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Efficacy of Lidan Tang on high-fat-diet induced gallstone in mice and possible mechanism

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Journal of Traditional Chinese Medicine 2020年第4期40卷 584-592页

作者： Gao Yan Liu Caipin Li Juntong Zhai Yingying Lin Meiyu wu qinglin Chu Shifeng Zhang Zhao Li Jianping Zhou Xin Li Yueting Chen Naihong State Key Lab of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaNeuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Pharmacy Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Department of Surgery Beijing Hospital of Integrated Traditional and Western MedicineBeijing 100039China Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhou 510405China College of Pharmacy Hunan University of Chinese MedicineChangsha 410208China

OBJECTIVE:To investigate efficacy of Lidan Tang(LDT)on gallstone induced by high fat diet in mice,and to study its underlying mechanism.METHODS:Mice were fed with high fat diet every day and treated with LDT(9.01 times of human clinic dosage).Mice were randomly divided into 6 groups as control group,gallstone model group(high-fat diet),positive control ursodeoxycholic acid(UDCA)group(80 mg·kg^-1·d^-1,i.g.),LDT low dose group(6 kg/d,i.g.),LDT middle dose group(12 kg/d,i.g.),and LDT high dose group(24 kg/d,i.g.).The whole experiment was lasted for 4 weeks.The levels of ALT,AST,LDH,CHO,HDL-C and LDL-C in serum were measured,the pathological sections were observed by hematoxylin-eosin staining,the activities of antioxidant enzymes were measured by kits,and the proteins related to oxidative stress and lipid transport were detected by Western blot analysis.RESULTS:LDT could significantly reduce the contents of ALT and AST in serum and improve the pathological tissue of liver.LDT could significantly reduce the content of MDA and LPO,and increase the level of GSH and GSH-PX in liver tissue.The data of Western blot showed that LDT had antioxidant effect promoting Keap1/Nrf2 pathway and regulated the process of lipid transport,which was statistically significant.In addition,LDT treatment inhibited the expression of ATP-binding cassette transports ABCG5/8 in liver,and reduced cholesterol transport from the hepatocytes to the gallbladder.CONCLUSION:LDT has protective effect on gallstones induced by high fat diet in mice,which might be based on the protective effect on liver,including enhancing the antioxidant capacity of liver and reducing the production of lipid peroxides.

关键词： Cholelithiasis ATP-binding cassette transporters Oxidative stress Lipids Lidan Tang

两张邮票引发的思考——万有引力与球心距的平方成反比的几何证明

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物理通报 2024年第6期 141-142页

作者：吴庆林李旭伟罗翀三明第一中学福建三明365001 三明市第三中学福建三明365001

牛顿以其高超的数学才能证明了质量均匀的球体和球外质点间的万有引力,可等效成球的质量集中在球心,从而转化为球心和质点之间的万有引力,这一结论出版于《自然哲学的数学原理》.书中虽有完备的证明,但书中欧几里德式的连环引理,且当下... 详细信息

牛顿以其高超的数学才能证明了质量均匀的球体和球外质点间的万有引力,可等效成球的质量集中在球心,从而转化为球心和质点之间的万有引力,这一结论出版于《自然哲学的数学原理》.书中虽有完备的证明,但书中欧几里德式的连环引理,且当下的主要译本中因翻译出现的表述模糊使其生涩难懂,对书中一些模糊的几何问题进行解释说明并在原书的基础上对这一结论进行详细的证明.

