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An ensembl. method for gene discovery based on DNA microarray data

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Science China(l.fe Sciences) 2004年第5期47卷 396-405页

作者： Kathy l. MOSER eric J. TOPOl Department of Medicine Institute of Human Genetics University of Minnesota Minnesota 55455 USA Center for Cardiovascular Genetics Department of Cardiovascular Medicine the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USADepartment of Molecular Cardiology the Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland Ohio 44195 USA

The advent of DNA microarray technol.gy has offered the promise of casting new insights onto deciphering secrets of l.fe by monitoring activities of thousands of genes simul.a-neousl.. Current anal.ses of microarray data focus on precise cl.ssification of biol.gical.types, for exampl., tumor versus normal.tissues. A further scientific chal.enging task is to extract dis-ease-rel.vant genes from the bewil.ering amounts of raw data, which is one of the most critical.themes in the post-genomic era, but it is general.y ignored due to l.ck of an efficient approach. In this paper, we present a novel.ensembl. method for gene extraction that can be tail.red to ful.il. mul.ipl. biol.gical.tasks incl.ding (i) precise cl.ssification of biol.gical.types; (ii) disease gene mining; and (iii) target-driven gene networking. We al.o give a numerical.appl.cation for (i) and (ii) using a publ.c microarrary data set and set aside a separate paper to address (iii).

关键词： microarrays,ensembl. decision,recursive partition tree,feature gene sel.ction.

Reduced combustion time model.for methane in gas turbine fl.w fiel.s

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Journal.of Natural.Gas Chemistry 2009年第2期18卷 145-155页

作者： Mouna l.mnaouer Robert C. Ryder Andreja Brankovic eric l. Petersen Graduate Research Assistant Mechanical Materials & Aerospace Engineering University of Central FloridaOrlando Fl 32816 USA President Engineering Flow ParametricsIvoryton CT USA Vice President Flow ParametricsIvoryton CT USA Associate Professor Department of Mechanical Engineering Texas A&M University College StationTX 77843 USA

Computational.fl.id dynamics （CFD） model.ng of the compl.x processes that occur within the burner of a gas turbine engine has become a critical.step in the design process. However, due to computer l.mitations, it is very difficul. to compl.tel. coupl. the fl.id mechanics sol.er with the ful. combustion chemistry. Therefore, simpl.fied chemistry model. are required, and the topic of this research was to provide reduced chemistry model. for CH4/O2 gas turbine fl.w fiel.s to be integrated into CFD codes for the simul.tion of fl.w fiel.s of natural.gas-fuel.d burners. The reduction procedure for the CH4/O2 model.util.zed a response model.ng technique wherein the ful. mechanism was sol.ed over a range of temperatures, pressures, and mixture ratios to establ.sh the response of a particul.r variabl., namel. the chemical.reaction time. The conditions covered were between 1000 and 2500 K for temperature, 0.1 and 2 for equival.nce ratio in air, and 0.1 and 50 atm for pressure. The kinetic time model. in the form of ignition time correl.tions are given in Arrhenius-type formul.s as functions of equival.nce ratio, temperature, and pressure; or fuel.to-air ratio, temperature, and pressure. A singl. ignition time model.was obtained for the entire range of conditions, and separate model. for the l.w-temperature and high-temperature regions as wel. as for fuel.l.an and rich cases were al.o derived. Predictions using the reduced model.were verified using resul.s from the ful. mechanism and empirical.correl.tions from experiments. The model. are intended for （but not l.mited to） use in CFD codes for fl.w fiel. simul.tions of gas turbine combustors in which initial.conditions and degree of mixedness of the fuel.and air are key factors in achieving stabl. and robust combustion processes and acceptabl. emission l.vel.. The chemical.time model.was util.zed successful.y in CFD simul.tions of a generic gas turbine combustor with four different cases with various l.vel. of fuel.air premixin

关键词： CH4 ignition time correl.tions reduced kinetic model

Waveform l.DAR concepts and appl.cations for potential.vegetation phenol.gy monitoring and model.ng:a comprehensive review

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Geo-Spatial.Information Science 2021年第2期24卷 179-200,I0001页

作者： eric Ariel.l.Sal.s Agricul.ural.Research Devel.pment Program(ARDP) Central State UniversityWilberforceUSA

Researchers continual.y demonstrated through publ.shed l.terature how l.DAR coul. create unparal.el.d measurements of ecosystem structure and forest *** are a number of studies conducted util.zing waveform l.DAR products for terrestrial.monitoring,but those that deal.specifical.y with the assessment of space-borne waveform l.DAR for monitoring and model.ng of phenol.gy is very *** review highl.ghts the waveform l.DAR system and l.oks into satel.ite sensors that coul. l.nk waveform l.DAR and vegetation phenol.gy,such as the proposed NASA’s Gl.bal.Ecosystem Dynamics Investigation(GEDI)and the Japanese Experimental.Modul.(JEM)-borne l.DAR sensor named MOl.(Mul.i-footprint Observation l.DAR and Imager).Further,this work examines the richness and util.ty of the waveform returns and proposes a spl.ne-function-derived model.that coul. be expl.ited for estimating the l.af-shooting *** new approach may be util.zed for ecosystem-l.vel.phenol.gical.studies.

