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Chinese Journal of Chemical Engineering 2017年第4期25卷 442-452页

作者： Alice Medeiros Lima Antonio Jose Goncalves Cruz wu hong kwong Chemical Engineering Graduate Program Federal University of Sdo CarlosRodovia Washington Luizkm 235-5P310Sao CarlosSP 13565-905Brazil Department of Chemical Engineering Federal University of Sao CarlosRodovia Washington Luizkm 235-SP 310Silo CarlosSP 13565-905Brazil

This paper proposes the use of the flexible tolerance method(FTM) modified with scaling of variables and hybridized with different unconstrained optimization methods to solve real constrained optimization *** benchmark problems used to analyze the performance of the methods were taken from G-Suite *** original method(FTM) and other four proposed methods:(i) FTM with scaling of variables(FTMS),(ii) FTMS hybridized with BFGS(FTMS-BFGS),(iii) FTMS hybridized with modified Powell's method(FTMS-Powell)and(iv) FTMS hybridized with PSO(FTMS-PSO), were implemented. The success rates of the methods were 80%,100%, 75%, 95% and 85%, for FTM, FTMS, FTMS-BFGS, FTMS-Powell and FTMS-PSO, respectively. Numerical experiments including real constrained problems indicated that FTMS gave the best performance, followed by FTMSPowell and FTMS-PSO. Despite the inferior performance compared to FTMS and FTMS-Powell, the FTMS-PSO method presented some advantages since good different initial points could be obtained, which allow exploring different routes through the solution space and to escape from local optima. The proposed methods proved to be an effective way of improving the performance of the original FTM.

关键词： Flexible tolerance method Modified Powell’s method BFGS PSO Scaling Hybridization

An improved flexible tolerance method for solving nonlinear constrained optimization problems:Application in mass integration

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Chinese Journal of Chemical Engineering 2017年第5期25卷 617-631页

作者： Alice Medeiros Lima wu hong kwong Antonio José Goncalves Cruz Chemical Engineering Graduate Program Federal University of Sao Carlos Department of Chemical Engineering Department of Chemical Engineering Federal University of Sao Carlos

This paper proposes the use of the flexible tolerance method(FTM) modified with adaptive Nelder–Mead parameters and barrier to solve constrained optimization problems. The problems used to analyze the performance of the methods were taken from G-Suite functions, and the methods with the best performance were applied in mass integration problems. Four methods were proposed:(1) flexible tolerance method(FTM) using adaptive parameters(FTMA),(2) flexible tolerance method with scaling(FTMS) and with adaptive parameters(FTMAS),(3) FTMS including the barrier modification(MFTMS) and(4) MFTMS hybridized with PSO(MFTMS-PSO). The success rates of these methods were 100%(MFTMS), 85%(MFTMS-PSO), 40%(FTMAS) and 30%(FTMA).Numerical experiments indicated that the MFTMS could efficiently and reliably improve the accuracy of global optima. In mass integration, the method was able, from current process situation, to reach the optimum process configuration that includes integration issues, which was not possible using FTM in its standard formulation. The hybridization of FTMS with PSO(without barrier), FTMS-PSO, was also able to solve mass integration problems efficiently.

关键词： Flexible tolerance method Adaptive parameters Scaling Constrained optimization Barrier PSO Mass integration

Effects of the support material addition on the hydrodynamic behavior of an anaerobic expanded granular sludge bed reactor

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Journal of Environmental Sciences 2017年第4期29卷 224-230页

作者： Tania Pérez-Pérez Gleyce Teixeira Correia wu hong kwong Ileana Pereda-Reyes Deny Oliva-Merencio Marcelo Zaiat Institute of Animal Science San Jose de las Lajas Mayabeque Cuba Department of Chemical Engineering Federal University of Sao Carlos Brazil Process Engineering Centre Instituto Superior Politecnico Jose Antonio Echeverria (Cujae) 11901 114 Street Marianao Havana Cuba Study Centre of Renevaable Energy Technologies Instituto Superior Politecnico rose Antonio Echeverria (Cujae) 11901 114 Street Marianao Havana Cuba Biological Processes Laboratory Center for Research Development and Innovation in Environmental Engineering Sao Carlos School of Engineering University of Sao Paulo Engenharia Ambiental - Bloco 4-F Av. Joao Dagnone 17.00 - Santa Angelina 13.563-120 Sao Carlos SP Brazil

As a support material, zeolite can be used to promote the granulation process due to its high settable property and the ability to retain biomass on its surface. The present paper reports on the influence of zeolite addition on the hydrodynamic behavior of an expanded granular sludge bed reactor（EGSB）. Different models were applied to fit the flow pattern and to compare EGSB hydrodynamic performance with and without the addition of zeolite. The experimental data fit the tanks in a series model for zeolite bed height of 5 cm and upflow velocity of 6 m/*** axial dispersion degree（D/uL） was obtained at lower heights of zeolite. The real hydraulic retention time（HRTr） was increased with both increased zeolite bed height and increased upflow velocity. The short-circuit results for 5 cm of zeolite bed and 6, 8 and 10 m/hr upflow velocity were 0.3, 0.24 and 0.19 respectively, demonstrating the feasibility of using zeolite for a proper hydrodynamic environment to operate the EGSB reactor. The presence of zeolite resulted in the higher percentage values of dead zones, ranging from 12% to 24%.Zeolite addition exerted a positive effect on the hydrodynamics pattern for this technology being advantageous for the anaerobic process because of its possible contribution to better biofilm agglomeration, granule formation and substrate-microorganism contact.