关键词：万有引力牛顿几何证明球心距

偶联剂对木塑复合材料冲击强度与热膨胀性能的影响(英文)

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南京林业大学学报（自然科学版） 2012年第3期36卷 91-95页

作者：黄润州 wu qinglin 张洋南京林业大学木材工业学院江苏南京210037 School of Renewable Natural Resources Louisiana State University Baton Rouge 70803 USA

以高密度聚乙烯(HDPE 6761)为基体,松木纤维(Pine)为增强材料,MAPE(EpoleneG2608)、MAPP(Exxelor VA1840)和Fusabond(WPC576D)为偶联剂,采用注塑法制备木塑复合材料(WPC),并测定了HDPE基体和不同配比WPC的热膨胀性能与冲击强度。结果表明:WPC的冲击强度明显低于高密度聚乙烯板(HDPE),较低的冲击强度是木塑复合材料的一个主要缺点,偶联剂的加入可以提高WPC的冲击强度;WPC的热膨胀系数明显低于HDPE,虽然偶联剂的加入可以较好地抑制热膨胀,但WPC的热膨胀系数的主要影响因素是木纤维的加入量及塑料基体的种类。

关键词：冲击强度热膨胀偶联剂木塑复合材料

基于网络文本分析的天堂寨景区旅游形象感知研究

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皖西学院学报 2024年第2期40卷 14-20页

作者：姜丹丹曹冲陈冉吴庆林皖西学院经济与管理学院安徽六安237012

基于天堂寨景区的网络文本,使用ROST CM6软件进行高频词分析、情感分析和语义网络分析,得到了景区的认知形象、情感形象和整体形象。研究发现:天堂寨景区的整体形象是以“风景”“景区”“天堂寨”为核心,游览景点有白马大峡谷、瀑布、... 详细信息

基于天堂寨景区的网络文本,使用ROST CM6软件进行高频词分析、情感分析和语义网络分析,得到了景区的认知形象、情感形象和整体形象。研究发现:天堂寨景区的整体形象是以“风景”“景区”“天堂寨”为核心,游览景点有白马大峡谷、瀑布、白马栈道等地;游客对于天堂寨景区的情感感知是以积极情感为主,体现在对自然生态景观的正面认知,消极情感体现在景区管理混乱、景区配套设施和服务差等方面,针对负面感知的问题,提出相应的政策建议。

关键词：网络文本分析旅游形象感知天堂寨景区

高质量科技期刊开放获取及论文处理费(APC)的调查与分析——以食品科学与工程领域为例

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江苏科技信息 2024年第9期41卷 102-104页

作者：李冬梅吴青林刘瑞华江西农业大学江西南昌330045

文章调查了《食品科学与工程领域高质量科技期刊分级目录(2022年版)》收入的155种期刊的开放获取出版情况、论文处理费、出版商、CC协议、JCR指标数据等,分析食品工程与技术领域高质量期刊的发展现状,从规范OA期刊出版、搭载群集出版传... 详细信息

文章调查了《食品科学与工程领域高质量科技期刊分级目录(2022年版)》收入的155种期刊的开放获取出版情况、论文处理费、出版商、CC协议、JCR指标数据等,分析食品工程与技术领域高质量期刊的发展现状,从规范OA期刊出版、搭载群集出版传播平台、优化期刊生态方面为国内高质量期刊的建设、评价与可持续发展提供参考。

关键词：开放获取论文处理费科技期刊质量评价

同方期刊数据库博看期刊评论

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天然纤维/聚合物复合材料的研究进展

南京林业大学学报（自然科学版） 2016年第3期40卷 163-169页

作者：黄润州冒海燕梅长彤徐信武 wu qinglin 南京林业大学材料科学与工程学院江苏南京210037 School of Renewable Natural Resources Louisiana State UniversityBaton Rouge 70803USA

从传统均相结构、共挤出型芯-表结构的天然纤维/聚合物复合材料、纳米纤维素及微(纳)米纤维/聚合物复合材料3个方面综述了国内外利用天然纤维增强聚合物复合材料的研究现状。芯-表结构的天然纤维/聚合物复合材料(NFPC)作为新型的绿色环... 详细信息

