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Porphyrin-like Fe-N4 sites with sulfur adjustment on hierarchical porous carbon for different rate-determining steps in oxygen reduction reaction

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Nano Research 2018年第12期11卷 6260-6269页

作者： Konglin wu Xin Chen Shoujie Liu Yuan Pan Weng-Chon Cheong wei Zhu Xing Cao Rongan Shen Wenxing Chen Jun LUO Wensheng Yan Lirong Zheng Zheng Chen Dingsheng wang Qing Peng Chen Chen Yadong Li Department ofChemistry Tsinghua UniversityBeijing 100084China Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials Department of ChemistryUniversity of Science and Technology BeijingBeijing 100083China College of Chemistry and Materials Science Key Laboratory of Functional Molecular Solidsthe Ministry of EducationAnhui Normal UniversityWuhu 241002China Center for Electron Microscopy Tianjin University of TechnologyTianjin 300384China NationaISynchrotron Radiation Laboratory (NSRL) University of Science and Technology of ChinaHefei 230029China Beijing Synchrotron Radiation Facility (NSRF) Institute of High Energy PhysicsChinese Academy of ScienceBeijing 100049China

We developed a strategy based on coordination polymer to synthesize singleatom site Fe/N and S-codoped hierarchical porous carbon (Fe1/N,S-PC). The as-obtained Fe1/N,S-PC exhibited superior oxygen reduction reaction (ORR) performance with a half-wave potential (E1/2, 0.904 V vs. RHE) that was better than that of commercial Pt/C (E1/2, 0.86 V vs. RHE), single-atom site Fe/N-doped hierarchical porous carbon (Fe1/N-PC) without S-doped (E1/2, 0.85 V vs. RHE), and many other nonprecious metal catalysts in alkaline medium. Moreover, the Fe1/N,S-PC revealed high methanol tolerance and firm stability. The excellent electrocatalytic activity of Fe1/N,S-PC is attributed to the synergistic effects from the atomically dispersed porphyrin-like Fe-N4 active sites, the heteroatom codoping (N and S), and the hierarchical porous structure in the carbon materials. The calculation based on density functional theory further indicates that the catalytic performance of Fe1/N,S-PC is better than that of Fe1/N-PC owing to the sulfur doping that yielded different rate-determining steps.

关键词： single-atom catalyst heteroatom codoping porous materials oxygen reduction electrocatalysis

不同头型回转体低速倾斜入水过程流场特性数值模拟

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北京理工大学学报 2017年第7期37卷 661-666,671页

作者：宋武超王聪魏英杰王威哈尔滨工业大学航天学院黑龙江哈尔滨150001

基于有限体积法和VOF多相流模型求解气、水两相流动的RANS方程,结合动网格技术,对回转体低速倾斜入水过程进行数值模拟研究.通过将数值计算结果与试验数据进行比较,验证了数值计算方法的有效性.基于该方法对不同头型回转体低速倾斜入水... 详细信息

基于有限体积法和VOF多相流模型求解气、水两相流动的RANS方程,结合动网格技术,对回转体低速倾斜入水过程进行数值模拟研究.通过将数值计算结果与试验数据进行比较,验证了数值计算方法的有效性.基于该方法对不同头型回转体低速倾斜入水过程进行分析,得到不同头型条件下回转体入水空泡形态发展规律、回转体运动特性及流体动力特性变化规律.研究结果表明:同一入水深度,入水空泡直径和流场中最小压力值随着回转体头部锥角的增加而增大;不同头型回转体,锥头母线同一位置处压力随着头部锥角的增加而增大;回转体阻力系数与其头部锥角大小直接相关,锥角较大时,阻力系数也较大,速度衰减也较快.

关键词：回转体倾斜入水头型空泡数值模拟

The influence of the Insight-HXMT/LE time response on timing analysis

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Research in Astronomy and Astrophysics 2021年第1期21卷 45-52页

作者： Deng-Ke Zhou Shi-Jie Zheng Li-Ming Song Yong Chen Cheng-Kui Li Xiao-Bo Li Tian-Xiang Chen wei-wei Cui wei Chen Da-wei Han wei Hu Jia Huo Rui-Can Ma Mao-Shun Li Tian-Ming Li wei Li He-Xin Liu Bo Lu Fang-Jun Lu Jin-Lu Qu You-Li Tuo Juan wang Yu-Sa wang Bai-Yang wu Guang-Cheng Xiao Yu-Peng Xu Yan-Ji Yang Shu Zhang Zi-Liang Zhang Xiao-Fan Zhao Yu-Xuan Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China College of Physics Jilin UniversityChangchun 130012China

