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The protective effect of cyclodextrin on the color quality and stability of Cabernet Sauvignon red wine

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Journal of Integrative Agriculture 2024年第1期23卷 310-323页

作者： Caiyun Liu Lulu wu Shuyue Fan Yongsheng Tao Yunkui Li College of Enology Northwest A&F UniversityYangling 712100China Ningxia Helan Mountain’s East Foothill Wine Experiment and Demonstration Station of Northwest A&F University Minning 750104China

The impact of cyclodextrins(CDs)on wine quality and stability remains largely *** study systematically assessed the protective effect of the post-fermentation addition of CDs on color stability of red wine from the viewpoints of color characteristics,copigmentation and phenolic *** grey relational analysis(GRA)and principal component analysis(PCA)methods were employed to dissect the key effective determinants related to color *** addition of CDs induced a significant hyperchromic effect of 8.19-25.40%,a significant bathochromic effect and an enhancement of the color ***,the evolution of anthocyanin forms and the content of monomeric anthocyanins revealed that β-CD is a superior favorable cofactor during wine aging,but for long-term aging,2-hp-β-CD and 2-hp-γ-CD are more beneficial in promoting the formation of polymerized anthocyanins and color *** work provides an important reference for the use of CDs to enhance the color quality and stability of red wines.

关键词： cyclodextrins color properties copigmentation Helan Mountain’s East Foothill red wine aging

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大黄素对动脉粥样硬化的干预

中国组织工程研究与临床康复 2007年第34期11卷 6856-6859页

作者：舒筱灿周利玲吴和平李树平韩伟李辉怀化医学高等专科学校湖南省怀化市418000

目的:观察大黄素对鹌鹑动脉粥样硬化模型血脂水平、血管病理形态的影响。方法:实验于2004-09/2005-01在怀化医学高等专科学校机能实验中心完成(省级示范实验室)。实验分组:选择日本种雄性鹌鹑70只,以普通饲料喂养1周后按随机数字表法分... 详细信息

目的:观察大黄素对鹌鹑动脉粥样硬化模型血脂水平、血管病理形态的影响。方法:实验于2004-09/2005-01在怀化医学高等专科学校机能实验中心完成(省级示范实验室)。实验分组:选择日本种雄性鹌鹑70只,以普通饲料喂养1周后按随机数字表法分为7组,每组10只。正常对照组:喂以普通饲料。高脂对照组:喂以高脂饲料(自配,100g普通饲料中含猪油15g,蛋黄5g,胆固醇1g)。20,40,80mg/kg大黄素组:高脂饲料+大黄素20,40,80mg/kg;吉非罗齐组:高脂饲料+吉非罗齐20mg/kg(降脂药物);维生素E组:高脂饲料+维生素E5mg/kg。各组均以灌胃法喂药,1次/d,连续8周。实验评估:实验8周末测定血清总胆固醇、三酰甘油、高、低密度脂蛋白胆固醇。②实验8周末将鹌鹑麻醉后处死,取出主动脉和左右头臂干动脉,苏木精-伊红染色进行肉眼观察和病理形态学检查。③实验8周末分离出肝脏,称质量,计算肝系数(肝质量/体质量)。结果:纳入鹌鹑70只,均进入结果分析。①脂代谢的变化:实验第8周末,高脂饲料组血清总胆固醇、三酰甘油水平明显高于正常对照组[分别为(8.28±0.85),(6.54±0.25)mmol/L;(1.79±0.15),(1.01±0.14)mmol/L],高密度脂蛋白胆固醇/总胆固醇比值低于正常对照组(分别为49.28±39.02,61.46±22.50),差异均有显著性意义(t=8.320,6.527,5.310,P<0.05);20,40,80mg/kg大黄素组、吉非罗齐组、维生素E组血清总胆固醇、三酰甘油水平低于高脂对照组[分别为(5.65±0.30),(5.05±0.20),(4.65±0.35),(5.25±0.25),(6.48±0.16),(8.28±0.85)mmol/L;(0.94±0.18),(0.84±0.16),(0.80±0.14),(0.82±0.10),(0.91±0.12),(1.79±0.15)mmol/L],高密度脂蛋白胆固醇/总胆固醇比值高于高脂对照组(分别为73.98±41.82,85.15±42.20,95.69±43.42,80.59±41.98,63.58±38.64,49.28±39.02),差异均有显著性意义(t=3.067,4.521,4.210,5.872,6.742,P<0.05)。②动脉组织形态:正常对照组鹌鹑动脉形态正常,高脂饲料组中层平滑肌细胞增生,并向内膜下迁移,内膜水肿,并可见胆固醇结晶。20,40,80mg/kg大黄素组、吉非罗齐组、维生素E组外观接近正常。③肝系数:高脂饲料组肝系数明显高于正常对照组、20,40,80mg/kg大黄素组、吉非罗齐组、维生素E组(分别为2.30±0.25,1.76±0.30,2.10±0.58,1.76±0.23,1.45±0.38,1.80±0.29,1.82±0.21),t=3.872,2.984,3.921,4.273,5.112,3.798.P<0.05。随着大黄素剂量增高,肝系数逐渐降低。结论:大黄素具有抑制动脉粥样硬化,降低血脂的作用,此作用具有剂量依赖性,并且与吉非罗齐和维生素E作用效果相近。