从传统均相结构、共挤出型芯-表结构的天然纤维/聚合物复合材料、纳米纤维素及微(纳)米纤维/聚合物复合材料3个方面综述了国内外利用天然纤维增强聚合物复合材料的研究现状。芯-表结构的天然纤维/聚合物复合材料(NFPC)作为新型的绿色环保型材料已成为研究热点。使用芯-表结构可以显著改善复合材料的综合性能,大大提高复合材料的使用率,并使其在原料使用和材料性能与功能上更符合循环经济和绿色环保的原则。芯-表结构NFPC的芯层与表层间的界面性能是影响芯-表结构NFPC整体性能的主要因素。在此基础上,笔者从农作物纤维/聚合物复合材料的高值化应用的角度,分析了天然纤维/聚合物复合材料研究方向和应用方面存在的主要问题及解决思路。

关键词：天然纤维/聚合物复合材料(NFPC) 芯-表结构共挤出

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皮层对皮-芯结构木塑复合材料性能的影响

南京林业大学学报（自然科学版） 2017年第5期41卷 135-140页

作者：黄润州梅长彤徐信武冒海燕 wu qinglin 戴翔南京林业大学材料科学与工程学院江苏南京210037 School of Renewable Natural Resources Louisiana State University 大亚科技股份有限公司江苏镇江212300

【目的】研究在两种不同芯层材料的复合体系下,增强材料含量与皮层厚度对共挤出(皮-芯结构)木塑复合材料弯曲与热膨胀性能的影响。【方法】以共挤出技术为加工工艺,选取短玻璃纤维(SGF)为皮层的增强材料,制备共挤出型(皮-芯结构)木塑复... 详细信息

【目的】研究在两种不同芯层材料的复合体系下,增强材料含量与皮层厚度对共挤出(皮-芯结构)木塑复合材料弯曲与热膨胀性能的影响。【方法】以共挤出技术为加工工艺,选取短玻璃纤维(SGF)为皮层的增强材料,制备共挤出型(皮-芯结构)木塑复合材料(WPC)。分析了在芯层1与芯层2两种复合体系下,不同皮层厚度(1.0、1.2及1.6 mm)和皮层填料含量(0%、10%、20%、30%和40%)对共挤出型皮-芯结构WPC的弯曲性能和热膨胀性能的影响。【结果】当表面为纯的高密度聚乙烯(HDPE)时,在芯层1和芯层2两个复合体系中,皮层越厚则复合材料的热膨胀系数(LTEC)越高,其热膨胀性能越差;当SGF的加入量恒定时,其LTEC随着皮层厚度的增加而降低。当皮层的弯曲模量比芯层低时,共挤出木塑复合材料的弯曲模量随着皮层厚度的升高逐渐降低;当芯层的弯曲模量比皮层低时,共挤出木塑复合材料的弯曲模量随皮层厚度的升高而升高。皮层为SGF/HDPE材料时,在芯层1和芯层2两个复合体系中,随着皮层SGF的含量从0%增加到40%时,其弯曲性能显著性提高,LTEC显著降低。当皮层的LTEC值比芯层大时,皮层厚度的降低可以降低共挤出木塑复合材料的LTEC;当皮层的LTEC值小于芯层时,共挤出木塑复合材料的LTEC随皮层厚度的增加而减少。【结论】通过改性芯层可以提高皮-芯结构木塑复合材料的整体性能,其增强趋势与表层的增强趋势相似。

关键词：皮-芯结构木塑复合材料共挤出热膨胀弯曲性能皮层厚度

Environment-tolerant ionic hydrogel-elastomer hybrids with robust interfaces,high transparence,and biocompatibility for a mechanical-thermal multimode sensor

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InfoMat 2023年第4期5卷 117-134页

作者： Ya Lu Yiying Yue Qinqin Ding Changtong Mei Xinwu Xu Shaohua Jiang Shuijian He qinglin wu Huining Xiao Jingquan Han Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsJoint International Research Lab of Lignocellulosic Functional MaterialsCollege of Materials Science and EngineeringNanjing Forestry UniversityNanjingthe People's Republic of China College of Biology and Environment Nanjing Forestry UniversityNanjingthe People's Republic of China School of Renewable Natural Resources Louisiana State UniversityBaton RougeLouisianaUSA Chemical Engineering Department New Brunswick UniversityFrederictonNew BrunswickCanada

