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Synthesis of free-standing Ga_2O_3 films for flexible devices by water etching of Sr_3Al_2O_6 sacrificial layers

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Chinese Physics B 2019年第1期28卷 166-170页

作者： Xia Wang Zhen-Ping wu Wei Cui Yu-Song Zhi Zhi-Peng Li pei-Gang Li Dao-You Guo Wei-Hua Tang Laboratory of Information Functional Materials and Devices School of ScienceBeijing University of Posts and TelecommunicationsBeijing 100876China State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100876China Center for Optoelectronics Materials and Devices Department of PhysicsZhejiang Sci-Tech UniversityHangzhou 310018China

Flexible electronic devices have attracted much attention due to their practical and commercial value. Integration of thin films with soft substrate is an effective way to fabricate flexible electronic devices. Ga_2O_3 thin films deposited directly on soft substrates would be amorphous mostly. However, the thickness of the thin film obtained by mechanical exfoliation method is difficult to control and the edge of the film is fragile and easy to be damaged. In this work, we fabricated free-standing Ga_2O_3 thin films using the water-soluble perovskite Sr_3Al_2O_6 as a sacrificial buffer layer. The obtained Ga_2O_3 thin films were polycrystalline. The thickness and dimension of the films were controllable. A flexible Ga_2O_3solar-blind UV photodetector was fabricated by transferring the free-standing Ga_2O_3 film on a flexible polyethylene terephthalate substrate. The results displayed that the photoelectric performances of the flexible Ga_2O_3 photodetector were not sensitive to bending of the device. The free-standing Ga_2O_3 thin films synthesized through the method described here can be transferred to any substrates or integrated with other thin films to fabricate electronic devices.

关键词： free-standing Ga2O3 thin film crystalline Sr3Al2O6 flexible photodetector

Comparative analysis of long noncoding RNAs in angiosperms and characterization of long noncoding RNAs in response to heat stress in Chinese cabbage

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Horticulture Research 2021年第1期8卷 693-713页

作者： Xiaoming Song Jingjing Hu Tong wu Qihang Yang Xuehuan Feng Hao Lin Shuyan Feng Chunlin Cui Ying Yu Rong Zhou Ke Gong Tong Yu Qiaoying pei Nan Li College of Life Sciences/Center for Genomics and Bio-computing North China University of Science and TechnologyTangshanHebeiChina Food Science and Technology Department University of Nebraska-LincolnLincolnNEUSA School of Life Science and Technology and Center for Informational Biology University of Electronic Science and Technology of ChinaChengduChina Department of Food Science Aarhus UniversityAarhusDenmark

Long noncoding RNAs(lncRNAs)are widely present in different species and play critical roles in response to abiotic ***,the functions of lncRNAs in Chinese cabbage under heat stress remain ***,we first conducted a global comparative analysis of 247,242 lncRNAs among 37 *** results indicated that lncRNAs were poorly conserved among different species,and only 960 lncRNAs were homologous to 524 miRNA *** then carried out lncRNA sequencing for a genome-wide analysis of lncRNAs and their target genes in Chinese cabbage at different stages of heat *** total,18,253 lncRNAs were identified,of which 1229 differentially expressed(DE)lncRNAs were characterized as being *** ceRNA network revealed that 38 lncRNAs,16 miRNAs,and 167 mRNAs were involved in the heat response in Chinese *** analysis of the cis-and trans-regulated genes indicated that the targets of DE lncRNAs were significantly enriched in the“protein processing in endoplasmic reticulum”and“plant hormone signal transduction”***,the majority of HSP and PYL genes involved in these two pathways exhibited similar expression patterns and responded to heat stress *** on the networks of DE lncRNA-mRNAs,29 and 22 lncRNAs were found to interact with HSP and PYL genes,***,the expression of several critical lncRNAs and their targets was verified by ***,we conducted a comparative analysis of lncRNAs among 37 species and performed a comprehensive analysis of lncRNAs in Chinese *** findings expand the knowledge of lncRNAs involved in the heat stress response in Chinese cabbage,and the identified lncRNAs provide an abundance of resources for future comparative and functional studies.

