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Momordica charantia fruit extract with antioxidant capacity improves the expression of tyrosine-phosphorylated proteins in epididymal fluid of chronic stress rats

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Journal of Integrative Medicine 2022年第6期20卷 534-542页

作者： Supatcharee Arun Therachon Kamollerd Nareelak Tangsrisakda Sudtida Bunsueb Arada Chaiyamoon Alexander Tsang-Hsien wu Sitthichai Iamsaard Department of Anatomy Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Research Institute for Human High Performance and Health Promotion(Hhp&hp) Khon Kaen UniversityKhon Kaen 40002Thailand The PhD Program for Translational Medicine College of Medical Science and TechnologyTaipei Medical University and Academia SinicaTaipei 11031TaiwanChina Graduate Institute of Medical Sciences National Defense Medical CenterTaipei 114TaiwanChina

Objective:Although the protective effects of Momordica charantia L.(MC)extract on chemical-induced testicular damage have been studied,the preventive effects of MC extract on functional proteins in the epididymis under chronic stress have never been *** study investigated the protective effects of MC fruit extract on protein secretion,especially tyrosine-phosphorylated proteins,in the epididymis of rats exposed to chronic unpredictable stress(CUS).Methods:Total phenolic compounds(TPC),total flavonoid compounds(TFC)and antioxidant capacities of MC extract were *** male rats were divided into 4 groups:control group,CUS group,and 2groups of CUS that received different doses of MC extract(40 or 80 mg/kg).In treated groups,rats were given MC daily,followed by induction of CUS(1 stressor was randomly applied from a battery of 9 potential stressors)for 60 consecutive *** corticosterone and testosterone levels were analyzed after the end of *** of heat-shock protein 70(HSP-70)and tyrosine-phosphorylated proteins present in the fluid of the head and tail of the epididymis were quantified using Western ***:MC extract contained TPC of(19.005±0.270)mg gallic acid equivalents and TFC of(0.306±0.012)mg catechin equivalents per gram,and had 2,2-diphenyl-1-picrylhydrazyl antioxidant capacity of(4.985±0.086)mg trolox equivalents per gram,radical 50%inhibitory concentration of(2.011±0.008)mg/mL and ferric reducing antioxidant power of(23.697±0.819)μmol Fe(Ⅱ)per *** level in the epididymis was significantly increased,while the corticosterone level was significantly improved in groups treated with MC extract,compared to the CUS ***,an 80 mg/kg dose of MC extract prevented the impairments of HSP-70 and tyrosine-phosphorylated protein expressions in the luminal fluid of the epididymis of CUS ***:MC fruit extract had antioxidant activities and improved the functional proteins secreted from

关键词： Momordica charantia L. Antioxidant activity Epididymis Tyrosine-phosphorylated proteins Chronic unpredictable stress

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1111例高原地区健康体检人群hp感染率、抗体分型及logistic回归分析

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公共卫生与预防医学 2024年第2期35卷 53-56页

作者：崔莹金宇刘晓玲龚梅巫雯嘉成都医学院第二附属医院·核工业四一六医院检验科四川成都610000

目的探究1 111例高原地区健康体检人群幽门螺杆菌(hp)感染率、抗体分型,并采用logistic回归分析hp感染的危险因素。方法以2022年1~12月1 111例高原地区健康体检人群为研究对象,统计hp感染率、抗体分型,并采用logistic回归分析hp感染... 详细信息

目的探究1 111例高原地区健康体检人群幽门螺杆菌(hp)感染率、抗体分型,并采用logistic回归分析hp感染的危险因素。方法以2022年1~12月1 111例高原地区健康体检人群为研究对象,统计hp感染率、抗体分型,并采用logistic回归分析hp感染发生的危险因素。结果高原地区健康体检人群中hp感率为62.47%(694/1 111),感染患者中I型hp感染率75.50%(524/694),高于II型hp感染24.50%(170/694),差异有统计学意义(χ^(2)=361.141,Php感染的AUC值大于抗体VacA、Ure阳性单独诊断(Z=6.740、7.608,Php感染发生的危险因素,经常食用大蒜[OR(95%CI)=0.559(0.346~0.903)]为保护因素(P=0.036、0.011、0.014、0.018)。结论高原地区健康体检人群hp感染率及抗体Ure阳性率较高,且慢性胃病史、经常使用腌制类或烧烤类食物等为hp感染发生的危险因素。

关键词：高原地区健康体检人群幽门螺杆菌感染抗体分型 logistic回归分析

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A mathematical analysis:From memristor to fracmemristor

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Chinese Physics B 2022年第6期31卷 1-8页

作者： wu-Yang Zhu Yi-Fei Pu Bo Liu Bo Yu Ji-Liu Zhou College of Computer Science Sichuan UniversityChengdu 610065China College of Physics and Engineering Chengdu Normal UniversityChengdu 611130China Chengdu University of Information Technology Chengdu 610225China

