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唑来膦酸合成工艺改进

中国医药工业杂志 2024年第4期55卷 506-509页

作者：王邵峰冯中吴士忠彭壮张贵民鲁南制药集团股份有限公司国家手性制药工程技术研究中心山东临沂273400

对唑来膦酸(1)的合成工艺进行了优化。以经济、易得的咪唑(3)和氯乙酸乙酯(4)为起始物,在叔丁醇钾碱性条件下,通过“一锅法”进行N-烷基化和水解反应,得中间体咪唑-1-乙酸盐酸盐(2盐酸盐)。2盐酸盐经三氯化磷膦酸化得1粗品,通过加大甲... 详细信息

对唑来膦酸(1)的合成工艺进行了优化。以经济、易得的咪唑(3)和氯乙酸乙酯(4)为起始物,在叔丁醇钾碱性条件下,通过“一锅法”进行N-烷基化和水解反应,得中间体咪唑-1-乙酸盐酸盐(2盐酸盐)。2盐酸盐经三氯化磷膦酸化得1粗品,通过加大甲烷磺酸、三氯化磷的投料量,延长反应时间,收率由46%提至87%;1粗品经水和丙酮精制得1,产品未检出明显杂质(HPLC纯度100.0%),总收率68%(以3计)。改进后的工艺生产成本较低,操作安全、简便,收率提高,适合工业化生产。

关键词：唑来膦酸一锅法膦酸化合成工艺改进

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软件漏洞起因的分类研究

计算机工程 2006年第20期32卷 163-165页

作者：李淼吴世忠长春光学精密与物理研究所中国信息安全产品测评认证中心北京100089

软件漏洞是发生安全事件的根源,当软件漏洞被利用时,会造成严重的后果。对CERT或者SANS公布的漏洞进行的分析表明:许多漏洞都归因于软件开发人员反复地犯同一类错误。该文对软件漏洞的起因进行分类,应用领域包括:开发人员的使用指南(以... 详细信息

软件漏洞是发生安全事件的根源,当软件漏洞被利用时,会造成严重的后果。对CERT或者SANS公布的漏洞进行的分析表明:许多漏洞都归因于软件开发人员反复地犯同一类错误。该文对软件漏洞的起因进行分类,应用领域包括:开发人员的使用指南(以避免犯共性的错误),软件工程专业学生的教学素材,以及软件测试人员或审计人员的“项目核查清单”。

关键词：软件漏洞分类法完全介入特征冲突

An Efficient Restrictive Blind Signature Scheme with Applications to Electronic Cash

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High Technology Letters 2002年第4期8卷 60-63页

作者：谭运猛 Yang Zongkai wu shizhong Dept. of Electronics & Information Eng. Huazhong University of Science and Technology Wuhan 430074 P.R.China National Information Security Testing Evaluation & Certification Center Beijing 100091 P.R.China

In this paper, a new restrictive blind signature scheme is proposed. Compared with Brands restrictive blind signature scheme, our scheme is even more restrictive and efficient. And our scheme is proved secure, too. A new withdrawal protocol of electronic cash system is designed by using our restrictive blind signature scheme, which is more efficient than the withdrawal protocol and is more appropriate for adopting pre processing and post processing.

关键词： restrictive blind signature scheme,applications to electronic

A Heuristic Algorithm on QoS Routing

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High Technology Letters 2002年第3期8卷 52-56页

This paper focuses on solving the delay constrained least cost routing problem, and propose a simple, distributed heuristic solution, called distributed recursive delay constrained least cost (DR DCLC) unicast routing algorithm. DR DCLC only requires local information to find the near optimal solution. The correctness of DR DCLC is proued by showing that it is always capable of constructing a loop free delay constrained path within finite time, if such a path exists. Simulation is also used to compare DR DCLC to the optimal DCLC algorithm and other algorithms.

关键词： routing quality of service distributed recursive algorithm delay constraints

Fracture Plane Control in Rock Blasting

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Journal of Earth Science 1998年第3期17卷 73-76页

作者： wu Li Zhang shizhong Chen Jianping Faculty of Engineering, China University of Geosciences, wuhan 430074

Blasting operation dissipates much of the blasting energy in crushing the rock at the borehole and the resulting cracks are randomly oriented. There is very little control of the fracture plane. In order to control the fracture plane, many methods have been applied. This paper discusses a new blasting method in which a high degree of fracture control can be achieved while minimizing the ground shock.

关键词： rock blasting fracture plane control notched borehole.