关键词：动脉粥样硬化大黄素吉非罗齐维生素E 鹌鹑

Association between central serous chorioretinopathy and Helicobacter pylori infection: a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1120-1127页

作者： Da-Wen wu Fei-Peng Jiang Ge Ge Mei-Xia Zhang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Research Laboratory of Macular Disease West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To investigate the association between central serous chorioretinopathy(CSC)and Helicobacter pylori(hp)by summarizing all available ***:The Scopus,Embase,EBSCO,PubMed,Web of Science,and Cochrane Library databases for all relevant studies published from inception to October 2022 were searched,and manually searched for relevant reference lists as a *** investigating the association between CSC and hp infection were ***,8 case-control studies were included in the Meta-analysis after study ***:The results showed no significant correlation between hp infection and CSC[odds ratio(OR)1.89,95%confidential interval(CI)0.58–6.15,I2=96%,P=0.29].After subgroup analysis based on the degree of development of the study(developing/developed countries),it was found that the results of the two subgroups were the same as the whole,and no significant difference between the two subgroups ***-regression showed that the effect of sample size on heterogeneity among studies was more prominent(Php infection and CSC,which still warrants further well-designed extensive sample studies to reach a more reliable conclusion and promote a better understanding of the treatment of CSC.

关键词： central serous chorioretinopathy Helicobacter pylori infection retinal diseases Meta-analysis

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飞秒激光辅助超声乳化成熟期硬核白内障手术

中华眼外伤职业眼病杂志 2018年第3期40卷 170-175页

作者：何雪洪陈伟张广斌吴护平李孟琼毛益辉厦门大学附属厦门眼科中心白内障科厦门361001 厦门大学附属厦角膜病科厦门361001

目的评价飞秒激光辅助成熟期硬核白内障超声乳化手术的效果。方法回顾性分析2015年1月至2016年5月，4级硬核成熟期白内障手术67例（67只眼）的临床资料。患者随机分为两组，分别用传统超声乳化术和飞秒激光辅助超声乳化术两种方式进行... 详细信息

目的评价飞秒激光辅助成熟期硬核白内障超声乳化手术的效果。方法回顾性分析2015年1月至2016年5月，4级硬核成熟期白内障手术67例（67只眼）的临床资料。患者随机分为两组，分别用传统超声乳化术和飞秒激光辅助超声乳化术两种方式进行手术。其中传统超声乳化组35例（35只眼），飞秒激光组32例（32只眼）。术后随访3个月。结果两组患者的年龄、术前视力及晶状体核硬度差异均无统计学意义（P〉0．05）。飞秒激光组累积超乳能量为（16．80±5．23）％，较传统超乳组的（24．41±10．29）％少（t=-3．760，P=0．000）。飞秒激光组有效超乳时间为（59．68±15．95）s，较传统超乳组的（87．53±25．37）s短（t=-5．320，P=0．000）。飞秒激光组术后角膜内皮水肿发生率更低。术后1周传统超乳组的角膜内皮细胞丢失量为（115．1±53．6）个／mm^2，高于飞秒激光组的（59．6±33．9）个／mm^2（t=0．047，P=0．000）；术后1个月传统超乳组角膜内皮细胞丢失量为（134．3±53．5）个／mm^2，仍高于飞秒激光组（91．9±45．3）个／mm^2（t=0．498，P=0．001）；术后3个月两组之间差异无统计学意义（t=0．505，P=0．163）。结论飞秒激光技术用于成熟期硬核白内障手术，可缩短超声乳化时间，降低超声乳化能量，术后角膜水肿发生率降低。

关键词：白内障晶状体超声乳化激光飞秒角膜内皮

Influence of sintering time on microstructure and properties of hot oscillatory pressing sintered W–Cu refractory alloys

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Tungsten 2024年第2期6卷 323-332页

