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Unveiling blood pressure-associated genes in aortic cells through integrative analysis of GWAS and RNA modification-associated variants

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Chronic Diseases and Translational medicine 2024年第2期10卷 118-129页

作者： Huan Zhang Yuxi Chen Peng Xu Dan Liu Naqiong wu Laiyuan Wang Xingbo mo Jiangsu Key Laboratory of Preventive and Translational medicine for Geriatric Diseases Department of EpidemiologySchool of Public HealthMedical College of Soochow UniversitySuzhouJiangsuChina Cardiometabolic Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Cardiovascular Epidemiology&Department of Epidemiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina mOE Key Laboratory of Geriatric Diseases and Immunology School of Public HealthCenter for Genetic Epidemiology and GenomicsMedical College of Soochow UniversitySuzhouJiangsuChina

Background Genome-wide association studies(GWAS)have identified more than a thousand loci for blood pressure(BP).Functional genes in these loci are cell-type *** aim of this study was to elucidate potentially functional genes associated with BP in the aorta through the utilization of RNA modification-associated single-nucleotide polymorphisms(RNAm-SNPs).methods Utilizing large-scale genetic data of 757,601 individuals from the UK Biobank and International Consortium of Blood Pressure consortium,we identified associations between RNAm-SNPs and *** association between RNAm-SNPs,gene expression,and BP were *** A total of 355 RNAm-SNPs related to m6A,m1A,m5C,m7G,and A-to-I modification were associated with *** related genes were enriched in the pancreatic secretion pathway and renin secretion *** BP GWAS signals were significantly enriched with m6A-SNPs,highlighting the potential functional relevance of m6A in physiological processes influencing ***,m6A-SNPs in CYP11B1,PDE3B,HDAC7,ACE,SLC4A7,PDE1A,FRK,mTHFR,NPPA,CACNA1D,and HDAC9 were *** methylation and differential expression of the BP genes in FTO-overexpression and mETTL14-knockdown vascular smooth muscle cells were ***-SNPs were associated with ascending and descending aorta diameter and the genes showed differential methylation between aortic dissection(AD)cases and *** scRNA-seq study,we identified ARID5A,HLA-DPB1,HLA-DRA,IRF1,LINC01091,mCL1,mLF1,mLXIPL,NAA16,NADK,RERG,SRm,and USP53 as differential expression genes for AD in aortic *** The present study identified RNAm-SNPs in BP loci and elucidated the associations between the RNAm-SNPs,gene expression,and *** identified BP-associated genes in aortic cells were associated with AD.

关键词： aortic dissection blood pressure genome-wide association study RNA modification single-cell

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： m.Ablikim m.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger m.Berlowski m.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen m.L.Chen S.J.Chen S.L.Chen S.m.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.q.Chen Z.J.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.q.Deng Z.Y.Deng A.Denig I.Denysenko m.Destefanis F.De mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.q.Feng J.H.Feng Y.T.Feng K.Fischer m.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.m.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong m.Y.Dong X.Dong m.C.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna m.Greco m.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.q.Guo L.B.Guo m.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.m.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche m.Irshad J.Jackson S.Janchiv J.H.Jeong q.Ji q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin m.q.Jing X.m.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang m.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf m.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff m.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.m.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li m.H.Li P.R.Li q.m.Li q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COmSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner mongolia University Hohhot 010021China Institute of modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKm angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong Gao Cong Li Ruo-Yu Liu Ruizhi Yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

Influences of yellow and green lights on the visual response of western flower thrips and field verification

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International Journal of Agricultural and Biological Engineering 2022年第4期15卷 49-56页

作者： qihang Liu mingqian Zhao Jin miao Guangchun Fu Yuqing wu Henan Institute of Science and Technology Xinxiang 453003HenanChina Institute of Plant Protection Henan Academy of Agricultural Sciences Zhengzhou 450002China

