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Acta Oceanologica Sinica 1989年第1期8卷 125-136页

作者： wu lun, liang haihua, ren fuhu and li maosong the department of geography, peking university, beijing, china the department of geology, peking university, beijing, china Dept of geography Peking Univ. Beijing China China

The origin of arcuate islands and deep-sea trenches has been studied for a long time and various interpretations have been proposed. In this paper, some analytical models are put forward from a geometrical viewpoint and then the theoretical dip angles of the underthrusting slabs of circum-Pacific island arcs are computed and compared with those of the Benioff zone. As a result, it is found that the dip angle of the underthrusting slab is one of the main factors determining the curvature of the arcuate structure. The authors consider that this result may contribute to the plate theory.

关键词： A preliminary analysis of arcuate structures-relationship of the island arc and deep-sea trench to the dip angle of Benioff zone deep

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Ergodicity of 3D Stochastic Burgers Equation

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Acta Mathematica Sinica,English Series 2024年第2期40卷 498-510页

作者： Zhao DONG Jiang lun wu Guo li ZHOU RCSDS Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190P.R.China department of Mathematics Computational FoundrySwansea UniversitySwansea SA18ENUK College of Mathematics and Statistics Chongqing UniversityChongqing 400044P.R.China

3D Burgers equation is an important model for *** is natural to expect the long-time behaviour for this hydrodynamics ***,there is no result about the long-time behaviour for this deterministic ***,if the system is perturbed by stochastic noise,we establish the existence and uniqueness of invariant measure for 3D stochastic Burgers equation.

关键词： 3D stochastic Burgers equations maximum principle ergodicity

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Population pharmacokinetics of valproate in Chinese children with epilepsy

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Acta Pharmacologica Sinica 2007年第10期28卷 1677-1684页

作者： De-chun JIANG~(2,3),li WANG~4,Yu-qin WANG~(2,6),lin li~3,Wei LU~5,Xiang-rong BAI~2~2 department of Pharmacy,Xuan-wu Hospital of Capital Medical university,beijing 100053,china ~4 department of Pediatrics,peking universityFirst Hospital,beijing 100034,china ~3 department of Pharmacology,Xuan-wu Hospital of Capital Medical university,Education Ministry KeyLaboratory for Neurodegenerative Diseases,beijing 100053,china ~5 School of Pharmaceutical Science,peking university,beijing 100083,china department of Pharmacy Xuan-wu Hospital of Capital Medical University Beijing China department of Pharmacology Xuan-wu Hospital of Capital Medical University Education Ministry Key Laboratory for Neurodegenerative Diseases Beijing China department of Pediatrics Peking University First Hospital Beijing China School of Pharmaceutical Science Peking University Beijing China

Aim:The aim of the present study is to establish a population pharmacokinetic（PPK） model of valproate （VPA） in Chinese epileptic children to promote thereasonable use of anti-epileptic ***:Sparse data of VPA serumconcentrations from 417 epileptic children were *** patients weredivided into 2 groups:the PPK model group （n=317） and the PPK valid group（n=100）.The PPK parameter values of VPA were calculated by NONMEM soft-ware using the data of the PPK model group.A basic model and a final modelwere set *** validate the 2 models,the concentrations of PPK valid groupwere predicted by each model,*** mean prediction error （MPE）,mean squared prediction error （MSPE）,root mean squared prediction error（RMSPE）,weight residues （WRES）,and the 95% confidence intervals （95%CI） were also ***,the values between the 2 models were ***:The PPK of VPA was determined by a 1-compartment model with afirst-order absorption *** basic model was:Ka=3.09 (h-1),V/F=20.4（L）,CL/F=0.296 （L/h）.The final model was:Ka=0.251+2.24·（1-HS）(h-1),V/F=2.88+0.157·WT （L）,CL/F=0.1060.98·CO+0.0157·AGE （L/h）.For thebasic model,the MPE,MSPE,RMSPE,WRES,and the 95% CI were-23.53（-30.36,-16.70）,3728.96 （2872.72,4585.20）,39.62 （34.34,44.90）,and-0.06 （-0.14,0.02）,*** the final model,the MPE,MSPE,RMSPE,WRES,and the95% CI were-1.16 （-4.85,2.53）,1002.83 （1050.64,1143.61）,23.04 （21.12,24.96）,and0.08 （-0.04,0.20）,*** final model was more optimal than the ***:The PPK model of VPA in Chinese epileptic children wassuccessfully *** will be valuable to facilitate individualized dosageregimens.