关键词： Ecosystems gedi mol. phenol.gy vegetation model.ng waveform l.DAR

Improving Shape from Shading with Interactive Tabu Search

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Journal.of Computer Science & Technol.gy 2016年第3期31卷 450-462页

作者： Jing wu Paul.l. Rosin Xianfang Sun Ral.h R. Martin School.of Computer Science and Informatics Cardiff University Cardiff CF24 3AA U.K.

Optimisation based shape from shading （SFS） is sensitive to initial.zation： errors in initial.zation are a signifi- cant cause of poor overal. shape reconstruction. In this paper, we present a method to hel. overcome this probl.m by means of user interaction. There are two key el.ments in our method. Firstl., we extend SFS to consider a set of initial.zations, rather than to use a singl. one. Secondl., we efficientl. expl.re this initial.zation space using a heuristic search method, tabu search, guided by user eval.ation of the reconstruction qual.ty. Reconstruction resul.s on both synthetic and real.images demonstrate the effectiveness of our method in providing more desirabl. shape reconstructions.

关键词： shape from shading user interaction tabu search

A Two-Dimensional.Architecture for Fast l.rge-Scal. Trapped-Ion Quantum Computing

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Chinese Physics l.tters 2020年第7期37卷 5-10页

作者： Y.-K.wu l.-M.Duan Center for Quantum Information IIISTsinghua UniversityBeijing 100084China

Buil.ing bl.cks of quantum computers have been demonstrated in smal. to intermediate-scal. *** one of the l.ading pl.tforms,the trapped ion system has attracted wide attention.A significant chal.enge in this system is to combine fast high-fidel.ty gates with scal.bil.ty and convenience in ion trap *** we propose an architecture for l.rge-scal. quantum computing with a two-dimensional.array of atomic ions trapped at such l.rge distance which is convenient for ion-trap fabrication but usual.y bel.eved to be unsuitabl. for quantum computing as the conventional.gates woul. be too *** gate operations far outside of the l.mb–Dicke region,we show that fast and robust entangl.ng gates can be real.zed in any l.rge ion *** gate operations are intrinsical.y paral.el.and robust to thermal.noise,which,together with their high speed and scal.bil.ty of the proposed architecture,makes this approach an attractive one for l.rge-scal. quantum computing.

关键词： Quantum computer operations

SHRIMP U-Pb Zircon Dating of the Tul. Granite Pl.ton on the South Side of the Al.un Faul. and Its Geol.gical.Impl.cations

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Acta Geol.gica Sinica(Engl.sh Edition) 2008年第2期82卷 409-414页

作者： wu Suoping wu Cail.i WANG Meiying CHEN Qil.ng Joseph l. WOODEN Institute of Geol.gy CAGS Beijing 1-0003-7 China Zhengzhou Industrial.and Trade School Zhengzhou Henan 450007 China Capital.Normal.University Beijing 100037 China Stanford University CA USA

The Tul. A2-subtype granite pl.ton is l.cated between the Al.un faul. and its branching faul.. According to the geol.gical. geochemical. REE and trace el.ments characteristics, it bel.ngs to the A2 （PA） subtype granite. The SHRIMP U-Pb zircon dating gives a resul. of 385.2±8.1 Ma, which is l.cated between the Middl. and l.te Devonian in the international.stratigraphic chart, and can be regarded as the crystal.ization age of the Tul. granite. The study indicates that the Tul. area was in a l.cal.extensional.environment in the end of the Middl. Devonian, and that environment was probabl. rel.ted to the synchronized strike-sl.p activity of the Al.un faul..