This study aimed to determine the effects of spectral light characteristics on the visual response of the western flower thrips,the strengthening mechanism of thrips response behavior regulated by light,and thrips response characteristics to contrast *** with combined and single wavelength were tested by using a self-made behavior response device for *** sources for trapping thrips were made to verify the trapping effect on thrips in a greenhouse,and the reasons for changes in thrips behavior were analyzed to characterize the mechanism of their phototactic *** results showed that the light mode(single,contrast,combined light)affected the thrips visual response and approach response,whereas in contrast light,the effects were *** light inhibited the thrips visual response,and when the illumination increased,the thrips visual response to single and combination light intensified,and the thrips approach sensitivity to green light increased in contrast and combination ***,the light mode did not affect the thrips visual response and sensitivity to spectral light *** degree of thrips visual response to yellow light was stronger than that to green light,while the degree of thrips visual response to green light was stronger than that to yellow light,indicating that the photo-induced mechanism of the thrips visual response differed from that of the thrips approach ***,in the greenhouse,the trapping effect of different light sources on thrips was positively correlated with *** trapping effect of green light was optimal,followed by a yellow light source,while the difference of light intensity(illumination,illumination energy)and its photo-thermal intensity between yellow and green light was the reason for the differences in the degree of visual trends and the trapping effects of ***,the sensitivity of thrips responding to different light depended on the difference in the hete

关键词： pest control western flower thrips yellow and green light visual response field verification light mode

基于YOLOX的类增量印刷电路板缺陷检测方法

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智能系统学报 2024年第4期19卷 1061-1070页

作者：吴瑞林葛泉波刘华平南京信息工程大学自动化学院清华大学计算机科学与技术系

为了应对更加实际的增量式印刷电路板缺陷检测场景，本文将知识蒸馏与YOLOX相结合，提出了一种基于YOLOX的类增量印刷电路板缺陷检测方法。在只使用新训练数据的情况下，模型能够检测出所有学过的缺陷类型。通过对模型的输出特征和中间... 详细信息

为了应对更加实际的增量式印刷电路板缺陷检测场景，本文将知识蒸馏与YOLOX相结合，提出了一种基于YOLOX的类增量印刷电路板缺陷检测方法。在只使用新训练数据的情况下，模型能够检测出所有学过的缺陷类型。通过对模型的输出特征和中间特征使用知识蒸馏来促进旧缺陷类别知识的传递，使得学生模型能够有效保留教师模型在旧缺陷类别上的检测性能。实验结果表明，本文方法能够显著缓解增量学习过程中的灾难性遗忘问题，在两阶段增量场景下，模型对所有缺陷的平均检测精度为88.5%，参数量为25.3×106，检测速度为39.8 f/s，便于工业设备部署的同时，可以满足增量式检测场景下印刷电路板(printed circuit board,PCB)质检的检测精度和检测速度要求。

关键词：深度学习印刷电路板类增量增量学习缺陷检测目标检测动态检测知识蒸馏灾难性遗忘

Sequential neoadjuvant chemotherapy using pegylated liposomal doxorubicin and cyclophosphamide followed by taxanes with complete trastuzumab and pertuzumab treatment for HER2-positive breast cancer: A phase Ⅱ single-arm study

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Chinese Journal of Cancer Research 2024年第1期36卷 55-65页

作者： Yaping Yang Liang Jin Yudong Li Nanyan Rao Chang Gong Shunrong Li Jiannan wu Jinghua Zhao Linxiaoxiao Ding Fengxia Gan Jun Zhang Ruifa Feng Zhenzhen Liu qiang Liu Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene RegulationGuangzhou 510120China Department of Thyroid and Breast Surgery Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518000China Breast and Thyroid Surgery Guilin Medical College Second Affiliated HospitalGuilin 541199China Department of Breast Disease Henan Breast Cancer Centerthe Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450008China