关键词： stress analysis characterization

新型冠状病毒肺炎疫情对疾病预防控制体系的影响及思考

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上海预防医学 2020年第4期32卷 303-308页

作者：李程跃施培武沈群红张朝阳陈政蒲川徐凌忠胡志马安宁龚朝晖徐天强王磐石汪华郝超高翔李力周庆誉郝模复旦大学卫生发展战略研究中心上海200032 浙江省医学科学院浙江杭州310012 清华大学公共管理学院北京100084 国家卫生健康委员会项目评价中心北京100044 中华预防医学会公共卫生管理分会基层公共卫生管理学组上海201800 重庆医科大学公共卫生与管理学院重庆400016 山东大学公共卫生学院山东济南250012 安徽医科大学安徽合肥230032 济宁医学院山东济宁272067 致公党中央医药卫生专业委员会北京100011 上海卫生健康委员会监督所上海200031 上海市卫生健康委员会上海200031 江苏省预防医学会江苏南京210009 常州市疾病预防控制中心江苏常州213003 健康相关社会风险预警协同创新中心上海200032

新冠肺炎疫情的发生暴露了我国疾病预防控制体系建设中还存在的一些问题。习近平总书记明确指出要“补短板、堵漏洞、强弱项”“改革完善疾病预防控制体系”。本文分析了我国疾病预防控制体系在政策、法规、管理、队伍和运行机制层面的... 详细信息

新冠肺炎疫情的发生暴露了我国疾病预防控制体系建设中还存在的一些问题。习近平总书记明确指出要“补短板、堵漏洞、强弱项”“改革完善疾病预防控制体系”。本文分析了我国疾病预防控制体系在政策、法规、管理、队伍和运行机制层面的主要问题和原因,从“法制、体制、机制”三个层面探讨了将“预防为主”纳入法制范畴,将健康中国纳入各部门行动计划,及时修订完善法律法规,调整建设适应新时代发展需要的疾病预防控制管理机构,打造高素质的专业队伍,加强区域健康信息互通,常态化联防联控的协调机制,完善适宜的投入机制,健全设备更新与储备制度等建议。

关键词：新冠肺炎疫情疾病预防控制体系问题策略

The Research Progress of Long Noncoding RNAs in Nasopharyngeal Carcinoma

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Journal of Cancer Therapy 2017年第8期8卷 751-763页

作者： pei Li Boyu wu Tao Jiang Wei Jiang Weiguo Huang Cancer Research Institute University of South China Hengyang China Post-Doctoral Mobile Stations of Preclinical Medicine University of South China Hengyang China Medical College of University of South China Hengyang China

Long noncoding RNA (lncRNA) is a leader of the degree of more than 200 nucleotides, almost do not have the function of protein coding endogenous RNA molecules. Recent studies show that, lncRNA is not encoded protein, but it has a wide range of biological functions, and lncRNA in human diseases, especially in oncology, more and more attention has been paid to its role. Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck in South China, which poses a serious threat to people’s health and life. Studies found that lncRNA is widely involved in the invasion, metastasis and prognosis of nasopharyngeal carcinoma (NPC). In this article, we will review the research progress of lncRNA in nasopharyngeal carcinoma.