关键词： Anaerobic digestion Axial dispersion degree EGSB reactor Hydrodynamics Upflow velocity Zeolite

Williams-Otto Plant Control Based on Production Planning Associated to Coordinated Decentralized Optimization and Plantwide Control Techniques

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Journal of Chemistry and Chemical Engineering 2016年第2期10卷 77-89页

作者： Anamaria de Oliveira Cardoso wu hong kwong Science and Technology Institute Federal University of Jequitinhonha and Mucuri Valleys Diamantina 39100-000 Brazil Department of Chemical Engineering Federal University of S6o Carlos Sao Carlos 13565-905 Brazil

Manufacturing plants are increasingly complex and integrated, requiring control systems able to identify the interactions between the various operating units. Production planning and control design of a process are tools that, if combined, bring many economic benefits to the processes since they aim to identify and maintain optimal decision operations to a system. This work uses such integration between production planning and plantwide control to propose a control system for the Williams-Otto plant from the definition of the operating optimal point for coordinated decentralized optimization, in which the original optimization problem decomposition into smaller coordinated problems ensure that the found local optimum also meets the requirements of the global system. The results for decentralized optimization are satisfactory and very similar to the global optimum problem and to the control system response proposed based on the optimal obtained. It is effective taking smooth actions, working with （economic） optimal set points （economically） of operation. The unification of production planning techniques and plantwide control techniques is an effective tool for the control system design for entire plants.

关键词： Coordination decentralized optimization plantwide control large-scale systems.

Mathematical Modeling of the Hydrodynamics of an EGSB Reactor

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Journal of Chemistry and Chemical Engineering 2014年第6期8卷 602-610页

作者： Gleyce Teixeira Correia Tania Pérez-Pérez Ileana Pereda-Reyes Deny Oliva Merencio Marcelo Zaiat wu hong kwong Department of Chemical Engineering Federal University of Sao Carlos Sao Carlos 13565-905 Brazil Institute of Animal Science Mayabeque 32700 Cuba Study Center of Process Engineering Instituto Superior Politécnico "José Antonio Eeheverria " Havana 19390 Cuba Study Center of Renewable Energy Technologies lnstituto Superior Politécnico "José Antonio Echeverria " Havana 19390 Cuba Department of Hydraulic and Sanitation School of Engineering of Sao Carlos University of Sao Paulo Sao Carlos 13563-120 Brazil

Generally, in the literature, the hydrodynamic behavior of an EGSB （expanded granular sludge bed） reactor is considered as a complete mix reactor. Few works study in detail the flow of such reactors. The aim of this work was to study, in detail, the hydrodynamics of an EGSB reactor and to propose a mathematical model to describe its flow. A 3.04 L reactor was used with HRT （hydraulic retention time） of 12 h, affluent flowrate of 4 mL·min^-1, and the recirculation flow rate was changed to study three different upflow velocities in the tube （6, 8 and 10 m·h^-1. The pulse input method was used, with the use of blue dextran as tracer. In order to consider the dimensional differences between the tube and the separator, the reactor was divided into two regions （tube and separator）. Initially, a model with two tubular reactors with dispersion in series was proposed and the Peclet number was adjusted for the two regions. It was observed that the region of the tube shows the behavior of a tubular reactor with high dispersion, whereas the region of the separator shows the behavior of a complete mix reactor. In order to simplify the equation, and by knowing that the concentration profile along the reactor was almost constant, a model of two CSTRs （continuous stirred tank reactors） was proposed in series and the number of reactors （N） was set. The best combination was five CSTRs, three in the tube region and two in the separator region. The presented models were equivalent and can be used to describe the hydrodynamic behavior of the EGSB reactor.

关键词： EGSB reactor hydrodynamics mathematical modeling.

Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan Guo hong-Bo Jin Cong-Feng Qiao Yue-Liang wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

High-dense nanocrystalline W-based alloy prepared by hot isostatic pressing with uniform microstructure, ultrahigh hardness and good thermal stability

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Tungsten 2025年第1期7卷 120-136页

作者： Zao-Ming wu Lin He Lin-Sen Ye Xiao-Feng Yang Jia-Jia Zhang hong-Bo Lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.W-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of W-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline W-based alloys has been *** microstructure analysis of nanocrystalline W-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of W and leads to the formation of nanocrystalline W-10Cr-5Y alloy.W-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that W-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

关键词： Hot isostatic pressing Microstructure Nanocrystalline tungsten Thermal stability Vickers hardness

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei wu Ji-Chuan Liu Zi-Ling Shi Quan-hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian wu Hui hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期68卷 46-95页

作者： Zhong-Liang Gong hong-Jie Zhang Yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong Yong Chen Chang-Jiang Yao Yuan-Yuan Zhu Liang-Jin Xu Yu-wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

关键词： photoactive metal complexes earth-abundant metals nonprecious metal complexes luminescence photochemistry