关键词： population pharmacokinetics valproic acid epilepsy children Bayesian method NONMEM software individualized dosage regimens

ANALYSIS OF DEPOSITED PRODUCTS AND REANODIZED POROUS LUBRICATING FILM ON A1 AFTER(NH_4)_2MoS_4 SOLUTION TREATMENT

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Acta Metallurgica Sinica(English Letters) 1993年第8期6卷 102-107页

作者： JIANG Guang wu Yinshun li Jiuqing liU Haiping university of Science and Technology beijing,beijing,china department of Surface Sciences and Corrosion Engineering,university of Science and Technology beijing,beijing 100083,china beijing Univ of Science and Technology Beijing China

Observation was carried out of the structure of sulphuric,oxalic or phosphoric film on Al after treatment of reanodizing and electrolytic depositing lubricant in (NH_4)_2MoS_4 solution,as well as of the deposited products by means of EMPA,TEM and energy spectro-scopic *** deposited products are mixture of compounds of S and Mo rather than single MoS_2 and most of them dcposited near the surface layer of the *** regular long pores without barrier layer occurred in the film,but the regular fine channels without relation to the structural element parameters of original anodized film were found in the thickened barrier layer of phosphoric *** may be remained as Mo sulphide in the film during heating under Ar protective environment.

关键词： Al anodizing reanodizing lubricating film MoS_2

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Design,modeling and experimental investigation of a novel solar sail with high area-to-mass ratios for efficient solar sailing

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Chinese Journal of Aeronautics 2024年第10期37卷 234-248页

作者： Zhongjing ren Chengyang li Ke wu Ziran WANG Haipeng WANG Peng YAN Key Laboratory of High-efficiency and Clean Mechanical Manufacture(Ministry of Education) School of Mechanical EngineeringShandong UniversityJinan 250061China china Manned Space Agency Beijing 100071China

Solar sailing is a promising propellant-free approach to propelling spacecraft in ***,the propelling efficiency of conventional solar sail spacecraft is limited by their areato-mass *** paper proposes a novel design of micro solar sails with area-to-mass ratios above 100 m2/kg for next-generation chip-scale *** thin films developed by Microelectromechanical Systems(MEMS)technologies were patterned into grid microstructures,and theoretical analysis of a sail prototype was *** electro-thermal and thermo-mechanical models of the solar sail in geospace were established by taking effects of Joule heating,solar radiation,and thermal re-emission into consideration,enabling rapid prediction of its threedimensional(3-D)reconfiguration from the as-released two-dimensional(2-D)*** of the ChipSail’s acceleration arising from the sail’s morphing was also analytically *** and characterization of the sail prototype made of multiple Al/Ni50Ti50 bilayer beams were ***-situ SEM imaging of the sail prototype in vacuum chamber witnessed an active and continuous 3-D reconfiguration under Joule heating,and over 90deformation was detected by applying a DC voltage of 0.078 *** and experimental work on the solar sail with at least 10 times higher area-to-mass ratios than conventional ones will lay a solid foundation for efficient solar sailing.

关键词： Solar sails Solar sailing High area-to-mass ratios Solar radiation pressure ChipSail

Generalized gradient projection neural networks for nonsmooth optimization problems

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Science china(Information Sciences) 2010年第5期53卷 990-1005页

作者： li GuoCheng 1 , SONG ShiJi 2 ? & wu Cheng 2 1 department of Mathematics, beijing Information Science and Technology university, beijing 100192, china 2 department of Automation, Tsinghua university, beijing 100084, china department of Mathematics Beijing Information Science and Technology University Beijing China department of Automation Tsinghua University Beijing China