关键词： Long Non-Coding RNA(lncRNA) Nasopharyngeal Carcinoma(NPC) Abnormal Expression Research Progress Regulation Mechanism

A New Route for the Rapid Synthesis of Metal–Organic Frameworks at Room Temperature

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CCS Chemistry 2023年第6期5卷 1462-1469页

作者： pei Zhang Xinchen Kang Liming Tao Lirong Zheng Junfeng Xiang Ran Duan Jikun Li Peng Chen Xueqing Xing Guang Mo Zhonghua wu Buxing Han Beijing National Laboratory for Molecular Sciences Key Laboratory of ColloidInterface and ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 School of Chemistry University of Chinese Academy of SciencesBeijing 100049 Key Laboratory of Science and Technology on Wear and Protection of Materials Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouGansu 730000 Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049 Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062

Rapid synthesis of metal–organic frameworks(MOFs),especially high-valence MOFs at roomtemperature without external energy,is a challenging *** this work,a stable radical solution has been *** MOFs with versatile metal nodes and ligands were rapidly synthesized at room temperature in the absence of external ***,MOFs with conjugated ligands achieved instantaneous architecture(in less than 1 s)and quantitative *** in the solution play a crucial role in the accelerated kinetics,and the new radical route paves a cyclic pathway for the MOF *** mechanism has been thoroughly investigated by electron paramagnetic resonance,in situ proton nuclear magnetic resonance,X-ray absorption spectra,in situ small-angle X-ray scattering-wide-angle X-ray scattering,and density functional theory calculations.

关键词： new route metal–organic frameworks solution chemistry room temperature synthesis rapid kinetics

Macrostate and Microstate of EEG Spatio-Temporal Nonlinear Dynamics in Zen Meditation

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Journal of Behavioral and Brain Science 2017年第13期7卷 705-721页

作者： pei-Chen Lo wu Jue Miao Tian Fang-Ling Liu Institute of Electrical and Control Engineering National Chiao Tung University Taiwan Shakyamuni Buddhist Foundation Taiwan

Macrostate and microstate characteristics of interregional nonlinear interdependence of brain dynamics are investigated for Zen-meditation and normal resting EEG. Evaluation of nonlinear interdependence based on nonlinear dynamic theory and phase space reconstruction is employed in the 30-channel electroencephalographic (EEG) signals to characterize the functioning interactions among different local neuronal networks. This paper presents a new scheme for exploring the microstate and macrostate of interregional brain neural network interactivity. Nonlinear interdependence quantified by similarity index is applied to the phase trajectory reconstructed from multi-channel EEG. The microstate similarity-index matrix (miSIM) is evaluated every 5 millisecond. The miSIMs are classified by K-means clustering. The cluster center corresponds to the macrostate SIM (maSIM) evaluated by conventional scheme. Zen-meditation EEG exhibits rather stationary and stronger interconnectivity among frontal midline regional neural oscillators, whereas resting EEG appears to drift away more often from the midline and extend to the inferior brain regions.

关键词： Electroencephalograph (EEG) Nonlinear Interconnectivity Microstate Macrostate Zen Meditation

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博落回中毒大鼠心肌组织代谢产物变化的研究

中国法医学杂志 2024年第1期39卷 39-43页

作者：方世勇石晓玲张静卢玉坤方培陈光吴茂旺徐祥皖南医学院法医学院安徽芜湖241000 安徽卫生健康职业学院安徽池州247000

目的基于气相色谱-质谱联用技术(GC-MS)的代谢组学方法研究博落回急性染毒模型大鼠心肌代谢产物的变化,寻找体内特征性代谢产物并探索相关毒性机制。方法博落回总碱提取物溶液灌胃给药,剂量382 mg/kg,对照组给予相同剂量的空白溶液,利用... 详细信息

目的基于气相色谱-质谱联用技术(GC-MS)的代谢组学方法研究博落回急性染毒模型大鼠心肌代谢产物的变化,寻找体内特征性代谢产物并探索相关毒性机制。方法博落回总碱提取物溶液灌胃给药,剂量382 mg/kg,对照组给予相同剂量的空白溶液,利用GC-MS方法对心肌样本进行分析,利用偏最小二乘法-判别分析对结果进行模式识别,通过VIP(The variable importance in the projection)值>1以及Student’s t检验(P<0.01)筛选出具有特征改变的差异代谢产物。结果与对照组相比较,发现21种潜在的特征性代谢产物,经KEGG通路富集分析发现,这些代谢产物主要参与甘氨酸、丝氨酸和苏氨酸代谢途径、甘油酯代谢途径以及丙酮酸代谢途径。结论经过对博落回染毒大鼠心肌代谢研究,发现了与中毒密切相关的代谢产物信息,为其中毒机制研究及法医学鉴定提供参考。