The memristor is also a basic electronic component,just like resistors,capacitors and *** is a nonlinear device with memory *** 2008,with hp’s announcement of the discovery of the TiO2 memristor,the new memristor system,memory capacitor(memcapacitor)and memory inductor(meminductor)were ***-order calculus has the characteristics of non-locality,weak singularity and long term memory which traditional integer-order calculus does not have,and can accurately portray or model real-world problems better than the classic integer-order *** recent years,researchers have extended the modeling method of memristor by fractional calculus,and proposed the fractionalorder memristor,but its concept is not *** paper reviews the existing memristive elements,including integer-order memristor systems and fractional-order memristor *** analyze their similarities and differences,give the derivation process,circuit schematic diagrams,and an outlook on the development direction of fractional-order memristive elements.

关键词： fractional calculus fractional-order memristor fracmemristor,memristor

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Water-Based Environmentally Friendly Pesticide Formulations Based on Cyclodextrin/Pesticide Loading System

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Journal of Renewable Materials 2023年第2期11卷 777-789页

作者： Xinyu Guo Zhe Sun Rui Zhao Hongyi Shang Jiangyu Liu Yong Xu Laihua Liu Xuemin wu Key Lab of Plant-Soil Interaction MOECenter for ResourcesEnvironment and Food SecurityCollege of Resources and Environmental SciencesChina Agricultural UniversityBeijing100193China Innovation Center of Pesticide Research Department of Applied ChemistryCollege of ScienceChina Agricultural UniversityBeijing100193China

Difenoconazole(DIF)is a representative variety of broad-spectrum triazole fungicides and liposoluble ***,the water solubility of DIF is so poor that its application is limited in plant *** addition,the conventional formulations of DIF always contain abundant organic solvents,which may cause pollution of the *** this study,two DIF/cyclodextrins(CDs)inclusion complexes(ICs)were successfully prepared,which were DIF/β-CD IC and DIF/hydroxypropyl-β-CD IC(DIF/hp-β-CD IC).The effect of cyclodextrins on the water solubility and the antifungal effect of liposoluble DIF pesticide were *** to the phase solubility test,the molar ratio and apparent stability constant of ICs were *** transform infrared spectroscopy,thermal gravity analysis,X-ray diffraction and scanning electron microscopy were used systematically to characterize the formation and characteristics of *** results noted that DIF successfully entered the cavities of two *** addition,the antifungal effect test proved the better performance of DIF/hp-β-CD IC,which exceeded that of DIF emulsifiable ***,our study provides informative direction for the intelligent use of liposoluble pesticides with cyclodextrins to develop water-based environmentally friendly formulations.

关键词： Water-based environmentally friendly pesticide formulations difenoconazole β-cyclodextrin hydroxypropyl-β-cyclodextrin inclusion complex preparation characterization

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艾司奥美拉唑镁肠溶片四联方案治疗老年消化性溃疡出血患者疗效及对hp清除率、胃肠激素和不良反应的影响

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老年医学与保健 2024年第2期30卷 493-497,518页

作者：崔红霞吴美英董一韩爱娜青岛市胶州中心医院消化内科山东青岛266300 青岛市胶州中心医院中医科山东青岛266300 青岛市胶州中心医院药学部山东青岛266300

目的分析老年消化性溃疡出血(peptic ulcer bleeding,PUB)患者接受艾司奥美拉唑镁肠溶片四联方案治疗的效果。方法对2019年1月-2023年8月青岛市胶州中心医院收治的180例老年PUB患者的资料进行回顾性分析,根据治疗方法不同分为观察组(n=... 详细信息

目的分析老年消化性溃疡出血(peptic ulcer bleeding,PUB)患者接受艾司奥美拉唑镁肠溶片四联方案治疗的效果。方法对2019年1月-2023年8月青岛市胶州中心医院收治的180例老年PUB患者的资料进行回顾性分析,根据治疗方法不同分为观察组(n=92)及对照组(n=88)。对照组予以雷尼替丁四联方案,观察组予以艾司奥美拉唑镁肠溶片四联方案,疗程均为2周。观察并比较2组疗效、hp清除率、症状改善情况、胃肠激素、炎症因子、不良反应、药物经济学。结果治疗2周后,观察组总有效率及hp清除率均高于对照组(P0.05);观察组治疗有效率的成本-效果(C/E值)低于对照组(Php清除,改善患者症状及胃肠激素水平,缓解炎症反应,药物经济学价值较高,具有一定的临床应用价值。

关键词：老年消化性溃疡出血艾司奥美拉唑镁肠溶片四联方案胃肠激素不良反应

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Effect of Chinese Herbal Medicines on Helicobacter pylori-associated gastroduodenal ulcers: a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2019年第4期39卷 459-465页