Generalized gradient projection neural network models are proposed to solve nonsmooth convex and nonconvex nonlinear programming problems over a closed convex subset of R n . By using Clarke’s generalized gradient, the neural network modeled by a differential inclusion is developed, and its dynamical behavior and optimization capabilities both for convex and nonconvex problems are rigorously analyzed in the framework of nonsmooth analysis and the differential inclusion theory. First for nonconvex optimization problems, the quasi convergence results similar to those achieved by previous work are proved. For convex optimization problems, the global convergence results are proved, i.e. any trajectory of the neural network converges to an asymptotically stable equilibrium point, which is an optimal solution of the primal problem whenever it exists. This result remains valid even if the initial condition is chosen outside the feasible set. In addition, an asymptotic control result involving a Tykhonov like regularization shows that any trajectory of the revised neural network can be forced to converge toward a particular optimal solution of the primal problem. Finally, two simulation optimization algorithms for solving the optimization and control problems are designed respectively, and three typical simulation experiments are illustrated to present the accuracy and efficiency of theoretical convergence results of this paper.

关键词： nonsmooth optimization problem generalized gradient projection networks differential inclu sions convergence

Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1624-1643页

作者： Can Cheng Hanhui Yao Heng li Jingwen liu Zhengyi liu Yang wu liang Zhu Hejie Hu Zhengdong Fang liang wu department of General Surgery the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China department of Comprehensive Surgery Anhui Provincial Cancer HospitalWest District of the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Provincial Hospital Health Management Center the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China department of Breast Surgery Henan Provincial People's HospitalPeople's Hospital of Zhengzhou UniversityPeople's Hospital of Henan UniversityZhengzhou 450003China

HMGA2,a pivotal transcription factor,functions as a versatile regulator implicated in the progression of diverse aggressive *** this study,mass spectrometry was employed to identify ubiquitin-specific proteases that potentially interact with HMGA2,and USP48 was identified as a deubiquitinating enzyme of *** enforced expression of USP48 significantly increased HMGA2 protein levels by inhibiting its degradation,while the deprivation of USP48 promoted HMGA2 degradation,thereby suppressing tumor invasion and *** discovered that USP48 undergoes SUMOylation at lysine 258,which enhances its binding affinity to *** subsequent phenotypic screening of small molecules,we identified DUB-IN-2 as a remarkably potent pharmacological inhibitor of ***,the small-molecule inhibitor targeting USP48 induces destabilization of ***,upregulation of USP48 or HMGA2 in cancerous tissues is indicative of poor prognosis for patients with colorectal cancer(CRC).Collectively,our study not only elucidates the regulatory mechanism of DUBs involved in HMGA2 stability and validates USP48 as a potential therapeutic target for CRC,but also identifies DUB-IN-2 as a potent inhibitor of USP48 and a promising candidate for CRC treatment.

关键词： Colorectal cancer Invasion and metastasis Post-translational modification Ubiquitination SUMOylation USP48 HMGA2 Specific inhibitors

Implantable CMOS neuro-stimulus chip for visual prosthesis

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Science china(Information Sciences) 2011年第4期54卷 898-908页

作者： ZHANG Xu 1,PEI WeiHua 1,HUANG BeiJu 1,WANG ShuJing 1,GUAN Ning 1,GUO Kai 1,WANG Yu 1,GUI Qiang 1,CHEN Jin 1,WANG Kai 2,wu HuiJuan 2,li XiaoXin 2,li Kai 3 & CHEN HongDa 1 1 State Key Laboratory on Integrated Optoelectronics,Institute of Semiconductors,Chinese Academy of Sciences,beijing 100083,china 2 department of Ophthalmology,People’s Hospital of peking university,beijing 100044,china 3 department of Epidemiology and Biostatistics,Health Science Center,peking university,beijing 100083,china State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Beijing China department of Ophthalmology People’s Hospital of Peking University Beijing China department of Epidemiology and Biostatistics Health Science Center Peking University Beijing China

A prototype chip with 2×2 pixels for implanting in blind patients affected by outer retinal degeneration is presented in this *** visual prosthesis chip imitates the degenerated photoreceptor cells,senses the incident light and stimulates the remaining healthy layers of retina or optic *** pixel integrates photodiode and stimulus pulse generator,converting the illumination on the eyes into 3-bit resolution bi-phasic current ***-chip charge cancellation modules are used to discharge each electrode site for tissue *** prototype chip is designed and fabricated in 0.18-μm N-well CMOS (complementary metal oxide semiconductor) 1P6M Mix-signal process,with a ±2.5 V dual voltage *** functionality of the fabricated chip is demonstrated on anesthetized *** responses in visual cortex are successfully evoked by the neuro-stimulus chip through an on-board trigger interface and flexible electrode.