The human skin,an important sensory organ,responds sensitively to external stimuli under various harsh conditions.However,the simultaneous achievement of mechanical/thermal sensitivity and extreme environmental tolerance remains an enormous challenge for skin-like hydrogel-based sensors.In this study,a novel skin-inspired hydrogel–elastomer hybrid with a sandwich structure and strong interfacial bonding for mechanical–thermal multimode sensing applications is developed.An inner-layered ionic hydrogel with a semiinterpenetrating network is prepared using sodium carboxymethyl cellulose(CMC)as a nanofiller,lithium chloride(LiCl)as an ionic transport conductor,and polyacrylamide(PAM)as a polymer matrix.The outer-layered polydimethylsiloxane(PDMS)elastomers fully encapsulating the hydrogel endow the hybrids with improved mechanical properties,intrinsic waterproofness,and long-term water retention(>98%).The silane modification of the hydrogels and elastomers imparts the hybrids with enhanced interfacial bonding strength and integrity.The hybrids exhibit a high transmittance(~91.2%),fatigue resistance,and biocompatibility.The multifunctional sensors assembled from the hybrids realize real-time temperature(temperature coefficient of resistance,approximately1.1%℃^(-1))responsiveness,wide-range strain sensing capability(gauge factor,~3.8)over a wide temperature range(from-20℃ to 60℃),and underwater information transmission.Notably,the dualparameter sensor can recognize the superimposed signals of temperature and strain.The designed prototype sensor arrays can detect the magnitude and spatial distribution of forces and temperatures.The comprehensive performance of the sensor prepared via a facile method is superior to that of most similar sensors previously reported.Finally,this study develops a new material platform for monitoring human health in extreme environments.

关键词： cellulose hydrogels polyacrylamide polydimethylsiloxane sensors

Highly reliable and efficient encoding systems for hexadecimal polypeptide-based data storage

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Fundamental Research 2023年第2期3卷 298-304页

作者： Yubin Ren Yi Zhang Yawei Liu qinglin wu Hong-Gang Hu Jingjing Li Chunhai Fan Dong Chen Kai Liu Hongjie Zhang Department of Chemistry Tsinghua UniversityBeijing 100084China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Institute of Process Equipment College of Energy Engineering and State Key Laboratory of Fluid Power and Mechatronic SystemsZhejiang UniversityHangzhou 310027China Institute of Translational Medicine Shanghai UniversityShanghai 200444China Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical Engineeringand Institute of Molecular MedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200240China

Polypeptides consisting of amino acid(AA)sequences are suitable for high-density information storage.However,the lack of suitable encoding systems,which accommodate the characteristics of polypeptide synthesis,storage and sequencing,impedes the application of polypeptides for large-scale digital data storage.To address this,two reliable and highly efficient encoding systems,i.e.RaptorQ-Arithmetic-Base64-Shuffle-RS(RABSR)and RaptorQArithmetic-Huffman-Rotary-Shuffle-RS(RAHRSR)systems,are developed for polypeptide data storage.The two encoding systems realized the advantages of compressing data,correcting errors of AA chain loss,correcting errors within AA chains,eliminating homopolymers,and pseudo-randomized encrypting.The coding efficiency without arithmetic compression and error correction of audios,pictures and texts by the RABSR system was 3.20,3.12 and 3.53 Bits/AA,respectively.While that using the RAHRSR system reached 4.89,4.80 and 6.84 Bits/AA,respectively.When implemented with redundancy for error correction and arithmetic compression to reduce redundancy,the coding efficiency of audios,pictures and texts by the RABSR system was 4.43,4.36 and 5.22 Bits/AA,respectively.This efficiency further increased to 7.24,7.11 and 9.82 Bits/AA by the RAHRSR system,respectively.Therefore,the developed hexadecimal polypeptide-based systems may provide a new scenario for highly reliable and highly efficient data storage.

关键词： Biomaterial Polypeptide Data storage Hexadecimal Encoding system