作者： Shi Xiaoshuang wu Haomeng Ma Xiangxue Yin Xiaolan Li Xia Ma Jinxin Wang Fengyun Tang Xudong Graduate School Beijing University of Chinese MedicineNo.11Beisanhuandong RoadChaoyang DistrictBeijing 100029China Department of Gastroenterology Xiyuan HospitalChina Academy of Chinese Medical SciencesXiyuan RoadHaidian DistrictBeijing 100091China The Second Affiliated Hospital of Guangzhou University of Chinese Medicine 55 Neihuan XiluXiaoguwei StreetPanyu DistrictGuangzhou Higher Education Mega CenterGuangzhou 510006China

OBJECTIVE: To evaluate the effect and safety of Chinese herbal medicines on Helicobacter pylori(hp)-associated gastroduodenal ***: All randomized controlled trials(RCTs)listed in the PubMed, EMBASE, Cochrane Library,China National Knowledge Infrastructure Database,WanFang, China Science and Technology Journal Database and SinoMed databases that were published in English or Chinese were searched, and the retrieval time range was from database inception to December 31, 2018. A comprehensive Meta-analysis of all publications was performed with RevMan 5.3 software, and the quality of the evidence report-ed in the results of Meta-analysis was analyzed with GRADE profiler software(version 3.6.1). Dichotomous data were analyzed by calculating odds ratios and 95% confidence intervals(CIs). Outcome measures included the hp clearance rate and percentage of adverse ***: Eight trials with 919 participants were included in this Meta-analysis. Compared with the effects of single drug therapy on hp-associated gastroduodenal ulcers, according to the statistical analysis, odds ratios for the hp clearance rate and percentage of adverse effects of Chinese herbal medicines administered as complementary medicines combined with drugs were 3.10 [95% CI(2.21, 4.36),P hp clearance rate and percentage of adverse effects were both very ***: Compared with using the drug therapy only, the combination of Chinese herbal medicines with the drug therapy more effectively eliminates hp and alleviates adverse reactions. However,the available studies were of low quality, and therefore more well-designed studies are required to further confirm the findings.

关键词： Peptic ulcer Helicobacter pylori Medicine,Chinese traditional Review Meta-analysis

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Thermosensitive injectable hydrogel loaded with hypoxia-induced exosomes maintains chondrocyte phenotype through NDRG3-mediated hypoxic response

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中国化学快报:英文版 2023年第8期34卷 227-231页

作者： Xiongbo Song Liling Gu Qiming Yang Jiarui wu Junrong Chen Xiaobin Tian Li Sun Long Chen Medical College Guizhou UniversityGuiyang 550000China Department of Orthopedics Guizhou Provincial People’s HospitalGuiyang 550000China Department of Orthopaedics The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000China

Current clinical treatments cannot effectively delay the progression of osteoarthritis(OA).Consequently,joint replacement surgery is required for late-stage OA when patients cannot tolerate pain and joint ***,the prevention of OA progression in the early and middle stages is an urgent clinical *** a previous study,we demonstrated that NDRG3-mediated hypoxic response might be closely related to the development and progression of *** this study,an injectable thermosensitive hydrogel was established by cross-linking Pluronic F-127 and hyaluronic acid(HA)for the sustained release of hypoxia-induced exosomes(HExos)derived from adipose-derived mesenchymal stem *** demonstrated that for OA at the early and middle stages,the HExos-loaded hp hydrogel could maintain the chondrocyte phenotype by enhancing chondrocyte autophagy,reducing chondrocyte apoptosis,and promoting chondrocyte activity and proliferation through the NDRG3-mediated hypoxic *** novel composite hydrogel,which could activate the NDRG3-mediated hypoxic response,may provide new ideas and a theoretical basis for the treatment of early-and mid-stage OA.

关键词： Osteoarthritis Injectable thermosensitive hydrogel Exosomes Hypoxic response NDRG3

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基于hp-EMD数据分解与CNN-LSTM深度学习的蔬菜价格预测模型

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上海农业学报 2024年第2期40卷 109-117页

作者：何志亚刘闯武官府刘云贵马建强红河哈尼族彝族自治州水利水电勘察设计研究院蒙自661199 河海大学农业科学与工程学院南京211100 红河哈尼族彝族自治州水利水电工程地质勘察咨询规划研究院蒙自661199