Objective: Despite cardiotoxicity overlap, the trastuzumab/pertuzumab and anthracycline combination remains crucial due to significant benefits. Pegylated liposomal doxorubicin(PLD), a less cardiotoxic anthracycline, was evaluated for efficacy and cardiac safety when combined with cyclophosphamide and followed by taxanes with trastuzumab/pertuzumab in human epidermal growth factor receptor-2(HER2)-positive early breast cancer(BC).methods: In this multicenter, phase II study, patients with confirmed HER2-positive early BC received four cycles of PLD(30-35 mg/m^(2)) and cyclophosphamide(600 mg/m^(2)), followed by four cycles of taxanes(docetaxel,90-100 mg/m^(2) or nab-paclitaxel, 260 mg/m^(2)), concomitant with eight cycles of trastuzumab(8 mg/kg loading dose,then 6 mg/kg) and pertuzumab(840 mg loading dose, then 420 mg) every 3 weeks. The primary endpoint was total pathological complete response(tp CR, yp T0/is yp N0). Secondary endpoints included breast p CR(bp CR),objective response rate(ORR), disease control rate, rate of breast-conserving surgery(BCS), and safety(with a focus on cardiotoxicity).Results: Between may 27, 2020 and may 11, 2022, 78 patients were treated with surgery, 42(53.8%) of whom had BCS. After neoadjuvant therapy, 47 [60.3%, 95% confidence interval(95% CI), 48.5%-71.2%] patients achieved tp CR, and 49(62.8%) achieved bp CR. ORRs were 76.9%(95% CI, 66.0%-85.7%) and 93.6%(95% CI,85.7%-97.9%) after 4-cycle and 8-cycle neoadjuvant therapy, respectively. Nine(11.5%) patients experienced asymptomatic left ventricular ejection fraction(LVEF) reductions of ≥10% from baseline, all with a minimum value of >55%. No treatment-related abnormal cardiac function changes were observed in mean N-terminal pro-BNP(NT-pro BNP), troponin I, or high-sensitivity ***: This dual HER2-blockade with sequential polychemotherapy showed promising activity with rapid tumor regression in HER2-positive BC. Importantly, this regimen showed an acceptable safety

关键词： Breast cancer HER2-positive breast cancer dual HER2 blockade neoadjuvant therapy sequential therapy

Contactin-associated protein-like 2(CNTNAP2)mutations impair the essentialα-secretase cleavages,leading to autism-like phenotypes

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1625-1636页

作者： qing Zhang mengen Xing Zhengkai Bao Lu Xu Yang Bai Wanqi Chen Wenhao Pan Fang Cai qunxian Wang Shipeng Guo Jing Zhang Zhe Wang Yili wu Yun Zhang Jia-Da Li Weihong Song Oujiang Laboratory(Zhejiang Lab for Regenerative medicine Vision and Brain Health)Zhejiang Key Laboratory of Alzheimer's DiseaseZhejiang Provincial Clinical Research Center for Mental DisordersSchool of Mental Health and Wenzhou Kangning HospitalThe Second Affiliated Hospital and Yuying Children's HospitalInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang 325035China Townsend Family Laboratories Department of PsychiatryBrain Research CenterThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Chongqing Key Laboratory of Translational medical Research in Cognitive Development and Learning and memory Disorders Ministry of Education Key Laboratory of Child Development and DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Center for medical Genetics Hunan Key Laboratory of Animal Models for Human DiseasesHunan Key Laboratory of Medical GeneticsHunan International Scientific and Technological Cooperation Base of Animal Models for Human DiseasesSchool of Life SciencesCentral South UniversityChangsha 410078 HunanChina The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijing 100053Chin

mutations in the Contactin-associated protein-like 2(CNTNAP2)gene are associated with autism spectrum disorder(ASD),and ectodomain shedding of the CNTNAP2 protein plays a role in its ***,key enzymes involved in the C-terminal cleavage of CNTNAP2 remain largely unknown,and the effect of ASD-associated mutations on this process and its role in ASD pathogenesis remain *** this report we showed that CNTNAP2 undergoes sequential cleavages by furin,ADAm10/17-dependent a-secretase and presenilindependent *** identified that the cleavage sites of ADAm10 and ADAm17 in CNTNAP2 locate at its C-terminal residue I79 and L96,and the main a-cleavage product C79 by ADAm10 is required for the subsequent y-secretase cleavage to generate CNTNAP2 intracellular domain(CICD).ASD-associated CNTNAP2 mutations impair the a-cleavage to generate C79,and the inhibition leads to ASDIlike repetitive and social behavior abnormalties in the Cntnap2l1254T knock-in ***,exogenous expression of 79 improves autism-ike phenotypes in the Cntnap2^(11254T) knock-in and Cntnap2^(-/-)knockout *** data demonstrates that the a-secretase is essential for CNTNAP2 processing and its *** study indicates that inhibition of the cleavage by pathogenic mutations underlies ASD pathogenesis,and upregulation of its C-terminal fragments could have therapeutical potentials for ASD treatment.