An Efficient Fair Electronic Cash System

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High Technology Letters 2003年第3期9卷 1-5页

作者：郭涛 Li Zhitang Tan Yunmeng wu shizhong Department of Computer Science & Technology Huazhong University of Science and Technology Wuhan 430074 P.R.China Department of Communication Science & Technology Huazhong University of Science and TechnologyWuhan 430074 P.R.China China National Information Security Testing Evaluation & Certification Center Beijing 100091P.R.China

In this paper, an efficient fair e-cash system is presented. Based on the improved Brands’ e-cash scheme, it is expanded by adding two roles, government and judges. The user can keep unconditionally anonymous in normal transactions. Authorized by the judges, the government can remove the identity of an illegal user with the help of the bank. So such misuse as blackmailing or money laundering can be prevented. Therefore, this scheme is more efficient, more suitable for adopting pre-processing and post-processing and more practical. In the paper, the details of the scheme are described, its security is proved, and its efficiency is analyzed.

关键词： e-cash electronic payment electronic commerce

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Supernatural Flight

China's Tibet 2005年第6期16卷 14-17页

作者： BY ZENG JIN, YI shizhong, wu HUIJUAN & YU LIWEI

What are the difficulties involving in flying to Tibet？ The answer： air routes that challenge pilot skills, airports that are hard to land on and takeoff, and a changeable climate hard to forecast.

关键词：西藏航空事业航线飞行技术历史事件

Radiomic features on contrast-enhanced images of the remnant liver predict the prognosis of hepatocellular carcinoma after partial hepatectomy

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iLIVER 2024年第1期3卷 15-29页

作者： Meilong wu Liping Liu Xiaojuan Wang Ying Xiao shizhong Yang Jiahong Dong Division of Hepatobiliary and Pancreas Surgery Department of General SurgeryShenzhen People's HospitalShenzhen 518020China The Second Clinical Medical College Jinan UniversityShenzhen 518020China The First Affiliated Hospital Southern University of Science and TechnologyShenzhen 518020China Hepato-pancreato-biliary Center Beijing Tsinghua Changgung HospitalBeijing 102218China Key Laboratory of Digital Intelligence Hepatology Chinese Ministry of EducationBeijing 102218China School of Clinical Medicine Tsinghua UniversityBeijing 100084China Research Unit of Precision Hepatobiliary Surgery Paradigm Chinese Academy of Medical SciencesBeijing 102218China Department of Pathology Beijing Tsinghua Changgung HospitalBeijing 102218China

Background and aims:Radiomic features extracted from preoperative contrast-enhanced computed tomography(CT)images have been shown to predict the prognosis of hepatocellular carcinoma(HCC).However,the prognostic role of radiomic features obtained from postoperative contrast-enhanced CT images of the remnant liver remains *** study explored the prognostic value of radiomic features extracted from postoperative contrast-enhanced CT images in patients with ***:Robust radiomic features were obtained from postoperative contrast-enhanced CT images for 78 patients with primary HCC and used to construct a radiomics score.A clinical model and a combined model that integrated clinicopathological indicators and the radiomics score were *** predictive performance of the model was assessed using the concordance index and net reclassification ***:The postoperative radiomics score for the remnant liver was an independent prognostic factor for diseasefree survival(DFS)and overall survival(OS).The combined model was not inferior to the clinical model in predicting DFS but was superior in predicting *** net reclassification index confirmed that the combined model was more accurate and efficient in predicting OS and *** radiomics score for DFS was significantly associated with tumor thrombus in the portal vein and the postoperative neutrophil-lymphocyte *** radiomics score for OS was associated with multiple tumors,microvascular invasion,and tumor thrombus in the portal ***:Postoperative contrast-enhanced CT radiomic features of the remnant liver were valuable prognostic indicators that could potentially reflect tumor burden and postoperative inflammatory status and provide more information for clinical decision-making.

关键词： Hepatocellular carcinoma Computed tomography Radiomics Postoperative Survival Remnant

Toxic chemistry of heavy metals on hochrysis galbana (parke)in inshore water

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Acta Oceanologica Sinica 1989年第2期8卷 237-251页

作者： Zheng Zhihong, Liu shizhong wu Yuduan Institute of Environmental Science, Xiamen University, Xiamen, China Zhejiang Institute of Marine Fishery, Zhoushan, Zheijiang , china

Effects of heavy metals on Isochrysis galbana (Parke ) were studied in our laboratory. The research focused on toxic effects of metals on algal cells, effects of water-soluble and lipid-soluble organic ligands on metal toxicity and processes of metal uptake by cells. Interactions between two metals and the mechanisms involved were also studied in detail. Finally, some relationships between toxicity and chemical property of metals were revealed.

关键词： Toxic chemistry of heavy metals on hochrysis galbana parke)in inshore water