现有蔬菜价格预测模型多针对单一品种且稳定性与适用性不足,鉴于此提出一种基于hp滤波法(Hodrick-Prescott filter)与经验模态分解法(Empirical mode decomposition,EMD)分解数据,并耦合卷积神经网络(Convolutional neural network,CNN)与长短期记忆模型(Long short-term memory,LSTM)的蔬菜价格预测模型。hp-EMD方法将价格序列分解为意义明确的分量以分析价格的波动规律,CNN-LSTM方法提取分量特征以提高模型的稳定性。以云南省2019—2021年西红柿、芹菜、菠菜、大白菜和大蒜的价格数据进行模型验证。结果表明:该模型预测的西红柿价格平均相对误差为5.03%、决定系数为0.85、均方根误差为0.30元(人民币,下同)∕kg,DM检验(Diebold mariano test)表明该模型显著优于其他模型。其他蔬菜预测结果的决定系数也均在0.8以上,表明该模型具有良好的适用性。

关键词：蔬菜价格 CNN LSTM 经验模态分解 hp滤波

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气相色谱法测定医用胶中α-氰基丙烯酸正丁酯和柠檬酸三乙酯的含量

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当代化工研究 2024年第5期 64-66页

作者：梅炜华吴小红汪家升董芳芳浙江伽奈维医疗科技有限公司浙江310000

目的:建立医用胶中α-氰基丙烯酸正丁酯和柠檬酸三乙酯含量的气相色谱测定方法。方法:气相色谱法:hp-5毛细管色谱柱;检测器:氢火焰离子化检测器;程序升温:初始温度100℃保持2min,以10℃/min的速率升温至180℃,保持3min;进样口温度:230℃... 详细信息

目的:建立医用胶中α-氰基丙烯酸正丁酯和柠檬酸三乙酯含量的气相色谱测定方法。方法:气相色谱法:hp-5毛细管色谱柱;检测器:氢火焰离子化检测器;程序升温:初始温度100℃保持2min,以10℃/min的速率升温至180℃,保持3min;进样口温度:230℃;检测器温度:250℃;柱流速:2mL/min;进样量:1.0μL,分流比30:1。结果:α-氰基丙烯酸正丁酯在浓度0.10~0.60mg/mL范围内线性良好,线性方程为y=373.54589x+1.08702,线性相关系数为0.9997,准确度为98.8%~100.3%,精密度RSD为0.572%,定量限为1.20ug/mL;柠檬酸三乙酯在浓度0.02~0.12mg/mL范围内线性良好,线性方程为y=259.92943x-0.12898,线性相关系数为0.9995,准确度为100.1%~100.3%,精密度RSD为1.016%,定量限为3.0ug/mL。结论:本法可用于医用胶中α-氰基丙烯酸正丁酯和柠檬酸三乙酯含量的测定。

关键词：气相色谱法医用胶 α-氰基丙烯酸正丁酯柠檬酸三乙酯含量

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甲状腺功能减退及左甲状腺素钠治疗与幽门螺杆菌感染的因果关系:一项孟德尔随机化研究

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临床药物治疗杂志 2024年第6期22卷 23-27页

作者：孙阿宁朱斌武明芬余克富赵志刚首都医科大学附属北京天坛医院药学部北京100070

目的探讨甲状腺功能减退(以下简称甲减)和左甲状腺素钠治疗与幽门螺杆菌(hp)感染的因果关系。方法采用两样本孟德尔随机化(MR)方法,从MRC Integrative Epidemiology Unit(IEU)数据库全基因组关联分析(GWAS)中选择甲减和左甲状腺素钠治疗... 详细信息

目的探讨甲状腺功能减退(以下简称甲减)和左甲状腺素钠治疗与幽门螺杆菌(hp)感染的因果关系。方法采用两样本孟德尔随机化(MR)方法,从MRC Integrative Epidemiology Unit(IEU)数据库全基因组关联分析(GWAS)中选择甲减和左甲状腺素钠治疗与hp感染的数据,使用Pheno Scanner数据库删除与混杂因素和结局相关的单核苷酸多态性,利用逆方差加权法(IVW)、MR-Egger回归法、加权中位数法、简单模式法和加权众数法5种统计方法进行因果推断,MR-Egger Q检验和IVW Q检验2种方法进行异质性检验,MR-Egger截距检验分析水平多效性,留一法评价结果的可靠性。结果IVW结果显示,甲减(OR=1.026,95%CI:1.009~1.043,P=0.003)和左甲状腺素钠治疗(OR=1.742,95%CI:1.123~2.702,P=0.013)与hp感染风险存在正向因果关系。IVW Q检验和MR-Egger Q检验显示不存在异质性(P>0.05),MR-Egger截距检验未检测到潜在的水平多效性(P>0.05),留一法显示分析结果稳健。结论遗传学预测的甲减和左甲状腺素钠治疗与hp感染存在因果关系,提示应加强甲减和接受左甲状腺素钠治疗的患者对hp感染的筛查和预防。

关键词：甲状腺功能减退左甲状腺素钠幽门螺杆菌感染孟德尔随机化

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