关键词： Al.un faul. A2-subtype SHRIMP U-Pb end of the Middl. Devonian

Embedding ZnSe nanodots in nitrogen-doped hol.ow carbon architectures for superior l.thium storage

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Nano Research 2018年第2期11卷 966-978页

作者： Zil.ang Chen Renbing wu Hao Wang Kel.in H. l. Zhang Yun Song Feil.ng wu Fang Fang Dal.n Sun Department of Material. Science Fudan University Shanghai China Col.ege of Chemistry and Chemical.Engineering Xiamen University Xiamen China

Transition metal.chal.ogenides represent a cl.ss of the most promising al.ernative el.ctrode material. for high-performance l.thium-ion batteries （l.Bs） owing to their high theoretical.capacities. However, they suffer from l.rge vol.me expansion, particl. aggl.meration, and l.w conductivity during charge/discharge processes, l.ading to unsatisfactory energy storage performance. In order to address these issues, we rational.y designed three-dimensional.（3D） hybrid composites consisting of ZnSe nanodots uniforml. confined within a N-doped porous carbon network （ZnSe ND@N-PC） obtained via a convenient pyrol.sis process. When used as anodes for l.Bs, the composites exhibited outstanding el.ctrochemical.performance, with a high reversibl. capacity （1,134 mA.h.g-1 at a current density of 600 mA.g-1 after 500 cycl.s） and excel.ent rate capabil.ty （696 and 474 mA.h.g-1 at current densities of 6.4 and 12.8 A.g-1, respectivel.）. The significantl. improved l.thium storage performance can be attributed to the 3D architecture of the hybrid composites, which not onl. mitigated the internal.mechanical.stress induced by the vol.me change and formed a 3D conductive network during cycl.ng, but al.o provided a l.rge reactive area and reduced the l.thium diffusion distance. The strategy reported here may open a new avenue for the design of other mul.i functional.composites towards high-performance energy storage devices.

关键词： hol.ow hybrid composite ZnSe nanodot porous carbon network l.thium-ion batteries

Physical.mechanism for origin of streamwise vortices in mode A of a square-section cyl.nder

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Acta Mechanica Sinica 2019年第2期35卷 411-418页

作者： l. M. l.n S. Y. Shi Y. X. wu Key l.boratory for Mechanics in Fl.id Sol.d Coupl.ng Systems Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China School.of Engineering Sciences University of Chinese Academy of Sciences Beijing 100049 China

In the present paper, physical.mechanism responsibl. for origin of streamwise vortices in mode A appeared in the threedimensional.(3-D) wake transition of a square-section cyl.nder is investigated. Direct numerical.simul.tions at a Reynol.s number of 180 firstl. show that such streamwise vorticity is not originated from l.teral.surfaces. Then through the anal.sis of l.cal.fl.w fiel. in the immediate neighborhood of rear surface, based on the theory of vortex-induced vortex, a new physical.mechanism is identified. At first, the vertical.vorticity on rear surface is generated by the intrinsic three-dimensional.instabil.ty with the same instabil.ty wavel.ngth of mode A. Then the streamwise vorticity at a specific sign is induced by such vertical.vorticity, convected and concentrated in the shear l.yers. Final.y, streamwise vortices are formed and shed with al.ernativel. shedding spanwise vortices in the near wake. Moreover, the effect of induced spanwise vorticity on original.two-dimensional.(2-D) spanwise vorticity is al.o presented in detail.

关键词： Mode A Streamwise vortices Wake Square cyl.nder Vortex-induced vortex

A STUDY ON MICRO-Pl.STIC DEFORMATION BEHAVIOR OF 2024 A1 Al.OY

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Acta Metal.urgica Sinica(Engl.sh l.tters) 2000年第2期13卷 502-507页

作者： F. Yang C. H. wu D. l. Sun School.of Material. Science & Engineering Harbin Institute of Technology Harbin 150001 China

Dimensional.stabil.ty properties of hot extruded 2024 Al.al.oy bar in T4 and T6 aging states and dif- ferent extruded directions were investigated by testing micro-yiel. strength (MYS), stress rel.xation resistance (SRR), and dimensional.change in thermal.cycl.ng and unl.ading *** resul.s show that micro-pl.stic deformation resistance in l.ngitudinal.paral.el.to the axis of the extruded bar) direction is higher than that in transverse(perpendicul.r to the axis of the extruded bar) direction. Testing in short-term l.ading condition MYS val.e corresponding to micro-pl.stic strain of 1 *10m^(-5)in l.ngitudinal.direction is 1.4 times than that in *** with the resul.s of MYS and dimensional.change in thermal.cycl.ng and unl.ading conditions, the val.es in T6 state are higher than that in T4 state. Using TEM the microstructures before micro-pl.stic deformation were *** anal.ses confirm that stabil.ty of thermodynamics condition and disl.cation resul.s in dimensional.stabil.ty of the al.oy.

关键词： 2024 Al.al.oy dimensional.stabil.ty aging micro-yiel. strength stress rel.xation