作者： Zi-Qian wu Wei Zhao Ka Gao Shi-Hao Du Qing-Quan Kong De-Jian Sun Yang Gao School of Materials Science and Engineering Zhengzhou University of AeronauticsZhengzhou 450015China School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of General Medicine Changhai HospitalShanghai 200000China Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering Wuhan University of Science and TechnologyWuhan 430081China Sichuan Province Engineering Technology Research Center of Powder Metallurgy Chengdu UniversityChengdu 610106China

W–Cu refractory alloys are widely used in aerospace,aviation,electronics,power,and other fi ***,because of its large melting point diff erence between alloy elements,the conventional powder metallurgy method required a long time of high temperature sintering is very likely to cause low density and abnormal grain size ***,90W-10Cu refractory alloys were successfully prepared by hot oscillatory pressing(HOP)under diff erent sintering time in this *** the infl uence of sintering time on the microstructure,grain size,density,Vickers hardness,room-tensile property,and electrical conductivity of the W–Cu refractory alloy was systematically *** results showed that during the short sintering time(30–90 min),the density,Vickers hardness,tensile strength,and electrical conductivity of the W–Cu refractory alloy increased signifi cantly to 98.7%,163.29 HV 30,507.3 MPa,and 14.2%International Annealed Copper Standard with the sintering time increasing,respectively,while its grain size showed no obvious *** the sintering time further increased to 120 min,the density was basically consistent with the sintering time of 90 ***,the prolonged high temperature sintering resulted in the grain growth of the samples,which caused the deterioration of the Vickers hardness,room-tensile strength,and conductivity properties of the W–Cu refractory *** the same sintering time,the density,Vickers hardness,and electrical conductivity of the HOP sintered W–Cu refractory alloy were signifi cantly higher than those of the hp sintered *** was indicated that high density,fi ne-grain,and excellent properties W–Cu refractory alloys could be prepared by hot oscillatory pressing under appropriate sintering time.

关键词： W–Cu refractory alloy Hot oscillatory pressing Sintering time Microstructure Property

Human Placental Mesenchymal Stem Cells Relieve Primary Sclerosing Cholangitis via Upregulation of TGR5 in Mdr2^(-/-)Mice and Human Intrahepatic Cholangiocyte Organoid Models

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Research 2024年第2期2023卷 355-372页

作者： Qigu Yao Wenyi Chen Yingduo Yu Feiqiong Gao Jiahang Zhou Jian wu Qiaoling Pan Jinfeng Yang Lingling Zhou Jiong Yu Hongcui Cao Lanjuan Li State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases Cllaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affliated HospitalZhejang University School of Medicine79 Qingchun Rd.Hangzhou 310003China National Clinical Research Center for Infectious Diseases HangzhouChina Key Laboratory of Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province 79 Qingchun Rd.Hangzhou 310003China Jjinan Microecological Biomedicine Shandong Laboratory Jinan 250117China

Primary sclerosing cholangitis(PSC)is a biliary disease accompanied by chronic inflammation of the liver and biliary *** stem cells(MSCs)are used to treat liver diseases because of their immune regulation and regeneration-promoting *** study was performed to explore the therapeutic potential of human placental MSCs(hp-MSCs)in PSC through the Takeda G protein-coupled receptor 5(TGR5)receptor *** tissues were collected from patients with PSC and healthy donors(n=4)for RNA sequencing and intrahepatic cholangiocyte organoid ***-MSCs were injected via the tail vein into Mdr2^(-/-),bile duct ligation(BDL),and 3,5-diethoxycarbonyl-1,4-dihydrocollidine(DDC)mouse models or co-cultured with organoids to confirm their therapeutic effect on biliary *** in bile acid metabolic profile were analyzed by liquid chromatography/tandem mass spectrometry(LC-MS/MS).Compared with healthy controls,liver tissues and intrahepatic cholangiocyte organoids from PSC patients were characterized by inflammation and cholestasis,and marked downregulation of bile acid receptor TGR5 ***-MSC treatment apparently reduced the inflammation,cholestasis,and fibrosis in Mdr2^(-/-),BDL,and DDC model *** activating the phosphatidylinositol 3 kinase/extracellular signal-regulated protein kinase pathway,hp-MSC treatment promoted the proliferation of cholangiocytes,and affected the transcription of downstream nuclear factorκB through regulation of the binding of TGR5 and Pellino3,thereby affecting the cholangiocyte inflammatory phenotype.