The LE is the low energy telescope that is carried on *** uses swept charge devices(SCDs)to detect soft X-ray ***’s time response is caused by the structure of the *** theoretical analysis and Monte Carlo simulations we discuss the influence of LE time response(LTR)on the timing analysis from three aspects:the power spectral density,the pulse profile and the time *** the LTR,the value of power spectral density monotonously decreases with the increasing *** power spectral density of a sinusoidal signal reduces by a half at frequency 536 *** corresponding frequency for quasi-periodic oscillation(QPO)signals is 458 *** root mean square(RMS)of QPOs holds a similar *** the LTR,the centroid frequency and full width at half maxima(FWHM)of QPOs signals do not *** LTR reduces the RMS of pulse profiles and shifts the pulse *** the time domain,the LTR only reduces the peak value of the cross-correlation function while it does not change the peak position;thus it will not affect the result of the time *** considering the time lag obtained from two instruments and one among them is LE,a 1.18 ms lag is expected caused by the *** time lag calculated in the frequency domain is the same as that in the time domain.

关键词： instrumentation:detectors methods:data analysis methods:analytical

Hepatopancreatoduodenectomy for advanced biliary malignancies

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Chinese Medical Journal 2022年第23期135卷 2851-2858页

作者： Xiangsong wu Maolan Li Wenguang wu Xu’an wang Huaifeng Li Runfa Bao Yijun Shu Jun Shen Jun Gu Xuefeng wang wei Gong Shuyou Peng Yingbin Liu Department of General Surgery Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Biliary-Pancreatic Surgery Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China State Key Laboratory of Oncogenes and Related Genes Shanghai 200092China Shanghai Key Laboratory of Biliary Tract Disease Research Shanghai 200092China Shanghai Research Center of Biliary Tract Disease Shanghai 200092China Department of General Surgery The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejing 310009China

Background:Hepatopancreatoduodenectomy(HPD)has been considered the only curative treatment for metastatic cholangiocarcinoma and some locally advanced gallbladder cancers(GBCs).However,HPD has not yet been included in treatment guidelines as a standard surgical procedure in consideration of its morbidity and mortality *** aim of this study was to evaluate the safety and effectiveness of HPD in treating biliary ***:The medical records of 57 patients with advanced biliary cancer undergoing HPD from January 2009 to December 2019 were retrospectively retrieved.A case-control analysis was conducted at our *** with advanced GBC who underwent HPD(HPD-GBC group)were compared with a control group(None-HPD-GBC group).Baseline characteristics,preoperative treatments,tumor pathologic features,operative results,and prognosis were ***:Thirteen patients with cholangiocarcinoma and 44 patients with GBC underwent HPD at our *** postoperative complications(grade III or greater)and postoperative pancreatic fistula were observed in 24(42.1%)and 15(26.3%)patients,*** postoperative death occurred in the present *** survival(OS)was longer in patients with advanced cholangiocarcinoma than in those with GBC(median survival time[MST],31 months vs.11 months;P<0.001).In the subgroup analysis of patients with advanced GBC,multivariate analysis demonstrated that T4 stage tumors(P=0.012),N2 tumors(P=0.001),and positive margin status(P=0.004)were independently associated with poorer *** with either one or more prognostic factors exhibited a shorter MST than patients without those prognostic factors(P<0.001).Conclusion:HPD could be performed with a relatively low mortality rate and an acceptable morbidity rate in an experienced highvolume *** patients with advanced GBC without an N2 or T4 tumor,HPD can be a preferable treatment option.

关键词： Hepatectomy Hepatopancreatoduodenectomy Gallbladder cancer Cholangiocarcinoma

Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2137-2152页

作者： Tarik Zahr Vijay K.Boda Jian Ge Lexiang Yu Zhongzhi wu Jianwen Que wei Li Li Qiang Naomi Berrie Diabetes Center Columbia UniversityNew YorkNY 10032USA Department of Molecular Pharmacology and Therapeutics Columbia UniversityNew YorkNY 10032USA Department of Pharmaceutical Sciences College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Drug Discovery Center College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Division of Digestive and Liver Diseases Columbia UniversityNew YorkNY 10032USA Center for Human Development Columbia UniversityNew YorkNY 10027USA Department of Pathology and Cell Biology Columbia UniversityNew YorkNY 10032USA Department of Medicine Columbia UniversityNew YorkNY 10032USA