关键词： biomedical microelectronics visual prosthesis functional electrical stimulation acute animal ex- periment electrical evoked potential (EEP) test

Nucleophilic amino acids as a renewable alternative to petrochemically-derived amines in glycerol epoxy resins

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Journal of Bioresources and Bioproducts 2024年第2期9卷 222-232页

作者： Yunyi liang Yonghong Luo Yingji wu Xiaona li Quyet Van Le Jianzhang li Changlei Xia Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China department of Materials Science and Engineering Institute of Green Manufacturing TechnologyKorea UniversitySeoul 02841South Korea

The standard epoxy resin curing agents revealed are from unsustainable petroleum-based sources,which produce poisonous exhaust when *** acids,a bio-based epoxy curing agent with amino and carboxyl groups,are another potential curing ***-soluble epoxy resins cured with lysine(Lys),glutamic acid(Glu),leucine(Leu),and serine(Ser)as amino acids were *** results showed that the water-soluble epoxy resin(glycerol epoxy resins,GER)was cured with Lys and Glu after *** transform infrared(FT-IR)spectroscopic analysis of the GER-Lys showed that the amino and carboxyl groups of Lys primarily reacted with the epoxy groups of *** elongation at break of Lys-cured GER(GER-Lys)cured at 70℃ with a molar ratio of 1꞉0.75 was 75.32%.The fact that elongations at break of GER-Lys(79.43%)were higher than those of GER-Glu(17.33%),respectively supports the decrease of crosslinking density by the amino acid-cured GER *** potential of Lys and Glu alternatives for petrochemical amines is demonstrated and provides promising opportunities for industrial application.

关键词： Curing agent Amino acids Bio-based epoxy resins Lysine Glutamic acid

Hyperglycemia activates FGFR1 via TLR4/c-Src pathway to induce inflammatory cardiomyopathy in diabetes

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1693-1710页

作者： Xiong Chen Jinfu Qian Shiqi liang Jianchang Qian wu Luo Yujuan Shi Hong Zhu Xiang Hu Gaojun wu Xiaokun li Guang liang department of Endocrinology the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China department of Wound Repair the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China department of Cardiology the First Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China School of Pharmaceutical Sciences Hangzhou Medical CollegeHangzhou 311399China

Protein tyrosine kinases (RTKs) modulate a wide range of pathophysiological events in several non-malignant disorders, including diabetic complications. To find new targets driving the development of diabetic cardiomyopathy (DCM), we profiled an RTKs phosphorylation array in diabetic mouse hearts and identified increased phosphorylated fibroblast growth factor receptor 1 (p-FGFR1) levels in cardiomyocytes, indicating that FGFR1 may contribute to the pathogenesis of DCM. Using primary cardiomyocytes and H9C2 cell lines, we discovered that high-concentration glucose (HG) transactivates FGFR1 kinase domain through toll-like receptor 4 (TLR4) and c-Src, independent of FGF ligands. Knocking down the levels of either TLR4 or c-Src prevents HG-activated FGFR1 in cardiomyocytes. RNA-sequencing analysis indicates that the elevated FGFR1 activity induces pro-inflammatory responses via MAPKs–NFκB signaling pathway in HG-challenged cardiomyocytes, which further results in fibrosis and hypertrophy. We then generated cardiomyocyte-specific FGFR1 knockout mice and showed that a lack of FGFR1 in cardiomyocytes prevents diabetes-induced cardiac inflammation and preserves cardiac function in mice. Pharmacological inhibition of FGFR1 by a selective inhibitor, AZD4547, also prevents cardiac inflammation, fibrosis, and dysfunction in both type 1 and type 2 diabetic mice. These studies have identified FGFR1 as a new player in driving DCM and support further testing of FGFR1 inhibitors for possible cardioprotective benefits.

关键词： Diabetic cardiomyopathy Protein tyrosine kinases FGFR1 Cardiomyocytes Inflammatory responses Toll-like receptor4 c-Src NFkB