇s economy requires the support of economic theories dedicated to structural issues. But new structural economics （NSE） is significantly different from old structural economics （OSE） in terms of development strategies and policies. They expound on the paths of industrial structure improvement and steady economic growth for developing countries from two different perspectives, comparative advantage and first-mover advantage, which result in a toss-up. From the clashing theories and observations of the true state of Chinese economy, we can see that the core features of China＇s current economic structure are a cumulative result of the insufficient ＂complementary＂ and ＂inducing＂ roles of government investment, which requires the introduction of certain investment models to design an effective structural adjustment plan. From the perspective of investment priority, scope （public service or production）, motives, capacity and decision-making and multi-sectoral coordination, this paper analyzes the key connections between NSE and OSE and strives to design an appropriate and accurate investment plan from the perspective of stability, flexibility and under- pinning in the hope of resolving the issues facing the structural adjustment of the Chinese economy. The first step is to identify investment priorities and enable the market to play the decisive role and the government the guiding role. The second step is to identify crucial nodes and adapt investments to trends of the new industrial revolution. The third step is to focus on the resolution of livelihood issues to steer China out of the low-income trap and clear of the middle-income trap. Not only do investment variables have to become an instrument to continuously improve Chi- na＇s factor endowment structure, but also investment as a mechanism underpinning development has to be adopted throughout the entire duration of the process of reform to fulfill the goal of structural adjustment pur

关键词： Structural adjustment of China' economy ~ New structuraleconomics Old structural economics - Investment model

Eclogites and their country gneisses: studies on inclusions in the accessory minerals of country gneisses

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Chinese Science Bulletin 1998年第1期43卷 65-68页

作者： Jingbo Liu yin wu Lianjie Guo Chinese Acad Sci Inst Geol Beijing 100029 Peoples R China

The mineral inclusions in accessory minerals of the country gneisses have been studied in order to interpret relation between eclogites and their country gneissic rocks. Omphacite inclusions have been identified in titanite and zircon, which indicates that the present mineral assemblages of country gneisses are the last retrograded assemblages and eclogites and their country gneissic rocks probably have a same metamorphic history.

关键词： eclogite inclusion omphacite.

Meeting the Demands of Socialist Core Values and Leading the People's Spiritual Needs

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学术界 2015年第10期 264-269页

作者： wu yin Yang Wei School of Marxism Beijing Jiaotong University Beijing 100044

The spiritual needs are uniquely human,which are the conditions of human existence and *** the process of socialist modernization construction in our country,the social economy develops rapidly and the material basis compacts *** people' s development is far *** socialist core values can lead people' s spiritual needs to be healthy and *** can also build the civic spiritual support system for social development,as well as help people establish the values and faiths that adapt to the socialist construction in our country.

关键词：社会主义现代化价值观社会主义建设人类生存物质基础社会经济支持系统社会发展

Destruction of Spiral Wave Using External Electric Field Modulated by Logistic Map

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Communications in Theoretical Physics 2007年第4期47卷 675-678页

作者： MA Jun CHEN Yong JIN wu-yin Department of Physics Lanzhou University of Technology Lanzhou 730050 China Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China School of Mechanical and Electronical Engineering Lanzhou University of Technology Lanzhou 730050 China

Evolution of spiral wave generated from the excitable media within the Barkley model is investigated. The external gradient electric field modulated by the logistic map is imposed on the media （along x- and y-axis）. Drift and break up of spiral wave are observed when the amplitude of the electric field is modulated by the chaotic signal from the logistic map, and the whole system could become homogeneous finally and the relevant results are compared when the gradient electric field is modulated by the Lorenz or Rossler chaotic signal.

关键词： spiral wave Barkley model logistic map

Molecular characterization of a proline transporter from Chilo suppressalis

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Insect Science 2011年第5期18卷 495-502页

作者： Jia Huang Shun-Fan wu Gong-yin Ye State Key Laboratory of Rice Biology Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects Instituteof Insect Sciences Zhejiang University Hangzhou China

Proline plays an important role in regulating synaptic neurotransmission in both mammalian and insect nervous systems. The full-length complementary DNA sequences encoding the proline transporter gene （CsProT） and its alternative spliced transcript （CsProT-ST） were cloned from the striped stem borer （SSB）, Chilo suppressalis, one of the most important rice pests in Asia. The comparison of amino acid sequences showed that CsProT is highly similar to the proline transporter isolated from Manduca sexta （MasProT）. The developmental changes of the relative messenger RNA expression levels of CsProT and CsProT-ST genes were examined in SSB. The expression level of CsProT-ST is much higher than that of CsProT in all developmental periods, suggesting that the Y-end spliced variant is the major transcript instead of CsProT. The highest ex- pression level of both genes in the pupal stage means that proline may be involved in some unclear functions in the metamorphosis from pupa to adulthood.

关键词： Chilo suppressalis mRNA expression neuromodulator proline transporter