Estrogen is imperative to mammalian reproductivity,metabolism,and ***,the hormone activating estrogen receptor(ERs)αcan cause major safety concerns due to the enrichment of ERαin female tissues and certain *** contrast,ERβis more broadly expressed in metabolic tissues and the ***,it is desirable to generate selective ERβagonist conjugates for maximizing the therapeutic effects of ERs while minimizing the risks of ERα***,we report the design and production of small molecule conjugates containing selective non-steroid ERβagonists Gtx878 or *** of aged mice with our synthesized conjugates improved aging-associated declines in insulin sensitivity,visceral adipose integrity,skeletal muscle function,and skin health,with validation in *** further uncovered the benefits of ERβconjugates in the skin using two inducible skin injury mouse models,showing increased skin basal cell proliferation,epidermal thickness,and wound ***,our ERβ-selective agonist conjugates offer novel therapeutic potential to improve aging-associated conditions and aid in rejuvenating skin health.

关键词： Estrogen receptorβ Aging Metabolism Skin injury Muscle metabolism Small molecule conjugates Regeneration Adiposity

Grain Size Evidence of Multiple Origins of Red Clays in the Jinhua-Quzhou Basin, South China

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Pedosphere 2013年第5期23卷 686-695页

作者： LI Jian-wu YE wei ZHANG Gan-Lin ZHU Li-Dong JIANG Yong-Jian GONG Zi-Tong Zhejiang Provincial Key Laboratory of Carbon Cycling in Forest Ecosystems and Carbon Sequestration Zhejiang A & F University State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Geography Process Lab Zhejiang Normal University Nanjing Institute of Geography and Limnology Chinese Academy of Sciences

Six typical red clay profiles were sampled from Tangxi （TX）, Langyaz （LYZ）, South Shangshanwen （SSW）, Xianqiao （XQ）, Qijian （Q J） and Huhaitang （HHT） of Jinhua-Quzhou Basin, Zhejiang Province of China to evaluate the characteristics of grain size composition, distribution and parameters of red clays and to reveal the origin of red clays and interpret possible implications for paleoclimate in subtropical China. The results showed that red clays in TX, LYZ and SSW were fine and uniform, with no 〉 2 mm gravels and little 〉 63μm fraction. They had a high content of 10-50 μm fraction, so-called ＂basic dust fraction＂, and showed unimodal distributions, which were very comparable to those of the Xiashu Loess in southeastern China and the loess in North China. All these features reflected marked aeolian characteristics of the red clays in these areas. Red clays in XQ and QJ were much coarser than those in TjjX, LYZ and SSW, with high contents of 〉 63μm fraction and even containing 〉 2 mm gravels in some layers. The grain size distribution patterns showed significantly progressive trends from the lower profile to the upmost layer and could not be compared with those of the loess in North China or the Xiashu Loess, implying they might be derived from underlying parent rocks and had some inherited properties from bedrock. Red clays in HHT had high contents of 〉 63μm fraetion and contain many 〉 2 mm gravels in each layer. The grain size frequency curves showed multiple-peaks and some abrupt variations were also observed on the profile, revealing its alluvial or diluvial origin in HHT. The multiple origins of red clays reflected the diversity and complexity of the Quaternary environment in South China. It can be concluded that grain size is an effective proxy indicator for the origin of most deposits.

关键词： aeolian characteristics grain size distribution loess paleoclimate Quaternary

Identification of SNPs and expression patterns of FZD3 gene and its effect on wool traits in Chinese Merino sheep(Xinjiang Type)

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Journal of Integrative Agriculture 2019年第10期18卷 2351-2360页

作者： ZHAO Bing-ru FU Xue-feng TIAN Ke-chuan HUANG Xi-xia DI Jiang BAI Yan XU Xin-ming TIAN Yue-zhen wu wei-wei ABLAT Sulayman ZENG wei-dan HANIKEZI Tulafu College of Animal Science Xinjiang Agricultural UniversityUrumqi 830052P.R.China Key Laboratory of Genetics Breeding and Reproduction of Xinjiang Cashmere and Wool Sheep Institute of Animal ScienceXinjiang Academy of Animal SciencesUrumqi 830011P.R.China