关键词：法医毒理学毒性代谢组学博落回气相色谱-质谱联用法

A multi-index coupling system of ice slope stability and its application

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Research in Cold and Arid Regions 2012年第3期4卷 185-194页

作者： WanSheng pei YuanMing Lai MingYi Zhang HongYu Xu wu Chen State Key Laboratory of Frozen Soil Engineering Cold andArid Regions Environmental Engineering Research InstituteChinese Academy of SciencesLanzhouGansu 730000China

Based on the Simplified Bishop Method, the minimum safety factor of ice slope both with and without tension cracks is calculated in combination with triaxial compression tests. It is found that there exists a critical depth for each crack. Then, factors influencing ice slope stability such as slope ratio, slope height, ice cohesion, internal friction angle, unit weight and temperature were analyzed. Meanwhile, a regression equation between the aforementioned factors and safety factor is obtained, with which sensitivity analysis is carried out. The performance function is built in combination with random distribution of physical and mechanical parameters to analyze the reliability index. The Advanced First Order Second Moment Method is employed on the solution to the perfor- mance function. The one-way coupling system of ice slope stability is therefore formed based on safety factor and reliability index. Finally, an illustrated example of ice slope is provided, which shows that failure probability is relatively high, up to 6.18%, alt- hough safety factor is 2.77. Thus, it is objective and reasonable to apply the coupled system method to the slope stability rating.

关键词： ice slope stability safety factor sensitivity analysis reliability index Advanced First Order Second Moment Method

Plasma levels of receptor interacting protein kinase-3 correlated with coronary artery disease

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Chinese Medical Journal 2019年第12期132卷 1400-1405页

作者： Xiao-Min Hu Xi Chen Hai-Yu Pang Hong-Hong Liu pei-pei Chen Jing-Lin Shi Si Tang Zhi-Hong wu Shu-Yang Zhang Medical Science Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Background: Necroptosis plays an important role in human atherosclerosis and atheroma development. Since receptor interacting protein kinase-3 (RIP3) acts as a key mediator of necroptosis, this study aimed to explore its relationship between plasma RIP3 levels and coronary artery disease (CAD) and discover a potential new biomarker for screening CAD subtypes and severity. Methods: A total of 318 patients with CAD who had coronary angiography and 166 controls in Peking Union Medical College Hospital from September 2017 to January 2018 were enrolled in this study. Patients with CAD were divided into three subgroups: patients with stable coronary artery disease (SCAD), patients with unstable angina (UA), and patients with myocardial infarction (MI). The severity of atherosclerosis was determined by Gensini score (GSS). Logistic regression was used to determine the relationship between plasma RIP3 levels and CAD. The correlation between plasma RIP3 and GSS was calculated using multiple linear regression models. Results: Overall, plasma RIP3 levels were significantly higher than serum RIP3 levels. Plasma RIP3 levels in patients with CAD were significantly higher than those in controls. Plasma RIP3 levels were strongly associated with CAD (odds ratio: 6.00, 95% confidence interval 3.04–11.81;P < 0.001). Plasma RIP3 levels increased linearly from controls to patients with SCAD, then patients with UA, and finally to patients with MI. We found a significantly positive correlation between proportion of cases of acute coronary syndrome in subjects and their plasma RIP3 level quartile. Plasma RIP3 levels were also associated with GSS (B 0.027;standard error 0.012;P < 0.05). Conclusions: Plasma RIP3 levels were independently associated with CAD. Plasma RIP3 levels could potentially supplement clinical assessment to screen CAD and determine CAD severity.

关键词： Receptor interacting protein kinase-3 Coronary artery disease Necroptosis Atherosclerosis Acute coronary syndrome Biomarker