关键词： inflammation TGR5 Human

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

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Signal Transduction and Targeted Therapy 2024年第1期9卷 105-149页

作者： Yumin Wang Jing Hu Shuang wu Joshua S.Fleishman Yulin Li Yinshi Xu Wailong Zou Jinhua Wang Yukuan Feng Jichao Chen Hongquan Wang Department of Respiratory and Critical Care Medicine Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Department of Pathogen Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300060PR China Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhan 430000PR China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA Department of Outpatient Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Beijing Key Laboratory of Drug Target and Screening Research Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050PR China Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060PR China

Ferroptosis,a unique modality of cell death with mechanistic and morphological differences from other cell death modes,plays a pivotal role in regulating tumorigenesis and offers a new opportunity for modulating anticancer drug *** epigenetic modifications and posttranslational modifications(PTMs)promote anticancer drug resistance,cancer progression,and *** studies indicate that epigenetic modifications can transcriptionally and translationally determine cancer cell vulnerability to ferroptosis and that ferroptosis functions as a driver in nervous system diseases(NSDs),cardiovascular diseases(CVDs),liver diseases,lung diseases,and kidney *** this review,we first summarize the core molecular mechanisms of ***,the roles of epigenetic processes,including histone PTMs,DNA methylation,and noncoding RNA regulation and PTMs,such as phosphorylation,ubiquitination,SUMOylation,acetylation,methylation,and ADP-ribosylation,are concisely *** roles of epigenetic modifications and PTMs in ferroptosis regulation in the genesis of diseases,including cancers,NSD,CVDs,liver diseases,lung diseases,and kidney diseases,as well as the application of epigenetic and PTM modulators in the therapy of these diseases,are then discussed in *** the mechanisms of ferroptosis regulation mediated by epigenetic modifications and PTMs in cancer and other diseases will facilitate the development of promising combination therapeutic regimens containing epigenetic or PTM-targeting agents and ferroptosis inducers that can be used to overcome chemotherapeutic resistance in cancer and could be used to prevent other *** addition,these mechanisms highlight potential therapeutic approaches to overcome chemoresistance in cancer or halt the genesis of other diseases.

关键词： diseases epigenetic overcome

The role of exercise in modulating the hp pathway to reduce glioma-induced epilepsy

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Traditional Medicine Research 2024年第12期9卷 66-74页

作者： Fu-Jun Shi Wei Cai Nan wu Yang Li Department of Neurosurgery Yinchuan First People’s Hospital Affiliated to Ningxia Medical UniversityYinchuan 750001China Department of Neurosurgery Tianjin Children’s HospitalTianjin 300000China

Background:Glioma-induced refractory epilepsy can be alleviated through conventional exercise,providing a potential therapeutic approach to manage this *** study aims to investigate the underlying ***:Bioinformatics methodologies were employed to scrutinize gene expression data from public repositories such as GEO,with a specific focus on mobility-related genes in *** differential and enrichment analyses,differentially expressed genes(DEGs)were identified,while protein-protein interaction networks elucidated pivotal hub ***:Our analysis revealed 32 DEGs,comprising 23 upregulated and 9 downregulated *** analysis underscored significant alterations in immune pathways in *** central hub genes,haptoglobin(hp)and prostaglandin-endoperoxide synthase 2(PTGS2),were found to be modulated by Arginase 1(ARG1)and Chemokine(C-X-C motif)ligand 8(CXCL8).GSVA analysis associated elevated PTGS2 expression with metabolic pathways,while increased hp expression was correlated with angiogenesis and *** experiments validated hp’s role in tumor cell proliferation,emphasizing its potential as a therapeutic ***:This study highlights the crucial involvement of hp and PTGS2 genes in the etiology of epilepsy,linked to discrepancies in the immune *** findings offer fresh perspectives on the management of epilepsy,emphasizing the neuroprotective possibilities of targeting specific gene pathway.

关键词： epilepsy gene expression bioinformatics immune pathways protein-protein interaction hub genes

基于改进hp自适应RPM的客机最速爬升轨迹优化

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计算机应用与软件 2024年第6期41卷 134-141,193页

作者：吴凯北京飞机维修工程有限公司西南航线中心一大队一中队四川成都610200

针对客机最快时间爬升优化问题,采用改进hp自适应Radau伪谱法将客机爬升连续时间最优控制问题离散化为非线性规划问题进行求解。实验仿真结果验证,优化得到的客机爬升轨迹在满足客机性能约束以及乘客乘机体验的前提下完成最快时间爬升,... 详细信息

针对客机最快时间爬升优化问题,采用改进hp自适应Radau伪谱法将客机爬升连续时间最优控制问题离散化为非线性规划问题进行求解。实验仿真结果验证,优化得到的客机爬升轨迹在满足客机性能约束以及乘客乘机体验的前提下完成最快时间爬升,达到巡航高度以及巡航速度。与hp自适应Radau伪谱法相比,在保证优化解最优性的基础上,以更高的求解效率优化客机爬升轨迹。

关键词：民航飞机轨迹优化伪谱法