As a member of the Frizzled family, Frizzled3 (FZD3) is a receptor of the canonical Wnt signaling pathway and plays a vital role in mammalian hair follicle developmental processes. However, its effects on wool traits are not clear. The objectives of this study were to identify the single nucleotide polymorphisms (SNPs) and the expression patterns of FZD3 gene, and then to determine whether it affected wool traits of Chinese Merino sheep (Xinjiang Type) or not. PCR-single stranded conformational polymorphism (PCR-SSCP) and sequencing were used to identify mutation loci, and general linear model (GLM) with SAS 9.1 was used for the association analysis between wool traits and SNPs. Quantitative real-time PCR (qRT-PCR) was used to investigate FZD3 gene expression levels. The results showed that six exons of FZD3 gene were amplified and two mutation loci were identified in exon 1 (NC_019459.2: g.101771685 T>C (SNP1)) and exon 3 (NC_019459.2: g.101810848, A>C (SNP2)), respectively. Association analysis showed that SNP1 was significantly associated with mean fiber diameter (MFD)(P=0.04) and live weight (LW)(P=0.0004), SNP2 was significantly associated with greasy fleece weight (GFW)(P=0.04). The expression level of FZD3 gene in skin tissues of the superfine wool (SF) group was significantly lower (P<0.05) than that of the fine wool (F) group. Moreover, it had a higher expression level (P<0.01) in skin tissues than in other tissues of Chinese Merino ewes. While, its expression level had a fluctuant expression in skin tissues at different developmental stages of embryos and born lambs, with the highest expression levels (P<0.01) at the 65th day of embryos. Our study revealed the genetic relationship between FZD3 variants and wool traits and two identified SNPs might serve as potential and valuable genetic markers for sheep breeding and lay a molecular genetic foundation for sheep marker-assisted selection (MAS).

关键词： Chinese Merino sheep (Xinjiang Type) FZD3 single nucleotide polymorphism (SNP) expression pattern association analysis wool traits

Acupoint Injection Decreases Anesthetic Cosumption during Combined Spinal-Epidural and Patient-Controlled Epidural Labor Analgesia

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Chinese Journal of Integrative Medicine 2022年第3期28卷 257-262页

作者： HUANG Min-li FANG Chang-ping ZHAO Hai-yan ZHANG Zi-jing wu Shu-zhen YI wei LI Shang-rong wu Ling-ling Department of Obstetrics and Gyn ecology The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou(510630)China Medical College of Acupuncture-Moxibustion and Rehabilitation Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Anesthesiology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou(510630)China

Objective:To explore if acupoint injection can improve analgesic effects or delivery outcomes in parturients who received combined spinal-epidural analgesia(CSEA)and patient-controlled epidural analgesia(PCEA)for labor ***:A total of 307 participants were prospectively collected from July 2017 to December *** participants were randomized into the combined acupoint injection with CSEA plus PCEA group(AICP group,n=168)and CSEA plus PCEA group(CP group,n=139)for labor analgesia using a random number *** groups received CSEA plus PCEA at cervical dilation 3 cm during labor process,and parturients of the AICP group were implemented acupoint injection for which bilateral acupoint of Zusanli(ST 36)and Sanyinjiao(SP 6)were selected in *** primary outcome was Visual Analogue Scale(VAS)score,and the secondary outcomes were obstetric outcomes and requirement of anesthetics *** evaluations were performed after ***:The VAS scores were significantly lower in the AICP group than in the CP group at 10,30,60,and 120 min after labor analgesia(all P<0.05).The latent phase of the AICP group was shorter than that of the CP group(P<0.05).There were less additional anesthetics consumption,lower incidences of uterine atony,fever,pruritus and urinary retention in the AICP group than those in the CP group(all P<0.05).Conclusion:Acupoint injection combined CSEA plus PCEA for labor analgesia can decrease the anesthetic consumption,improve analgesic quality,and reduce adverse reactions in the parturients.(Registration ***-2000003120)

关键词： acupoint injection combined spinal-epidural analgesia labor analgesia anesthetic consumption multimodal analgesia

Laparoscopic spleen-preserving distal pancreatectomy for pancreatic neoplasms:A retrospective study

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World Journal of Gastroenterology 2014年第38期20卷 13966-13972页

作者： Jia-Fei Yan Xiao-wu Xu wei-wei Jin Chao-Jie Huang Ke Chen Ren-Chao Zhang Ajoodhea Harsha Yi-Ping Mou Department of General Surgery Sir Run Run Shaw HospitalInstitute of Micro-invasive SurgeryZhejiang University School of Medicine

AIM: To describe the clinical characteristics, technical procedures, and outcomes of patients undergoing laparoscopic spleen-preserving distal pancreatectomy (LSPDP) for benign and malignant pancreatic neoplasms.

关键词： Laparoscopic surgery Splenic preservation Distal pancreatectomy Pancreatic tumor Pancreas