关键词： NAP2 cleavage subsequent

生物电阻抗的液体负荷和营养状态指标与维持性血液透析患者预后的关系

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中华医学杂志 2024年第24期104卷 2234-2241页

作者：李婷邬步云陈凤羽刘康毛慧娟江苏省人民医院(南京医科大学第一附属医院)肾内科南京

目的探讨生物电阻抗(BIA)的液体负荷和营养状态指标与维持性血液透析(mHD)患者预后的关系。方法回顾性队列研究。分析2014年1月至2016年12月江苏省人民医院mHD患者的临床资料。2022年4至10月期间收集南京市鼓楼区健康志愿者的BIA数据, ... 详细信息

目的探讨生物电阻抗(BIA)的液体负荷和营养状态指标与维持性血液透析(mHD)患者预后的关系。方法回顾性队列研究。分析2014年1月至2016年12月江苏省人民医院mHD患者的临床资料。2022年4至10月期间收集南京市鼓楼区健康志愿者的BIA数据, 确定细胞质量指数(BCmI)的分界值;参考既往研究, 采用0.15作为多余水分和细胞外液比值(OH/ECW)的分界值。根据分界值将数据转换为二分类变量对mHD患者进行分组, 采用Kaplan-meier法绘制生存曲线, Cox比例风险回归模型分析全因死亡的危险因素。结果共纳入mHD患者706例, 男407例, 女299例, 年龄(54±15)岁。根据BCmI是否m2和OH/ECW是否≥0.15将mHD患者分为无液体超负荷和营养不良、液体超负荷、营养不良、液体超负荷和营养不良共四组, 各组分别有269、186、151、100例患者。随访时间[m(q1, q3)]33(26, 37)个月, 随访期间162例患者死亡。Kaplan-meier生存分析结果显示, 上述四组患者的中位生存期分别为52个月(95%CI:41～54个月)、46个月(95%CI:44～49个月)、37个月(95%CI:34～40个月)和34个月(95%CI:30～38个月), 组间差异有统计学意义(PmHD患者预后相关, 与无液体超负荷和营养不良患者相比, 营养不良和液体超负荷患者全因死亡风险增加。

关键词：肾功能衰竭, 慢性血液透析电阻抗液体负荷营养状态预后

Gradient microstructure,recrystallization and mechanical properties of copper processed by high pressure surface rolling

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Journal of materials Science & Technology 2022年第31期126卷 182-190页

作者： J.Guo q.Y.He q.S.mei X.Huang G.L.wu O.V.mishin College of materials Science and Engineering Chongqing UniversityChongqing400045China Southwest Technology and Engineering Research Institute Chongqing 400039China School of Power and mechanical Engineering Wuhan UniversityWuhan 430072China Beijing Advanced Innovation Center for materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Department of mechanical Engineering Technical University of Denmark2800 Kgs.LyngbyDenmark

The microstructure,hardness and tensile properties have been studied in copper processed by high pressure surface rolling(HPSR)both in the as-deformed condition and after subsequent annealing at 150℃.It is found that a gradient structure with significant differences in the scale of microstructural features is formed by *** deformed microstructure varies from nano-and ultrafine-scale structures with a large fraction of high angle boundaries near the surface to lightly deformed grains at depths of 1-3 mm below the *** tests of 1-mm-thick specimens demonstrate that the asdeformed material has a high strength and a low uniform *** at 150℃results in partial recrystallization,which creates new through-thickness *** for the topmost layer and several bands in the adjacent layer,recrystallization is more pronounced close to the *** fraction recrystallized is at least 80%at depths of 60-300μm after annealing for 960 *** fraction recrystallized in the subsurface decreases with increasing depth,and the deformed layer at depths greater than 500μm re-mains largely non-recrystallized after *** partially recrystallized condition demonstrates an improved combination of strength and ductility.

关键词： High pressure surface rolling Copper Gradient microstructure Annealing Hardness Strength Ductility